PubMed:2458354
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1728-1739 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T2 | 1810-1821 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T3 | 2198-2209 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-185 | Sentence | denotes | Characterization of a human eosinophil proteoglycan, and augmentation of its biosynthesis and size by interleukin 3, interleukin 5, and granulocyte/macrophage colony stimulating factor. |
| T2 | 186-510 | Sentence | denotes | Human eosinophils were cultured for up to 7 days in enriched medium in the absence or presence of recombinant human interleukin (IL) 3, mouse IL 5, or recombinant human granulocyte/macrophage colony stimulating factor (GM-CSF) and then were radiolabeled with [35S]sulfate to characterize their cell-associated proteoglycans. |
| T3 | 511-727 | Sentence | denotes | Freshly isolated eosinophils that were not exposed to any of these cytokines synthesized Mr approximately 80,000 Pronase-resistant 35S-labeled proteoglycans which contained Mr approximately 80,000 glycosaminoglycans. |
| T4 | 728-1006 | Sentence | denotes | RNA blot analysis of total eosinophil RNA, probed with a cDNA that encodes a proteoglycan peptide core of the promyelocytic leukemia HL-60 cell, revealed that the mRNA which encodes the analogous molecule in eosinophils was approximately 1.3 kilobases, like that in HL-60 cells. |
| T5 | 1007-1360 | Sentence | denotes | When eosinophils were cultured for 1 day or longer in the presence of 10 pM IL 3, 1 pM IL 5, or 10 pM GM-CSF, the rates of [35S]sulfate incorporation were increased approximately 2-fold, and the cells synthesized Mr approximately 300,000 Pronase-resistant 35S-labeled proteoglycans which contained Mr approximately 30,000 35S-labeled glycosaminoglycans. |
| T6 | 1361-1559 | Sentence | denotes | Approximately 93% of the 35S-labeled glycosaminoglycans bound to the proteoglycans synthesized by noncytokine- and cytokine-treated eosinophils were susceptible to degradation by chondroitinase ABC. |
| T7 | 1560-1832 | Sentence | denotes | As assessed by high performance liquid chromatography, 6-16% of these chondroitinase ABC-generated 35S-labeled disaccharides were disulfated disaccharides derived from chondroitin sulfate E; the remainder were monosulfated disaccharides derived from chondroitin sulfate A. |
| T8 | 1833-2023 | Sentence | denotes | Utilizing GM-CSF as a model of the cytokines, it was demonstrated that the GM-CSF-treated cells synthesized larger glycosaminoglycans onto beta-D-xyloside than the noncytokine-treated cells. |
| T9 | 2024-2225 | Sentence | denotes | Thus, IL 3, IL 5, and GM-CSF induce human eosinophils to augment proteoglycan biosynthesis by increasing the size of the newly synthesized proteoglycans and their individual chondroitin sulfate chains. |
| T1 | 0-185 | Sentence | denotes | Characterization of a human eosinophil proteoglycan, and augmentation of its biosynthesis and size by interleukin 3, interleukin 5, and granulocyte/macrophage colony stimulating factor. |
| T2 | 186-510 | Sentence | denotes | Human eosinophils were cultured for up to 7 days in enriched medium in the absence or presence of recombinant human interleukin (IL) 3, mouse IL 5, or recombinant human granulocyte/macrophage colony stimulating factor (GM-CSF) and then were radiolabeled with [35S]sulfate to characterize their cell-associated proteoglycans. |
| T3 | 511-727 | Sentence | denotes | Freshly isolated eosinophils that were not exposed to any of these cytokines synthesized Mr approximately 80,000 Pronase-resistant 35S-labeled proteoglycans which contained Mr approximately 80,000 glycosaminoglycans. |
| T4 | 728-1006 | Sentence | denotes | RNA blot analysis of total eosinophil RNA, probed with a cDNA that encodes a proteoglycan peptide core of the promyelocytic leukemia HL-60 cell, revealed that the mRNA which encodes the analogous molecule in eosinophils was approximately 1.3 kilobases, like that in HL-60 cells. |
