PubMed:24403070
Annnotations
GlyCosmos6-UBERON
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 136-147 | Body_part | denotes | chromosomes |
T2 | 210-219 | Body_part | denotes | organisms |
T3 | 534-543 | Body_part | denotes | junctions |
T4 | 724-733 | Body_part | denotes | junctions |
c_corpus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-4 | PR:Q9ZRV4 | denotes | Mlh1 |
T2 | 0-4 | PR:P38920 | denotes | Mlh1 |
T3 | 0-4 | PR:Q54KD8 | denotes | Mlh1 |
T5 | 0-4 | PR:Q9JK91 | denotes | Mlh1 |
T6 | 0-4 | PR:P97679 | denotes | Mlh1 |
T7 | 0-4 | PR:Q9P7W6 | denotes | Mlh1 |
T8 | 0-4 | PR:000010442 | denotes | Mlh1 |
T9 | 0-4 | PR:P40692 | denotes | Mlh1 |
T4 | 0-4 | CVCL_G669 | denotes | Mlh1 |
T10 | 5-9 | PR:F4JN26 | denotes | Mlh3 |
T11 | 5-9 | PR:Q12083 | denotes | Mlh3 |
T12 | 5-9 | PR:000010443 | denotes | Mlh3 |
T13 | 5-9 | PR:Q9UHC1 | denotes | Mlh3 |
T16 | 35-38 | SO:0000352 | denotes | DNA |
T15 | 35-38 | CHEBI:16991 | denotes | DNA |
T17 | 35-38 | D004247 | denotes | DNA |
T14 | 35-38 | GO:0005574 | denotes | DNA |
T18 | 39-54 | GO:0006298 | denotes | mismatch repair |
T20 | 68-71 | CHEBI:16768 | denotes | Msh |
T24 | 68-71 | D009074 | denotes | Msh |
T25 | 68-71 | D009074 | denotes | Msh |
T26 | 68-72 | PR:000010666 | denotes | Msh2 |
T27 | 68-72 | PR:P25847 | denotes | Msh2 |
T28 | 68-72 | PR:P43246 | denotes | Msh2 |
T29 | 68-72 | P22711 | denotes | Msh2 |
T30 | 68-72 | PR:P22711 | denotes | Msh2 |
T31 | 68-72 | PR:P54275 | denotes | Msh2 |
T32 | 68-72 | PR:O74773 | denotes | Msh2 |
T33 | 68-72 | PR:P43247 | denotes | Msh2 |
T34 | 68-72 | PR:Q553L4 | denotes | Msh2 |
T35 | 68-72 | PR:O24617 | denotes | Msh2 |
T37 | 73-76 | CHEBI:16768 | denotes | Msh |
T41 | 73-76 | D009074 | denotes | Msh |
T42 | 73-76 | D009074 | denotes | Msh |
T43 | 73-77 | PR:O65607 | denotes | Msh3 |
T44 | 73-77 | PR:000010667 | denotes | Msh3 |
T45 | 73-77 | PR:Q59Y41 | denotes | Msh3 |
T46 | 73-77 | PR:P25336 | denotes | Msh3 |
T47 | 73-77 | PR:P20585 | denotes | Msh3 |
T48 | 73-77 | PR:P26359 | denotes | Msh3 |
T49 | 73-77 | PR:P13705 | denotes | Msh3 |
T50 | 73-77 | PR:Q1ZXH0 | denotes | Msh3 |
T51 | 89-101 | P38446 | denotes | endonuclease |
T52 | 89-101 | P13717 | denotes | endonuclease |
T53 | 89-101 | P20314 | denotes | endonuclease |
T54 | 125-135 | SO:0000857 | denotes | homologous |
T55 | 172-180 | GO:0051324 | denotes | prophase |
T56 | 252-258 | SO:0000985 | denotes | double |
T57 | 259-265 | SO:0001111 | denotes | strand |
T58 | 288-294 | SO:0001026 | denotes | genome |
T60 | 299-323 | 350141 | denotes | Saccharomyces cerevisiae |
T63 | 299-323 | 9511 | denotes | Saccharomyces cerevisiae |
T61 | 299-323 | D012441 | denotes | Saccharomyces cerevisiae |
T62 | 299-323 | 4932 | denotes | Saccharomyces cerevisiae |
T64 | 328-334 | SO:0000985 | denotes | double |
T65 | 335-341 | SO:0001111 | denotes | strand |
T66 | 389-395 | SO:0001111 | denotes | strand |
T67 | 518-524 | SO:0000985 | denotes | double |
T68 | 525-543 | D045566 | denotes | Holliday junctions |
T69 | 594-601 | SO:0000853 | denotes | homolog |
T71 | 621-630 | GO:0007127 | denotes | Meiosis I |
T73 | 640-645 | 214355 | denotes | yeast |
T72 | 640-645 | D015003 | denotes | yeast |
T75 | 660-663 | CHEBI:16768 | denotes | Msh |
T79 | 660-663 | D009074 | denotes | Msh |
T80 | 660-663 | D009074 | denotes | Msh |
T81 | 660-664 | PR:P40965 | denotes | Msh4 |
T82 | 660-664 | PR:000010668 | denotes | Msh4 |
T83 | 660-664 | PR:F4JP48 | denotes | Msh4 |
T84 | 660-664 | PR:Q99MT2 | denotes | Msh4 |
