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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-190 Sentence denotes Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells.
TextSentencer_T2 191-202 Sentence denotes BACKGROUND:
TextSentencer_T3 203-286 Sentence denotes Tumor cells benefit from their ability to avoid apoptosis and invade other tissues.
TextSentencer_T4 287-376 Sentence denotes The endoplasmic reticulum (ER) membrane protein Sec62 is a key player in these processes.
TextSentencer_T5 377-520 Sentence denotes Sec62 is essential for cell migration and protects tumor cells against thapsigargin-induced ER stress, which are both linked to cytosolic Ca²⁺.
TextSentencer_T6 521-629 Sentence denotes SEC62 silencing leads to elevated cytosolic Ca²⁺ and increased ER Ca²⁺ leakage after thapsigargin treatment.
TextSentencer_T7 630-744 Sentence denotes Sec62 protein levels are significantly increased in different tumors, including prostate, lung and thyroid cancer.
TextSentencer_T8 745-753 Sentence denotes METHODS:
TextSentencer_T9 754-889 Sentence denotes In lung cancer, the influence of Sec62 protein levels on patient survival was analyzed using the Kaplan-Meier method and log-rank test.
TextSentencer_T10 890-1047 Sentence denotes To elucidate the underlying pathophysiological functions of Sec62, Ca²⁺ imaging techniques, real-time cell analysis and cell migration assays were performed.
TextSentencer_T11 1048-1326 Sentence denotes The effects of treatment with the calmodulin antagonists, trifluoperazine (TFP) and ophiobolin A, on cellular Ca²⁺ homeostasis, cell growth and cell migration were compared with the effects of siRNA-mediated Sec62 depletion or the expression of a mutated SEC62 variant in vitro.
TextSentencer_T12 1327-1425 Sentence denotes Using Biacore analysis we examined the Ca²⁺-sensitive interaction of Sec62 with the Sec61 complex.
TextSentencer_T13 1426-1434 Sentence denotes RESULTS:
TextSentencer_T14 1435-1511 Sentence denotes Sec62 overproduction significantly correlated with reduced patient survival.
TextSentencer_T15 1512-1628 Sentence denotes Therefore, Sec62 is not only a predictive marker for this type of tumor, but also an interesting therapeutic target.
TextSentencer_T16 1629-1783 Sentence denotes The present study suggests a regulatory function for Sec62 in the major Ca²⁺ leakage channel in the ER, Sec61, by a direct and Ca²⁺-sensitive interaction.
TextSentencer_T17 1784-1854 Sentence denotes A Ca²⁺-binding motif in Sec62 is essential for its molecular function.
TextSentencer_T18 1855-2016 Sentence denotes Treatment of cells with calmodulin antagonists mimicked Sec62 depletion by inhibiting cell migration and rendering the cells sensitive to thapsigargin treatment.
TextSentencer_T19 2017-2029 Sentence denotes CONCLUSIONS:
TextSentencer_T20 2030-2199 Sentence denotes Targeting tumors that overproduce Sec62 with calmodulin antagonists in combination with targeted thapsigargin analogues may offer novel personalized therapeutic options.
T1 0-190 Sentence denotes Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells.
T2 191-202 Sentence denotes BACKGROUND:
T3 203-286 Sentence denotes Tumor cells benefit from their ability to avoid apoptosis and invade other tissues.
T4 287-376 Sentence denotes The endoplasmic reticulum (ER) membrane protein Sec62 is a key player in these processes.
T5 377-520 Sentence denotes Sec62 is essential for cell migration and protects tumor cells against thapsigargin-induced ER stress, which are both linked to cytosolic Ca²⁺.
T6 521-629 Sentence denotes SEC62 silencing leads to elevated cytosolic Ca²⁺ and increased ER Ca²⁺ leakage after thapsigargin treatment.
T7 630-744 Sentence denotes Sec62 protein levels are significantly increased in different tumors, including prostate, lung and thyroid cancer.
T8 745-753 Sentence denotes METHODS:
T9 754-889 Sentence denotes In lung cancer, the influence of Sec62 protein levels on patient survival was analyzed using the Kaplan-Meier method and log-rank test.
T10 890-1047 Sentence denotes To elucidate the underlying pathophysiological functions of Sec62, Ca²⁺ imaging techniques, real-time cell analysis and cell migration assays were performed.
