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PubMed:24283717 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-127 Sentence denotes Deletion of thioredoxin-interacting protein preserves retinal neuronal function by preventing inflammation and vascular injury.
T2 128-151 Sentence denotes BACKGROUND AND PURPOSE:
T3 152-255 Sentence denotes Retinal neurodegeneration is an early and critical event in several diseases associated with blindness.
T4 256-313 Sentence denotes Clinically, therapies that target neurodegeneration fail.
T5 314-467 Sentence denotes We aimed to elucidate the multiple roles by which thioredoxin-interacting protein (TXNIP) contributes to initial and sustained retinal neurodegeneration.
T6 468-490 Sentence denotes EXPERIMENTAL APPROACH:
T7 491-601 Sentence denotes Neurotoxicity was induced by intravitreal injection of NMDA into wild-type (WT) and TXNIP-knockout (TKO) mice.
T8 602-716 Sentence denotes The expression of apoptotic and inflammatory markers was assessed by immunohistochemistry, elisa and Western blot.
T9 717-849 Sentence denotes Microvascular degeneration was assessed by periodic acid-Schiff and haematoxylin staining and retinal function by electroretinogram.
T10 850-1078 Sentence denotes KEY RESULTS: NMDA induced early (1 day) and significant retinal PARP activation, a threefold increase in TUNEL-positive nuclei and 40% neuronal loss in ganglion cell layer (GCL); and vascular permeability in WT but not TKO mice.
T11 1079-1199 Sentence denotes NMDA induced glial activation, expression of TNF-α and IL-1β that co-localized with Müller cells in WT but not TKO mice.
T12 1200-1379 Sentence denotes In parallel, NMDA triggered the expression of NOD-like receptor protein (NLRP3), activation of caspase-1, and release of IL-1β and TNF-α in primary WT but not TKO Müller cultures.
T13 1380-1563 Sentence denotes After 14 days, NMDA induced 1.9-fold microvascular degeneration, 60% neuronal loss in GCL and increased TUNEL-labelled cells in the GCL and inner nuclear layer in WT but not TKO mice.
T14 1564-1670 Sentence denotes Electroretinogram analysis showed more significant reductions in b-wave amplitudes in WT than in TKO mice.
T15 1671-1699 Sentence denotes CONCLUSION AND IMPLICATIONS:
T16 1700-1889 Sentence denotes Targeting TXNIP expression prevented early retinal ganglion cell death, glial activation, retinal inflammation and secondary neuro/microvascular degeneration and preserved retinal function.
T17 1890-1973 Sentence denotes TXNIP is a promising new therapeutic target for retinal neurodegenerative diseases.
T1 0-127 Sentence denotes Deletion of thioredoxin-interacting protein preserves retinal neuronal function by preventing inflammation and vascular injury.
T2 128-151 Sentence denotes BACKGROUND AND PURPOSE:
T3 152-255 Sentence denotes Retinal neurodegeneration is an early and critical event in several diseases associated with blindness.
T4 256-313 Sentence denotes Clinically, therapies that target neurodegeneration fail.
T5 314-467 Sentence denotes We aimed to elucidate the multiple roles by which thioredoxin-interacting protein (TXNIP) contributes to initial and sustained retinal neurodegeneration.
T6 468-490 Sentence denotes EXPERIMENTAL APPROACH:
T7 491-601 Sentence denotes Neurotoxicity was induced by intravitreal injection of NMDA into wild-type (WT) and TXNIP-knockout (TKO) mice.
T8 602-716 Sentence denotes The expression of apoptotic and inflammatory markers was assessed by immunohistochemistry, elisa and Western blot.
T9 717-849 Sentence denotes Microvascular degeneration was assessed by periodic acid-Schiff and haematoxylin staining and retinal function by electroretinogram.
T10 850-1078 Sentence denotes KEY RESULTS: NMDA induced early (1 day) and significant retinal PARP activation, a threefold increase in TUNEL-positive nuclei and 40% neuronal loss in ganglion cell layer (GCL); and vascular permeability in WT but not TKO mice.
T11 1079-1199 Sentence denotes NMDA induced glial activation, expression of TNF-α and IL-1β that co-localized with Müller cells in WT but not TKO mice.
T12 1200-1379 Sentence denotes In parallel, NMDA triggered the expression of NOD-like receptor protein (NLRP3), activation of caspase-1, and release of IL-1β and TNF-α in primary WT but not TKO Müller cultures.
T13 1380-1563 Sentence denotes After 14 days, NMDA induced 1.9-fold microvascular degeneration, 60% neuronal loss in GCL and increased TUNEL-labelled cells in the GCL and inner nuclear layer in WT but not TKO mice.
T14 1564-1670 Sentence denotes Electroretinogram analysis showed more significant reductions in b-wave amplitudes in WT than in TKO mice.
T15 1671-1699 Sentence denotes CONCLUSION AND IMPLICATIONS:
T16 1700-1889 Sentence denotes Targeting TXNIP expression prevented early retinal ganglion cell death, glial activation, retinal inflammation and secondary neuro/microvascular degeneration and preserved retinal function.
T17 1890-1973 Sentence denotes TXNIP is a promising new therapeutic target for retinal neurodegenerative diseases.

