PubMed:24581344 / 1145-1600
Annnotations
PubMed_Structured_Abstracts
{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T3","span":{"begin":0,"end":455},"obj":"RESULTS"}],"text":"In general, disruption of collagen was associated with increased expression of disease markers by VICs in whole organ leaflet culture. Compared to intact control leaflets, collagen-deficient leaflets demonstrated increased VIC proliferation and apoptosis, increased expression of disease-related markers such as alpha-smooth muscle actin, alkaline phosphatase, and osteocalcin, and an increase in calcification as evidenced by positive von Kossa staining."}
Goldhamster2_Cellosaurus
{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T6","span":{"begin":382,"end":384},"obj":"CVCL_8754|Cancer_cell_line|Homo sapiens"},{"id":"T7","span":{"begin":382,"end":384},"obj":"CVCL_H241|Cancer_cell_line|Homo sapiens"}],"text":"In general, disruption of collagen was associated with increased expression of disease markers by VICs in whole organ leaflet culture. Compared to intact control leaflets, collagen-deficient leaflets demonstrated increased VIC proliferation and apoptosis, increased expression of disease-related markers such as alpha-smooth muscle actin, alkaline phosphatase, and osteocalcin, and an increase in calcification as evidenced by positive von Kossa staining."}
GoldHamster
{"project":"GoldHamster","denotations":[{"id":"T74","span":{"begin":26,"end":34},"obj":"2714"},{"id":"T75","span":{"begin":26,"end":34},"obj":"D003094"},{"id":"T76","span":{"begin":26,"end":34},"obj":"CHEBI:3815"},{"id":"T73","span":{"begin":26,"end":34},"obj":"GO:0005202"},{"id":"T77","span":{"begin":79,"end":86},"obj":"D004194"},{"id":"T78","span":{"begin":79,"end":86},"obj":"D004194"},{"id":"T79","span":{"begin":98,"end":102},"obj":"GO:0120095"},{"id":"T80","span":{"begin":112,"end":117},"obj":"UBERON:0000062"},{"id":"T81","span":{"begin":112,"end":117},"obj":"UBERON:0003103"},{"id":"T83","span":{"begin":172,"end":180},"obj":"2714"},{"id":"T84","span":{"begin":172,"end":180},"obj":"D003094"},{"id":"T85","span":{"begin":172,"end":180},"obj":"CHEBI:3815"},{"id":"T82","span":{"begin":172,"end":180},"obj":"GO:0005202"},{"id":"T86","span":{"begin":223,"end":226},"obj":"PR:000006898"},{"id":"T87","span":{"begin":223,"end":226},"obj":"P23943"},{"id":"T88","span":{"begin":223,"end":226},"obj":"P22389"},{"id":"T89","span":{"begin":227,"end":240},"obj":"UBERON:2000098"},{"id":"T90","span":{"begin":245,"end":254},"obj":"GO:0097194"},{"id":"T91","span":{"begin":245,"end":254},"obj":"GO:0006915"},{"id":"T92","span":{"begin":280,"end":287},"obj":"D004194"},{"id":"T93","span":{"begin":280,"end":287},"obj":"D004194"},{"id":"T94","span":{"begin":312,"end":317},"obj":"CHEBI:30216"},{"id":"T95","span":{"begin":318,"end":331},"obj":"UBERON:0001135"},{"id":"T96","span":{"begin":318,"end":331},"obj":"UBERON:0000953"},{"id":"T99","span":{"begin":332,"end":337},"obj":"P53491"},{"id":"T100","span":{"begin":332,"end":337},"obj":"P45520"},{"id":"T101","span":{"begin":332,"end":337},"obj":"O00937"},{"id":"T102","span":{"begin":332,"end":337},"obj":"Q05214"},{"id":"T103","span":{"begin":332,"end":337},"obj":"P13363"},{"id":"T104","span":{"begin":332,"end":337},"obj":"Q39596"},{"id":"T105","span":{"begin":332,"end":337},"obj":"P30161"},{"id":"T106