PubMed:24581344 / 0-618 JSONTXT

{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T1","span":{"begin":470,"end":473},"obj":"CVCL_6758|Undefined_cell_line_type|Cricetulus griseus"},{"id":"T2","span":{"begin":470,"end":473},"obj":"CVCL_E689|Transformed_cell_line|Homo sapiens"},{"id":"T3","span":{"begin":555,"end":558},"obj":"CVCL_N817|Cancer_cell_line|Homo sapiens"}],"text":"Manipulation of valve composition to elucidate the role of collagen in aortic valve calcification.\nBACKGROUND: Extracellular matrix (ECM) disarray is found in calcific aortic valvular disease (CAVD), yet much remains to be learned about the role of individual ECM components in valvular interstitial cell (VIC) function and dysfunction. Previous clinical analyses have shown that calcification is associated with decreased collagen content, while previous in vitro work has suggested that the presence of collagen attenuates the responsiveness of VICs to pro-calcific stimuli. The current study uses whole leaflet cult"}

{"project":"GoldHamster","denotations":[{"id":"T1","span":{"begin":16,"end":21},"obj":"UBERON:0003978"},{"id":"T3","span":{"begin":59,"end":67},"obj":"2714"},{"id":"T4","span":{"begin":59,"end":67},"obj":"D003094"},{"id":"T5","span":{"begin":59,"end":67},"obj":"CHEBI:3815"},{"id":"T2","span":{"begin":59,"end":67},"obj":"GO:0005202"},{"id":"T7","span":{"begin":71,"end":83},"obj":"UBERON:0002137"},{"id":"T6","span":{"begin":71,"end":83},"obj":"109730"},{"id":"T10","span":{"begin":111,"end":131},"obj":"GO:0031012"},{"id":"T11","span":{"begin":125,"end":131},"obj":"UBERON:0027368"},{"id":"T12","span":{"begin":133,"end":136},"obj":"PR:Q13201"},{"id":"T14","span":{"begin":133,"end":136},"obj":"PR:000010492"},{"id":"T13","span":{"begin":133,"end":136},"obj":"UBERON:4000022"},{"id":"T15","span":{"begin":184,"end":191},"obj":"D004194"},{"id":"T16","span":{"begin":184,"end":191},"obj":"D004194"},{"id":"T17","span":{"begin":193,"end":197},"obj":"C535984"},{"id":"T18","span":{"begin":260,"end":263},"obj":"PR:Q13201"},{"id":"T20","span":{"begin":260,"end":263},"obj":"PR:000010492"},{"id":"T19","span":{"begin":260,"end":263},"obj":"UBERON:4000022"},{"id":"T21","span":{"begin":287,"end":304},"obj":"CL:0000178"},{"id":"T22","span":{"begin":306,"end":309},"obj":"PR:000006898"},{"id":"T23","span":{"begin":306,"end":309},"obj":"P23943"},{"id":"T24","span":{"begin":306,"end":309},"obj":"P22389"},{"id":"T26","span":{"begin":423,"end":431},"obj":"2714"},{"id":"T27","span":{"begin":423,"end":431},"obj":"D003094"},{"id":"T28","span":{"begin":423,"end":431},"obj":"CHEBI:3815"},{"id":"T25","span":{"begin":423,"end":431},"obj":"GO:0005202"},{"id":"T30","span":{"begin":505,"end":513},"obj":"2714"},{"id":"T31","span":{"begin":505,"end":513},"obj":"D003094"},{"id":"T32","span":{"begin":505,"end":513},"obj":"CHEBI:3815"},{"id":"T29","span":{"begin":505,"end":513},"obj":"GO:0005202"},{"id":"T33","span":{"begin":547,"end":551},"obj":"GO:0120095"},{"id":"T38","span":{"begin":555,"end":558},"obj":"SO:0001439"},{"id":"T34","span":{"begin":555,"end":558},"obj":"CVCL_N817"},{"id":"T35","span":{"begin":555,"end":558},"obj":"CHEBI:32871"},{"id":"T36","span":{"begin":555,"end":558},"obj":"CHEBI:32865"},{"id":"T37","span":{"begin":555,"end":558},"obj":"CHEBI:50342"},{"id":"T39","span":{"begin":555,"end":558},"obj":"CHEBI:32866"}],"text":"Manipulation of valve composition to elucidate the role of collagen in aortic valve calcification.\nBACKGROUND: Extracellular matrix (ECM) disarray is found in calcific aortic valvular disease (CAVD), yet much remains to be learned about the role of individual ECM components in valvular interstitial cell (VIC) function and dysfunction. Previous clinical analyses have shown that calcification is associated with decreased collagen content, while previous in vitro work has suggested that the presence of collagen attenuates the responsiveness of VICs to pro-calcific stimuli. The current study uses whole leaflet cult"}

{"project":"Allie","denotations":[{"id":"SS1_24581344_2_0","span":{"begin":111,"end":131},"obj":"expanded"},{"id":"SS2_24581344_2_0","span":{"begin":133,"end":136},"obj":"abbr"},{"id":"SS1_24581344_2_1","span":{"begin":159,"end":191},"obj":"expanded"},{"id":"SS2_24581344_2_1","span":{"begin":193,"end":197},"obj":"abbr"},{"id":"SS1_24581344_2_2","span":{"begin":278,"end":304},"obj":"expanded"},{"id":"SS2_24581344_2_2","span":{"begin":306,"end":309},"obj":"abbr"}],"relations":[{"id":"AE1_24581344_2_0","pred":"abbreviatedTo","subj":"SS1_24581344_2_0","obj":"SS2_24581344_2_0"},{"id":"AE1_24581344_2_1","pred":"abbreviatedTo","subj":"SS1_24581344_2_1","obj":"SS2_24581344_2_1"},{"id":"AE1_24581344_2_2","pred":"abbreviatedTo","subj":"SS1_24581344_2_2","obj":"SS2_24581344_2_2"}],"text":"Manipulation of valve composition to elucidate the role of collagen in aortic valve calcification.\nBACKGROUND: Extracellular matrix (ECM) disarray is found in calcific aortic valvular disease (CAVD), yet much remains to be learned about the role of individual ECM components in valvular interstitial cell (VIC) function and dysfunction. Previous clinical analyses have shown that calcification is associated with decreased collagen content, while previous in vitro work has suggested that the presence of collagen attenuates the responsiveness of VICs to pro-calcific stimuli. The current study uses whole leaflet cult"}