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-127 Sentence denotes Deletion of thioredoxin-interacting protein preserves retinal neuronal function by preventing inflammation and vascular injury.
TextSentencer_T2 128-151 Sentence denotes BACKGROUND AND PURPOSE:
TextSentencer_T3 152-255 Sentence denotes Retinal neurodegeneration is an early and critical event in several diseases associated with blindness.
TextSentencer_T4 256-313 Sentence denotes Clinically, therapies that target neurodegeneration fail.
TextSentencer_T5 314-467 Sentence denotes We aimed to elucidate the multiple roles by which thioredoxin-interacting protein (TXNIP) contributes to initial and sustained retinal neurodegeneration.
TextSentencer_T6 468-490 Sentence denotes EXPERIMENTAL APPROACH:
TextSentencer_T7 491-601 Sentence denotes Neurotoxicity was induced by intravitreal injection of NMDA into wild-type (WT) and TXNIP-knockout (TKO) mice.
TextSentencer_T8 602-716 Sentence denotes The expression of apoptotic and inflammatory markers was assessed by immunohistochemistry, elisa and Western blot.
TextSentencer_T9 717-849 Sentence denotes Microvascular degeneration was assessed by periodic acid-Schiff and haematoxylin staining and retinal function by electroretinogram.
TextSentencer_T10 850-1078 Sentence denotes KEY RESULTS: NMDA induced early (1 day) and significant retinal PARP activation, a threefold increase in TUNEL-positive nuclei and 40% neuronal loss in ganglion cell layer (GCL); and vascular permeability in WT but not TKO mice.
TextSentencer_T11 1079-1199 Sentence denotes NMDA induced glial activation, expression of TNF-α and IL-1β that co-localized with Müller cells in WT but not TKO mice.
TextSentencer_T12 1200-1379 Sentence denotes In parallel, NMDA triggered the expression of NOD-like receptor protein (NLRP3), activation of caspase-1, and release of IL-1β and TNF-α in primary WT but not TKO Müller cultures.
TextSentencer_T13 1380-1563 Sentence denotes After 14 days, NMDA induced 1.9-fold microvascular degeneration, 60% neuronal loss in GCL and increased TUNEL-labelled cells in the GCL and inner nuclear layer in WT but not TKO mice.
TextSentencer_T14 1564-1670 Sentence denotes Electroretinogram analysis showed more significant reductions in b-wave amplitudes in WT than in TKO mice.
TextSentencer_T15 1671-1699 Sentence denotes CONCLUSION AND IMPLICATIONS:
TextSentencer_T16 1700-1889 Sentence denotes Targeting TXNIP expression prevented early retinal ganglion cell death, glial activation, retinal inflammation and secondary neuro/microvascular degeneration and preserved retinal function.
TextSentencer_T17 1890-1973 Sentence denotes TXNIP is a promising new therapeutic target for retinal neurodegenerative diseases.
T1 0-127 Sentence denotes Deletion of thioredoxin-interacting protein preserves retinal neuronal function by preventing inflammation and vascular injury.
T2 128-151 Sentence denotes BACKGROUND AND PURPOSE:
T3 152-255 Sentence denotes Retinal neurodegeneration is an early and critical event in several diseases associated with blindness.
T4 256-313 Sentence denotes Clinically, therapies that target neurodegeneration fail.
T5 314-467 Sentence denotes We aimed to elucidate the multiple roles by which thioredoxin-interacting protein (TXNIP) contributes to initial and sustained retinal neurodegeneration.
T6 468-490 Sentence denotes EXPERIMENTAL APPROACH:
T7 491-601 Sentence denotes Neurotoxicity was induced by intravitreal injection of NMDA into wild-type (WT) and TXNIP-knockout (TKO) mice.
T8 602-716 Sentence denotes The expression of apoptotic and inflammatory markers was assessed by immunohistochemistry, elisa and Western blot.
T9 717-849 Sentence denotes Microvascular degeneration was assessed by periodic acid-Schiff and haematoxylin staining and retinal function by electroretinogram.
T10 850-1078 Sentence denotes KEY RESULTS: NMDA induced early (1 day) and significant retinal PARP activation, a threefold increase in TUNEL-positive nuclei and 40% neuronal loss in ganglion cell layer (GCL); and vascular permeability in WT but not TKO mice.
T11 1079-1199 Sentence denotes NMDA induced glial activation, expression of TNF-α and IL-1β that co-localized with Müller cells in WT but not TKO mice.
T12 1200-1379 Sentence denotes In parallel, NMDA triggered the expression of NOD-like receptor protein (NLRP3), activation of caspase-1, and release of IL-1β and TNF-α in primary WT but not TKO Müller cultures.
T13 1380-1563 Sentence denotes After 14 days, NMDA induced 1.9-fold microvascular degeneration, 60% neuronal loss in GCL and increased TUNEL-labelled cells in the GCL and inner nuclear layer in WT but not TKO mice.
T14 1564-1670 Sentence denotes Electroretinogram analysis showed more significant reductions in b-wave amplitudes in WT than in TKO mice.
T15 1671-1699 Sentence denotes CONCLUSION AND IMPLICATIONS:
T16 1700-1889 Sentence denotes Targeting TXNIP expression prevented early retinal ganglion cell death, glial activation, retinal inflammation and secondary neuro/microvascular degeneration and preserved retinal function.
T17 1890-1973 Sentence denotes TXNIP is a promising new therapeutic target for retinal neurodegenerative diseases.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 914-918 gene:142 denotes PARP
T1 1002-1010 disease:C0085648 denotes ganglion
T2 914-918 gene:142 denotes PARP
T3 1002-1010 disease:C1258666 denotes ganglion
T4 914-918 gene:1302 denotes PARP
T5 1002-1010 disease:C0085648 denotes ganglion
T6 914-918 gene:1302 denotes PARP
T7 1002-1010 disease:C1258666 denotes ganglion
R1 T0 T1 associated_with PARP,ganglion
R2 T2 T3 associated_with PARP,ganglion
R3 T4 T5 associated_with PARP,ganglion
R4 T6 T7 associated_with PARP,ganglion

