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PubMed:24459295 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
24459295_0 677-683 ProteinMutation denotes G2019S rs34637584
24459295_1 722-728 ProteinMutation denotes G2019S rs34637584
24459295_2 905-911 ProteinMutation denotes G2019S rs34637584

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-5 CHEBI:29256 denotes Thiol
T2 0-5 CHEBI:29917 denotes Thiol
T3 6-17 D010544 denotes peroxidases
T4 29-34 PR:Q5S006 denotes LRRK2
T5 29-34 PR:000003033 denotes LRRK2
T6 29-34 PR:Q5S007 denotes LRRK2
T7 106-116 2294143 denotes Drosophila
T8 106-116 504603 denotes Drosophila
T9 106-116 2294139 denotes Drosophila
T10 106-116 2294145 denotes Drosophila
T11 106-116 2294141 denotes Drosophila
T12 106-116 2294142 denotes Drosophila
T13 106-116 2294144 denotes Drosophila
T14 106-116 2294140 denotes Drosophila
T15 106-116 D004330 denotes Drosophila
T16 106-116 2080301 denotes Drosophila
T18 131-138 6308 denotes leucine
T19 131-138 SO:0001437 denotes leucine
T17 131-138 CHEBI:15603 denotes leucine
T20 131-138 D007930 denotes leucine
T21 131-138 CHEBI:25017 denotes leucine
T22 131-138 D007930 denotes leucine
T23 144-150 SO:0001068 denotes repeat
T24 161-166 PR:Q5S006 denotes LRRK2
T25 161-166 PR:000003033 denotes LRRK2
T26 161-166 PR:Q5S007 denotes LRRK2
T31 198-217 D010300 denotes Parkinson's disease
T32 198-217 D010300 denotes Parkinson's disease
T35 224-229 PR:Q5S006 denotes LRRK2
T36 224-229 PR:000003033 denotes LRRK2
T37 224-229 PR:Q5S007 denotes LRRK2
T107 253-268 Q5REY3 denotes peroxiredoxin-3
T108 253-268 Q9Z0V6 denotes peroxiredoxin-3
T109 253-268 P30048 denotes peroxiredoxin-3
T110 253-268 P35705 denotes peroxiredoxin-3
T111 253-268 PR:000013193 denotes peroxiredoxin-3
T106 253-268 D061105 denotes peroxiredoxin-3
T112 270-275 PR:P30048 denotes PRDX3
T113 270-275 PR:000013193 denotes PRDX3
T114 270-275 PR:Q21824 denotes PRDX3
T115 270-275 PR:Q9Z0V6 denotes PRDX3
T116 270-275 PR:P20108 denotes PRDX3
T119 310-327 5499 denotes hydrogen peroxide
T120 310-327 D006861 denotes hydrogen peroxide
T121 310-327 CHEBI:16240 denotes hydrogen peroxide
T122 310-327 D006861 denotes hydrogen peroxide
T124 335-347 GO:0005739 denotes mitochondria
T125 397-402 PR:Q5S006 denotes LRRK2
T126 397-402 PR:000003033 denotes LRRK2
T127 397-402 PR:Q5S007 denotes LRRK2
T128 407-412 PR:P30048 denotes PRDX3
T129 407-412 PR:000013193 denotes PRDX3
T130 407-412 PR:Q21824 denotes PRDX3
T131 407-412 PR:Q9Z0V6 denotes PRDX3
T132 407-412 PR:P20108 denotes PRDX3
T133 416-426 2294143 denotes Drosophila
T134 416-426 504603 denotes Drosophila
T135 416-426 2294139 denotes Drosophila
T136 416-426 2294145 denotes Drosophila
T137 416-426 2294141 denotes Drosophila
T138 416-426 2294142 denotes Drosophila
T139 416-426 2294144 denotes Drosophila
T140 416-426 2294140 denotes Drosophila
T141 416-426 D004330 denotes Drosophila
T142 416-426 2080301 denotes Drosophila
T143 446-456 SO:0000781 denotes transgenic
T144 457-462 PR:Q5S006 denotes LRRK2
T145 457-462 PR:000003033 denotes LRRK2
T146 457-462 PR:Q5S007 denotes LRRK2
T147 467-472 PR:P30048 denotes PRDX3
T148 467-472 PR:000013193 denotes PRDX3
