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PubMed_ArguminSci

Id	Subject	Object	Predicate	Lexical cue
T1	115-224	DRI_Challenge	denotes	The human hypertrophic cardiomyopathy mutation R453C results in one of the more severe forms of the myopathy.
T2	225-398	DRI_Background	denotes	Arg-453 is found in a conserved surface loop of the upper 50-kDa domain of the myosin motor domain and lies between the nucleotide binding pocket and the actin binding site.
T3	399-527	DRI_Approach	denotes	It connects to the cardiomyopathy loop via a long α-helix, helix O, and to Switch-2 via the fifth strand of the central β-sheet.
T4	528-625	DRI_Approach	denotes	The mutation is, therefore, in a position to perturb a wide range of myosin molecular activities.
T5	626-767	DRI_Outcome	denotes	We report here the first detailed biochemical kinetic analysis of the motor domain of the human β-cardiac myosin carrying the R453C mutation.
T6	956-1077	DRI_Outcome	denotes	U.S.A. 110, 12607-12612) found reduced ATPase and in vitro motility but increased force production using an optical trap.
T7	1078-1183	DRI_Outcome	denotes	Surprisingly, our results show that the mutation alters few biochemical kinetic parameters significantly.
T8	1184-1395	DRI_Approach	denotes	The exceptions are the rate constants for ATP binding to the motor domain (reduced by 35%) and the ATP hydrolysis step/recovery stroke (slowed 3-fold), which could be the rate-limiting step for the ATPase cycle.
T9	1396-1575	DRI_Outcome	denotes	Effects of the mutation on the recovery stroke are consistent with a perturbation of Switch-2 closure, which is required for the recovery stroke and the subsequent ATP hydrolysis.

sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-114	Sentence	denotes	The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosin.
T2	115-224	Sentence	denotes	The human hypertrophic cardiomyopathy mutation R453C results in one of the more severe forms of the myopathy.
T3	225-398	Sentence	denotes	Arg-453 is found in a conserved surface loop of the upper 50-kDa domain of the myosin motor domain and lies between the nucleotide binding pocket and the actin binding site.
T4	399-527	Sentence	denotes	It connects to the cardiomyopathy loop via a long α-helix, helix O, and to Switch-2 via the fifth strand of the central β-sheet.
T5	528-625	Sentence	denotes	The mutation is, therefore, in a position to perturb a wide range of myosin molecular activities.
T6	626-767	Sentence	denotes	We report here the first detailed biochemical kinetic analysis of the motor domain of the human β-cardiac myosin carrying the R453C mutation.
T7	768-817	Sentence	denotes	A recent report of the same mutation (Sommese, R.
T8	818-863	Sentence	denotes	F., Sung, J., Nag, S., Sutton, S., Deacon, J.
T9	864-890	Sentence	denotes	C., Choe, E., Leinwand, L.
T10	891-922	Sentence	denotes	A., Ruppel, K., and Spudich, J.
T11	923-938	Sentence	denotes	A. (2013) Proc.
T12	939-944	Sentence	denotes	Natl.
T13	945-950	Sentence	denotes	Acad.
T14	951-955	Sentence	denotes	Sci.
T15	956-962	Sentence	denotes	U.S.A.
T16	963-1077	Sentence	denotes	110, 12607-12612) found reduced ATPase and in vitro motility but increased force production using an optical trap.
T17	1078-1183	Sentence	denotes	Surprisingly, our results show that the mutation alters few biochemical kinetic parameters significantly.
T18	1184-1395	Sentence	denotes	The exceptions are the rate constants for ATP binding to the motor domain (reduced by 35%) and the ATP hydrolysis step/recovery stroke (slowed 3-fold), which could be the rate-limiting step for the ATPase cycle.
T19	1396-1575	Sentence	denotes	Effects of the mutation on the recovery stroke are consistent with a perturbation of Switch-2 closure, which is required for the recovery stroke and the subsequent ATP hydrolysis.

DisGeNET

Id	Subject	Object	Predicate	Lexical cue
T0	1382-1388	gene:1769	denotes	ATPase
T1	1312-1318	disease:C0038454	denotes	stroke
R1	T0	T1	associated_with	ATPase,stroke

PubmedHPO

Id	Subject	Object	Predicate	Lexical cue
T1	125-152	HP_0001639	denotes	hypertrophic cardiomyopathy
T2	138-152	HP_0001638	denotes	cardiomyopathy
T3	215-223	HP_0003198	denotes	myopathy
T4	418-432	HP_0001638	denotes	cardiomyopathy
T5	1312-1318	HP_0001297	denotes	stroke
T6	1436-1442	HP_0001297	denotes	stroke
T7	1534-1540	HP_0001297	denotes	stroke

DisGeNET5_gene_disease

Id	Subject	Object	Predicate	Lexical cue
24344137-9#198#204#gene1769	1382-1388	gene1769	denotes	ATPase
24344137-9#128#134#diseaseC0038454	1312-1318	diseaseC0038454	denotes	stroke
198#204#gene1769128#134#diseaseC0038454	24344137-9#198#204#gene1769	24344137-9#128#134#diseaseC0038454	associated_with	ATPase,stroke

HP-phenotype

Id	Subject	Object	Predicate	Lexical cue	hp_id
T1	4-31	Phenotype	denotes	hypertrophic cardiomyopathy	HP:0001639
T2	125-152	Phenotype	denotes	hypertrophic cardiomyopathy	HP:0001639
T3	215-223	Phenotype	denotes	myopathy	HP:0003198
T4	418-432	Phenotype	denotes	cardiomyopathy	HP:0001638
T5	1312-1318	Phenotype	denotes	stroke	HP:0001297
T6	1436-1442	Phenotype	denotes	stroke	HP:0001297
T7	1534-1540	Phenotype	denotes	stroke	HP:0001297

mondo_disease

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	4-31	Disease	denotes	hypertrophic cardiomyopathy	http://purl.obolibrary.org/obo/MONDO_0005045
T2	125-152	Disease	denotes	hypertrophic cardiomyopathy	http://purl.obolibrary.org/obo/MONDO_0005045
T3	215-223	Disease	denotes	myopathy	http://purl.obolibrary.org/obo/MONDO_0005336
T4	418-432	Disease	denotes	cardiomyopathy	http://purl.obolibrary.org/obo/MONDO_0004994
T5	1312-1318	Disease	denotes	stroke	http://purl.obolibrary.org/obo/MONDO_0005098\|http://purl.obolibrary.org/obo/MONDO_0011057
T7	1436-1442	Disease	denotes	stroke	http://purl.obolibrary.org/obo/MONDO_0005098\|http://purl.obolibrary.org/obo/MONDO_0011057
T9	1534-1540	Disease	denotes	stroke	http://purl.obolibrary.org/obo/MONDO_0005098\|http://purl.obolibrary.org/obo/MONDO_0011057

NCBITAXON

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	91-96	OrganismTaxon	denotes	human	9606
T2	119-124	OrganismTaxon	denotes	human	9606
T3	716-721	OrganismTaxon	denotes	human	9606

Anatomy-UBERON

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T1	451-456	Body_part	denotes	helix	http://purl.obolibrary.org/obo/UBERON_0002488
T2	458-463	Body_part	denotes	helix	http://purl.obolibrary.org/obo/UBERON_0002488