| T5 | 1007-1360 | Sentence | denotes | When eosinophils were cultured for 1 day or longer in the presence of 10 pM IL 3, 1 pM IL 5, or 10 pM GM-CSF, the rates of [35S]sulfate incorporation were increased approximately 2-fold, and the cells synthesized Mr approximately 300,000 Pronase-resistant 35S-labeled proteoglycans which contained Mr approximately 30,000 35S-labeled glycosaminoglycans. |
| T6 | 1361-1559 | Sentence | denotes | Approximately 93% of the 35S-labeled glycosaminoglycans bound to the proteoglycans synthesized by noncytokine- and cytokine-treated eosinophils were susceptible to degradation by chondroitinase ABC. |
| T7 | 1560-1832 | Sentence | denotes | As assessed by high performance liquid chromatography, 6-16% of these chondroitinase ABC-generated 35S-labeled disaccharides were disulfated disaccharides derived from chondroitin sulfate E; the remainder were monosulfated disaccharides derived from chondroitin sulfate A. |
| T8 | 1833-2023 | Sentence | denotes | Utilizing GM-CSF as a model of the cytokines, it was demonstrated that the GM-CSF-treated cells synthesized larger glycosaminoglycans onto beta-D-xyloside than the noncytokine-treated cells. |
| T9 | 2024-2225 | Sentence | denotes | Thus, IL 3, IL 5, and GM-CSF induce human eosinophils to augment proteoglycan biosynthesis by increasing the size of the newly synthesized proteoglycans and their individual chondroitin sulfate chains. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1728-1739 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T2 | 1810-1821 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T3 | 2198-2209 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1728-1739 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T2 | 1810-1821 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T3 | 2198-2209 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 852-860 | HP_0001909 | denotes | leukemia |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1728-1739 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T2 | 1810-1821 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T3 | 2198-2209 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 838-860 | Disease | denotes | promyelocytic leukemia | http://purl.obolibrary.org/obo/MONDO_0012883 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 852-860 | Phenotype | denotes | leukemia | HP:0001909 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1728-1739 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T2 | 1810-1821 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T3 | 2198-2209 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 1728-1739 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T2 | 1810-1821 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T3 | 2198-2209 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 852-860 | Phenotype | denotes | leukemia | HP:0001909 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 28-38 | Cell | denotes | eosinophil | http://purl.obolibrary.org/obo/CL:0000771 |
| T2 | 136-147 | Cell | denotes | granulocyte | http://purl.obolibrary.org/obo/CL:0000094 |
| T3 | 148-158 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T5 | 192-203 | Cell | denotes | eosinophils | http://purl.obolibrary.org/obo/CL:0000771 |
| T6 | 355-366 | Cell | denotes | granulocyte | http://purl.obolibrary.org/obo/CL:0000094 |
| T7 | 367-377 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T9 | 528-539 | Cell | denotes | eosinophils | http://purl.obolibrary.org/obo/CL:0000771 |
| T10 | 755-765 | Cell | denotes | eosinophil | http://purl.obolibrary.org/obo/CL:0000771 |
| T11 | 838-851 | Cell | denotes | promyelocytic | http://purl.obolibrary.org/obo/CL:0000836 |
| T12 | 936-947 | Cell | denotes | eosinophils | http://purl.obolibrary.org/obo/CL:0000771 |
| T13 | 1012-1023 | Cell | denotes | eosinophils | http://purl.obolibrary.org/obo/CL:0000771 |
| T14 | 1493-1504 | Cell | denotes | eosinophils | http://purl.obolibrary.org/obo/CL:0000771 |