","span":{"begin":332,"end":337},"obj":"P53476"},{"id":"T107","span":{"begin":332,"end":337},"obj":"P51775"},{"id":"T108","span":{"begin":332,"end":337},"obj":"P60011"},{"id":"T109","span":{"begin":332,"end":337},"obj":"Q9P4D1"},{"id":"T110","span":{"begin":332,"end":337},"obj":"P50138"},{"id":"T111","span":{"begin":332,"end":337},"obj":"O65314"},{"id":"T112","span":{"begin":332,"end":337},"obj":"P26183"},{"id":"T113","span":{"begin":332,"end":337},"obj":"Q75D00"},{"id":"T114","span":{"begin":332,"end":337},"obj":"P53502"},{"id":"T115","span":{"begin":332,"end":337},"obj":"P11426"},{"id":"T116","span":{"begin":332,"end":337},"obj":"P80709"},{"id":"T117","span":{"begin":332,"end":337},"obj":"Q8X119"},{"id":"T118","span":{"begin":332,"end":337},"obj":"Q6TCF2"},{"id":"T119","span":{"begin":332,"end":337},"obj":"Q99023"},{"id":"T120","span":{"begin":332,"end":337},"obj":"A5DQP9"},{"id":"T121","span":{"begin":332,"end":337},"obj":"P60009"},{"id":"T122","span":{"begin":332,"end":337},"obj":"O65315"},{"id":"T123","span":{"begin":332,"end":337},"obj":"P26182"},{"id":"T124","span":{"begin":332,"end":337},"obj":"Q9UVF3"},{"id":"T125","span":{"begin":332,"end":337},"obj":"Q2U7A3"},{"id":"T126","span":{"begin":332,"end":337},"obj":"Q92192"},{"id":"T127","span":{"begin":332,"end":337},"obj":"Q9UVZ8"},{"id":"T128","span":{"begin":332,"end":337},"obj":"P53689"},{"id":"T129","span":{"begin":332,"end":337},"obj":"P68555"},{"id":"T130","span":{"begin":332,"end":337},"obj":"P53455"},{"id":"T131","span":{"begin":332,"end":337},"obj":"O13419"},{"id":"T132","span":{"begin":332,"end":337},"obj":"P60010"},{"id":"T133","span":{"begin":332,"end":337},"obj":"Q39758"},{"id":"T134","span":{"begin":332,"end":337},"obj":"P81085"},{"id":"T135","span":{"begin":332,"end":337},"obj":"P48465"},{"id":"T136","span":{"begin":332,"end":337},"obj":"P78711"},{"id":"T137","span":{"begin":332,"end":337},"obj":"P17128"},{"id":"T138","span":{"begin":332,"end":337},"obj":"P91754"},{"id":"T139","span":{"begin":332,"end":337},"obj":"Q24733"},{"id":"T140","span":{"begin":332,"end":337},"obj":"P14235"},{"id":"T141","span":{"begin":332,"end":337},"obj":"Q92193"},{"id":"T142","span":{"begin":332,"end":337},"obj":"Q11212"},{"id":"T143","span":{"begin":332,"end":337},"obj":"P45521"},{"id":"T144","span":{"begin":332,"end":337},"obj":"P53477"},{"id":"T145","span":{"begin":332,"end":337},"obj":"P53499"},{"id":"T146","span":{"begin":332,"end":337},"obj":"P24902"},{"id":"T147","span":{"begin":332,"end":337},"obj":"Q8SWN8"},{"id":"T148","span":{"begin":332,"end":337},"obj":"O17320"},{"id":"T149","span":{"begin":332,"end":337},"obj":"P10365"},{"id":"T151","span":{"begin":332,"end":337},"obj":"O16808"},{"id":"T152","span":{"begin":332,"end":337},"obj":"P53498"},{"id":"T153","span":{"begin":332,"end":337},"obj":"Q9UVX4"},{"id":"T154","span":{"begin":332,"end":337},"obj":"O81221"},{"id":"T155","span":{"begin":332,"end":337},"obj":"P20904"},{"id":"T156","span":{"begin":332,"end":337},"obj":"O65316"},{"id":"T157","span":{"begin":332,"end":337},"obj":"O74258"},{"id":"T158","span":{"begin":332,"end":337},"obj":"P53500"},{"id":"T159","span":{"begin":332,"end":337},"obj":"P10989"},{"id":"T160","span":{"begin":332,"end":337},"obj":"P90689"},{"id":"T150","span":{"begin":332,"end":337},"obj":"D000199"},{"id":"T161","span":{"begin":339,"end