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PubMed:24454829 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-133 Sentence denotes Altered dynamics in the circadian oscillation of clock genes in dermal fibroblasts of patients suffering from idiopathic hypersomnia.
TextSentencer_T2 134-361 Sentence denotes From single cell organisms to the most complex life forms, the 24-hour circadian rhythm is important for numerous aspects of physiology and behavior such as daily periodic fluctuations in body temperature and sleep-wake cycles.
TextSentencer_T3 362-582 Sentence denotes Influenced by environmental cues - mainly by light input -, the central pacemaker in the thalamic suprachiasmatic nuclei (SCN) controls and regulates the internal clock mechanisms which are present in peripheral tissues.
TextSentencer_T4 583-910 Sentence denotes In order to correlate modifications in the molecular mechanisms of circadian rhythm with the pathophysiology of idiopathic hypersomnia, this study aimed to investigate the dynamics of the expression of circadian clock genes in dermal fibroblasts of idiopathic hypersomniacs (IH) in comparison to those of healthy controls (HC).
TextSentencer_T5 911-1062 Sentence denotes Ten clinically and polysomnographically proven IH patients were recruited from the department of sleep medicine of the University Hospital of Muenster.
TextSentencer_T6 1063-1173 Sentence denotes Clinical diagnosis was done by two consecutive polysomnographies (PSG) and Multiple Sleep Latency Test (MSLT).
TextSentencer_T7 1174-1235 Sentence denotes Fourteen clinical healthy volunteers served as control group.
TextSentencer_T8 1236-1312 Sentence denotes Dermal fibroblasts were obtained via punch biopsy and grown in cell culture.
TextSentencer_T9 1313-1541 Sentence denotes The expression of circadian clock genes was investigated by semiquantitative Reverse Transcriptase-PCR qRT-PCR analysis, confirming periodical oscillation of expression of the core circadian clock genes BMAL1, PER1/2 and CRY1/2.
TextSentencer_T10 1542-1812 Sentence denotes The amplitude of the rhythmically expressed BMAL1, PER1 and PER2 was significantly dampened in dermal fibroblasts of IH compared to HC over two circadian periods whereas the overall expression of only the key transcriptional factor BMAL1 was significantly reduced in IH.
TextSentencer_T11 1813-1901 Sentence denotes Our study suggests for the first time an aberrant dynamics in the circadian clock in IH.
TextSentencer_T12 1902-2024 Sentence denotes These findings may serve to better understand some clinical features of the pathophysiology in sleep - wake rhythms in IH.
T1 0-133 Sentence denotes Altered dynamics in the circadian oscillation of clock genes in dermal fibroblasts of patients suffering from idiopathic hypersomnia.
T2 134-361 Sentence denotes From single cell organisms to the most complex life forms, the 24-hour circadian rhythm is important for numerous aspects of physiology and behavior such as daily periodic fluctuations in body temperature and sleep-wake cycles.
T3 362-582 Sentence denotes Influenced by environmental cues - mainly by light input -, the central pacemaker in the thalamic suprachiasmatic nuclei (SCN) controls and regulates the internal clock mechanisms which are present in peripheral tissues.
T4 583-910 Sentence denotes In order to correlate modifications in the molecular mechanisms of circadian rhythm with the pathophysiology of idiopathic hypersomnia, this study aimed to investigate the dynamics of the expression of circadian clock genes in dermal fibroblasts of idiopathic hypersomniacs (IH) in comparison to those of healthy controls (HC).
T5 911-1062 Sentence denotes Ten clinically and polysomnographically proven IH patients were recruited from the department of sleep medicine of the University Hospital of Muenster.
T6 1063-1173 Sentence denotes Clinical diagnosis was done by two consecutive polysomnographies (PSG) and Multiple Sleep Latency Test (MSLT).
T7 1174-1235 Sentence denotes Fourteen clinical healthy volunteers served as control group.
T8 1236-1312 Sentence denotes Dermal fibroblasts were obtained via punch biopsy and grown in cell culture.
T9 1313-1541 Sentence denotes The expression of circadian clock genes was investigated by semiquantitative Reverse Transcriptase-PCR qRT-PCR analysis, confirming periodical oscillation of expression of the core circadian clock genes BMAL1, PER1/2 and CRY1/2.
T10 1542-1812 Sentence denotes The amplitude of the rhythmically expressed BMAL1, PER1 and PER2 was significantly dampened in dermal fibroblasts of IH compared to HC over two circadian periods whereas the overall expression of only the key transcriptional factor BMAL1 was significantly reduced in IH.
T11 1813-1901 Sentence denotes Our study suggests for the first time an aberrant dynamics in the circadian clock in IH.
T12 1902-2024 Sentence denotes These findings may serve to better understand some clinical features of the pathophysiology in sleep - wake rhythms in IH.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 49-54 gene:9575 denotes clock
T1 110-132 disease:C0751757 denotes idiopathic hypersomnia
R1 T0 T1 associated_with clock,idiopathic hypersomnia