T11 1048-1326 Sentence denotes The effects of treatment with the calmodulin antagonists, trifluoperazine (TFP) and ophiobolin A, on cellular Ca²⁺ homeostasis, cell growth and cell migration were compared with the effects of siRNA-mediated Sec62 depletion or the expression of a mutated SEC62 variant in vitro.
T12 1327-1425 Sentence denotes Using Biacore analysis we examined the Ca²⁺-sensitive interaction of Sec62 with the Sec61 complex.
T13 1426-1434 Sentence denotes RESULTS:
T14 1435-1511 Sentence denotes Sec62 overproduction significantly correlated with reduced patient survival.
T15 1512-1628 Sentence denotes Therefore, Sec62 is not only a predictive marker for this type of tumor, but also an interesting therapeutic target.
T16 1629-1783 Sentence denotes The present study suggests a regulatory function for Sec62 in the major Ca²⁺ leakage channel in the ER, Sec61, by a direct and Ca²⁺-sensitive interaction.
T17 1784-1854 Sentence denotes A Ca²⁺-binding motif in Sec62 is essential for its molecular function.
T18 1855-2016 Sentence denotes Treatment of cells with calmodulin antagonists mimicked Sec62 depletion by inhibiting cell migration and rendering the cells sensitive to thapsigargin treatment.
T19 2017-2029 Sentence denotes CONCLUSIONS:
T20 2030-2199 Sentence denotes Targeting tumors that overproduce Sec62 with calmodulin antagonists in combination with targeted thapsigargin analogues may offer novel personalized therapeutic options.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 148-153 gene:7095 denotes SEC62
T1 55-61 disease:C3825627 denotes stress
T2 76-86 gene:805 denotes calmodulin
T3 55-61 disease:C3825627 denotes stress
T4 76-86 gene:808 denotes calmodulin
T5 55-61 disease:C3825627 denotes stress
T6 76-86 gene:801 denotes calmodulin
T7 55-61 disease:C3825627 denotes stress
T8 335-340 gene:7095 denotes Sec62
T9 472-478 disease:C3825627 denotes stress
T10 630-635 gene:7095 denotes Sec62
T11 729-743 disease:C0549473 denotes thyroid cancer
T12 630-635 gene:7095 denotes Sec62
T13 729-743 disease:C0007115 denotes thyroid cancer
R1 T0 T1 associated_with SEC62,stress
R2 T2 T3 associated_with calmodulin,stress
R3 T4 T5 associated_with calmodulin,stress
R4 T6 T7 associated_with calmodulin,stress
R5 T8 T9 associated_with Sec62,stress
R6 T10 T11 associated_with Sec62,thyroid cancer
R7 T12 T13 associated_with Sec62,thyroid cancer

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 203-208 HP_0002664 denotes Tumor
T2 428-433 HP_0002664 denotes tumor
T3 692-698 HP_0002664 denotes tumors
T4 737-743 HP_0002664 denotes cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_24304694_3_0 291-312 expanded denotes endoplasmic reticulum
SS2_24304694_3_0 314-316 abbr denotes ER
SS1_24304694_10_0 1106-1121 expanded denotes trifluoperazine
SS2_24304694_10_0 1123-1126 abbr denotes TFP
AE1_24304694_3_0 SS1_24304694_3_0 SS2_24304694_3_0 abbreviatedTo endoplasmic reticulum,ER
AE1_24304694_10_0 SS1_24304694_10_0 SS2_24304694_10_0 abbreviatedTo trifluoperazine,TFP

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
24304694-5#0#5#gene7095 630-635 gene7095 denotes Sec62
24304694-5#99#113#diseaseC0007115 729-743 diseaseC0007115 denotes thyroid cancer
24304694-5#99#113#diseaseC0549473 729-743 diseaseC0549473 denotes thyroid cancer
0#5#gene709599#113#diseaseC0007115 24304694-5#0#5#gene7095 24304694-5#99#113#diseaseC0007115 associated_with Sec62,thyroid cancer
0#5#gene709599#113#diseaseC0549473 24304694-5#0#5#gene7095 24304694-5#99#113#diseaseC0549473 associated_with Sec62,thyroid cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1815 630-635 gene:7095 denotes Sec62
T1816 729-743 disease:C0007115 denotes thyroid cancer
R1 T1815 T1816 associated_with Sec62,thyroid cancer
R2 T1815 T1816 associated_with Sec62,thyroid cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 278-285 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 720-724 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T3 757-761 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 720-724 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T2 757-761 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T3 278-285 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues