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PubMed:24297178 JSONTXT

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c_corpus

Id Subject Object Predicate Lexical cue
T3 60-84 D002285 denotes ductal carcinoma in situ
T4 60-84 D002285 denotes ductal carcinoma in situ
T10 86-90 CVCL_5552 denotes DCIS
T9 86-90 D002285 denotes DCIS
T11 86-90 D002285 denotes DCIS
T14 138-162 D002285 denotes ductal carcinoma in situ
T15 138-162 D002285 denotes ductal carcinoma in situ
T21 164-168 CVCL_5552 denotes DCIS
T20 164-168 D002285 denotes DCIS
T22 164-168 D002285 denotes DCIS
T24 275-279 CVCL_5552 denotes DCIS
T23 275-279 D002285 denotes DCIS
T25 275-279 D002285 denotes DCIS
T26 311-316 PR:000009131 denotes CD49f
T27 318-322 PR:Q07490 denotes CD24
T28 318-322 PR:P25063 denotes CD24
T29 318-322 PR:000001932 denotes CD24
T30 318-322 PR:P24807 denotes CD24
T49 353-377 A0A2I7G3B0 denotes aldehyde dehydrogenase 1
T50 353-377 Q9FDS1 denotes aldehyde dehydrogenase 1
T51 353-377 P30840 denotes aldehyde dehydrogenase 1
T52 353-377 C5I9X1 denotes aldehyde dehydrogenase 1
T53 353-377 D000080924 denotes aldehyde dehydrogenase 1
T57 471-475 CVCL_5552 denotes DCIS
T56 471-475 D002285 denotes DCIS
T58 471-475 D002285 denotes DCIS
T59 528-540 CHEBI:47807 denotes sulforaphane
T60 528-540 C016766 denotes sulforaphane
T61 528-540 C016766 denotes sulforaphane
T63 558-562 CVCL_5552 denotes DCIS
T62 558-562 D002285 denotes DCIS
T64 558-562 D002285 denotes DCIS
T83 587-611 A0A2I7G3B0 denotes aldehyde dehydrogenase 1
T84 587-611 Q9FDS1 denotes aldehyde dehydrogenase 1
T85 587-611 P30840 denotes aldehyde dehydrogenase 1
T86 587-611 C5I9X1 denotes aldehyde dehydrogenase 1
T87 587-611 D000080924 denotes aldehyde dehydrogenase 1
T97 613-617 GO:0004030 denotes ALDH
T104 613-618 PR:P13601 denotes ALDH1
T105 613-618 PR:P24549 denotes ALDH1
T106 613-618 P81178 denotes ALDH1
T107 613-618 PR:P00352 denotes ALDH1
T108 613-618 PR:P54115 denotes ALDH1
T109 613-618 PR:000003920 denotes ALDH1
T110 613-618 P11884 denotes ALDH1
T111 679-688 GO:0009058 denotes formation
T112 744-753 D035683 denotes microRNAs
T114 757-761 CVCL_5552 denotes DCIS
T113 757-761 D002285 denotes DCIS
T115 757-761 D002285 denotes DCIS
T116 785-794 D035683 denotes microRNAs
T117 812-815 PR:000010459 denotes miR
T118 812-815 PR:Q9HAP2 denotes miR
T119 812-815 PR:Q9DBD2 denotes miR
T120 812-815 P13087 denotes miR
T121 812-815 D3ZDI6 denotes miR
T122 812-815 Q93105 denotes miR
T123 812-815 PR:Q5T0T0 denotes miR
T124 812-815 Q8BM54 denotes miR
T125 812-815 Q8WY64 denotes miR
T126 812-815 PR:000010844 denotes miR
T127 812-815 PR:Q2VPU4 denotes miR
T128 812-815 PR:000010182 denotes miR
T129 812-815 PR:Q6TEM9 denotes miR
T130 821-824 PR:000010459 denotes miR
T131 821-824 PR:Q9HAP2 denotes miR
T132 821-824 PR:Q9DBD2 denotes miR
T133 821-824 P13087 denotes miR
T134 821-824 D3ZDI6 denotes miR
T135 821-824 Q93105 denotes miR
T136 821-824 PR:Q5T0T0 denotes miR
T137 821-824 Q8BM54 denotes miR
T138 821-824 Q8WY64 denotes miR
T139 821-824 PR:000010844 denotes miR
T140 821-824 PR:Q2VPU4 denotes miR
T141 821-824 PR:000010182 denotes miR
T142 821-824 PR:Q6TEM9 denotes miR
T143 825-828 CVCL_8999 denotes 29a
T144 834-837 PR:000010459 denotes miR
T145 834-837 PR:Q9HAP2 denotes miR
T146 834-837 PR:Q9DBD2 denotes miR
T147 834-837 P13087 denotes miR
T148 834-837 D3ZDI6 denotes miR
T149 834-837 Q93105 denotes miR
T150 834-837 PR:Q5T0T0 denotes miR
T151 834-837 Q8BM54 denotes miR
T152 834-837 Q8WY64 denotes miR
T153 834-837 PR:000010844 denotes miR
T154 834-837 PR:Q2VPU4 denotes miR
T155 834-837 PR:000010182 denotes miR
T156 834-837 PR:Q6TEM9 denotes miR
T158 887-891 CVCL_5552 denotes DCIS
T157 887-891 D002285 denotes DCIS
T159 887-891 D002285 denotes DCIS
T160 923-926 PR:O70456 denotes SFN
T161 923-926 PR:P31947 denotes SFN
T162 923-926 PR:000014742 denotes SFN
T163 923-926 PR:Q9Y3B8 denotes SFN
T164 923-926 PR:000013903 denotes SFN
T166 953-957 CVCL_5552 denotes DCIS
T165 953-957 D002285 denotes DCIS
T167 953-957 D002285 denotes DCIS
T168 1013-1031 GO:1990182 denotes exosomal secretion
T170 1022-1031 UBERON:0000456 denotes secretion
T171 1117-1135 GO:1990182 denotes exosomal secretion
T173 1126-1135 UBERON:0000456 denotes secretion
T174 1139-1142 PR:000010459 denotes miR
T175 1139-1142 PR:Q9HAP2 denotes miR
T176 1139-1142 PR:Q9DBD2 denotes miR
T177 1139-1142 P13087 denotes miR
T178 1139-1142 D3ZDI6 denotes miR
T179 1139-1142 Q93105 denotes miR
T180 1139-1142 PR:Q5T0T0 denotes miR
T181 1139-1142 Q8BM54 denotes miR
T182 1139-1142 Q8WY64 denotes miR
T183 1139-1142 PR:000010844 denotes miR
T184 1139-1142 PR:Q2VPU4 denotes miR
T185 1139-1142 PR:000010182 denotes miR
T186 1139-1142 PR:Q6TEM9 denotes miR
T187 1153-1159 PR:Q54JW9 denotes impact
T188 1153-1159 PR:Q642J4 denotes impact
T189 1160-1169 GO:0023052 denotes signaling
T190 1180-1186 UBERON:0000310 denotes breast
T191 1180-1193 D001943 denotes breast cancer
T192 1180-1193 D001943 denotes breast cancer