T85 | 660-664 | PR:O15457 | denotes | Msh4 |
T86 | 660-664 | PR:Q23405 | denotes | Msh4 |
T88 | 665-668 | CHEBI:16768 | denotes | Msh |
T92 | 665-668 | D009074 | denotes | Msh |
T93 | 665-668 | D009074 | denotes | Msh |
T94 | 665-669 | PR:Q6MG62 | denotes | Msh5 |
T95 | 665-669 | PR:Q9QUM7 | denotes | Msh5 |
T96 | 665-669 | PR:O43196 | denotes | Msh5 |
T97 | 665-669 | PR:Q19272 | denotes | Msh5 |
T98 | 665-669 | PR:F4JEP5 | denotes | Msh5 |
T99 | 665-669 | PR:000010669 | denotes | Msh5 |
T100 | 665-669 | PR:Q12175 | denotes | Msh5 |
T101 | 708-714 | SO:0000985 | denotes | double |
T102 | 715-733 | D045566 | denotes | Holliday junctions |
T103 | 789-792 | CVCL_4007 | denotes | Sgs |
T104 | 789-792 | C537328 | denotes | Sgs |
T105 | 789-792 | C536632 | denotes | Sgs |
T106 | 789-793 | PR:P35187 | denotes | Sgs1 |
T107 | 789-793 | PR:Q9SQY0 | denotes | Sgs1 |
T108 | 789-793 | PR:Q8L840 | denotes | Sgs1 |
T114 | 804-808 | PR:P39875 | denotes | Exo1 |
T115 | 804-808 | PR:Q24558 | denotes | Exo1 |
T116 | 804-808 | PR:Q54ED2 | denotes | Exo1 |
T117 | 804-808 | PR:Q803U7 | denotes | Exo1 |
T118 | 804-808 | PR:Q9UQ84 | denotes | Exo1 |
T119 | 804-808 | PR:Q9QZ11 | denotes | Exo1 |
T120 | 804-808 | PR:P53695 | denotes | Exo1 |
T121 | 804-808 | PR:000007245 | denotes | Exo1 |
T122 | 804-808 | PR:Q8L6Z7 | denotes | Exo1 |
T123 | 816-837 | Q6QGE6 | denotes | putative endonuclease |
T124 | 816-837 | Q6QGD3 | denotes | putative endonuclease |
T128 | 825-846 | GO:0004519 | denotes | endonuclease activity |
T131 | 862-865 | SO:0000352 | denotes | DNA |
T129 | 862-865 | GO:0005574 | denotes | DNA |
T130 | 862-865 | CHEBI:16991 | denotes | DNA |
T132 | 862-865 | D004247 | denotes | DNA |
T133 | 866-881 | GO:0006298 | denotes | mismatch repair |
T137 | 889-893 | CVCL_G669 | denotes | Mlh1 |
T134 | 889-893 | PR:Q9ZRV4 | denotes | Mlh1 |
T135 | 889-893 | PR:P38920 | denotes | Mlh1 |
T136 | 889-893 | PR:Q54KD8 | denotes | Mlh1 |
T138 | 889-893 | PR:Q9JK91 | denotes | Mlh1 |
T139 | 889-893 | PR:P97679 | denotes | Mlh1 |
T140 | 889-893 | PR:Q9P7W6 | denotes | Mlh1 |
T141 | 889-893 | PR:000010442 | denotes | Mlh1 |
T142 | 889-893 | PR:P40692 | denotes | Mlh1 |
T143 | 894-898 | PR:F4JN26 | denotes | Mlh3 |
T144 | 894-898 | PR:Q12083 | denotes | Mlh3 |
T145 | 894-898 | PR:000010443 | denotes | Mlh3 |
T146 | 894-898 | PR:Q9UHC1 | denotes | Mlh3 |
T147 | 912-916 | PR:Q9ZRV4 | denotes | Mlh1 |
T148 | 912-916 | PR:P38920 | denotes | Mlh1 |
T149 | 912-916 | PR:Q54KD8 | denotes | Mlh1 |
T151 | 912-916 | PR:Q9JK91 | denotes | Mlh1 |
T152 | 912-916 | PR:P97679 | denotes | Mlh1 |
T153 | 912-916 | PR:Q9P7W6 | denotes | Mlh1 |
T154 | 912-916 | PR:000010442 | denotes | Mlh1 |
T155 | 912-916 | PR:P40692 | denotes | Mlh1 |
T150 | 912-916 | CVCL_G669 | denotes | Mlh1 |
T156 | 917-921 | PR:F4JN26 | denotes | Mlh3 |
T157 | 917-921 | PR:Q12083 | denotes | Mlh3 |
T158 | 917-921 | PR:000010443 | denotes | Mlh3 |
T159 | 917-921 | PR:Q9UHC1 | denotes | Mlh3 |
T161 | 966-969 | CHEBI:16768 | denotes | Msh |
T165 | 966-969 | D009074 | denotes | Msh |
T166 | 966-969 | D009074 | denotes | Msh |
T167 | 966-970 | PR:000010666 | denotes | Msh2 |
T168 | 966-970 | PR:P25847 | denotes | Msh2 |
T169 | 966-970 | PR:P43246 | denotes | Msh2 |
T170 | 966-970 | P22711 | denotes | Msh2 |
T171 | 966-970 | PR:P22711 | denotes | Msh2 |
T172 | 966-970 | PR:P54275 | denotes | Msh2 |
T173 | 966-970 | PR:O74773 | denotes | Msh2 |
T174 | 966-970 | PR:P43247 | denotes | Msh2 |
T175 | 966-970 | PR:Q553L4 | denotes | Msh2 |
