> top > docs > PubMed:24201825 > annotations

PubMed:24201825 JSONTXT

Annnotations TAB JSON ListView MergeView

Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 27-34 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 27-34 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 389-396 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 389-396 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T5 625-632 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T6 625-632 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T7 899-906 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T8 899-906 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T9 1104-1111 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T10 1104-1111 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T11 1174-1181 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T12 1174-1181 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T13 1267-1274 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T14 1267-1274 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T15 1556-1563 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T16 1556-1563 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 27-34 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T3 389-396 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T5 625-632 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T7 899-906 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T9 1104-1111 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T11 1174-1181 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T13 1267-1274 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T15 1556-1563 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-94 Sentence denotes Structural glycobiology of heparin dynamics on the exosite 2 of coagulation cascade proteases:
TextSentencer_T2 95-155 Sentence denotes Implications for glycosaminoglycans antithrombotic activity.
TextSentencer_T3 156-303 Sentence denotes fIIa and fXa are two of the main targets of antithrombin, a serine proteases inhibitor that plays a major role in the regulation of blood clotting.
TextSentencer_T4 304-503 Sentence denotes The formation of ternary complexes between such molecules and glycosaminoglycans, as heparin, is the main path for inhibiting those enzymes, which may occur through two distinct mechanisms of action.
TextSentencer_T5 504-765 Sentence denotes While these serine proteases present distinct susceptibilities to these paths, in which fIIa demands an interaction with heparin, neither the molecular basis of this differential inhibition nor the role of fIIa glycosylation on this process is fully understood.
TextSentencer_T6 766-955 Sentence denotes Thus, the present work evaluated through molecular dynamics simulations the effects of glycosylation on fIIa and the consequences of heparin binding to both proteases function and dynamics.
TextSentencer_T7 956-1159 Sentence denotes Based on the obtained data, fIIa N-linked glycan promoted an increase in the active site pocket size by stabilizing regions that encircle it, while heparin binding was observed to reverse such an effect.
TextSentencer_T8 1160-1320 Sentence denotes Additionally, heparin orientation observed on the surface of fIIa, but not fXa, allows a linear long-chain heparin binding to antithrombin in ternary complexes.
TextSentencer_T9 1321-1454 Sentence denotes Finally, the enzymes catalytic triad organization was disrupted due to a strong glycosaminoglycan binding to the proteases exosite 2.
TextSentencer_T10 1455-1693 Sentence denotes Such data support an atomic-level explanation for the higher inhibition constant of the antithrombin-heparin complex over fIIa than fXa, as well as for the different susceptibilities of those enzymes for antithrombin mechanisms of action.
T1 0-94 Sentence denotes Structural glycobiology of heparin dynamics on the exosite 2 of coagulation cascade proteases:
T2 95-155 Sentence denotes Implications for glycosaminoglycans antithrombotic activity.
T3 156-303 Sentence denotes fIIa and fXa are two of the main targets of antithrombin, a serine proteases inhibitor that plays a major role in the regulation of blood clotting.
T4 304-503 Sentence denotes The formation of ternary complexes between such molecules and glycosaminoglycans, as heparin, is the main path for inhibiting those enzymes, which may occur through two distinct mechanisms of action.
T5 504-765 Sentence denotes While these serine proteases present distinct susceptibilities to these paths, in which fIIa demands an interaction with heparin, neither the molecular basis of this differential inhibition nor the role of fIIa glycosylation on this process is fully understood.
T6 766-955 Sentence denotes Thus, the present work evaluated through molecular dynamics simulations the effects of glycosylation on fIIa and the consequences of heparin binding to both proteases function and dynamics.
T7 956-1159 Sentence denotes Based on the obtained data, fIIa N-linked glycan promoted an increase in the active site pocket size by stabilizing regions that encircle it, while heparin binding was observed to reverse such an effect.
T8 1160-1320 Sentence denotes Additionally, heparin orientation observed on the surface of fIIa, but not fXa, allows a linear long-chain heparin binding to antithrombin in ternary complexes.
T9 1321-1454 Sentence denotes Finally, the enzymes catalytic triad organization was disrupted due to a strong glycosaminoglycan binding to the proteases exosite 2.
T10 1455-1693 Sentence denotes Such data support an atomic-level explanation for the higher inhibition constant of the antithrombin-heparin complex over fIIa than fXa, as well as for the different susceptibilities of those enzymes for antithrombin mechanisms of action.
T1 0-94 Sentence denotes Structural glycobiology of heparin dynamics on the exosite 2 of coagulation cascade proteases:
T2 95-155 Sentence denotes Implications for glycosaminoglycans antithrombotic activity.
T3 156-303 Sentence denotes fIIa and fXa are two of the main targets of antithrombin, a serine proteases inhibitor that plays a major role in the regulation of blood clotting.
T4 304-503 Sentence denotes The formation of ternary complexes between such molecules and glycosaminoglycans, as heparin, is the main path for inhibiting those enzymes, which may occur through two distinct mechanisms of action.
T5 504-765 Sentence denotes While these serine proteases present distinct susceptibilities to these paths, in which fIIa demands an interaction with heparin, neither the molecular basis of this differential inhibition nor the role of fIIa glycosylation on this process is fully understood.
T6 766-955 Sentence denotes Thus, the present work evaluated through molecular dynamics simulations the effects of glycosylation on fIIa and the consequences of heparin binding to both proteases function and dynamics.
T7 956-1159 Sentence denotes Based on the obtained data, fIIa N-linked glycan promoted an increase in the active site pocket size by stabilizing regions that encircle it, while heparin binding was observed to reverse such an effect.
T8 1160-1320 Sentence denotes Additionally, heparin orientation observed on the surface of fIIa, but not fXa, allows a linear long-chain heparin binding to antithrombin in ternary complexes.
T9 1321-1454 Sentence denotes Finally, the enzymes catalytic triad organization was disrupted due to a strong glycosaminoglycan binding to the proteases exosite 2.
T10 1455-1693 Sentence denotes Such data support an atomic-level explanation for the higher inhibition constant of the antithrombin-heparin complex over fIIa than fXa, as well as for the different susceptibilities of those enzymes for antithrombin mechanisms of action.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 27-34 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 27-34 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 389-396 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 389-396 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T5 625-632 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T6 625-632 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T7 899-906 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T8 899-906 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T9 1104-1111 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T10 1104-1111 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T11 1174-1181 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T12 1174-1181 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T13 1267-1274 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T14 1267-1274 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T15 1556-1563 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T16 1556-1563 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 288-293 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 288-293 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 27-34 FMAID:167420 denotes heparin
_T2 27-34 FMAID:82839 denotes heparin
_T3 112-130 FMAID:63011 denotes glycosaminoglycans
_T4 112-130 FMAID:167395 denotes glycosaminoglycans
_T5 184-188 FMAID:214734 denotes main
_T6 216-222 FMAID:196753 denotes serine
_T7 216-222 FMAID:67710 denotes serine
_T8 216-222 FMAID:165609 denotes serine
_T9 216-222 FMAID:82764 denotes serine
_T10 288-293 FMAID:256053 denotes blood
_T11 366-384 FMAID:167395 denotes glycosaminoglycans
_T12 366-384 FMAID:63011 denotes glycosaminoglycans
_T13 389-396 FMAID:82839 denotes heparin
_T14 389-396 FMAID:167420 denotes heparin
_T15 405-409 FMAID:214734 denotes main
_T16 516-522 FMAID:165609 denotes serine
_T17 516-522 FMAID:196753 denotes serine
_T18 516-522 FMAID:67710 denotes serine
_T19 516-522 FMAID:82764 denotes serine
_T20 625-632 FMAID:167420 denotes heparin
_T21 625-632 FMAID:82839 denotes heparin
_T22 899-906 FMAID:82839 denotes heparin
_T23 899-906 FMAID:167420 denotes heparin
_T24 1104-1111 FMAID:82839 denotes heparin
_T25 1104-1111 FMAID:167420 denotes heparin
_T26 1174-1181 FMAID:167420 denotes heparin
_T27 1174-1181 FMAID:82839 denotes heparin
_T28 1210-1217 FMAID:146300 denotes surface
_T29 1210-1217 FMAID:50594 denotes surface
_T30 1210-1225 FMAID:132414 denotes surface of fIIa
_T31 1210-1225 FMAID:36975 denotes surface of fIIa
_T32 1267-1274 FMAID:82839 denotes heparin
_T33 1267-1274 FMAID:167420 denotes heparin
_T34 1358-1370 FMAID:67498 denotes organization
_T35 1358-1370 FMAID:166081 denotes organization
_T36 1401-1418 FMAID:63011 denotes glycosaminoglycan
_T37 1401-1418 FMAID:167395 denotes glycosaminoglycan
_T38 1556-1563 FMAID:167420 denotes heparin
_T39 1556-1563 FMAID:82839 denotes heparin

uniprot-human

Id Subject Object Predicate Lexical cue
T1 84-93 http://www.uniprot.org/uniprot/P63128 denotes proteases
T2 223-232 http://www.uniprot.org/uniprot/P63128 denotes proteases
T3 523-532 http://www.uniprot.org/uniprot/P63128 denotes proteases
T4 923-932 http://www.uniprot.org/uniprot/P63128 denotes proteases
T5 1434-1443 http://www.uniprot.org/uniprot/P63128 denotes proteases
T6 84-93 http://www.uniprot.org/uniprot/P10265 denotes proteases
T7 223-232 http://www.uniprot.org/uniprot/P10265 denotes proteases
T8 523-532 http://www.uniprot.org/uniprot/P10265 denotes proteases
T9 923-932 http://www.uniprot.org/uniprot/P10265 denotes proteases
T10 1434-1443 http://www.uniprot.org/uniprot/P10265 denotes proteases
T11 84-93 http://www.uniprot.org/uniprot/P63119 denotes proteases
T12 223-232 http://www.uniprot.org/uniprot/P63119 denotes proteases
T13 523-532 http://www.uniprot.org/uniprot/P63119 denotes proteases
T14 923-932 http://www.uniprot.org/uniprot/P63119 denotes proteases
T15 1434-1443 http://www.uniprot.org/uniprot/P63119 denotes proteases
T16 84-93 http://www.uniprot.org/uniprot/P63120 denotes proteases
T17 223-232 http://www.uniprot.org/uniprot/P63120 denotes proteases
T18 523-532 http://www.uniprot.org/uniprot/P63120 denotes proteases
T19 923-932 http://www.uniprot.org/uniprot/P63120 denotes proteases
T20 1434-1443 http://www.uniprot.org/uniprot/P63120 denotes proteases
T21 84-93 http://www.uniprot.org/uniprot/P63121 denotes proteases
T22 223-232 http://www.uniprot.org/uniprot/P63121 denotes proteases
T23 523-532 http://www.uniprot.org/uniprot/P63121 denotes proteases
T24 923-932 http://www.uniprot.org/uniprot/P63121 denotes proteases
T25 1434-1443 http://www.uniprot.org/uniprot/P63121 denotes proteases
T26 84-93 http://www.uniprot.org/uniprot/P63122 denotes proteases
T27 223-232 http://www.uniprot.org/uniprot/P63122 denotes proteases
T28 523-532 http://www.uniprot.org/uniprot/P63122 denotes proteases
T29 923-932 http://www.uniprot.org/uniprot/P63122 denotes proteases
T30 1434-1443 http://www.uniprot.org/uniprot/P63122 denotes proteases
T31 84-93 http://www.uniprot.org/uniprot/P63123 denotes proteases
T32 223-232 http://www.uniprot.org/uniprot/P63123 denotes proteases
T33 523-532 http://www.uniprot.org/uniprot/P63123 denotes proteases
T34 923-932 http://www.uniprot.org/uniprot/P63123 denotes proteases
T35 1434-1443 http://www.uniprot.org/uniprot/P63123 denotes proteases
T36 84-93 http://www.uniprot.org/uniprot/P63124 denotes proteases
T37 223-232 http://www.uniprot.org/uniprot/P63124 denotes proteases
T38 523-532 http://www.uniprot.org/uniprot/P63124 denotes proteases
T39 923-932 http://www.uniprot.org/uniprot/P63124 denotes proteases
T40 1434-1443 http://www.uniprot.org/uniprot/P63124 denotes proteases
T41 84-93 http://www.uniprot.org/uniprot/P63125 denotes proteases
T42 223-232 http://www.uniprot.org/uniprot/P63125 denotes proteases
T43 523-532 http://www.uniprot.org/uniprot/P63125 denotes proteases
T44 923-932 http://www.uniprot.org/uniprot/P63125 denotes proteases
T45 1434-1443 http://www.uniprot.org/uniprot/P63125 denotes proteases
T46 84-93 http://www.uniprot.org/uniprot/P63127 denotes proteases
T47 223-232 http://www.uniprot.org/uniprot/P63127 denotes proteases
T48 523-532 http://www.uniprot.org/uniprot/P63127 denotes proteases
T49 923-932 http://www.uniprot.org/uniprot/P63127 denotes proteases
T50 1434-1443 http://www.uniprot.org/uniprot/P63127 denotes proteases
T51 84-93 http://www.uniprot.org/uniprot/P63129 denotes proteases
T52 223-232 http://www.uniprot.org/uniprot/P63129 denotes proteases
T53 523-532 http://www.uniprot.org/uniprot/P63129 denotes proteases
T54 923-932 http://www.uniprot.org/uniprot/P63129 denotes proteases
T55 1434-1443 http://www.uniprot.org/uniprot/P63129 denotes proteases
T56 84-93 http://www.uniprot.org/uniprot/P63131 denotes proteases
T57 223-232 http://www.uniprot.org/uniprot/P63131 denotes proteases
T58 523-532 http://www.uniprot.org/uniprot/P63131 denotes proteases
T59 923-932 http://www.uniprot.org/uniprot/P63131 denotes proteases
T60 1434-1443 http://www.uniprot.org/uniprot/P63131 denotes proteases
T61 84-93 http://www.uniprot.org/uniprot/Q9Y6I0 denotes proteases
T62 223-232 http://www.uniprot.org/uniprot/Q9Y6I0 denotes proteases
T63 523-532 http://www.uniprot.org/uniprot/Q9Y6I0 denotes proteases
T64 923-932 http://www.uniprot.org/uniprot/Q9Y6I0 denotes proteases
T65 1434-1443 http://www.uniprot.org/uniprot/Q9Y6I0 denotes proteases
T66 216-242 http://www.uniprot.org/uniprot/P05154 denotes serine proteases inhibitor

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 482-492 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanisms
T2 1672-1682 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanisms

GO-BP

Id Subject Object Predicate Lexical cue
T1 64-75 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T2 216-242 http://purl.obolibrary.org/obo/GO_0004867 denotes serine proteases inhibitor
T3 274-284 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T4 288-302 http://purl.obolibrary.org/obo/GO_0007596 denotes blood clotting
T5 294-302 http://purl.obolibrary.org/obo/GO_0050817 denotes clotting
T6 308-317 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T7 715-728 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T8 853-866 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

GO-MF

Id Subject Object Predicate Lexical cue
T1 899-914 http://purl.obolibrary.org/obo/GO_0008201 denotes heparin binding
T2 1104-1119 http://purl.obolibrary.org/obo/GO_0008201 denotes heparin binding
T3 1267-1282 http://purl.obolibrary.org/obo/GO_0008201 denotes heparin binding
T4 907-914 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T5 1112-1119 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T6 1275-1282 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T7 1419-1426 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T8 907-914 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T9 1112-1119 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T10 1275-1282 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T11 1419-1426 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T12 907-914 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T13 1112-1119 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T14 1275-1282 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T15 1419-1426 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T16 907-914 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T17 1112-1119 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T18 1275-1282 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T19 1419-1426 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T20 1401-1426 http://purl.obolibrary.org/obo/GO_0005539 denotes glycosaminoglycan binding
T21 1419-1443 http://purl.obolibrary.org/obo/GO_0002020 denotes binding to the proteases

GO-CC

Id Subject Object Predicate Lexical cue
T1 694-697 http://purl.obolibrary.org/obo/GO_0005731 denotes nor
T2 1352-1357 http://purl.obolibrary.org/obo/GO_0030315 denotes triad

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 288-293 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T2 288-302 http://purl.obolibrary.org/obo/UBERON_0010210 denotes blood clotting

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 288-293 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T2 288-293 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 27-34 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T2 389-396 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T3 625-632 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T4 899-906 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T5 1104-1111 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T6 1174-1181 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T7 1267-1274 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T8 1556-1563 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1358-1370 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organization
PD-UBERON-AE-B_T2 288-293 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T3 288-302 http://purl.obolibrary.org/obo/UBERON_0010210 denotes blood clotting

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 288-293 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 288-293 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178