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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 111-729 BACKGROUND denotes Extracellular matrix (ECM) disarray is found in calcific aortic valvular disease (CAVD), yet much remains to be learned about the role of individual ECM components in valvular interstitial cell (VIC) function and dysfunction. Previous clinical analyses have shown that calcification is associated with decreased collagen content, while previous in vitro work has suggested that the presence of collagen attenuates the responsiveness of VICs to pro-calcific stimuli. The current study uses whole leaflet cultures to examine the contributions of endogenous collagen in regulating the phenotype and calcification of VICs.
T2 739-1135 METHODS denotes A "top-down" approach was used to characterize changes in VIC phenotype in response to collagen alterations in the native 3D environment. Collagen-deficient leaflets were created via enzymatic treatment and cultured statically for six days in vitro. After culture, leaflets were harvested for analysis of DNA, proliferation, apoptosis, ECM composition, calcification, and gene/protein expression.
T3 1145-1600 RESULTS denotes In general, disruption of collagen was associated with increased expression of disease markers by VICs in whole organ leaflet culture. Compared to intact control leaflets, collagen-deficient leaflets demonstrated increased VIC proliferation and apoptosis, increased expression of disease-related markers such as alpha-smooth muscle actin, alkaline phosphatase, and osteocalcin, and an increase in calcification as evidenced by positive von Kossa staining.
T4 1614-1931 CONCLUSIONS denotes These results indicate that disruption of the endogenous collagen structure in aortic valves is sufficient to stimulate pathological consequences in valve leaflet cultures, thereby highlighting the importance of collagen and the valve extracellular matrix in general in maintaining homeostasis of the valve phenotype.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 470-473 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T2 470-473 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has
T3 555-558 CVCL_N817|Cancer_cell_line|Homo sapiens denotes pro
T4 739-740 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T5 786-793 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changes
T6 1527-1529 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T7 1527-1529 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an

GoldHamster

Id Subject Object Predicate Lexical cue
T1 16-21 UBERON:0003978 denotes valve
T3 59-67 2714 denotes collagen
T4 59-67 D003094 denotes collagen
T5 59-67 CHEBI:3815 denotes collagen
T2 59-67 GO:0005202 denotes collagen
T7 71-83 UBERON:0002137 denotes aortic valve
T6 71-83 109730 denotes aortic valve
T10 111-131 GO:0031012 denotes Extracellular matrix
T11 125-131 UBERON:0027368 denotes matrix
T12 133-136 PR:Q13201 denotes ECM
T14 133-136 PR:000010492 denotes ECM
T13 133-136 UBERON:4000022 denotes ECM
T15 184-191 D004194 denotes disease
T16 184-191 D004194 denotes disease
T17 193-197 C535984 denotes CAVD
T18 260-263 PR:Q13201 denotes ECM
T20 260-263 PR:000010492 denotes ECM
T19 260-263 UBERON:4000022 denotes ECM
T21 287-304 CL:0000178 denotes interstitial cell
T22 306-309 PR:000006898 denotes VIC
T23 306-309 P23943 denotes VIC
T24 306-309 P22389 denotes VIC
T26 423-431 2714 denotes collagen
T27 423-431 D003094 denotes collagen
T28 423-431 CHEBI:3815 denotes collagen
T25 423-431 GO:0005202 denotes collagen
T30 505-513 2714 denotes collagen
T31 505-513 D003094 denotes collagen
T32 505-513 CHEBI:3815 denotes collagen
T29 505-513 GO:0005202 denotes collagen
T33 547-551 GO:0120095 denotes VICs
T38 555-558 SO:0001439 denotes pro
T34 555-558 CVCL_N817 denotes pro
T35 555-558 CHEBI:32871 denotes pro
T36 555-558 CHEBI:32865 denotes pro
T37 555-558 CHEBI:50342 denotes pro
T39 555-558 CHEBI:32866 denotes pro