T176 | 966-970 | PR:O24617 | denotes | Msh2 |
T178 | 971-974 | CHEBI:16768 | denotes | Msh |
T182 | 971-974 | D009074 | denotes | Msh |
T183 | 971-974 | D009074 | denotes | Msh |
T184 | 971-975 | PR:O65607 | denotes | Msh3 |
T185 | 971-975 | PR:000010667 | denotes | Msh3 |
T186 | 971-975 | PR:Q59Y41 | denotes | Msh3 |
T187 | 971-975 | PR:P25336 | denotes | Msh3 |
T188 | 971-975 | PR:P20585 | denotes | Msh3 |
T189 | 971-975 | PR:P26359 | denotes | Msh3 |
T190 | 971-975 | PR:P13705 | denotes | Msh3 |
T191 | 971-975 | PR:Q1ZXH0 | denotes | Msh3 |
T192 | 987-999 | P38446 | denotes | endonuclease |
T193 | 987-999 | P13717 | denotes | endonuclease |
T194 | 987-999 | P20314 | denotes | endonuclease |
T195 | 1018-1024 | SO:0001111 | denotes | strand |
T196 | 1035-1050 | D004278 | denotes | supercoiled DNA |
T197 | 1047-1050 | GO:0005574 | denotes | DNA |
T199 | 1047-1050 | SO:0000352 | denotes | DNA |
T201 | 1100-1104 | PR:Q9ZRV4 | denotes | Mlh1 |
T202 | 1100-1104 | PR:P38920 | denotes | Mlh1 |
T203 | 1100-1104 | PR:Q54KD8 | denotes | Mlh1 |
T205 | 1100-1104 | PR:Q9JK91 | denotes | Mlh1 |
T206 | 1100-1104 | PR:P97679 | denotes | Mlh1 |
T207 | 1100-1104 | PR:Q9P7W6 | denotes | Mlh1 |
T208 | 1100-1104 | PR:000010442 | denotes | Mlh1 |
T209 | 1100-1104 | PR:P40692 | denotes | Mlh1 |
T204 | 1100-1104 | CVCL_G669 | denotes | Mlh1 |
T210 | 1105-1109 | PR:F4JN26 | denotes | Mlh3 |
T211 | 1105-1109 | PR:Q12083 | denotes | Mlh3 |
T212 | 1105-1109 | PR:000010443 | denotes | Mlh3 |
T213 | 1105-1109 | PR:Q9UHC1 | denotes | Mlh3 |
T214 | 1108-1131 | GO:0016894 | denotes | 3 endonuclease activity |
T215 | 1110-1122 | P38446 | denotes | endonuclease |
T216 | 1110-1122 | P13717 | denotes | endonuclease |
T217 | 1110-1122 | P20314 | denotes | endonuclease |
T221 | 1180-1183 | SO:0000352 | denotes | DNA |
T220 | 1180-1183 | CHEBI:16991 | denotes | DNA |
T222 | 1180-1183 | D004247 | denotes | DNA |
T219 | 1180-1183 | GO:0005574 | denotes | DNA |
T223 | 1184-1199 | GO:0006298 | denotes | mismatch repair |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-102 | Sentence | denotes | Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease. |
T2 | 103-295 | Sentence | denotes | Crossing over between homologous chromosomes is initiated in meiotic prophase in most sexually reproducing organisms by the appearance of programmed double strand breaks throughout the genome. |
T3 | 296-469 | Sentence | denotes | In Saccharomyces cerevisiae the double-strand breaks are resected to form three prime single-strand tails that primarily invade complementary sequences in unbroken homologs. |
T4 | 470-631 | Sentence | denotes | These invasion intermediates are converted into double Holliday junctions and then resolved into crossovers that facilitate homolog segregation during Meiosis I. |
T5 | 632-899 | Sentence | denotes | Work in yeast suggests that Msh4-Msh5 stabilizes invasion intermediates and double Holliday junctions, which are resolved into crossovers in steps requiring Sgs1 helicase, Exo1, and a putative endonuclease activity encoded by the DNA mismatch repair factor Mlh1-Mlh3. |
T6 | 900-1051 | Sentence | denotes | We purified Mlh1-Mlh3 and showed that it is a metal-dependent and Msh2-Msh3-stimulated endonuclease that makes single-strand breaks in supercoiled DNA. |
T7 | 1052-1200 | Sentence | denotes | These observations support a direct role for an Mlh1-Mlh3 endonuclease activity in resolving recombination intermediates and in DNA mismatch repair. |
