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PubMed:24477591 JSONTXT

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LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 1704-1711 OrganismTaxon denotes tobacco NCBItxid:4097

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes The -930A>G polymorphism of the CYBA gene is associated with premature coronary artery disease.
T2 96-152 Sentence denotes A case-control study and gene-risk factors interactions.
T3 153-269 Sentence denotes Reactive oxygen species (ROS) are involved in the pathogenesis of atherosclerosis and coronary artery disease (CAD).
T4 270-447 Sentence denotes NADPH oxidases are the main source of ROS in the vasculature. p22phox is a critical component of vascular NADPH oxidases and is encoded by the CYBA (cytochrome b245 alpha) gene.
T5 448-584 Sentence denotes The -930A>G CYBA polymorphism (rs9932581:A>G) modulates the activity of the CYBA promoter, and influences CYBA transcriptional activity.
T6 585-754 Sentence denotes The aim of the present study was to analyze a possible association between the -930A>G polymorphism and CAD and to search for gene-traditional risk factors interactions.
T7 755-781 Sentence denotes 480 subjects were studied:
T8 782-852 Sentence denotes 240 patients with premature CAD, 240 age and sex matched blood donors.
T9 853-965 Sentence denotes The -930A>G polymorphism was genotyped using the TaqMan® Pre-designed SNP Genotyping Assay (Applied Biosystems).
T10 966-1060 Sentence denotes The -930G allele carrier state was a risk factor for CAD (OR 2.03, 95% CI 1.21-3.44, P=0.007).
T11 1061-1167 Sentence denotes A synergistic effect of the -930G allele with overweight/obesity (BMI≥25) and cigarette smoking was found.
T12 1168-1397 Sentence denotes The estimated CAD risk for BMI≥25 and the -930G allele interaction was about 160% greater than that predicted by assuming additivity of the effects, and about 40% greater for interaction of cigarette smoking and the -930G allele.
T13 1398-1528 Sentence denotes Overweight/obesity was a risk factor for CAD only in the -930G allele carriers (P<10(-10)) but not in the AA homozygotes (P=1.00).
T14 1529-1621 Sentence denotes In conclusion the -930A>G CYBA polymorphism is associated with CAD in the Polish population.
T15 1622-1727 Sentence denotes The -930G allele carriers are particularly at risk of consequences of obesity and tobacco smoke exposure.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
9588 4-11 SequenceVariant denotes -930A>G DBSNP:rs9932581
9589 32-36 GeneOrGeneProduct denotes CYBA NCBIGene:1535
9590 71-94 DiseaseOrPhenotypicFeature denotes coronary artery disease MESH:D003324
9591 153-176 ChemicalEntity denotes Reactive oxygen species MESH:D017382
9592 178-181 ChemicalEntity denotes ROS MESH:D017382
9593 219-234 DiseaseOrPhenotypicFeature denotes atherosclerosis MESH:D050197
9594 239-262 DiseaseOrPhenotypicFeature denotes coronary artery disease MESH:D003324
9595 264-267 DiseaseOrPhenotypicFeature denotes CAD MESH:D003324
9596 270-284 GeneOrGeneProduct denotes NADPH oxidases NCBIGene:1666
9597 308-311 ChemicalEntity denotes ROS MESH:D017382
9598 332-339 GeneOrGeneProduct denotes p22phox NCBIGene:1535
9599 376-390 GeneOrGeneProduct denotes NADPH oxidases NCBIGene:1666
9600 413-417 GeneOrGeneProduct denotes CYBA NCBIGene:1535
9601 419-440 GeneOrGeneProduct denotes cytochrome b245 alpha NCBIGene:1535
9602 452-459 SequenceVariant denotes -930A>G DBSNP:rs9932581
9603 460-464 GeneOrGeneProduct denotes CYBA NCBIGene:1535
9604 479-488 SequenceVariant denotes rs9932581 DBSNP:rs9932581
9605 489-492 SequenceVariant denotes A>G DBSNP:rs9932581
9606 524-528 GeneOrGeneProduct denotes CYBA NCBIGene:1535
9607 554-558 GeneOrGeneProduct denotes CYBA NCBIGene:1535
9608 664-671 SequenceVariant denotes -930A>G DBSNP:rs9932581
9609 689-692 DiseaseOrPhenotypicFeature denotes CAD MESH:D003324
9610 786-794 OrganismTaxon denotes patients NCBITaxon:9606
9611 810-813 DiseaseOrPhenotypicFeature denotes CAD MESH:D003324
9612 857-864 SequenceVariant denotes -930A>G DBSNP:rs9932581
9613 970-975 SequenceVariant denotes -930G DBSNP:rs9932581
9614 1019-1022 DiseaseOrPhenotypicFeature denotes CAD MESH:D003324
9615 1089-1094 SequenceVariant denotes -930G DBSNP:rs9932581
9616 1107-1117 DiseaseOrPhenotypicFeature denotes overweight MESH:D050177
9617 1118-1125 DiseaseOrPhenotypicFeature denotes obesity MESH:D009765
9618 1182-1185 DiseaseOrPhenotypicFeature denotes CAD MESH:D003324
9619 1210-1215 SequenceVariant denotes -930G DBSNP:rs9932581
9620 1384-1389 SequenceVariant denotes -930G DBSNP:rs9932581
9621 1398-1408 DiseaseOrPhenotypicFeature denotes Overweight MESH:D050177
9622 1409-1416 DiseaseOrPhenotypicFeature denotes obesity MESH:D009765
9623 1439-1442 DiseaseOrPhenotypicFeature denotes CAD MESH:D003324
9624 1455-1460 SequenceVariant denotes -930G DBSNP:rs9932581
9625 1547-1554 SequenceVariant denotes -930A>G DBSNP:rs9932581
9626 1555-1559 GeneOrGeneProduct denotes CYBA NCBIGene:1535
9627 1592-1595 DiseaseOrPhenotypicFeature denotes CAD MESH:D003324
9628 1626-1631 SequenceVariant denotes -930G DBSNP:rs9932581
9629 1692-1699 DiseaseOrPhenotypicFeature denotes obesity MESH:D009765
9630 1704-1711 OrganismTaxon denotes tobacco NCBITaxon:4097

