> top > docs > PubMed:24475205 > annotations

PubMed:24475205 JSONTXT

Annnotations TAB JSON ListView MergeView

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 89-281 DRI_Challenge denotes The in vitro production of mammalian embryos suffers from high frequencies of developmental failure due to excessive levels of permanent embryo arrest and apoptosis caused by oxidative stress.
T2 282-523 DRI_Background denotes The p66Shc stress adaptor protein controls oxidative stress response of somatic cells by regulating intracellular ROS levels through multiple pathways, including mitochondrial ROS generation and the repression of antioxidant gene expression.
T3 524-813 DRI_Approach denotes We have previously demonstrated a strong relationship with elevated p66Shc levels, reduced antioxidant levels and greater intracellular ROS generation with the high incidence of permanent cell cycle arrest of 2-4 cell embryos cultured under high oxygen tensions or after oxidant treatment.
T4 814-969 DRI_Background denotes The main objective of this study was to establish a functional role for p66Shc in regulating the oxidative stress response during early embryo development.
T5 970-1202 DRI_Outcome denotes Using RNA interference in bovine zygotes we show that p66Shc knockdown embryos exhibited increased MnSOD levels, reduced intracellular ROS and DNA damage that resulted in a greater propensity for development to the blastocyst stage.
T6 1203-1415 DRI_Background denotes P66Shc knockdown embryos were stress resistant exhibiting significantly reduced intracellular ROS levels, DNA damage, permanent 2-4 cell embryo arrest and diminished apoptosis frequencies after oxidant treatment.
T7 1416-1532 DRI_Outcome denotes The results of this study demonstrate that p66Shc controls the oxidative stress response in early mammalian embryos.
T8 1533-1681 DRI_Outcome denotes Small molecule inhibition of p66Shc may be a viable clinical therapy to increase the developmental potential of in vitro produced mammalian embryos.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 524-526 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T2 556-557 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T3 864-865 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T4 1011-1013 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T5 1141-1142 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T6 1569-1572 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may
T7 1576-1577 CVCL_6479|Finite_cell_line|Mus musculus denotes a

GoldHamster

Id Subject Object Predicate Lexical cue
T5 4-11 PR:000003182 denotes p66(Shc
T15 21-28 SO:0000104 denotes protein
T14 21-28 PR:000000001 denotes protein
T11 21-28 GO:0003675 denotes protein
T12 21-28 CHEBI:36080 denotes protein
T13 21-28 CHEBI:11122 denotes protein
T16 73-79 9913 denotes bovine
T17 226-232 UBERON:0000922 denotes embryo
T18 244-253 GO:0097194 denotes apoptosis
T19 244-253 GO:0006915 denotes apoptosis
T24 286-292 PR:000003182 denotes p66Shc
T33 308-315 PR:000000001 denotes protein
T31 308-315 CHEBI:36080 denotes protein
T32 308-315 CHEBI:11122 denotes protein
T34 308-315 SO:0000104 denotes protein
T30 308-315 GO:0003675 denotes protein
T35 382-395 GO:0005622 denotes intracellular
T36 396-399 PR:P08922 denotes ROS
T38 396-399 PR:000014165 denotes ROS
T37 396-399 CHEBI:26523 denotes ROS
T39 458-461 PR:P08922 denotes ROS
T41 458-461 PR:000014165 denotes ROS
T40 458-461 CHEBI:26523 denotes ROS
T42 458-472 GO:1903409 denotes ROS generation
T43 495-506 CHEBI:22586 denotes antioxidant
T44 507-511 SO:0000704 denotes gene
T45 507-522 GO:0010467 denotes gene expression
T50 592-598 PR:000003182 denotes p66Shc
T56 615-626 CHEBI:22586 denotes antioxidant
T57 646-659 GO:0005622 denotes intracellular
T58 660-663 PR:P08922 denotes ROS
T60 660-663 PR:000014165 denotes ROS
T59 660-663 CHEBI:26523 denotes ROS
T61 660-674 GO:1903409 denotes ROS generation
T62 712-722 UBERON:2000098 denotes cell cycle
T64 712-729 GO:0007050 denotes cell cycle arrest
T67 770-776 7806 denotes oxygen
T66 770-776 CHEBI:25805 denotes oxygen
T68 795-802 CHEBI:63248 denotes oxidant
T73 886-892 PR:000003182 denotes p66Shc
T79 944-956 UBERON:0019248 denotes early embryo
T81 950-968 GO:0009790 denotes embryo development
T85 976-979 SO:0000356 denotes RNA
T82 976-979 CHEBI:33697 denotes RNA
T83 976-979 D012313 denotes RNA
T84 976-979 GO:0005562 denotes RNA
T86 976-992 GO:0016246 denotes RNA interference
T87 996-1002 9913 denotes bovine
T92 1024-1030 PR:000003182 denotes p66Shc
T98 1069-1074 Q8Z2V9 denotes MnSOD
T99 1069-1074 P66828 denotes MnSOD
T100 1069-1074 P86254 denotes MnSOD
T101 1069-1074 Q9RUV2 denotes MnSOD
T102 1069-1074 PR:000023964 denotes MnSOD
T103 1069-1074 P00448 denotes MnSOD
T104 1069-1074 P66829 denotes MnSOD
T105 1091-1104 GO:0005622 denotes intracellular
T106 1105-1108 PR:P08922 denotes ROS
T108 1105-1108 PR:000014165 denotes ROS
T107 1105-1108 CHEBI:26523 denotes ROS
T111 1113-1116 SO:0000352 denotes DNA
T110 1113-1116 CHEBI:16991 denotes DNA
T112 1113-1116 D004247 denotes DNA
T109 1113-1116 GO:0005574 denotes DNA
T113 1185-1195 UBERON:0002532 denotes blastocyst
T114 1185-1195 UBERON:0000358 denotes blastocyst
T119 1203-1209 PR:000003182 denotes P66Shc
T125 1283-1296 GO:0005622 denotes intracellular
T126 1297-1300 PR:P08922 denotes ROS
T128 1297-1300 PR:000014165 denotes ROS
T127 1297-1300 CHEBI:26523 denotes ROS
T131 1309-1312 SO:0000352 denotes DNA
T129 1309-1312 GO:0005574 denotes DNA
T130 1309-1312 CHEBI:16991 denotes DNA
T132 1309-1312 D004247 denotes DNA
T133 1333-1346 UBERON:0019251 denotes 4 cell embryo
T135 1369-1378 GO:0097194 denotes apoptosis
T136 1369-1378 GO:0006915 denotes apoptosis
T137 1397-1404 CHEBI:63248 denotes oxidant
T142 1459-1465 PR:000003182 denotes p66Shc
T148 1539-1547 CHEBI:25367 denotes molecule
T153 1562-1568 PR:000003182 denotes p66Shc

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 444-457 HP_0001427 denotes mitochondrial