sentences

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Characterization of a stem-like subpopulation in basal-like ductal carcinoma in situ (DCIS) lesions.
T2 101-202 Sentence denotes Previously, we found that basal-like ductal carcinoma in situ (DCIS) contains cancer stem-like cells.
T3 203-387 Sentence denotes Here, we characterize stem-like subpopulations in a model of basal-like DCIS and identify subpopulations of CD49f+/CD24- stem-like cells that possess aldehyde dehydrogenase 1 activity.
T4 388-482 Sentence denotes We found that these cells show enhanced migration potential compared with non-stem DCIS cells.
T5 483-689 Sentence denotes We also found that the chemopreventive agent sulforaphane can target these DCIS stem-like cells, reduce aldehyde dehydrogenase 1 (ALDH1) expression, and decrease mammosphere and progenitor colony formation.
T6 690-908 Sentence denotes Furthermore, we characterized exosomal trafficking of microRNAs in DCIS and found that several microRNAs (miRs) including miR-140, miR-29a, and miR-21 are differentially expressed in exosomes from DCIS stem-like cells.
T7 909-1086 Sentence denotes We found that SFN treatment could reprogram DCIS stem-like cells as evidenced by significant changes in exosomal secretion more closely resembling that of non-stem cancer cells.
T8 1087-1200 Sentence denotes Finally, we demonstrated that exosomal secretion of miR-140 might impact signaling in nearby breast cancer cells.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 22-26 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem
T2 186-190 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem
T3 225-229 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem
T4 324-328 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem
T5 466-470 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem
T6 563-567 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem
T7 892-896 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem
T8 958-962 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem
T9 1068-1072 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 179-185 HP_0002664 denotes cancer
T2 1073-1079 HP_0002664 denotes cancer
T3 1180-1193 HP_0003002 denotes breast cancer
T4 1180-1193 HP_0100013 denotes breast cancer
T5 1187-1193 HP_0002664 denotes cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_24297178_0_0 60-84 expanded denotes ductal carcinoma in situ
SS2_24297178_0_0 86-90 abbr denotes DCIS
SS1_24297178_1_0 138-162 expanded denotes ductal carcinoma in situ
SS2_24297178_1_0 164-168 abbr denotes DCIS
SS1_24297178_4_0 587-611 expanded denotes aldehyde dehydrogenase 1
SS2_24297178_4_0 613-618 abbr denotes ALDH1
SS1_24297178_5_0 744-753 expanded denotes microRNAs
SS2_24297178_5_0 796-800 abbr denotes miRs
AE1_24297178_0_0 SS1_24297178_0_0 SS2_24297178_0_0 abbreviatedTo ductal carcinoma in situ,DCIS
AE1_24297178_1_0 SS1_24297178_1_0 SS2_24297178_1_0 abbreviatedTo ductal carcinoma in situ,DCIS
AE1_24297178_4_0 SS1_24297178_4_0 SS2_24297178_4_0 abbreviatedTo aldehyde dehydrogenase 1,ALDH1
AE1_24297178_5_0 SS1_24297178_5_0 SS2_24297178_5_0 abbreviatedTo microRNAs,miRs