| T15 | 2066-2077 | Cell | denotes | eosinophils | http://purl.obolibrary.org/obo/CL:0000771 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 28-38 | Body_part | denotes | eosinophil | http://purl.obolibrary.org/obo/CL_0017502 |
| T2 | 136-147 | Body_part | denotes | granulocyte | http://purl.obolibrary.org/obo/CL_0000094 |
| T3 | 148-158 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T4 | 192-203 | Body_part | denotes | eosinophils | http://purl.obolibrary.org/obo/CL_0017502 |
| T5 | 355-366 | Body_part | denotes | granulocyte | http://purl.obolibrary.org/obo/CL_0000094 |
| T6 | 367-377 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T7 | 528-539 | Body_part | denotes | eosinophils | http://purl.obolibrary.org/obo/CL_0017502 |
| T8 | 755-765 | Body_part | denotes | eosinophil | http://purl.obolibrary.org/obo/CL_0017502 |
| T9 | 936-947 | Body_part | denotes | eosinophils | http://purl.obolibrary.org/obo/CL_0017502 |
| T10 | 1012-1023 | Body_part | denotes | eosinophils | http://purl.obolibrary.org/obo/CL_0017502 |
| T11 | 1493-1504 | Body_part | denotes | eosinophils | http://purl.obolibrary.org/obo/CL_0017502 |
| T12 | 2066-2077 | Body_part | denotes | eosinophils | http://purl.obolibrary.org/obo/CL_0017502 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 838-860 | Disease | denotes | promyelocytic leukemia | MONDO:0012883 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 22-27 | Organism | denotes | human | 9606 |
| T2 | 186-191 | Organism | denotes | Human | 9606 |
| T3 | 296-301 | Organism | denotes | human | 9606 |
| T4 | 322-327 | Organism | denotes | mouse | 10088|10090 |
| T6 | 349-354 | Organism | denotes | human | 9606 |
| T7 | 2060-2065 | Organism | denotes | human | 9606 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-185 | Sentence | denotes | Characterization of a human eosinophil proteoglycan, and augmentation of its biosynthesis and size by interleukin 3, interleukin 5, and granulocyte/macrophage colony stimulating factor. |
| T2 | 186-510 | Sentence | denotes | Human eosinophils were cultured for up to 7 days in enriched medium in the absence or presence of recombinant human interleukin (IL) 3, mouse IL 5, or recombinant human granulocyte/macrophage colony stimulating factor (GM-CSF) and then were radiolabeled with [35S]sulfate to characterize their cell-associated proteoglycans. |
| T3 | 511-727 | Sentence | denotes | Freshly isolated eosinophils that were not exposed to any of these cytokines synthesized Mr approximately 80,000 Pronase-resistant 35S-labeled proteoglycans which contained Mr approximately 80,000 glycosaminoglycans. |
| T4 | 728-1006 | Sentence | denotes | RNA blot analysis of total eosinophil RNA, probed with a cDNA that encodes a proteoglycan peptide core of the promyelocytic leukemia HL-60 cell, revealed that the mRNA which encodes the analogous molecule in eosinophils was approximately 1.3 kilobases, like that in HL-60 cells. |
| T5 | 1007-1360 | Sentence | denotes | When eosinophils were cultured for 1 day or longer in the presence of 10 pM IL 3, 1 pM IL 5, or 10 pM GM-CSF, the rates of [35S]sulfate incorporation were increased approximately 2-fold, and the cells synthesized Mr approximately 300,000 Pronase-resistant 35S-labeled proteoglycans which contained Mr approximately 30,000 35S-labeled glycosaminoglycans. |
| T6 | 1361-1559 | Sentence | denotes | Approximately 93% of the 35S-labeled glycosaminoglycans bound to the proteoglycans synthesized by noncytokine- and cytokine-treated eosinophils were susceptible to degradation by chondroitinase ABC. |
| T7 | 1560-2023 | Sentence | denotes | As assessed by high performance liquid chromatography, 6-16% of these chondroitinase ABC-generated 35S-labeled disaccharides were disulfated disaccharides derived from chondroitin sulfate E; the remainder were monosulfated disaccharides derived from chondroitin sulfate A. Utilizing GM-CSF as a model of the cytokines, it was demonstrated that the GM-CSF-treated cells synthesized larger glycosaminoglycans onto beta-D-xyloside than the noncytokine-treated cells. |
