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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-123 Sentence denotes LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia.
TextSentencer_T2 124-272 Sentence denotes The dramatic increase in the prevalence of obesity reflects a lack of progress in combating one of the most serious health problems of this century.
TextSentencer_T3 273-469 Sentence denotes Recent studies have improved our understanding of the appetitive network by focusing on the paraventricular hypothalamus (PVH), a key region responsible for the homeostatic balance of food intake.
TextSentencer_T4 470-652 Sentence denotes Here we show that mice with PVH-specific ablation of LIM domain only 4 (Lmo4) become rapidly obese when fed regular chow due to hyperphagia rather than to reduced energy expenditure.
TextSentencer_T5 653-804 Sentence denotes Brain slice recording of LMO4-deficient PVH neurons showed reduced basal cellular excitability together with reduced voltage-activated Ca(2+) currents.
TextSentencer_T6 805-952 Sentence denotes Real-time PCR quantification revealed that LMO4 regulates the expression of Ca(2+) channels (Cacna1h, Cacna1e) that underlie neuronal excitability.
TextSentencer_T7 953-1128 Sentence denotes By increasing neuronal activity using designer receptors exclusively activated by designer drugs technology, we could suppress food intake of PVH-specific LMO4-deficient mice.
TextSentencer_T8 1129-1249 Sentence denotes Together, these results demonstrate that reduced neural activity in LMO4-deficient PVH neurons accounts for hyperphagia.
TextSentencer_T9 1250-1333 Sentence denotes Thus, maintaining PVH activity is important to prevent hyperphagia-induced obesity.
T1 0-123 Sentence denotes LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia.
T2 124-272 Sentence denotes The dramatic increase in the prevalence of obesity reflects a lack of progress in combating one of the most serious health problems of this century.
T3 273-469 Sentence denotes Recent studies have improved our understanding of the appetitive network by focusing on the paraventricular hypothalamus (PVH), a key region responsible for the homeostatic balance of food intake.
T4 470-652 Sentence denotes Here we show that mice with PVH-specific ablation of LIM domain only 4 (Lmo4) become rapidly obese when fed regular chow due to hyperphagia rather than to reduced energy expenditure.
T5 653-804 Sentence denotes Brain slice recording of LMO4-deficient PVH neurons showed reduced basal cellular excitability together with reduced voltage-activated Ca(2+) currents.
T6 805-952 Sentence denotes Real-time PCR quantification revealed that LMO4 regulates the expression of Ca(2+) channels (Cacna1h, Cacna1e) that underlie neuronal excitability.
T7 953-1128 Sentence denotes By increasing neuronal activity using designer receptors exclusively activated by designer drugs technology, we could suppress food intake of PVH-specific LMO4-deficient mice.
T8 1129-1249 Sentence denotes Together, these results demonstrate that reduced neural activity in LMO4-deficient PVH neurons accounts for hyperphagia.
T9 1250-1333 Sentence denotes Thus, maintaining PVH activity is important to prevent hyperphagia-induced obesity.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-4 gene:8048 denotes LMO4
T1 111-122 disease:C0020505 denotes hyperphagia
T2 0-4 gene:8543 denotes LMO4
T3 111-122 disease:C0020505 denotes hyperphagia
T4 542-546 gene:8048 denotes Lmo4
T5 563-568 disease:C0028754 denotes obese
T6 523-540 gene:8543 denotes LIM domain only 4
T7 598-609 disease:C0020505 denotes hyperphagia
T8 523-540 gene:8048 denotes LIM domain only 4
T9 598-609 disease:C0020505 denotes hyperphagia
T10 542-546 gene:8543 denotes Lmo4
T11 563-568 disease:C0028754 denotes obese
T12 523-540 gene:8543 denotes LIM domain only 4
T13 563-568 disease:C0028754 denotes obese
T14 542-546 gene:8543 denotes Lmo4
T15 598-609 disease:C0020505 denotes hyperphagia
T16 523-540 gene:8048 denotes LIM domain only 4
T17 563-568 disease:C0028754 denotes obese
T18 542-546 gene:8048 denotes Lmo4
T19 598-609 disease:C0020505 denotes hyperphagia
T20 1197-1201 gene:8048 denotes LMO4
T21 1237-1248 disease:C0020505 denotes hyperphagia
T22 1197-1201 gene:8543 denotes LMO4
T23 1237-1248 disease:C0020505 denotes hyperphagia
R1 T0 T1 associated_with LMO4,hyperphagia
R2 T2 T3 associated_with LMO4,hyperphagia
R3 T4 T5 associated_with Lmo4,obese
R4 T6 T7 associated_with LIM domain only 4,hyperphagia
R5 T8 T9 associated_with LIM domain only 4,hyperphagia
R6 T10 T11 associated_with Lmo4,obese
R7 T12 T13 associated_with LIM domain only 4,obese
R8 T14 T15 associated_with Lmo4,hyperphagia
R9 T16 T17 associated_with LIM domain only 4,obese
R10 T18 T19 associated_with Lmo4,hyperphagia
R11 T20 T21 associated_with LMO4,hyperphagia
R12 T22 T23 associated_with LMO4,hyperphagia

