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LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 103-107 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T4 411-422 OrganismTaxon denotes hippocampus NCBItxid:72046
T5 587-590 OrganismTaxon denotes rat NCBItxid:10116|NCBItxid:10114
T7 646-650 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T10 1068-1072 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-108 Sentence denotes Cholecystokinin-octapeptide restored morphine-induced hippocampal long-term potentiation impairment in rats.
T2 109-259 Sentence denotes Cholecystokinin-octapeptide (CCK-8), which is a typical brain-gut peptide, exerts a wide range of biological activities on the central nervous system.
T3 260-451 Sentence denotes We have previously reported that CCK-8 significantly alleviated morphine-induced amnesia and reversed spine density decreases in the CA1 region of the hippocampus in morphine-treated animals.
T4 452-651 Sentence denotes Here, we investigated the effects of CCK-8 on long-term potentiation (LTP) in the lateral perforant path (LPP)-granule cell synapse of rat dentate gyrus (DG) in acute saline or morphine-treated rats.
T5 652-752 Sentence denotes Population spikes (PS), which were evoked by stimulation of the LPP, were recorded in the DG region.
T6 753-930 Sentence denotes Acute morphine (30mg/kg, s.c.) treatment significantly attenuated hippocampal LTP and CCK-8 (1μg, i.c.v.) restored the amplitude of PS that was attenuated by morphine injection.
T7 931-1073 Sentence denotes Furthermore, microinjection of CCK-8 (0.1 and 1μg, i.c.v.) also significantly augmented hippocampal LTP in saline-treated (1ml/kg, s.c.) rats.
T8 1074-1240 Sentence denotes Pre-treatment of the CCK2 receptor antagonist L-365,260 (10μg, i.c.v) reversed the effects of CCK-8, but the CCK1 receptor antagonist L-364,718 (10μg, i.c.v) did not.
T9 1241-1444 Sentence denotes The present results demonstrate that CCK-8 attenuates the effect of morphine on hippocampal LTP through CCK2 receptors and suggest an ameliorative function of CCK-8 on morphine-induced memory impairment.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
9489 0-27 ChemicalEntity denotes Cholecystokinin-octapeptide MESH:D012844
9490 37-45 ChemicalEntity denotes morphine MESH:D009020
9491 103-107 OrganismTaxon denotes rats NCBITaxon:10116
9492 109-136 ChemicalEntity denotes Cholecystokinin-octapeptide MESH:D012844
9493 138-143 ChemicalEntity denotes CCK-8 MESH:D012844
9494 293-298 ChemicalEntity denotes CCK-8 MESH:D012844
9495 324-332 ChemicalEntity denotes morphine MESH:D009020
9496 341-348 DiseaseOrPhenotypicFeature denotes amnesia MESH:D000647
9497 426-434 ChemicalEntity denotes morphine MESH:D009020
9498 489-494 ChemicalEntity denotes CCK-8 MESH:D012844
9499 587-590 OrganismTaxon denotes rat NCBITaxon:10116
9500 629-637 ChemicalEntity denotes morphine MESH:D009020
9501 646-650 OrganismTaxon denotes rats NCBITaxon:10116
9502 759-767 ChemicalEntity denotes morphine MESH:D009020
9503 839-844 ChemicalEntity denotes CCK-8 MESH:D012844
9504 911-919 ChemicalEntity denotes morphine MESH:D009020
9505 962-967 ChemicalEntity denotes CCK-8 MESH:D012844
9506 1068-1072 OrganismTaxon denotes rats NCBITaxon:10116
9507 1095-1108 GeneOrGeneProduct denotes CCK2 receptor NCBIGene:25706
9508 1120-1129 ChemicalEntity denotes L-365,260 MESH:C058121
9509 1168-1173 ChemicalEntity denotes CCK-8 MESH:D012844
9510 1183-1196 GeneOrGeneProduct denotes CCK1 receptor NCBIGene:24889
9511 1208-1217 ChemicalEntity denotes L-364,718 MESH:D020109
9512 1278-1283 ChemicalEntity denotes CCK-8 MESH:D012844
9513 1309-1317 ChemicalEntity denotes morphine MESH:D009020
9514 1345-1359 GeneOrGeneProduct denotes CCK2 receptors NCBIGene:25706
9515 1400-1405 ChemicalEntity denotes CCK-8 MESH:D012844
9516 1409-1417 ChemicalEntity denotes morphine MESH:D009020
9517 1426-1443 DiseaseOrPhenotypicFeature denotes memory impairment MESH:D008569

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-15 GeneOrGeneProduct denotes Cholecystokinin
T2 71-75 GeneOrGeneProduct denotes term
T3 109-124 GeneOrGeneProduct denotes Cholecystokinin
T4 138-143 GeneOrGeneProduct denotes CCK-8
T5 165-170 GeneOrGeneProduct denotes brain
T6 244-251 GeneOrGeneProduct denotes nervous
T7 293-298 GeneOrGeneProduct denotes CCK-8
T8 362-367 GeneOrGeneProduct denotes spine
T9 489-494 GeneOrGeneProduct denotes CCK-8
T10 503-507 GeneOrGeneProduct denotes term
T11 552-556 GeneOrGeneProduct denotes path
T12 571-575 GeneOrGeneProduct denotes cell
T13 663-669 GeneOrGeneProduct denotes spikes
T14 808-818 GeneOrGeneProduct denotes attenuated
T15 839-844 GeneOrGeneProduct denotes CCK-8
T16 897-907 GeneOrGeneProduct denotes attenuated
T17 962-967 GeneOrGeneProduct denotes CCK-8
T18 973-978 GeneOrGeneProduct denotes and 1
T19 1095-1108 GeneOrGeneProduct denotes CCK2 receptor
T20 1168-1173 GeneOrGeneProduct denotes CCK-8
T21 1183-1187 GeneOrGeneProduct denotes CCK1
T22 1188-1196 GeneOrGeneProduct denotes receptor
T23 1278-1283 GeneOrGeneProduct denotes CCK-8
T24 1345-1349 GeneOrGeneProduct denotes CCK2
T25 1400-1405 GeneOrGeneProduct denotes CCK-8

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-15 GeneOrGeneProduct denotes Cholecystokinin
T2 46-53 GeneOrGeneProduct denotes induced
T3 66-70 GeneOrGeneProduct denotes long
T4 71-75 GeneOrGeneProduct denotes term
T5 109-124 GeneOrGeneProduct denotes Cholecystokinin
T6 138-143 GeneOrGeneProduct denotes CCK-8
T7 165-170 GeneOrGeneProduct denotes brain
T8 171-174 GeneOrGeneProduct denotes gut
T9 198-203 GeneOrGeneProduct denotes range
T10 218-228 GeneOrGeneProduct denotes activities
T11 244-251 GeneOrGeneProduct denotes nervous
T12 293-298 GeneOrGeneProduct denotes CCK-8
T13 333-340 GeneOrGeneProduct denotes induced
T14 362-367 GeneOrGeneProduct denotes spine
T15 393-396 GeneOrGeneProduct denotes CA1
T16 489-494 GeneOrGeneProduct denotes CCK-8
T17 498-502 GeneOrGeneProduct denotes long
T18 503-507 GeneOrGeneProduct denotes term
T19 534-541 GeneOrGeneProduct denotes lateral
T20 552-556 GeneOrGeneProduct denotes path
T21 571-575 GeneOrGeneProduct denotes cell
T22 663-669 GeneOrGeneProduct denotes spikes
T23 808-818 GeneOrGeneProduct denotes attenuated
T24 839-844 GeneOrGeneProduct denotes CCK-8
T25 897-907 GeneOrGeneProduct denotes attenuated
T26 962-967 GeneOrGeneProduct denotes CCK-8
T27 973-978 GeneOrGeneProduct denotes and 1
T28 1095-1108 GeneOrGeneProduct denotes CCK2 receptor
T29 1109-1119 GeneOrGeneProduct denotes antagonist
T30 1168-1173 GeneOrGeneProduct denotes CCK-8
T31 1183-1187 GeneOrGeneProduct denotes CCK1
T32 1188-1196 GeneOrGeneProduct denotes receptor
T33 1197-1207 GeneOrGeneProduct denotes antagonist
T34 1278-1283 GeneOrGeneProduct denotes CCK-8
T35 1284-1294 GeneOrGeneProduct denotes attenuates
T36 1345-1349 GeneOrGeneProduct denotes CCK2
T37 1350-1359 GeneOrGeneProduct denotes receptors
T38 1400-1405 GeneOrGeneProduct denotes CCK-8
T39 1418-1425 GeneOrGeneProduct denotes induced

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 341-348 DiseaseOrPhenotypicFeature denotes amnesia D000647
T2 1426-1443 DiseaseOrPhenotypicFeature denotes memory impairment DISEASE

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-15 GeneOrGeneProduct denotes Cholecystokinin
T2 109-124 GeneOrGeneProduct denotes Cholecystokinin
T3 552-556 GeneOrGeneProduct denotes path
T4 663-669 GeneOrGeneProduct denotes spikes
T5 1095-1108 GeneOrGeneProduct denotes CCK2 receptor
T6 1183-1187 GeneOrGeneProduct denotes CCK1
T7 1345-1349 GeneOrGeneProduct denotes CCK2

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 341-348 DiseaseOrPhenotypicFeature denotes amnesia 0001152
T2 558-561 DiseaseOrPhenotypicFeature denotes LPP 0018879|0015597
T4 716-719 DiseaseOrPhenotypicFeature denotes LPP 0018879|0015597

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 341-348 DiseaseOrPhenotypicFeature denotes amnesia D000647
T2 1426-1443 DiseaseOrPhenotypicFeature denotes memory impairment DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 341-348 DiseaseOrPhenotypicFeature denotes amnesia D000647
T2 1426-1443 DiseaseOrPhenotypicFeature denotes memory impairment DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 0-27 ChemicalEntity denotes Cholecystokinin-octapeptide ChemicalEntity
T2 37-45 ChemicalEntity denotes morphine D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303
T5 109-136 ChemicalEntity denotes Cholecystokinin-octapeptide ChemicalEntity
T6 138-143 ChemicalEntity denotes CCK-8 http://purl.obolibrary.org/obo/CHEBI_80327
T7 293-298 ChemicalEntity denotes CCK-8 http://purl.obolibrary.org/obo/CHEBI_80327
T8 324-332 ChemicalEntity denotes morphine D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303
T11 426-434 ChemicalEntity denotes morphine D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303
T14 489-494 ChemicalEntity denotes CCK-8 http://purl.obolibrary.org/obo/CHEBI_80327
T15 522-525 ChemicalEntity denotes LTP http://purl.obolibrary.org/obo/CHEBI_137264
T16 558-561 ChemicalEntity denotes LPP http://purl.obolibrary.org/obo/CHEBI_6468
T17 629-637 ChemicalEntity denotes morphine D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303
T20 716-719 ChemicalEntity denotes LPP http://purl.obolibrary.org/obo/CHEBI_6468
T21 759-767 ChemicalEntity denotes morphine D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303
T24 831-834 ChemicalEntity denotes LTP http://purl.obolibrary.org/obo/CHEBI_137264
T25 839-844 ChemicalEntity denotes CCK-8 http://purl.obolibrary.org/obo/CHEBI_80327
T26 911-919 ChemicalEntity denotes morphine D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303
T29 962-967 ChemicalEntity denotes CCK-8 http://purl.obolibrary.org/obo/CHEBI_80327
T30 1031-1034 ChemicalEntity denotes LTP http://purl.obolibrary.org/obo/CHEBI_137264
T31 1120-1129 ChemicalEntity denotes L-365,260 ChemicalEntity
T32 1168-1173 ChemicalEntity denotes CCK-8 http://purl.obolibrary.org/obo/CHEBI_80327
T33 1208-1217 ChemicalEntity denotes L-364,718 ChemicalEntity
T34 1278-1283 ChemicalEntity denotes CCK-8 http://purl.obolibrary.org/obo/CHEBI_80327
T35 1309-1317 ChemicalEntity denotes morphine D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303
T38 1333-1336 ChemicalEntity denotes LTP http://purl.obolibrary.org/obo/CHEBI_137264
T39 1400-1405 ChemicalEntity denotes CCK-8 http://purl.obolibrary.org/obo/CHEBI_80327
T40 1409-1417 ChemicalEntity denotes morphine D009020|http://purl.obolibrary.org/obo/CHEBI_58097|http://purl.obolibrary.org/obo/CHEBI_17303

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 103-107 OrganismTaxon denotes rats
T2 587-590 OrganismTaxon denotes rat
T3 646-650 OrganismTaxon denotes rats
T4 1068-1072 OrganismTaxon denotes rats

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T40 1409-1417 ChemicalEntity denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020
T39 1400-1405 ChemicalEntity denotes CCK-8 http://purl.obolibrary.org/obo/CHEBI_80327
T38 1333-1336 ChemicalEntity denotes LTP http://purl.obolibrary.org/obo/CHEBI_137264
T35 1309-1317 ChemicalEntity denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020
T34 1278-1283 ChemicalEntity denotes CCK-8 http://purl.obolibrary.org/obo/CHEBI_80327
T33 1208-1217 ChemicalEntity denotes L-364,718 ChemicalEntity
T32 1168-1173 ChemicalEntity denotes CCK-8 http://purl.obolibrary.org/obo/CHEBI_80327
T31 1120-1129 ChemicalEntity denotes L-365,260 ChemicalEntity
T30 1031-1034 ChemicalEntity denotes LTP http://purl.obolibrary.org/obo/CHEBI_137264
T29 962-967 ChemicalEntity denotes CCK-8 http://purl.obolibrary.org/obo/CHEBI_80327
T26 911-919 ChemicalEntity denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020
T25 839-844 ChemicalEntity denotes CCK-8 http://purl.obolibrary.org/obo/CHEBI_80327
T24 831-834 ChemicalEntity denotes LTP http://purl.obolibrary.org/obo/CHEBI_137264
T21 759-767 ChemicalEntity denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020
T20 716-719 ChemicalEntity denotes LPP http://purl.obolibrary.org/obo/CHEBI_6468
T17 629-637 ChemicalEntity denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020
T16 558-561 ChemicalEntity denotes LPP http://purl.obolibrary.org/obo/CHEBI_6468
T15 522-525 ChemicalEntity denotes LTP http://purl.obolibrary.org/obo/CHEBI_137264
T14 489-494 ChemicalEntity denotes CCK-8 http://purl.obolibrary.org/obo/CHEBI_80327
T11 426-434 ChemicalEntity denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020
T8 324-332 ChemicalEntity denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020
T7 293-298 ChemicalEntity denotes CCK-8 http://purl.obolibrary.org/obo/CHEBI_80327
T6 138-143 ChemicalEntity denotes CCK-8 http://purl.obolibrary.org/obo/CHEBI_80327
T5 109-136 ChemicalEntity denotes Cholecystokinin-octapeptide ChemicalEntity
T2 37-45 ChemicalEntity denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097|D009020
T1 0-27 ChemicalEntity denotes Cholecystokinin-octapeptide ChemicalEntity
T97702 1345-1349 GeneOrGeneProduct denotes CCK2
T12317 1183-1187 GeneOrGeneProduct denotes CCK1
T69923 1095-1108 GeneOrGeneProduct denotes CCK2 receptor
T4 663-669 GeneOrGeneProduct denotes spikes
T3 552-556 GeneOrGeneProduct denotes path
T25198 109-124 GeneOrGeneProduct denotes Cholecystokinin
T88192 0-15 GeneOrGeneProduct denotes Cholecystokinin
T78934 1426-1443 DiseaseOrPhenotypicFeature denotes memory impairment DISEASE
T35741 341-348 DiseaseOrPhenotypicFeature denotes amnesia D000647
T89451 1068-1072 OrganismTaxon denotes rats
T64265 646-650 OrganismTaxon denotes rats
T41031 587-590 OrganismTaxon denotes rat
T96911 103-107 OrganismTaxon denotes rats

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1426-1443 HP_0002354 denotes memory impairment

Allie

Id Subject Object Predicate Lexical cue
SS1_24309294_3_0 498-520 expanded denotes long-term potentiation
SS2_24309294_3_0 522-525 abbr denotes LTP
SS1_24309294_3_1 534-556 expanded denotes lateral perforant path
SS2_24309294_3_1 558-561 abbr denotes LPP
SS1_24309294_3_2 591-604 expanded denotes dentate gyrus
SS2_24309294_3_2 606-608 abbr denotes DG
SS1_24309294_4_0 652-669 expanded denotes Population spikes
SS2_24309294_4_0 671-673 abbr denotes PS
AE1_24309294_3_0 SS1_24309294_3_0 SS2_24309294_3_0 abbreviatedTo long-term potentiation,LTP
AE1_24309294_3_1 SS1_24309294_3_1 SS2_24309294_3_1 abbreviatedTo lateral perforant path,LPP
AE1_24309294_3_2 SS1_24309294_3_2 SS2_24309294_3_2 abbreviatedTo dentate gyrus,DG
AE1_24309294_4_0 SS1_24309294_4_0 SS2_24309294_4_0 abbreviatedTo Population spikes,PS