PubMed:24214978
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 331-339 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T1 | 331-339 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-64 | Sentence | denotes | O-GlcNAcylation of cofilin promotes breast cancer cell invasion. |
| T2 | 65-250 | Sentence | denotes | O-GlcNAcylation is a post-translational modification that regulates a broad range of nuclear and cytoplasmic proteins and is emerging as a key regulator of various biological processes. |
| T3 | 251-482 | Sentence | denotes | Previous studies have shown that increased levels of global O-GlcNAcylation and O-GlcNAc transferase (OGT) are linked to the incidence of metastasis in breast cancer patients, but the molecular basis behind this is not fully known. |
| T4 | 483-653 | Sentence | denotes | In this study, we have determined that the actin-binding protein cofilin is O-GlcNAcylated by OGT and mainly, if not completely, mediates OGT modulation of cell mobility. |
| T5 | 654-829 | Sentence | denotes | O-GlcNAcylation at Ser-108 of cofilin is required for its proper localization in invadopodia at the leading edge of breast cancer cells during three-dimensional cell invasion. |
| T6 | 830-1015 | Sentence | denotes | Loss of O-GlcNAcylation of cofilin leads to destabilization of invadopodia and impairs cell invasion, although the actin-severing activity or lamellipodial localization is not affected. |
| T7 | 1016-1209 | Sentence | denotes | Our study provides insights into the mechanism of post-translational modification in fine-tuning the regulation of cofilin activity and suggests its important implications in cancer metastasis. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 331-339 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
| T2 | 331-339 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 331-339 | gene:8473 | denotes | O-GlcNAc |
| T1 | 389-399 | disease:C0027627 | denotes | metastasis |
| T2 | 331-339 | gene:8473 | denotes | O-GlcNAc |
| T3 | 389-399 | disease:C2939420 | denotes | metastasis |
| T4 | 331-339 | gene:8473 | denotes | O-GlcNAc |
| T5 | 403-416 | disease:C0006142 | denotes | breast cancer |
| T6 | 331-339 | gene:8473 | denotes | O-GlcNAc |
| T7 | 403-416 | disease:C0678222 | denotes | breast cancer |
| R1 | T0 | T1 | associated_with | O-GlcNAc,metastasis |
| R2 | T2 | T3 | associated_with | O-GlcNAc,metastasis |
| R3 | T4 | T5 | associated_with | O-GlcNAc,breast cancer |
| R4 | T6 | T7 | associated_with | O-GlcNAc,breast cancer |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 403-416 | HP_0003002 | denotes | breast cancer |
| T2 | 403-416 | HP_0100013 | denotes | breast cancer |
| T3 | 410-416 | HP_0002664 | denotes | cancer |
| T4 | 770-783 | HP_0003002 | denotes | breast cancer |
| T5 | 770-783 | HP_0100013 | denotes | breast cancer |
| T6 | 777-783 | HP_0002664 | denotes | cancer |
| T7 | 1191-1197 | HP_0002664 | denotes | cancer |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_24214978_2_0 | 331-351 | expanded | denotes | O-GlcNAc transferase |
| SS2_24214978_2_0 | 353-356 | abbr | denotes | OGT |
| AE1_24214978_2_0 | SS1_24214978_2_0 | SS2_24214978_2_0 | abbreviatedTo | O-GlcNAc transferase,OGT |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 24214978-2#80#88#gene8473 | 331-339 | gene8473 | denotes | O-GlcNAc |
| 24214978-2#138#148#diseaseC0027627 | 389-399 | diseaseC0027627 | denotes | metastasis |
| 24214978-2#152#165#diseaseC0006142 | 403-416 | diseaseC0006142 | denotes | breast cancer |
| 24214978-2#152#165#diseaseC0678222 | 403-416 | diseaseC0678222 | denotes | breast cancer |
| 80#88#gene8473138#148#diseaseC0027627 | 24214978-2#80#88#gene8473 | 24214978-2#138#148#diseaseC0027627 | associated_with | O-GlcNAc,metastasis |
| 80#88#gene8473152#165#diseaseC0006142 | 24214978-2#80#88#gene8473 | 24214978-2#152#165#diseaseC0006142 | associated_with | O-GlcNAc,breast cancer |
| 80#88#gene8473152#165#diseaseC0678222 | 24214978-2#80#88#gene8473 | 24214978-2#152#165#diseaseC0678222 | associated_with | O-GlcNAc,breast cancer |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 333-339 | chem:24139 | denotes | GlcNAc |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 36-49 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T2 | 403-416 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T3 | 770-783 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T4 | 1191-1197 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 331-339 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 331-339 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 36-49 | Phenotype | denotes | breast cancer | HP:0003002 |
| T2 | 403-416 | Phenotype | denotes | breast cancer | HP:0003002 |