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 160-177 HP_0002180 denotes neurodegeneration
T2 245-254 HP_0000618 denotes blindness
T3 290-307 HP_0002180 denotes neurodegeneration
T4 449-466 HP_0002180 denotes neurodegeneration

Allie

Id Subject Object Predicate Lexical cue
SS1_24283717_4_0 364-395 expanded denotes thioredoxin-interacting protein
SS2_24283717_4_0 397-402 abbr denotes TXNIP
SS1_24283717_6_0 556-565 expanded denotes wild-type
SS2_24283717_6_0 567-569 abbr denotes WT
SS1_24283717_6_1 575-589 expanded denotes TXNIP-knockout
SS2_24283717_6_1 591-594 abbr denotes TKO
SS1_24283717_10_0 1002-1021 expanded denotes ganglion cell layer
SS2_24283717_10_0 1023-1026 abbr denotes GCL
AE1_24283717_4_0 SS1_24283717_4_0 SS2_24283717_4_0 abbreviatedTo thioredoxin-interacting protein,TXNIP
AE1_24283717_6_0 SS1_24283717_6_0 SS2_24283717_6_0 abbreviatedTo wild-type,WT
AE1_24283717_6_1 SS1_24283717_6_1 SS2_24283717_6_1 abbreviatedTo TXNIP-knockout,TKO
AE1_24283717_10_0 SS1_24283717_10_0 SS2_24283717_10_0 abbreviatedTo ganglion cell layer,GCL

