PubMed:24561985 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/24561985","sourcedb":"PubMed","sourceid":"24561985","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/24561985","text":"Association of adiponectin gene -11377C\u003eG polymorphism with adiponectin levels and the metabolic syndrome in Thais.\nThe metabolic syndrome is related to increased risk of developing cardiovascular disease and type 2 diabetes. Adiponectin is an adipocyte-secreted protein with insulin-sensitizing and anti-atherogenic properties. The aims of this study were to evaluate adiponectin levels and biochemical parameters in metabolic-syndrome subjects and healthy controls. The study also sought to identify links between two polymorphisms, -11377C\u003eG (rs266729) and +45T\u003eG (rs2241766) of the adiponectin gene, in relation to adiponectin levels and the metabolic syndrome. Three hundres and thirty-two Thai volunteers: 164 metabolic-syndrome subjects and 168 healthy control subjects were investigated. The adiponectin and HDL-C levels of the metabolic-syndrome group were significantly lower than the control group (p\u003c0.001). Decreased concentration of adiponectin was associated with -11377C\u003eG polymorphism (p\u003c0.001); this polymorphism was significantly more frequent in the metabolic syndrome group than in the control group (p\u003c0.001). However, +45T\u003eG polymorphism of the adiponectin gene was found not to be related to adiponectin level or metabolic syndrome. Therefore, -11377C\u003eG polymorphism was related to the metabolic syndrome susceptibility, and this polymorphism impacted on circulating adiponectin concentrations among Thais.","tracks":[{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":15,"end":26},"obj":"gene:9370"},{"id":"T1","span":{"begin":87,"end":105},"obj":"disease:C0524620"},{"id":"T2","span":{"begin":1168,"end":1179},"obj":"gene:9370"},{"id":"T3","span":{"begin":1237,"end":1255},"obj":"disease:C0524620"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"24561985-0#15#26#gene9370","span":{"begin":15,"end":26},"obj":"gene9370"},{"id":"24561985-0#87#105#diseaseC0524620","span":{"begin":87,"end":105},"obj":"diseaseC0524620"}],"relations":[{"id":"15#26#gene937087#105#diseaseC0524620","pred":"associated_with","subj":"24561985-0#15#26#gene9370","obj":"24561985-0#87#105#diseaseC0524620"}],"attributes":[{"subj":"24561985-0#15#26#gene9370","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"24561985-0#87#105#diseaseC0524620","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"PubTator4TogoVar","denotations":[{"id":"45","span":{"begin":546,"end":554},"obj":"SNP"},{"id":"47","span":{"begin":568,"end":577},"obj":"SNP"}],"attributes":[{"id":"A45","pred":"resolved_to","subj":"45","obj":"tmVar:rs266729;VariantGroup:0;CorrespondingGene:9370;RS#:266729;CorrespondingSpecies:9606"},{"id":"A47","pred":"resolved_to","subj":"47","obj":"tmVar:rs2241766;VariantGroup:1;CorrespondingGene:9370;RS#:2241766;CorrespondingSpecies:9606"},{"subj":"45","pred":"source","obj":"PubTator4TogoVar"},{"subj":"47","pred":"source","obj":"PubTator4TogoVar"}]},{"project":"PubTatorOnTogoVar","denotations":[{"id":"45","span":{"begin":546,"end":554},"obj":"SNP"},{"id":"47","span":{"begin":568,"end":577},"obj":"SNP"},{"id":"T1","span":{"begin":546,"end":554},"obj":"SNP"},{"id":"T2","span":{"begin":568,"end":577},"obj":"SNP"}],"attributes":[{"id":"A45","pred":"resolved_to","subj":"45","obj":"tmVar:rs266729;VariantGroup:0;CorrespondingGene:9370;RS#:266729;CorrespondingSpecies:9606"},{"id":"A47","pred":"resolved_to","subj":"47","obj":"tmVar:rs2241766;VariantGroup:1;CorrespondingGene:9370;RS#:2241766;CorrespondingSpecies:9606"},{"id":"A1","pred":"resolved_to","subj":"T1","obj":"tmVar:rs266729;VariantGroup:0;CorrespondingGene:9370;RS#:266729;CorrespondingSpecies:9606"},{"id":"A2","pred":"resolved_to","subj":"T2","obj":"tmVar:rs2241766;VariantGroup:1;CorrespondingGene:9370;RS#:2241766;CorrespondingSpecies:9606"},{"subj":"45","pred":"source","obj":"PubTatorOnTogoVar"},{"subj":"47","pred":"source","obj":"PubTatorOnTogoVar"},{"subj":"T1","pred":"source","obj":"PubTatorOnTogoVar"},{"subj":"T2","pred":"source","obj":"PubTatorOnTogoVar"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"DisGeNET","color":"#93daec","default":true},{"id":"DisGeNET5_gene_disease","color":"#ece493"},{"id":"PubTator4TogoVar","color":"#ca93ec"},{"id":"PubTatorOnTogoVar","color":"#93ecb0"}]}]}}