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 71-94 DiseaseOrPhenotypicFeature denotes coronary artery disease 0005010
T2 219-234 DiseaseOrPhenotypicFeature denotes atherosclerosis 0005311
T3 239-262 DiseaseOrPhenotypicFeature denotes coronary artery disease 0005010

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 5-9 SequenceVariant denotes 930A
T2 453-457 SequenceVariant denotes 930A
T3 479-488 SequenceVariant denotes rs9932581
T4 665-669 SequenceVariant denotes 930A
T5 858-862 SequenceVariant denotes 930A
T6 971-975 SequenceVariant denotes 930G
T7 1090-1094 SequenceVariant denotes 930G
T8 1211-1215 SequenceVariant denotes 930G
T9 1385-1389 SequenceVariant denotes 930G
T10 1456-1460 SequenceVariant denotes 930G
T11 1548-1552 SequenceVariant denotes 930A
T12 1627-1631 SequenceVariant denotes 930G

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 32-36 GeneOrGeneProduct denotes CYBA
T2 270-275 GeneOrGeneProduct denotes NADPH
T3 332-339 GeneOrGeneProduct denotes p22phox
T4 376-381 GeneOrGeneProduct denotes NADPH
T5 413-417 GeneOrGeneProduct denotes CYBA
T6 419-429 GeneOrGeneProduct denotes cytochrome
T7 435-440 GeneOrGeneProduct denotes alpha
T8 460-464 GeneOrGeneProduct denotes CYBA
T9 524-528 GeneOrGeneProduct denotes CYBA
T10 554-558 GeneOrGeneProduct denotes CYBA
T11 559-574 GeneOrGeneProduct denotes transcriptional
T12 983-990 GeneOrGeneProduct denotes carrier
T13 1008-1014 GeneOrGeneProduct denotes factor
T14 1428-1434 GeneOrGeneProduct denotes factor
T15 1555-1559 GeneOrGeneProduct denotes CYBA