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 101-202 DRI_Approach denotes Previously, we found that basal-like ductal carcinoma in situ (DCIS) contains cancer stem-like cells.
T2 203-310 DRI_Approach denotes Here, we characterize stem-like subpopulations in a model of basal-like DCIS and identify subpopulations of
T3 334-387 DRI_Approach denotes cells that possess aldehyde dehydrogenase 1 activity.
T4 388-482 DRI_Outcome denotes We found that these cells show enhanced migration potential compared with non-stem DCIS cells.
T5 483-689 DRI_Approach denotes We also found that the chemopreventive agent sulforaphane can target these DCIS stem-like cells, reduce aldehyde dehydrogenase 1 (ALDH1) expression, and decrease mammosphere and progenitor colony formation.
T6 690-908 DRI_Challenge denotes Furthermore, we characterized exosomal trafficking of microRNAs in DCIS and found that several microRNAs (miRs) including miR-140, miR-29a, and miR-21 are differentially expressed in exosomes from DCIS stem-like cells.
T7 909-1086 DRI_Outcome denotes We found that SFN treatment could reprogram DCIS stem-like cells as evidenced by significant changes in exosomal secretion more closely resembling that of non-stem cancer cells.
T8 1087-1200 DRI_Outcome denotes Finally, we demonstrated that exosomal secretion of miR-140 might impact signaling in nearby breast cancer cells.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 60-91 Disease denotes ductal carcinoma in situ (DCIS) http://purl.obolibrary.org/obo/MONDO_0005023
T2 138-169 Disease denotes ductal carcinoma in situ (DCIS) http://purl.obolibrary.org/obo/MONDO_0005023
T3 179-185 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T4 275-279 Disease denotes DCIS http://purl.obolibrary.org/obo/MONDO_0005023
T5 471-475 Disease denotes DCIS http://purl.obolibrary.org/obo/MONDO_0005023
T6 558-562 Disease denotes DCIS http://purl.obolibrary.org/obo/MONDO_0005023
T7 757-761 Disease denotes DCIS http://purl.obolibrary.org/obo/MONDO_0005023
T8 887-891 Disease denotes DCIS http://purl.obolibrary.org/obo/MONDO_0005023
T9 953-957 Disease denotes DCIS http://purl.obolibrary.org/obo/MONDO_0005023
T10 1073-1079 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T11 1180-1193 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 22-26 Body_part denotes stem http://purl.obolibrary.org/obo/MAT_0000239
T2 186-190 Body_part denotes stem http://purl.obolibrary.org/obo/MAT_0000239
T3 225-229 Body_part denotes stem http://purl.obolibrary.org/obo/MAT_0000239
T4 324-328 Body_part denotes stem http://purl.obolibrary.org/obo/MAT_0000239
T5 466-470 Body_part denotes stem http://purl.obolibrary.org/obo/MAT_0000239
T6 563-567 Body_part denotes stem http://purl.obolibrary.org/obo/MAT_0000239
T7 892-896 Body_part denotes stem http://purl.obolibrary.org/obo/MAT_0000239
T8 958-962 Body_part denotes stem http://purl.obolibrary.org/obo/MAT_0000239
T9 1068-1072 Body_part denotes stem http://purl.obolibrary.org/obo/MAT_0000239

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 60-84 Phenotype denotes ductal carcinoma in situ HP:0030075
T2 138-162 Phenotype denotes ductal carcinoma in situ HP:0030075
T3 179-185 Phenotype denotes cancer HP:0002664
T4 1073-1079 Phenotype denotes cancer HP:0002664
T5 1180-1193 Phenotype denotes breast cancer HP:0003002

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1180-1186 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 49-54 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324
T2 127-132 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324
T3 264-269 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324
T4 1073-1085 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T5 1187-1199 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064