T41 666-674 2714 denotes collagen
T42 666-674 D003094 denotes collagen
T43 666-674 CHEBI:3815 denotes collagen
T40 666-674 GO:0005202 denotes collagen
T44 724-728 GO:0120095 denotes VICs
T45 797-800 PR:000006898 denotes VIC
T46 797-800 P23943 denotes VIC
T47 797-800 P22389 denotes VIC
T49 826-834 2714 denotes collagen
T50 826-834 D003094 denotes collagen
T51 826-834 CHEBI:3815 denotes collagen
T48 826-834 GO:0005202 denotes collagen
T53 877-885 2714 denotes Collagen
T54 877-885 D003094 denotes Collagen
T55 877-885 CHEBI:3815 denotes Collagen
T52 877-885 GO:0005202 denotes Collagen
T56 922-931 SO:0001185 denotes enzymatic
T59 1044-1047 SO:0000352 denotes DNA
T57 1044-1047 GO:0005574 denotes DNA
T58 1044-1047 CHEBI:16991 denotes DNA
T60 1044-1047 D004247 denotes DNA
T61 1049-1062 UBERON:2000098 denotes proliferation
T62 1064-1073 GO:0097194 denotes apoptosis
T63 1064-1073 GO:0006915 denotes apoptosis
T64 1075-1078 PR:Q13201 denotes ECM
T66 1075-1078 PR:000010492 denotes ECM
T65 1075-1078 UBERON:4000022 denotes ECM
T67 1111-1115 SO:0000704 denotes gene
T72 1116-1123 SO:0000104 denotes protein
T71 1116-1123 PR:000000001 denotes protein
T68 1116-1123 GO:0003675 denotes protein
T69 1116-1123 CHEBI:36080 denotes protein
T70 1116-1123 CHEBI:11122 denotes protein
T74 1171-1179 2714 denotes collagen
T75 1171-1179 D003094 denotes collagen
T76 1171-1179 CHEBI:3815 denotes collagen
T73 1171-1179 GO:0005202 denotes collagen
T77 1224-1231 D004194 denotes disease
T78 1224-1231 D004194 denotes disease
T79 1243-1247 GO:0120095 denotes VICs
T80 1257-1262 UBERON:0000062 denotes organ
T81 1257-1262 UBERON:0003103 denotes organ
T83 1317-1325 2714 denotes collagen
T84 1317-1325 D003094 denotes collagen
T85 1317-1325 CHEBI:3815 denotes collagen
T82 1317-1325 GO:0005202 denotes collagen
T86 1368-1371 PR:000006898 denotes VIC
T87 1368-1371 P23943 denotes VIC
T88 1368-1371 P22389 denotes VIC
T89 1372-1385 UBERON:2000098 denotes proliferation
T90 1390-1399 GO:0097194 denotes apoptosis
T91 1390-1399 GO:0006915 denotes apoptosis
T92 1425-1432 D004194 denotes disease
T93 1425-1432 D004194 denotes disease
T94 1457-1462 CHEBI:30216 denotes alpha
T95 1463-1476 UBERON:0001135 denotes smooth muscle
T96 1463-1476 UBERON:0000953 denotes smooth muscle
T99 1477-1482 P53491 denotes actin
T100 1477-1482 P45520 denotes actin
T101 1477-1482 O00937 denotes actin
T102 1477-1482 Q05214 denotes actin
T103 1477-1482 P13363 denotes actin
T104 1477-1482 Q39596 denotes actin
T105 1477-1482 P30161 denotes actin
T106 1477-1482 P53476 denotes actin
T107 1477-1482 P51775 denotes actin
T108 1477-1482 P60011 denotes actin
T109 1477-1482 Q9P4D1 denotes actin
T110 1477-1482 P50138 denotes actin
T111 1477-1482 O65314 denotes actin
T112 1477-1482 P26183 denotes actin
T113 1477-1482 Q75D00 denotes actin
T114 1477-1482 P53502 denotes actin
T115 1477-1482 P11426 denotes actin
T116 1477-1482 P80709 denotes actin
T117 1477-1482 Q8X119 denotes actin
T118 1477-1482 Q6TCF2 denotes actin
T119 1477-1482 Q99023 denotes actin
T120 1477-1482 A5DQP9 denotes actin
T121 1477-1482 P60009 denotes actin
T122 1477-1482 O65315 denotes actin
T123 1477-1482 P26182 denotes actin
T124 1477-1482 Q9UVF3 denotes actin
T125 1477-1482 Q2U7A3 denotes actin
T126 1477-1482 Q92192 denotes actin
T127 1477-1482 Q9UVZ8 denotes actin
T128 1477-1482 P53689 denotes actin
T129 1477-1482 P68555 denotes actin
T130 1477-1482 P53455 denotes actin
T131 1477-1482 O13419 denotes actin
T132 1477-1482 P60010 denotes actin
T133 1477-1482 Q39758 denotes actin
T134 1477-1482 P81085 denotes actin
T135 1477-1482 P48465 denotes actin
T136 1477-1482 P78711 denotes actin
T137 1477-1482 P17128 denotes actin
T138 1477-1482 P91754 denotes actin
T139 1477-1482 Q24733 denotes actin
T140 1477-1482 P14235 denotes actin
T141 1477-1482 Q92193 denotes actin
T142 1477-1482 Q11212 denotes actin
T143 1477-1482 P45521 denotes actin
T144 1477-1482 P53477 denotes actin
T145 1477-1482 P53499 denotes actin