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 32-36 GeneOrGeneProduct denotes CYBA
T2 98-102 GeneOrGeneProduct denotes case
T3 131-138 GeneOrGeneProduct denotes factors
T4 270-275 GeneOrGeneProduct denotes NADPH
T5 276-284 GeneOrGeneProduct denotes oxidases
T6 293-297 GeneOrGeneProduct denotes main
T7 332-339 GeneOrGeneProduct denotes p22phox
T8 376-381 GeneOrGeneProduct denotes NADPH
T9 382-390 GeneOrGeneProduct denotes oxidases
T10 413-417 GeneOrGeneProduct denotes CYBA
T11 419-429 GeneOrGeneProduct denotes cytochrome
T12 435-440 GeneOrGeneProduct denotes alpha
T13 460-464 GeneOrGeneProduct denotes CYBA
T14 508-516 GeneOrGeneProduct denotes activity
T15 524-528 GeneOrGeneProduct denotes CYBA
T16 554-558 GeneOrGeneProduct denotes CYBA
T17 559-574 GeneOrGeneProduct denotes transcriptional
T18 575-583 GeneOrGeneProduct denotes activity
T19 733-740 GeneOrGeneProduct denotes factors
T20 983-990 GeneOrGeneProduct denotes carrier
T21 1008-1014 GeneOrGeneProduct denotes factor
T22 1118-1125 GeneOrGeneProduct denotes obesity
T23 1268-1277 GeneOrGeneProduct denotes predicted
T24 1409-1416 GeneOrGeneProduct denotes obesity
T25 1428-1434 GeneOrGeneProduct denotes factor
T26 1468-1476 GeneOrGeneProduct denotes carriers
T27 1555-1559 GeneOrGeneProduct denotes CYBA
T28 1639-1647 GeneOrGeneProduct denotes carriers
T29 1692-1699 GeneOrGeneProduct denotes obesity

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 71-94 DiseaseOrPhenotypicFeature denotes coronary artery disease D003324
T2 219-234 DiseaseOrPhenotypicFeature denotes atherosclerosis D050197
T3 239-262 DiseaseOrPhenotypicFeature denotes coronary artery disease D003324
T4 264-267 DiseaseOrPhenotypicFeature denotes CAD D003324
T5 689-692 DiseaseOrPhenotypicFeature denotes CAD D003324
T6 810-813 DiseaseOrPhenotypicFeature denotes CAD D003324
T7 1019-1022 DiseaseOrPhenotypicFeature denotes CAD D003324
T8 1107-1117 DiseaseOrPhenotypicFeature denotes overweight D050177
T9 1118-1125 DiseaseOrPhenotypicFeature denotes obesity D009765
T10 1182-1185 DiseaseOrPhenotypicFeature denotes CAD D003324
T11 1398-1408 DiseaseOrPhenotypicFeature denotes Overweight D050177
T12 1409-1416 DiseaseOrPhenotypicFeature denotes obesity D009765
T13 1439-1442 DiseaseOrPhenotypicFeature denotes CAD D003324
T14 1592-1595 DiseaseOrPhenotypicFeature denotes CAD D003324
T15 1692-1699 DiseaseOrPhenotypicFeature denotes obesity D009765

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 32-36 GeneOrGeneProduct denotes CYBA
T2 270-275 GeneOrGeneProduct denotes NADPH
T3 332-339 GeneOrGeneProduct denotes p22phox
T4 376-381 GeneOrGeneProduct denotes NADPH
T5 413-417 GeneOrGeneProduct denotes CYBA
T6 419-429 GeneOrGeneProduct denotes cytochrome
T7 435-440 GeneOrGeneProduct denotes alpha
T8 460-464 GeneOrGeneProduct denotes CYBA
T9 524-528 GeneOrGeneProduct denotes CYBA
T10 554-558 GeneOrGeneProduct denotes CYBA
T11 559-583 GeneOrGeneProduct denotes transcriptional activity
T12 1555-1559 GeneOrGeneProduct denotes CYBA

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 71-94 DiseaseOrPhenotypicFeature denotes coronary artery disease 0005010
T2 219-234 DiseaseOrPhenotypicFeature denotes atherosclerosis 0005311
T3 239-262 DiseaseOrPhenotypicFeature denotes coronary artery disease 0005010
T4 264-267 DiseaseOrPhenotypicFeature denotes CAD 0100077|0018922|0005010
T7 689-692 DiseaseOrPhenotypicFeature denotes CAD 0100077|0018922|0005010
T10 810-813 DiseaseOrPhenotypicFeature denotes CAD 0100077|0018922|0005010
T13 1019-1022 DiseaseOrPhenotypicFeature denotes CAD 0100077|0018922|0005010
T16 1118-1125 DiseaseOrPhenotypicFeature denotes obesity 0011122
T17 1182-1185 DiseaseOrPhenotypicFeature denotes CAD 0100077|0018922|0005010
T20 1409-1416 DiseaseOrPhenotypicFeature denotes obesity 0011122
T21 1439-1442 DiseaseOrPhenotypicFeature denotes CAD 0100077|0018922|0005010
T24 1592-1595 DiseaseOrPhenotypicFeature denotes CAD 0100077|0018922|0005010
T27 1692-1699 DiseaseOrPhenotypicFeature denotes obesity 0011122