T149 467-472 PR:Q21824 denotes PRDX3
T150 467-472 PR:Q9Z0V6 denotes PRDX3
T151 467-472 PR:P20108 denotes PRDX3
T152 473-478 D004175 denotes flies
T153 542-547 PR:Q5S006 denotes LRRK2
T154 542-547 PR:000003033 denotes LRRK2
T155 542-547 PR:Q5S007 denotes LRRK2
T156 552-557 PR:Q5S006 denotes LRRK2
T157 552-557 PR:000003033 denotes LRRK2
T158 552-557 PR:Q5S007 denotes LRRK2
T159 558-563 PR:P30048 denotes PRDX3
T160 558-563 PR:000013193 denotes PRDX3
T161 558-563 PR:Q21824 denotes PRDX3
T162 558-563 PR:Q9Z0V6 denotes PRDX3
T163 558-563 PR:P20108 denotes PRDX3
T164 564-569 D004175 denotes flies
T165 577-587 P15984 denotes peroxidase
T166 577-587 Q9SCX8 denotes peroxidase
T167 577-587 P85957 denotes peroxidase
T168 577-587 Q01603 denotes peroxidase
T169 577-587 Q55080 denotes peroxidase
T170 577-587 P85317 denotes peroxidase
T171 577-587 Q05855 denotes peroxidase
T172 577-587 A8NK72 denotes peroxidase
T173 577-587 P84714 denotes peroxidase
T176 577-587 P28313 denotes peroxidase
T177 577-587 P28314 denotes peroxidase
T178 577-587 P16147 denotes peroxidase
T180 577-587 B3EWG7 denotes peroxidase
T174 577-587 D009195 denotes peroxidase
T175 577-587 CHEBI:8027 denotes peroxidase
T179 577-587 1600930 denotes peroxidase
T181 588-593 CVCL_Z366 denotes mimic
T182 595-602 CHEBI:77543 denotes Ebselen
T183 595-602 C042986 denotes Ebselen
T184 595-602 C042986 denotes Ebselen
T185 642-647 PR:P30048 denotes PRDX3
T186 642-647 PR:000013193 denotes PRDX3
T187 642-647 PR:Q21824 denotes PRDX3
T188 642-647 PR:Q9Z0V6 denotes PRDX3
T189 642-647 PR:P20108 denotes PRDX3
T190 657-662 PR:Q5S006 denotes LRRK2
T191 657-662 PR:000003033 denotes LRRK2
T192 657-662 PR:Q5S007 denotes LRRK2
T193 695-705 2294143 denotes Drosophila
T194 695-705 504603 denotes Drosophila
T195 695-705 2294139 denotes Drosophila
T196 695-705 2294145 denotes Drosophila
T197 695-705 2294141 denotes Drosophila
T198 695-705 2294142 denotes Drosophila
T199 695-705 2294144 denotes Drosophila
T200 695-705 2294140 denotes Drosophila
T201 695-705 D004330 denotes Drosophila
T202 695-705 2080301 denotes Drosophila
T203 744-753 MOP:0000569 denotes reduction
T218 757-767 1600930 denotes peroxidase
T204 757-767 P15984 denotes peroxidase
T205 757-767 Q9SCX8 denotes peroxidase
T206 757-767 P85957 denotes peroxidase
T207 757-767 Q01603 denotes peroxidase
T208 757-767 Q55080 denotes peroxidase
T209 757-767 P85317 denotes peroxidase
T210 757-767 Q05855 denotes peroxidase
T211 757-767 A8NK72 denotes peroxidase
T212 757-767 P84714 denotes peroxidase
T215 757-767 P28313 denotes peroxidase
T216 757-767 P28314 denotes peroxidase
T217 757-767 P16147 denotes peroxidase
T219 757-767 B3EWG7 denotes peroxidase
T213 757-767 D009195 denotes peroxidase
T214 757-767 CHEBI:8027 denotes peroxidase
T220 818-826 UBERON:0000104 denotes lifespan
T221 856-862 GO:0060361 denotes flight
T222 863-870 UBERON:0001015 denotes muscles
T223 884-889 D004175 denotes flies
T224 935-942 CHEBI:77543 denotes Ebselen
T225 935-942 C042986 denotes Ebselen
T226 935-942 C042986 denotes Ebselen
T227 965-971 SO:0000814 denotes rescue
T228 1022-1032 2294143 denotes Drosophila
T229 1022-1032 504603 denotes Drosophila
