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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-116 Sentence denotes Activation of VCAM-1 and its associated molecule CD44 leads to increased malignant potential of breast cancer cells.
TextSentencer_T2 117-324 Sentence denotes VCAM-1 (CD106), a transmembrane glycoprotein, was first reported to play an important role in leukocyte adhesion, leukocyte transendothelial migration and cell activation by binding to integrin VLA-1 (α4β1).
TextSentencer_T3 325-554 Sentence denotes In the present study, we observed that VCAM-1 expression can be induced in many breast cancer epithelial cells by cytokine stimulation in vitro and its up-regulation directly correlated with advanced clinical breast cancer stage.
TextSentencer_T4 555-792 Sentence denotes We found that VCAM-1 over-expression in the NMuMG breast epithelial cells controls the epithelial and mesenchymal transition (EMT) program to increase cell motility rates and promote chemoresistance to doxorubicin and cisplatin in vitro.
TextSentencer_T5 793-1040 Sentence denotes Conversely, in the established MDAMB231 metastatic breast cancer cell line, we confirmed that knockdown of endogenous VCAM-1 expression reduced cell proliferation and inhibited TGFβ1 or IL-6 mediated cell migration, and increased chemosensitivity.
TextSentencer_T6 1041-1191 Sentence denotes Furthermore, we demonstrated that knockdown of endogenous VCAM-1 expression in MDAMB231 cells reduced tumor formation in a SCID xenograft mouse model.
TextSentencer_T7 1192-1300 Sentence denotes Signaling studies showed that VCAM-1 physically associates with CD44 and enhances CD44 and ABCG2 expression.
TextSentencer_T8 1301-1495 Sentence denotes Our findings uncover the possible mechanism of VCAM-1 activation facilitating breast cancer progression, and suggest that targeting VCAM-1 is an attractive strategy for therapeutic intervention.
T1 0-116 Sentence denotes Activation of VCAM-1 and its associated molecule CD44 leads to increased malignant potential of breast cancer cells.
T2 117-324 Sentence denotes VCAM-1 (CD106), a transmembrane glycoprotein, was first reported to play an important role in leukocyte adhesion, leukocyte transendothelial migration and cell activation by binding to integrin VLA-1 (α4β1).
T3 325-554 Sentence denotes In the present study, we observed that VCAM-1 expression can be induced in many breast cancer epithelial cells by cytokine stimulation in vitro and its up-regulation directly correlated with advanced clinical breast cancer stage.
T4 555-792 Sentence denotes We found that VCAM-1 over-expression in the NMuMG breast epithelial cells controls the epithelial and mesenchymal transition (EMT) program to increase cell motility rates and promote chemoresistance to doxorubicin and cisplatin in vitro.
T5 793-1040 Sentence denotes Conversely, in the established MDAMB231 metastatic breast cancer cell line, we confirmed that knockdown of endogenous VCAM-1 expression reduced cell proliferation and inhibited TGFβ1 or IL-6 mediated cell migration, and increased chemosensitivity.
T6 1041-1191 Sentence denotes Furthermore, we demonstrated that knockdown of endogenous VCAM-1 expression in MDAMB231 cells reduced tumor formation in a SCID xenograft mouse model.
T7 1192-1300 Sentence denotes Signaling studies showed that VCAM-1 physically associates with CD44 and enhances CD44 and ABCG2 expression.
T8 1301-1495 Sentence denotes Our findings uncover the possible mechanism of VCAM-1 activation facilitating breast cancer progression, and suggest that targeting VCAM-1 is an attractive strategy for therapeutic intervention.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 49-53 gene:960 denotes CD44
T1 96-109 disease:C0678222 denotes breast cancer
T2 49-53 gene:960 denotes CD44
T3 96-109 disease:C0006142 denotes breast cancer
T4 14-20 gene:7412 denotes VCAM-1
T5 96-109 disease:C0678222 denotes breast cancer
T6 14-20 gene:7412 denotes VCAM-1
T7 96-109 disease:C0006142 denotes breast cancer
T8 364-370 gene:7412 denotes VCAM-1
T9 405-418 disease:C0006142 denotes breast cancer
T10 364-370 gene:7412 denotes VCAM-1
T11 534-553 disease:C2216702 denotes breast cancer stage
T12 364-370 gene:7412 denotes VCAM-1
T13 405-418 disease:C0678222 denotes breast cancer
T14 1433-1439 gene:7412 denotes VCAM-1
T15 1379-1392 disease:C0678222 denotes breast cancer
T16 1433-1439 gene:7412 denotes VCAM-1
T17 1379-1392 disease:C0006142 denotes breast cancer
T18 1348-1354 gene:7412 denotes VCAM-1
T19 1379-1392 disease:C0678222 denotes breast cancer
T20 1348-1354 gene:7412 denotes VCAM-1
T21 1379-1392 disease:C0006142 denotes breast cancer
R1 T0 T1 associated_with CD44,breast cancer
R2 T2 T3 associated_with CD44,breast cancer
R3 T4 T5 associated_with VCAM-1,breast cancer
R4 T6 T7 associated_with VCAM-1,breast cancer
R5 T8 T9 associated_with VCAM-1,breast cancer
R6 T10 T11 associated_with VCAM-1,breast cancer stage
R7 T12 T13 associated_with VCAM-1,breast cancer
R8 T14 T15 associated_with VCAM-1,breast cancer
R9 T16 T17 associated_with VCAM-1,breast cancer
R10 T18 T19 associated_with VCAM-1,breast cancer
R11 T20 T21 associated_with VCAM-1,breast cancer