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 71-94 DiseaseOrPhenotypicFeature denotes coronary artery disease D003324
T2 219-234 DiseaseOrPhenotypicFeature denotes atherosclerosis D050197
T3 239-262 DiseaseOrPhenotypicFeature denotes coronary artery disease D003324
T4 264-267 DiseaseOrPhenotypicFeature denotes CAD D003324
T5 689-692 DiseaseOrPhenotypicFeature denotes CAD D003324
T6 810-813 DiseaseOrPhenotypicFeature denotes CAD D003324
T7 1019-1022 DiseaseOrPhenotypicFeature denotes CAD D003324
T8 1107-1117 DiseaseOrPhenotypicFeature denotes overweight D050177
T9 1118-1125 DiseaseOrPhenotypicFeature denotes obesity D009765
T10 1182-1185 DiseaseOrPhenotypicFeature denotes CAD D003324
T11 1398-1408 DiseaseOrPhenotypicFeature denotes Overweight D050177
T12 1409-1416 DiseaseOrPhenotypicFeature denotes obesity D009765
T13 1439-1442 DiseaseOrPhenotypicFeature denotes CAD D003324
T14 1592-1595 DiseaseOrPhenotypicFeature denotes CAD D003324
T15 1692-1699 DiseaseOrPhenotypicFeature denotes obesity D009765

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 71-94 DiseaseOrPhenotypicFeature denotes coronary artery disease D003324
T2 219-234 DiseaseOrPhenotypicFeature denotes atherosclerosis D050197
T3 239-262 DiseaseOrPhenotypicFeature denotes coronary artery disease D003324
T4 264-267 DiseaseOrPhenotypicFeature denotes CAD D003324
T5 689-692 DiseaseOrPhenotypicFeature denotes CAD D003324
T6 810-813 DiseaseOrPhenotypicFeature denotes CAD D003324
T7 1019-1022 DiseaseOrPhenotypicFeature denotes CAD D003324
T8 1107-1117 DiseaseOrPhenotypicFeature denotes overweight D050177
T9 1118-1125 DiseaseOrPhenotypicFeature denotes obesity D009765
T10 1182-1185 DiseaseOrPhenotypicFeature denotes CAD D003324
T11 1398-1408 DiseaseOrPhenotypicFeature denotes Overweight D050177
T12 1409-1416 DiseaseOrPhenotypicFeature denotes obesity D009765
T13 1439-1442 DiseaseOrPhenotypicFeature denotes CAD D003324
T14 1592-1595 DiseaseOrPhenotypicFeature denotes CAD D003324
T15 1692-1699 DiseaseOrPhenotypicFeature denotes obesity D009765

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 153-176 ChemicalEntity denotes Reactive oxygen species D017382|http://purl.obolibrary.org/obo/CHEBI_26523
T3 178-181 ChemicalEntity denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T4 270-275 ChemicalEntity denotes NADPH http://purl.obolibrary.org/obo/CHEBI_57783|http://purl.obolibrary.org/obo/CHEBI_16474
T6 276-284 ChemicalEntity denotes oxidases D010088
T7 308-311 ChemicalEntity denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T8 376-381 ChemicalEntity denotes NADPH http://purl.obolibrary.org/obo/CHEBI_57783|http://purl.obolibrary.org/obo/CHEBI_16474
T10 382-390 ChemicalEntity denotes oxidases D010088
T11 419-429 ChemicalEntity denotes cytochrome http://purl.obolibrary.org/obo/CHEBI_4056
T12 1712-1717 ChemicalEntity denotes smoke D012906

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 786-794 OrganismTaxon denotes patients
T2 1704-1711 OrganismTaxon denotes tobacco