GlyCosmos6-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-4 | http://purl.obolibrary.org/obo/CLO_0007748 | denotes | Mlh1 |
T2 | 838-846 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T3 | 889-893 | http://purl.obolibrary.org/obo/CLO_0007748 | denotes | Mlh1 |
T4 | 912-916 | http://purl.obolibrary.org/obo/CLO_0007748 | denotes | Mlh1 |
T5 | 1100-1104 | http://purl.obolibrary.org/obo/CLO_0007748 | denotes | Mlh1 |
T6 | 1123-1131 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 299-323 | OrganismTaxon | denotes | Saccharomyces cerevisiae | NCBItxid:4932 |
UseCases_ArguminSci_Discourse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-102 | DRI_Approach | denotes | Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease. |
T2 | 103-295 | DRI_Approach | denotes | Crossing over between homologous chromosomes is initiated in meiotic prophase in most sexually reproducing organisms by the appearance of programmed double strand breaks throughout the genome. |
T3 | 296-469 | DRI_Approach | denotes | In Saccharomyces cerevisiae the double-strand breaks are resected to form three prime single-strand tails that primarily invade complementary sequences in unbroken homologs. |
T4 | 470-631 | DRI_Approach | denotes | These invasion intermediates are converted into double Holliday junctions and then resolved into crossovers that facilitate homolog segregation during Meiosis I. |
T5 | 632-899 | DRI_Approach | denotes | Work in yeast suggests that Msh4-Msh5 stabilizes invasion intermediates and double Holliday junctions, which are resolved into crossovers in steps requiring Sgs1 helicase, Exo1, and a putative endonuclease activity encoded by the DNA mismatch repair factor Mlh1-Mlh3. |
T6 | 900-1051 | DRI_Approach | denotes | We purified Mlh1-Mlh3 and showed that it is a metal-dependent and Msh2-Msh3-stimulated endonuclease that makes single-strand breaks in supercoiled DNA. |
T7 | 1052-1200 | DRI_Challenge | denotes | These observations support a direct role for an Mlh1-Mlh3 endonuclease activity in resolving recombination intermediates and in DNA mismatch repair. |
PubMed_ArguminSci
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 103-295 | DRI_Approach | denotes | Crossing over between homologous chromosomes is initiated in meiotic prophase in most sexually reproducing organisms by the appearance of programmed double strand breaks throughout the genome. |
T2 | 296-469 | DRI_Approach | denotes | In Saccharomyces cerevisiae the double-strand breaks are resected to form three prime single-strand tails that primarily invade complementary sequences in unbroken homologs. |
T3 | 470-631 | DRI_Approach | denotes | These invasion intermediates are converted into double Holliday junctions and then resolved into crossovers that facilitate homolog segregation during Meiosis I. |
T4 | 632-899 | DRI_Approach | denotes | Work in yeast suggests that Msh4-Msh5 stabilizes invasion intermediates and double Holliday junctions, which are resolved into crossovers in steps requiring Sgs1 helicase, Exo1, and a putative endonuclease activity encoded by the DNA mismatch repair factor Mlh1-Mlh3. |
T5 | 900-1051 | DRI_Approach | denotes | We purified Mlh1-Mlh3 and showed that it is a metal-dependent and Msh2-Msh3-stimulated endonuclease that makes single-strand breaks in supercoiled DNA. |
T6 | 1052-1200 | DRI_Challenge | denotes | These observations support a direct role for an Mlh1-Mlh3 endonuclease activity in resolving recombination intermediates and in DNA mismatch repair. |