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 706-717 HP_0100786 denotes hypersomnia
T2 843-856 HP_0100786 denotes hypersomniacs

Allie

Id Subject Object Predicate Lexical cue
SS1_24454829_2_0 460-482 expanded denotes suprachiasmatic nuclei
SS2_24454829_2_0 484-487 abbr denotes SCN
SS1_24454829_3_0 832-856 expanded denotes idiopathic hypersomniacs
SS2_24454829_3_0 858-860 abbr denotes IH
SS1_24454829_3_1 888-904 expanded denotes healthy controls
SS2_24454829_3_1 906-908 abbr denotes HC
SS1_24454829_5_0 1110-1127 expanded denotes polysomnographies
SS2_24454829_5_0 1129-1132 abbr denotes PSG
SS1_24454829_5_1 1138-1165 expanded denotes Multiple Sleep Latency Test
SS2_24454829_5_1 1167-1171 abbr denotes MSLT
AE1_24454829_2_0 SS1_24454829_2_0 SS2_24454829_2_0 abbreviatedTo suprachiasmatic nuclei,SCN
AE1_24454829_3_0 SS1_24454829_3_0 SS2_24454829_3_0 abbreviatedTo idiopathic hypersomniacs,IH
AE1_24454829_3_1 SS1_24454829_3_1 SS2_24454829_3_1 abbreviatedTo healthy controls,HC
AE1_24454829_5_0 SS1_24454829_5_0 SS2_24454829_5_0 abbreviatedTo polysomnographies,PSG
AE1_24454829_5_1 SS1_24454829_5_1 SS2_24454829_5_1 abbreviatedTo Multiple Sleep Latency Test,MSLT

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
24454829-0#49#54#gene9575 49-54 gene9575 denotes clock
24454829-0#110#132#diseaseC0033138 110-132 diseaseC0033138 denotes idiopathic hypersomnia
24454829-0#110#132#diseaseC0751757 110-132 diseaseC0751757 denotes idiopathic hypersomnia
49#54#gene9575110#132#diseaseC0033138 24454829-0#49#54#gene9575 24454829-0#110#132#diseaseC0033138 associated_with clock,idiopathic hypersomnia
49#54#gene9575110#132#diseaseC0751757 24454829-0#49#54#gene9575 24454829-0#110#132#diseaseC0751757 associated_with clock,idiopathic hypersomnia

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T624 49-54 gene:9575 denotes clock
T625 110-132 disease:C0033138 denotes idiopathic hypersomnia
R1 T624 T625 associated_with clock,idiopathic hypersomnia
R2 T624 T625 associated_with clock,idiopathic hypersomnia

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 151-160 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organisms
PD-UBERON-AE-B_T2 426-433 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
PD-UBERON-AE-B_T3 574-581 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 574-581 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 151-160 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organisms
PD-UBERON-AE-B_T3 426-433 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
PD-UBERON-AE-B_T4 460-482 http://purl.obolibrary.org/obo/UBERON_0002034 denotes suprachiasmatic nuclei