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T12 1712-1717 ChemicalEntity denotes smoke D012906
T11 419-429 ChemicalEntity denotes cytochrome http://purl.obolibrary.org/obo/CHEBI_4056
T10 382-390 ChemicalEntity denotes oxidases D010088
T8 376-381 ChemicalEntity denotes NADPH http://purl.obolibrary.org/obo/CHEBI_16474|http://purl.obolibrary.org/obo/CHEBI_57783
T7 308-311 ChemicalEntity denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T6 276-284 ChemicalEntity denotes oxidases D010088
T4 270-275 ChemicalEntity denotes NADPH http://purl.obolibrary.org/obo/CHEBI_16474|http://purl.obolibrary.org/obo/CHEBI_57783
T3 178-181 ChemicalEntity denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T1 153-176 ChemicalEntity denotes Reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523|D017382
T77513 1555-1559 GeneOrGeneProduct denotes CYBA
T90340 559-583 GeneOrGeneProduct denotes transcriptional activity
T95824 554-558 GeneOrGeneProduct denotes CYBA
T9 524-528 GeneOrGeneProduct denotes CYBA
T61721 460-464 GeneOrGeneProduct denotes CYBA
T40185 435-440 GeneOrGeneProduct denotes alpha
T41164 419-429 GeneOrGeneProduct denotes cytochrome
T5 413-417 GeneOrGeneProduct denotes CYBA
T55138 376-381 GeneOrGeneProduct denotes NADPH
T70179 332-339 GeneOrGeneProduct denotes p22phox
T2 270-275 GeneOrGeneProduct denotes NADPH
T54976 32-36 GeneOrGeneProduct denotes CYBA
T15 1692-1699 DiseaseOrPhenotypicFeature denotes obesity D009765
T14 1592-1595 DiseaseOrPhenotypicFeature denotes CAD D003324
T13 1439-1442 DiseaseOrPhenotypicFeature denotes CAD D003324
T70563 1409-1416 DiseaseOrPhenotypicFeature denotes obesity D009765
T27408 1398-1408 DiseaseOrPhenotypicFeature denotes Overweight D050177
T13123 1182-1185 DiseaseOrPhenotypicFeature denotes CAD D003324
T76483 1118-1125 DiseaseOrPhenotypicFeature denotes obesity D009765
T27893 1107-1117 DiseaseOrPhenotypicFeature denotes overweight D050177
T93894 1019-1022 DiseaseOrPhenotypicFeature denotes CAD D003324
T46598 810-813 DiseaseOrPhenotypicFeature denotes CAD D003324
T58571 689-692 DiseaseOrPhenotypicFeature denotes CAD D003324
T61723 264-267 DiseaseOrPhenotypicFeature denotes CAD D003324
T99242 239-262 DiseaseOrPhenotypicFeature denotes coronary artery disease D003324
T67598 219-234 DiseaseOrPhenotypicFeature denotes atherosclerosis D050197
T5496 71-94 DiseaseOrPhenotypicFeature denotes coronary artery disease D003324
T87404 1704-1711 OrganismTaxon denotes tobacco
T89866 786-794 OrganismTaxon denotes patients
T50467 1627-1631 SequenceVariant denotes 930G
T24375 1548-1552 SequenceVariant denotes 930A
T67093 1456-1460 SequenceVariant denotes 930G
T19867 1385-1389 SequenceVariant denotes 930G
T57283 1211-1215 SequenceVariant denotes 930G
T78009 1090-1094 SequenceVariant denotes 930G
T9852 971-975 SequenceVariant denotes 930G
T75672 858-862 SequenceVariant denotes 930A
T19197 665-669 SequenceVariant denotes 930A
T29046 479-488 SequenceVariant denotes rs9932581
T9009 453-457 SequenceVariant denotes 930A
T61950 5-9 SequenceVariant denotes 930A

DisGeNET

Id Subject Object Predicate Lexical cue
T0 32-36 gene:1535 denotes CYBA
T1 71-94 disease:C0010054 denotes coronary artery disease
T2 32-36 gene:1535 denotes CYBA
T3 71-94 disease:C0010068 denotes coronary artery disease
T4 32-36 gene:1535 denotes CYBA
T5 71-94 disease:C1956346 denotes coronary artery disease
R1 T0 T1 associated_with CYBA,coronary artery disease
R2 T2 T3 associated_with CYBA,coronary artery disease
R3 T4 T5 associated_with CYBA,coronary artery disease

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 219-234 HP_0002621 denotes atherosclerosis
T2 239-262 HP_0001677 denotes coronary artery disease
T3 1118-1125 HP_0001513 denotes obesity
T4 1409-1416 HP_0001513 denotes obesity
T5 1692-1699 HP_0001513 denotes obesity

Allie

Id Subject Object Predicate Lexical cue
SS1_24477591_2_0 153-176 expanded denotes Reactive oxygen species
SS2_24477591_2_0 178-181 abbr denotes ROS
SS1_24477591_2_1 239-262 expanded denotes coronary artery disease
SS2_24477591_2_1 264-267 abbr denotes CAD
AE1_24477591_2_0 SS1_24477591_2_0 SS2_24477591_2_0 abbreviatedTo Reactive oxygen species,ROS
AE1_24477591_2_1 SS1_24477591_2_1 SS2_24477591_2_1 abbreviatedTo coronary artery disease,CAD