| T8 | 2024-2225 | Sentence | denotes | Thus, IL 3, IL 5, and GM-CSF induce human eosinophils to augment proteoglycan biosynthesis by increasing the size of the newly synthesized proteoglycans and their individual chondroitin sulfate chains. |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 1728-1739 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T2 | 1810-1821 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T3 | 2198-2209 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 22-27 | OrganismTaxon | denotes | human | 9606 |
| T2 | 186-191 | OrganismTaxon | denotes | Human | 9606 |
| T3 | 296-301 | OrganismTaxon | denotes | human | 9606 |
| T4 | 322-327 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T6 | 349-354 | OrganismTaxon | denotes | human | 9606 |
| T7 | 2060-2065 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 28-38 | Body_part | denotes | eosinophil | FMA:62861 |
| T2 | 136-147 | Body_part | denotes | granulocyte | FMA:62854 |
| T3 | 148-158 | Body_part | denotes | macrophage | FMA:63261 |
| T4 | 192-203 | Body_part | denotes | eosinophils | FMA:62861 |
| T5 | 355-366 | Body_part | denotes | granulocyte | FMA:62854 |
| T6 | 367-377 | Body_part | denotes | macrophage | FMA:63261 |
| T7 | 528-539 | Body_part | denotes | eosinophils | FMA:62861 |
| T8 | 755-765 | Body_part | denotes | eosinophil | FMA:62861 |
| T9 | 838-851 | Body_part | denotes | promyelocytic | FMA:83530 |
| T10 | 936-947 | Body_part | denotes | eosinophils | FMA:62861 |
| T11 | 1012-1023 | Body_part | denotes | eosinophils | FMA:62861 |
| T12 | 1493-1504 | Body_part | denotes | eosinophils | FMA:62861 |
| T13 | 2066-2077 | Body_part | denotes | eosinophils | FMA:62861 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 28-38 | Body_part | denotes | eosinophil | http://purl.obolibrary.org/obo/CL_0017502 |
| T2 | 136-147 | Body_part | denotes | granulocyte | http://purl.obolibrary.org/obo/CL_0000094 |
| T3 | 148-158 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T4 | 192-203 | Body_part | denotes | eosinophils | http://purl.obolibrary.org/obo/CL_0017502 |
| T5 | 355-366 | Body_part | denotes | granulocyte | http://purl.obolibrary.org/obo/CL_0000094 |
| T6 | 367-377 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T7 | 528-539 | Body_part | denotes | eosinophils | http://purl.obolibrary.org/obo/CL_0017502 |
| T8 | 755-765 | Body_part | denotes | eosinophil | http://purl.obolibrary.org/obo/CL_0017502 |
| T9 | 936-947 | Body_part | denotes | eosinophils | http://purl.obolibrary.org/obo/CL_0017502 |
| T10 | 1012-1023 | Body_part | denotes | eosinophils | http://purl.obolibrary.org/obo/CL_0017502 |
| T11 | 1493-1504 | Body_part | denotes | eosinophils | http://purl.obolibrary.org/obo/CL_0017502 |
| T12 | 2066-2077 | Body_part | denotes | eosinophils | http://purl.obolibrary.org/obo/CL_0017502 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 28-38 | Cell | denotes | eosinophil | http://purl.obolibrary.org/obo/CL:0000771 |
| T2 | 136-147 | Cell | denotes | granulocyte | http://purl.obolibrary.org/obo/CL:0000094 |
| T3 | 148-158 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T5 | 192-203 | Cell | denotes | eosinophils | http://purl.obolibrary.org/obo/CL:0000771 |
| T6 | 355-366 | Cell | denotes | granulocyte | http://purl.obolibrary.org/obo/CL:0000094 |
| T7 | 367-377 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T9 | 528-539 | Cell | denotes | eosinophils | http://purl.obolibrary.org/obo/CL:0000771 |
| T10 | 755-765 | Cell | denotes | eosinophil | http://purl.obolibrary.org/obo/CL:0000771 |
| T11 | 838-851 | Cell | denotes | promyelocytic | http://purl.obolibrary.org/obo/CL:0000836 |
| T12 | 936-947 | Cell | denotes | eosinophils | http://purl.obolibrary.org/obo/CL:0000771 |
| T13 | 1012-1023 | Cell | denotes | eosinophils | http://purl.obolibrary.org/obo/CL:0000771 |
| T14 | 1493-1504 | Cell | denotes | eosinophils | http://purl.obolibrary.org/obo/CL:0000771 |
| T15 | 2066-2077 | Cell | denotes | eosinophils | http://purl.obolibrary.org/obo/CL:0000771 |