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
24283717-12#10#15#gene10628 1710-1715 gene10628 denotes TXNIP
24283717-12#51#59#diseaseC0085648 1751-1759 diseaseC0085648 denotes ganglion
24283717-12#51#59#diseaseC1258666 1751-1759 diseaseC1258666 denotes ganglion
24283717-13#0#5#gene10628 1890-1895 gene10628 denotes TXNIP
24283717-13#56#82#diseaseC0524851 1946-1972 diseaseC0524851 denotes neurodegenerative diseases
24283717-7#51#55#gene1302 914-918 gene1302 denotes PARP
24283717-7#51#55#gene142 914-918 gene142 denotes PARP
24283717-7#139#147#diseaseC0085648 1002-1010 diseaseC0085648 denotes ganglion
24283717-7#139#147#diseaseC1258666 1002-1010 diseaseC1258666 denotes ganglion
24283717-7#139#147#diseaseC0085648 1002-1010 diseaseC0085648 denotes ganglion
24283717-7#139#147#diseaseC1258666 1002-1010 diseaseC1258666 denotes ganglion
10#15#gene1062851#59#diseaseC0085648 24283717-12#10#15#gene10628 24283717-12#51#59#diseaseC0085648 associated_with TXNIP,ganglion
10#15#gene1062851#59#diseaseC1258666 24283717-12#10#15#gene10628 24283717-12#51#59#diseaseC1258666 associated_with TXNIP,ganglion
0#5#gene1062856#82#diseaseC0524851 24283717-13#0#5#gene10628 24283717-13#56#82#diseaseC0524851 associated_with TXNIP,neurodegenerative diseases
51#55#gene1302139#147#diseaseC0085648 24283717-7#51#55#gene1302 24283717-7#139#147#diseaseC0085648 associated_with PARP,ganglion
51#55#gene1302139#147#diseaseC1258666 24283717-7#51#55#gene1302 24283717-7#139#147#diseaseC1258666 associated_with PARP,ganglion
51#55#gene1302139#147#diseaseC0085648 24283717-7#51#55#gene1302 24283717-7#139#147#diseaseC0085648 associated_with PARP,ganglion
51#55#gene1302139#147#diseaseC1258666 24283717-7#51#55#gene1302 24283717-7#139#147#diseaseC1258666 associated_with PARP,ganglion
51#55#gene142139#147#diseaseC0085648 24283717-7#51#55#gene142 24283717-7#139#147#diseaseC0085648 associated_with PARP,ganglion
51#55#gene142139#147#diseaseC1258666 24283717-7#51#55#gene142 24283717-7#139#147#diseaseC1258666 associated_with PARP,ganglion
51#55#gene142139#147#diseaseC0085648 24283717-7#51#55#gene142 24283717-7#139#147#diseaseC0085648 associated_with PARP,ganglion
51#55#gene142139#147#diseaseC1258666 24283717-7#51#55#gene142 24283717-7#139#147#diseaseC1258666 associated_with PARP,ganglion

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T189 1710-1715 gene:10628 denotes TXNIP
T190 1751-1759 disease:C0085648 denotes ganglion
R1 T189 T190 associated_with TXNIP,ganglion
R2 T189 T190 associated_with TXNIP,ganglion

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1002-1010 http://purl.obolibrary.org/obo/UBERON_0000045 denotes ganglion
PD-UBERON-AE-B_T2 1751-1759 http://purl.obolibrary.org/obo/UBERON_0000045 denotes ganglion
PD-UBERON-AE-B_T3 1011-1021 http://purl.obolibrary.org/obo/UBERON_0000119 denotes cell layer

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 62-70 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neuronal
PD-UBERON-AE-B_T2 985-993 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neuronal
PD-UBERON-AE-B_T3 1449-1457 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neuronal
PD-UBERON-AE-B_T4 1002-1010 http://purl.obolibrary.org/obo/UBERON_0000045 denotes ganglion
PD-UBERON-AE-B_T5 1751-1759 http://purl.obolibrary.org/obo/UBERON_0000045 denotes ganglion
PD-UBERON-AE-B_T6 1011-1021 http://purl.obolibrary.org/obo/UBERON_0000119 denotes cell layer