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 405-418 HP_0003002 denotes breast cancer
T2 405-418 HP_0100013 denotes breast cancer
T3 412-418 HP_0002664 denotes cancer
T4 534-547 HP_0003002 denotes breast cancer
T5 534-547 HP_0100013 denotes breast cancer
T6 541-547 HP_0002664 denotes cancer
T7 844-857 HP_0003002 denotes breast cancer
T8 844-857 HP_0100013 denotes breast cancer
T9 851-857 HP_0002664 denotes cancer
T10 1143-1148 HP_0002664 denotes tumor
T11 1379-1392 HP_0003002 denotes breast cancer
T12 1379-1392 HP_0100013 denotes breast cancer
T13 1386-1392 HP_0002664 denotes cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_24583847_3_0 642-679 expanded denotes epithelial and mesenchymal transition
SS2_24583847_3_0 681-684 abbr denotes EMT
AE1_24583847_3_0 SS1_24583847_3_0 SS2_24583847_3_0 abbreviatedTo epithelial and mesenchymal transition,EMT

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
24583847-0#14#20#gene7412 14-20 gene7412 denotes VCAM-1
24583847-0#49#53#gene960 49-53 gene960 denotes CD44
24583847-0#96#109#diseaseC0006142 96-109 diseaseC0006142 denotes breast cancer
24583847-0#96#109#diseaseC0678222 96-109 diseaseC0678222 denotes breast cancer
24583847-0#96#109#diseaseC0006142 96-109 diseaseC0006142 denotes breast cancer
24583847-0#96#109#diseaseC0678222 96-109 diseaseC0678222 denotes breast cancer
24583847-2#39#45#gene7412 364-370 gene7412 denotes VCAM-1
24583847-2#209#228#diseaseC2216702 534-553 diseaseC2216702 denotes breast cancer stage
14#20#gene741296#109#diseaseC0006142 24583847-0#14#20#gene7412 24583847-0#96#109#diseaseC0006142 associated_with VCAM-1,breast cancer
14#20#gene741296#109#diseaseC0678222 24583847-0#14#20#gene7412 24583847-0#96#109#diseaseC0678222 associated_with VCAM-1,breast cancer
14#20#gene741296#109#diseaseC0006142 24583847-0#14#20#gene7412 24583847-0#96#109#diseaseC0006142 associated_with VCAM-1,breast cancer
14#20#gene741296#109#diseaseC0678222 24583847-0#14#20#gene7412 24583847-0#96#109#diseaseC0678222 associated_with VCAM-1,breast cancer
49#53#gene96096#109#diseaseC0006142 24583847-0#49#53#gene960 24583847-0#96#109#diseaseC0006142 associated_with CD44,breast cancer
49#53#gene96096#109#diseaseC0678222 24583847-0#49#53#gene960 24583847-0#96#109#diseaseC0678222 associated_with CD44,breast cancer
49#53#gene96096#109#diseaseC0006142 24583847-0#49#53#gene960 24583847-0#96#109#diseaseC0006142 associated_with CD44,breast cancer
49#53#gene96096#109#diseaseC0678222 24583847-0#49#53#gene960 24583847-0#96#109#diseaseC0678222 associated_with CD44,breast cancer
39#45#gene7412209#228#diseaseC2216702 24583847-2#39#45#gene7412 24583847-2#209#228#diseaseC2216702 associated_with VCAM-1,breast cancer stage

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2652 14-20 gene:7412 denotes VCAM-1
T2653 96-109 disease:C0006142 denotes breast cancer
T2654 49-53 gene:960 denotes CD44
R1 T2652 T2653 associated_with VCAM-1,breast cancer
R2 T2652 T2653 associated_with VCAM-1,breast cancer
R3 T2654 T2653 associated_with CD44,breast cancer
R4 T2654 T2653 associated_with CD44,breast cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 96-102 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 405-411 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 534-540 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 605-611 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 844-850 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 1379-1385 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T7 657-668 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 657-668 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T2 96-102 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 405-411 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 534-540 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 605-611 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 844-850 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T7 1379-1385 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T8 605-622 http://purl.obolibrary.org/obo/UBERON_0008367 denotes breast epithelial