T230 1022-1032 2294139 denotes Drosophila
T231 1022-1032 2294145 denotes Drosophila
T232 1022-1032 2294141 denotes Drosophila
T233 1022-1032 2294142 denotes Drosophila
T234 1022-1032 2294144 denotes Drosophila
T235 1022-1032 2294140 denotes Drosophila
T236 1022-1032 D004330 denotes Drosophila
T237 1022-1032 2080301 denotes Drosophila
T238 1038-1048 P15984 denotes peroxidase
T239 1038-1048 Q9SCX8 denotes peroxidase
T240 1038-1048 P85957 denotes peroxidase
T241 1038-1048 Q01603 denotes peroxidase
T242 1038-1048 Q55080 denotes peroxidase
T243 1038-1048 P85317 denotes peroxidase
T244 1038-1048 Q05855 denotes peroxidase
T245 1038-1048 A8NK72 denotes peroxidase
T246 1038-1048 P84714 denotes peroxidase
T249 1038-1048 P28313 denotes peroxidase
T250 1038-1048 P28314 denotes peroxidase
T251 1038-1048 P16147 denotes peroxidase
T253 1038-1048 B3EWG7 denotes peroxidase
T252 1038-1048 1600930 denotes peroxidase
T247 1038-1048 D009195 denotes peroxidase
T248 1038-1048 CHEBI:8027 denotes peroxidase
T254 1049-1054 CVCL_Z366 denotes mimic
T255 1171-1181 2294143 denotes Drosophila
T256 1171-1181 504603 denotes Drosophila
T257 1171-1181 2294139 denotes Drosophila
T258 1171-1181 2294145 denotes Drosophila
T259 1171-1181 2294141 denotes Drosophila
T260 1171-1181 2294142 denotes Drosophila
T261 1171-1181 2294144 denotes Drosophila
T262 1171-1181 2294140 denotes Drosophila
T263 1171-1181 D004330 denotes Drosophila
T264 1171-1181 2080301 denotes Drosophila
T265 1293-1304 D010544 denotes peroxidases
T266 1329-1334 PR:Q5S006 denotes LRRK2
T267 1329-1334 PR:000003033 denotes LRRK2
T268 1329-1334 PR:Q5S007 denotes LRRK2
T269 1343-1350 CHEBI:63248 denotes oxidant
T270 1435-1440 CHEBI:29256 denotes thiol
T271 1435-1440 CHEBI:29917 denotes thiol
T272 1441-1452 D010544 denotes peroxidases
T273 1456-1478 CHEBI:63726 denotes neuroprotective agents
T274 1456-1478 D018696 denotes neuroprotective agents
T275 1456-1478 D018696 denotes neuroprotective agents
T276 1503-1508 PR:Q5S006 denotes LRRK2
T277 1503-1508 PR:000003033 denotes LRRK2
T278 1503-1508 PR:Q5S007 denotes LRRK2

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 198-207 HP_0001300 denotes Parkinson
T2 831-844 HP_0001427 denotes mitochondrial
T3 1078-1091 HP_0001427 denotes mitochondrial

Allie

Id Subject Object Predicate Lexical cue
SS1_24459295_1_0 131-159 expanded denotes leucine-rich repeat kinase 2
SS2_24459295_1_0 161-166 abbr denotes LRRK2
SS1_24459295_1_1 198-217 expanded denotes Parkinson's disease
SS2_24459295_1_1 219-221 abbr denotes PD
SS1_24459295_2_0 253-268 expanded denotes peroxiredoxin-3
SS2_24459295_2_0 270-275 abbr denotes PRDX3
AE1_24459295_1_0 SS1_24459295_1_0 SS2_24459295_1_0 abbreviatedTo leucine-rich repeat kinase 2,LRRK2
AE1_24459295_1_1 SS1_24459295_1_1 SS2_24459295_1_1 abbreviatedTo Parkinson's disease,PD
AE1_24459295_2_0 SS1_24459295_2_0 SS2_24459295_2_0 abbreviatedTo peroxiredoxin-3,PRDX3

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-28 DRI_Background denotes Thiol peroxidases ameliorate
T2 29-49 Token_Label.OUTSIDE denotes LRRK2 mutant-induced
T3 50-117 DRI_Background denotes mitochondrial and dopaminergic neuronal degeneration in Drosophila.