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 167-174 HP_0001513 denotes obesity
T2 563-568 HP_0001513 denotes obese
T3 598-609 HP_0002591 denotes hyperphagia
T4 1237-1248 HP_0002591 denotes hyperphagia
T5 1305-1316 HP_0002591 denotes hyperphagia
T6 1325-1332 HP_0001513 denotes obesity

Allie

Id Subject Object Predicate Lexical cue
SS1_24381275_2_0 365-393 expanded denotes paraventricular hypothalamus
SS2_24381275_2_0 395-398 abbr denotes PVH
SS1_24381275_3_0 523-540 expanded denotes LIM domain only 4
SS2_24381275_3_0 542-546 abbr denotes Lmo4
AE1_24381275_2_0 SS1_24381275_2_0 SS2_24381275_2_0 abbreviatedTo paraventricular hypothalamus,PVH
AE1_24381275_3_0 SS1_24381275_3_0 SS2_24381275_3_0 abbreviatedTo LIM domain only 4,Lmo4

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
24381275-3#53#70#gene8048 523-540 gene8048 denotes LIM domain only 4
24381275-3#53#70#gene8543 523-540 gene8543 denotes LIM domain only 4
24381275-3#72#76#gene8543 542-546 gene8543 denotes Lmo4
24381275-3#93#98#diseaseC0028754 563-568 diseaseC0028754 denotes obese
53#70#gene804893#98#diseaseC0028754 24381275-3#53#70#gene8048 24381275-3#93#98#diseaseC0028754 associated_with LIM domain only 4,obese
53#70#gene854393#98#diseaseC0028754 24381275-3#53#70#gene8543 24381275-3#93#98#diseaseC0028754 associated_with LIM domain only 4,obese
72#76#gene854393#98#diseaseC0028754 24381275-3#72#76#gene8543 24381275-3#93#98#diseaseC0028754 associated_with Lmo4,obese

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2105 523-540 gene:8048 denotes LIM domain only 4
T2106 563-568 disease:C0028754 denotes obese
R1 T2105 T2106 associated_with LIM domain only 4,obese
R2 T2105 T2106 associated_with LIM domain only 4,obese

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 381-393 http://purl.obolibrary.org/obo/UBERON_0001898 denotes hypothalamus

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 653-658 http://purl.obolibrary.org/obo/UBERON_0000955 denotes Brain
PD-UBERON-AE-B_T2 51-59 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neuronal
PD-UBERON-AE-B_T3 697-704 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons
PD-UBERON-AE-B_T4 930-938 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neuronal
PD-UBERON-AE-B_T5 967-975 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neuronal
PD-UBERON-AE-B_T6 1216-1223 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons
PD-UBERON-AE-B_T7 381-393 http://purl.obolibrary.org/obo/UBERON_0001898 denotes hypothalamus