T146 1477-1482 P24902 denotes actin
T147 1477-1482 Q8SWN8 denotes actin
T148 1477-1482 O17320 denotes actin
T149 1477-1482 P10365 denotes actin
T151 1477-1482 O16808 denotes actin
T152 1477-1482 P53498 denotes actin
T153 1477-1482 Q9UVX4 denotes actin
T154 1477-1482 O81221 denotes actin
T155 1477-1482 P20904 denotes actin
T156 1477-1482 O65316 denotes actin
T157 1477-1482 O74258 denotes actin
T158 1477-1482 P53500 denotes actin
T159 1477-1482 P10989 denotes actin
T160 1477-1482 P90689 denotes actin
T150 1477-1482 D000199 denotes actin
T161 1484-1504 P19147 denotes alkaline phosphatase
T162 1484-1504 P83456 denotes alkaline phosphatase
T164 1484-1504 PR:000023540 denotes alkaline phosphatase
T165 1484-1504 O60109 denotes alkaline phosphatase
T166 1484-1504 P21948 denotes alkaline phosphatase
T167 1484-1504 P00634 denotes alkaline phosphatase
T168 1484-1504 P86348 denotes alkaline phosphatase
T169 1484-1504 P81800 denotes alkaline phosphatase
T170 1484-1504 Q05205 denotes alkaline phosphatase
T163 1484-1504 D000469 denotes alkaline phosphatase
T171 1493-1504 GO:0016791 denotes phosphatase
T173 1510-1521 P86313 denotes osteocalcin
T174 1510-1521 P28317 denotes osteocalcin
T175 1510-1521 P0C225 denotes osteocalcin
T177 1510-1521 P84351 denotes osteocalcin
T178 1510-1521 PR:000030444 denotes osteocalcin
T179 1510-1521 A2D4U1 denotes osteocalcin
T180 1510-1521 P04640 denotes osteocalcin
T181 1510-1521 P39056 denotes osteocalcin
T182 1510-1521 P86315 denotes osteocalcin
T183 1510-1521 A2T6K4 denotes osteocalcin
T184 1510-1521 Q800Y1 denotes osteocalcin
T185 1510-1521 Q7LZI4 denotes osteocalcin
T186 1510-1521 P40147 denotes osteocalcin
T187 1510-1521 P84349 denotes osteocalcin
T188 1510-1521 P83238 denotes osteocalcin
T189 1510-1521 P86312 denotes osteocalcin
T190 1510-1521 P02823 denotes osteocalcin
T191 1510-1521 Q6DJ00 denotes osteocalcin
T192 1510-1521 P81455 denotes osteocalcin
T193 1510-1521 Q8HYY9 denotes osteocalcin
T194 1510-1521 P0C226 denotes osteocalcin
T195 1510-1521 P83005 denotes osteocalcin
T196 1510-1521 P02821 denotes osteocalcin
T197 1510-1521 A2D670 denotes osteocalcin
T198 1510-1521 P40148 denotes osteocalcin
T199 1510-1521 P02818 denotes osteocalcin
T200 1510-1521 P83473 denotes osteocalcin
T201 1510-1521 P84350 denotes osteocalcin
T202 1510-1521 P83489 denotes osteocalcin
T203 1510-1521 P84348 denotes osteocalcin
T204 1510-1521 P86546 denotes osteocalcin
T205 1510-1521 P86314 denotes osteocalcin
T206 1510-1521 P02820 denotes osteocalcin
T207 1510-1521 P15504 denotes osteocalcin
T208 1510-1521 P02819 denotes osteocalcin
T209 1510-1521 P02822 denotes osteocalcin
T176 1510-1521 D015675 denotes osteocalcin
T211 1671-1679 2714 denotes collagen
T212 1671-1679 D003094 denotes collagen
T213 1671-1679 CHEBI:3815 denotes collagen
T210 1671-1679 GO:0005202 denotes collagen
T215 1763-1776 UBERON:0011741 denotes valve leaflet
T217 1826-1834 2714 denotes collagen
T218 1826-1834 D003094 denotes collagen
T219 1826-1834 CHEBI:3815 denotes collagen
T216 1826-1834 GO:0005202 denotes collagen
T220 1843-1848 UBERON:0003978 denotes valve
T222 1849-1869 GO:0031012 denotes extracellular matrix
T223 1863-1869 UBERON:0027368 denotes matrix
T224 1896-1907 GO:0042592 denotes homeostasis
T225 1915-1920 UBERON:0003978 denotes valve

Allie

Id Subject Object Predicate Lexical cue
SS1_24581344_2_0 111-131 expanded denotes Extracellular matrix
SS2_24581344_2_0 133-136 abbr denotes ECM
SS1_24581344_2_1 159-191 expanded denotes calcific aortic valvular disease
SS2_24581344_2_1 193-197 abbr denotes CAVD
SS1_24581344_2_2 278-304 expanded denotes valvular interstitial cell
SS2_24581344_2_2 306-309 abbr denotes VIC
AE1_24581344_2_0 SS1_24581344_2_0 SS2_24581344_2_0 abbreviatedTo Extracellular matrix,ECM
AE1_24581344_2_1 SS1_24581344_2_1 SS2_24581344_2_1 abbreviatedTo calcific aortic valvular disease,CAVD
AE1_24581344_2_2 SS1_24581344_2_2 SS2_24581344_2_2 abbreviatedTo valvular interstitial cell,VIC