T4 118-223 DRI_Approach denotes Mutations in leucine-rich repeat kinase 2 (LRRK2) are common causes of familial Parkinson's disease (PD).
T5 224-358 DRI_Background denotes LRRK2 has been shown to bind peroxiredoxin-3 (PRDX3), the most important scavenger of hydrogen peroxide in the mitochondria, in vitro.
T6 359-479 DRI_Outcome denotes Here, we examined the interactions of LRRK2 and PRDX3 in Drosophila models by crossing transgenic LRRK2 and PRDX3 flies.
T7 480-603 DRI_Approach denotes As proof of principle experiments, we subsequently challenged LRRK2 and LRRK2/PRDX3 flies with a peroxidase mimic, Ebselen.
T8 604-721 DRI_Outcome denotes We demonstrated that co-expression of PRDX3 with the LRRK2 kinase mutant G2019S in bigenic Drosophila ameliorated the
T9 722-743 Token_Label.OUTSIDE denotes G2019S mutant-induced
T10 744-918 DRI_Outcome denotes reduction in peroxidase capacity, loss of dopaminergic neurons, shortened lifespan and mitochondrial defects of flight muscles in monogenic flies expressing the G2019S alone.
T11 919-1033 DRI_Background denotes Challenges with Ebselen recapitulated similar rescue of these phenotypic features in mutant-expressing Drosophila.
T12 1034-1182 DRI_Outcome denotes The peroxidase mimic preserved neuronal and mitochondrial and neuronal integrity and improved mobility and survival in mutant-expressing Drosophila.
T13 1183-1328 DRI_Outcome denotes Taken together, our study provides the first in vivo evidence to suggest that phosphoinhibition of endogenous peroxidases could be a mechanism in
T14 1329-1359 Token_Label.OUTSIDE denotes LRRK2-induced oxidant-mediated
T15 1360-1374 DRI_Outcome denotes neurotoxicity.
T16 1375-1519 DRI_Outcome denotes Our therapeutic experiments also highlight the potential of thiol peroxidases as neuroprotective agents in PD patients carrying LRRK2 mutations.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 118-223 DRI_Approach denotes Mutations in leucine-rich repeat kinase 2 (LRRK2) are common causes of familial Parkinson's disease (PD).
T2 224-358 DRI_Background denotes LRRK2 has been shown to bind peroxiredoxin-3 (PRDX3), the most important scavenger of hydrogen peroxide in the mitochondria, in vitro.
T3 359-479 DRI_Outcome denotes Here, we examined the interactions of LRRK2 and PRDX3 in Drosophila models by crossing transgenic LRRK2 and PRDX3 flies.
T4 480-603 DRI_Approach denotes As proof of principle experiments, we subsequently challenged LRRK2 and LRRK2/PRDX3 flies with a peroxidase mimic, Ebselen.
T5 604-721 DRI_Outcome denotes We demonstrated that co-expression of PRDX3 with the LRRK2 kinase mutant G2019S in bigenic Drosophila ameliorated the
T6 744-918 DRI_Outcome denotes reduction in peroxidase capacity, loss of dopaminergic neurons, shortened lifespan and mitochondrial defects of flight muscles in monogenic flies expressing the G2019S alone.
T7 919-1033 DRI_Background denotes Challenges with Ebselen recapitulated similar rescue of these phenotypic features in mutant-expressing Drosophila.
T8 1034-1182 DRI_Outcome denotes The peroxidase mimic preserved neuronal and mitochondrial and neuronal integrity and improved mobility and survival in mutant-expressing Drosophila.
T9 1183-1328 DRI_Outcome denotes Taken together, our study provides the first in vivo evidence to suggest that phosphoinhibition of endogenous peroxidases could be a mechanism in
T10 1360-1374 DRI_Outcome denotes neurotoxicity.
T11 1375-1519 DRI_Outcome denotes Our therapeutic experiments also highlight the potential of thiol peroxidases as neuroprotective agents in PD patients carrying LRRK2 mutations.