":359},"obj":"P19147"},{"id":"T162","span":{"begin":339,"end":359},"obj":"P83456"},{"id":"T164","span":{"begin":339,"end":359},"obj":"PR:000023540"},{"id":"T165","span":{"begin":339,"end":359},"obj":"O60109"},{"id":"T166","span":{"begin":339,"end":359},"obj":"P21948"},{"id":"T167","span":{"begin":339,"end":359},"obj":"P00634"},{"id":"T168","span":{"begin":339,"end":359},"obj":"P86348"},{"id":"T169","span":{"begin":339,"end":359},"obj":"P81800"},{"id":"T170","span":{"begin":339,"end":359},"obj":"Q05205"},{"id":"T163","span":{"begin":339,"end":359},"obj":"D000469"},{"id":"T171","span":{"begin":348,"end":359},"obj":"GO:0016791"},{"id":"T173","span":{"begin":365,"end":376},"obj":"P86313"},{"id":"T174","span":{"begin":365,"end":376},"obj":"P28317"},{"id":"T175","span":{"begin":365,"end":376},"obj":"P0C225"},{"id":"T177","span":{"begin":365,"end":376},"obj":"P84351"},{"id":"T178","span":{"begin":365,"end":376},"obj":"PR:000030444"},{"id":"T179","span":{"begin":365,"end":376},"obj":"A2D4U1"},{"id":"T180","span":{"begin":365,"end":376},"obj":"P04640"},{"id":"T181","span":{"begin":365,"end":376},"obj":"P39056"},{"id":"T182","span":{"begin":365,"end":376},"obj":"P86315"},{"id":"T183","span":{"begin":365,"end":376},"obj":"A2T6K4"},{"id":"T184","span":{"begin":365,"end":376},"obj":"Q800Y1"},{"id":"T185","span":{"begin":365,"end":376},"obj":"Q7LZI4"},{"id":"T186","span":{"begin":365,"end":376},"obj":"P40147"},{"id":"T187","span":{"begin":365,"end":376},"obj":"P84349"},{"id":"T188","span":{"begin":365,"end":376},"obj":"P83238"},{"id":"T189","span":{"begin":365,"end":376},"obj":"P86312"},{"id":"T190","span":{"begin":365,"end":376},"obj":"P02823"},{"id":"T191","span":{"begin":365,"end":376},"obj":"Q6DJ00"},{"id":"T192","span":{"begin":365,"end":376},"obj":"P81455"},{"id":"T193","span":{"begin":365,"end":376},"obj":"Q8HYY9"},{"id":"T194","span":{"begin":365,"end":376},"obj":"P0C226"},{"id":"T195","span":{"begin":365,"end":376},"obj":"P83005"},{"id":"T196","span":{"begin":365,"end":376},"obj":"P02821"},{"id":"T197","span":{"begin":365,"end":376},"obj":"A2D670"},{"id":"T198","span":{"begin":365,"end":376},"obj":"P40148"},{"id":"T199","span":{"begin":365,"end":376},"obj":"P02818"},{"id":"T200","span":{"begin":365,"end":376},"obj":"P83473"},{"id":"T201","span":{"begin":365,"end":376},"obj":"P84350"},{"id":"T202","span":{"begin":365,"end":376},"obj":"P83489"},{"id":"T203","span":{"begin":365,"end":376},"obj":"P84348"},{"id":"T204","span":{"begin":365,"end":376},"obj":"P86546"},{"id":"T205","span":{"begin":365,"end":376},"obj":"P86314"},{"id":"T206","span":{"begin":365,"end":376},"obj":"P02820"},{"id":"T207","span":{"begin":365,"end":376},"obj":"P15504"},{"id":"T208","span":{"begin":365,"end":376},"obj":"P02819"},{"id":"T209","span":{"begin":365,"end":376},"obj":"P02822"},{"id":"T176","span":{"begin":365,"end":376},"obj":"D015675"}],"text":"In general, disruption of collagen was associated with increased expression of disease markers by VICs in whole organ leaflet culture. Compared to intact control leaflets, collagen-deficient leaflets demonstrated increased VIC proliferation and apoptosis, increased expression of disease-related markers such as alpha-smooth muscle actin, alkaline phosphatase, and osteocalcin, and an increase in calcification as evidenced by positive von Kossa staining."}