| T3 | 770-783 | Phenotype | denotes | breast cancer | HP:0003002 |
| T4 | 1191-1197 | Phenotype | denotes | cancer | HP:0002664 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 36-49 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T2 | 403-416 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T3 | 770-783 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T4 | 1191-1197 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 43-54 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
| T2 | 777-789 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 36-42 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T2 | 162-173 | Body_part | denotes | cytoplasmic | http://purl.obolibrary.org/obo/GO_0005737 |
| T3 | 403-409 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T4 | 770-776 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-64 | Sentence | denotes | O-GlcNAcylation of cofilin promotes breast cancer cell invasion. |
| T2 | 65-250 | Sentence | denotes | O-GlcNAcylation is a post-translational modification that regulates a broad range of nuclear and cytoplasmic proteins and is emerging as a key regulator of various biological processes. |
| T3 | 251-482 | Sentence | denotes | Previous studies have shown that increased levels of global O-GlcNAcylation and O-GlcNAc transferase (OGT) are linked to the incidence of metastasis in breast cancer patients, but the molecular basis behind this is not fully known. |
| T4 | 483-653 | Sentence | denotes | In this study, we have determined that the actin-binding protein cofilin is O-GlcNAcylated by OGT and mainly, if not completely, mediates OGT modulation of cell mobility. |
| T5 | 654-829 | Sentence | denotes | O-GlcNAcylation at Ser-108 of cofilin is required for its proper localization in invadopodia at the leading edge of breast cancer cells during three-dimensional cell invasion. |
| T6 | 830-1015 | Sentence | denotes | Loss of O-GlcNAcylation of cofilin leads to destabilization of invadopodia and impairs cell invasion, although the actin-severing activity or lamellipodial localization is not affected. |
| T7 | 1016-1209 | Sentence | denotes | Our study provides insights into the mechanism of post-translational modification in fine-tuning the regulation of cofilin activity and suggests its important implications in cancer metastasis. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-64 | Sentence | denotes | O-GlcNAcylation of cofilin promotes breast cancer cell invasion. |
| T2 | 65-250 | Sentence | denotes | O-GlcNAcylation is a post-translational modification that regulates a broad range of nuclear and cytoplasmic proteins and is emerging as a key regulator of various biological processes. |
| T3 | 251-482 | Sentence | denotes | Previous studies have shown that increased levels of global O-GlcNAcylation and O-GlcNAc transferase (OGT) are linked to the incidence of metastasis in breast cancer patients, but the molecular basis behind this is not fully known. |
| T4 | 483-653 | Sentence | denotes | In this study, we have determined that the actin-binding protein cofilin is O-GlcNAcylated by OGT and mainly, if not completely, mediates OGT modulation of cell mobility. |
| T5 | 654-829 | Sentence | denotes | O-GlcNAcylation at Ser-108 of cofilin is required for its proper localization in invadopodia at the leading edge of breast cancer cells during three-dimensional cell invasion. |
| T6 | 830-1015 | Sentence | denotes | Loss of O-GlcNAcylation of cofilin leads to destabilization of invadopodia and impairs cell invasion, although the actin-severing activity or lamellipodial localization is not affected. |
| T7 | 1016-1209 | Sentence | denotes | Our study provides insights into the mechanism of post-translational modification in fine-tuning the regulation of cofilin activity and suggests its important implications in cancer metastasis. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 331-339 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 331-339 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 36-42 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T2 | 162-173 | Body_part | denotes | cytoplasmic | http://purl.obolibrary.org/obo/GO_0005737 |
| T3 | 403-409 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T4 | 770-776 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 36-49 | Phenotype | denotes | breast cancer | HP:0003002 |
| T2 | 403-416 | Phenotype | denotes | breast cancer | HP:0003002 |
| T3 | 770-783 | Phenotype | denotes | breast cancer | HP:0003002 |
| T4 | 1191-1197 | Phenotype | denotes | cancer | HP:0002664 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 43-54 | Cell | denotes | cancer cell | http://purl.obolibrary.org/obo/CL:0001064 |
| T2 | 777-789 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |