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PubMed:24158441 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-149 Sentence denotes Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase.
T2 150-237 Sentence denotes In metazoans, the highly conserved MAPK signaling pathway regulates cell fate decision.
T3 238-353 Sentence denotes Aberrant activation of this pathway has been implicated in multiple human cancers and some developmental disorders.
T4 354-515 Sentence denotes KSR1 functions as an essential scaffold that binds the individual components of the cascade and coordinates their assembly into multiprotein signaling platforms.
T5 516-597 Sentence denotes The mechanism of KSR1 regulation is highly complex and not completely understood.
T6 598-687 Sentence denotes In this study, we identified Tyr(728) as a novel regulatory phosphorylation site in KSR1.
T7 688-820 Sentence denotes We show that Tyr(728) is phosphorylated by LCK, uncovering an additional and unexpected link between Src kinases and MAPK signaling.
T8 821-979 Sentence denotes To understand how phosphorylation of Tyr(728) may regulate the role of KSR1 in signal transduction, we integrated structural modeling and biochemical studies.
T9 980-1107 Sentence denotes We demonstrate that Tyr(728) is involved in maintaining the conformation of the KSR1 kinase domain required for binding to MEK.
T10 1108-1224 Sentence denotes It also affects phosphorylation and activation of MEK by RAF kinases and consequently influences cell proliferation.
T11 1225-1337 Sentence denotes Moreover, our studies suggest that phosphorylation of Tyr(728) may affect the intrinsic kinase activity of KSR1.
T12 1338-1543 Sentence denotes Together, we propose that phosphorylation of Tyr(728) may regulate the transition between the scaffolding and the catalytic function of KSR1 serving as a control point used to fine-tune cellular responses.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 312-319 HP_0002664 denotes cancers

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 306-311 OrganismTaxon denotes human 9606