PubMed:24129563
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 66-74 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
| T3 | 935-943 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
| T5 | 971-979 | Glycan_Motif | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T1 | 66-74 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T2 | 935-943 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 971-979 | GlycoEpitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-116 | Sentence | denotes | Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1. |
| T2 | 117-285 | Sentence | denotes | Pancreatic cancer, the fourth most prevalent cancer-related cause of death in the United States, is a disease with a dismal survival rate of 5% 5 years after diagnosis. |
| T3 | 286-386 | Sentence | denotes | One of the survival proteins responsible for its extraordinary ability to evade cell death is HSP70. |
| T4 | 387-571 | Sentence | denotes | A naturally derived compound, triptolide, and its water-soluble prodrug, Minnelide, down-regulate the expression of this protein in pancreatic cancer cells, thereby causing cell death. |
| T5 | 572-643 | Sentence | denotes | However, the mechanism of action of triptolide has not been elucidated. |
| T6 | 644-799 | Sentence | denotes | Our study shows that triptolide-induced down-regulation of HSP70 expression is associated with a decrease in glycosylation of the transcription factor Sp1. |
| T7 | 800-956 | Sentence | denotes | We further show that triptolide inhibits glycosylation of Sp1, inhibiting the hexosamine biosynthesis pathway, particularly the enzyme O-GlcNAc transferase. |
| T8 | 957-1066 | Sentence | denotes | Inhibition of O-GlcNAc transferase prevents nuclear localization of Sp1 and affects its DNA binding activity. |
| T9 | 1067-1197 | Sentence | denotes | This in turn down-regulates prosurvival pathways like NF-κB, leading to inhibition of HSF1 and HSP70 and eventually to cell death. |
| T10 | 1198-1380 | Sentence | denotes | In this study, we evaluated the mechanism by which triptolide affects glycosylation of Sp1, which in turn affects downstream pathways controlling survival of pancreatic cancer cells. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 66-74 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
| T2 | 66-74 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
| T3 | 935-943 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
| T4 | 935-943 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
| T5 | 971-979 | https://glytoucan.org/Structures/Glycans/G49108TO | denotes | O-GlcNAc |
| T6 | 971-979 | https://glytoucan.org/Structures/Glycans/G89565QL | denotes | O-GlcNAc |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 66-74 | gene:8473 | denotes | O-GlcNAc |
| T1 | 33-50 | disease:C0235974 | denotes | pancreatic cancer |
| T2 | 66-74 | gene:8473 | denotes | O-GlcNAc |
| T3 | 33-50 | disease:C0346647 | denotes | pancreatic cancer |
| T4 | 91-115 | gene:6667 | denotes | transcription factor Sp1 |
| T5 | 33-50 | disease:C0235974 | denotes | pancreatic cancer |
| T6 | 91-115 | gene:6667 | denotes | transcription factor Sp1 |
| T7 | 33-50 | disease:C0346647 | denotes | pancreatic cancer |
| R1 | T0 | T1 | associated_with | O-GlcNAc,pancreatic cancer |
| R2 | T2 | T3 | associated_with | O-GlcNAc,pancreatic cancer |
| R3 | T4 | T5 | associated_with | transcription factor Sp1,pancreatic cancer |
| R4 | T6 | T7 | associated_with | transcription factor Sp1,pancreatic cancer |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 117-134 | HP_0002894 | denotes | Pancreatic cancer |
| T2 | 128-134 | HP_0002664 | denotes | cancer |
| T3 | 162-168 | HP_0002664 | denotes | cancer |
| T4 | 519-536 | HP_0002894 | denotes | pancreatic cancer |
| T5 | 530-536 | HP_0002664 | denotes | cancer |
| T6 | 1356-1373 | HP_0002894 | denotes | pancreatic cancer |
| T7 | 1367-1373 | HP_0002664 | denotes | cancer |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 24129563-0#66#74#gene8473 | 66-74 | gene8473 | denotes | O-GlcNAc |
| 24129563-0#33#50#diseaseC0235974 | 33-50 | diseaseC0235974 | denotes | pancreatic cancer |
| 24129563-0#33#50#diseaseC0346647 | 33-50 | diseaseC0346647 | denotes | pancreatic cancer |
| 66#74#gene847333#50#diseaseC0235974 | 24129563-0#66#74#gene8473 | 24129563-0#33#50#diseaseC0235974 | associated_with | O-GlcNAc,pancreatic cancer |
| 66#74#gene847333#50#diseaseC0346647 | 24129563-0#66#74#gene8473 | 24129563-0#33#50#diseaseC0346647 | associated_with | O-GlcNAc,pancreatic cancer |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 68-74 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T2 | 937-943 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T3 | 973-979 | chem:24139 | denotes | GlcNAc |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 66-74 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T2 | 935-943 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T3 | 971-979 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 33-50 | Phenotype | denotes | pancreatic cancer | HP:0002894 |
| T2 | 117-134 | Phenotype | denotes | Pancreatic cancer | HP:0002894 |
| T3 | 162-168 | Phenotype | denotes | cancer | HP:0002664 |
| T4 | 519-536 | Phenotype | denotes | pancreatic cancer | HP:0002894 |
| T5 | 1356-1373 | Phenotype | denotes | pancreatic cancer | HP:0002894 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 33-50 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T3 | 117-134 | Disease | denotes | Pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T5 | 162-168 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T6 | 519-536 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
| T8 | 1356-1373 | Disease | denotes | pancreatic cancer | http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 66-74 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T2 | 935-943 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T3 | 971-979 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 66-74 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T2 | 935-943 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 971-979 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 33-50 | Phenotype | denotes | pancreatic cancer | HP:0002894 |
| T2 | 117-134 | Phenotype | denotes | Pancreatic cancer | HP:0002894 |
| T3 | 162-168 | Phenotype | denotes | cancer | HP:0002664 |
| T4 | 519-536 | Phenotype | denotes | pancreatic cancer | HP:0002894 |
| T5 | 1356-1373 | Phenotype | denotes | pancreatic cancer | HP:0002894 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 530-542 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T2 | 1367-1379 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 33-50 | Disease | denotes | pancreatic cancer | MONDO:0005192|MONDO:0009831 |
| T3 | 117-134 | Disease | denotes | Pancreatic cancer | MONDO:0005192|MONDO:0009831 |
| T5 | 162-168 | Disease | denotes | cancer | MONDO:0004992 |
| T6 | 519-536 | Disease | denotes | pancreatic cancer | MONDO:0005192|MONDO:0009831 |
| T8 | 1356-1373 | Disease | denotes | pancreatic cancer | MONDO:0005192|MONDO:0009831 |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 66-74 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T2 | 935-943 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 971-979 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-116 | Sentence | denotes | Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1. |
| T2 | 117-285 | Sentence | denotes | Pancreatic cancer, the fourth most prevalent cancer-related cause of death in the United States, is a disease with a dismal survival rate of 5% 5 years after diagnosis. |
| T3 | 286-386 | Sentence | denotes | One of the survival proteins responsible for its extraordinary ability to evade cell death is HSP70. |
| T4 | 387-571 | Sentence | denotes | A naturally derived compound, triptolide, and its water-soluble prodrug, Minnelide, down-regulate the expression of this protein in pancreatic cancer cells, thereby causing cell death. |
| T5 | 572-643 | Sentence | denotes | However, the mechanism of action of triptolide has not been elucidated. |
| T6 | 644-799 | Sentence | denotes | Our study shows that triptolide-induced down-regulation of HSP70 expression is associated with a decrease in glycosylation of the transcription factor Sp1. |
| T7 | 800-956 | Sentence | denotes | We further show that triptolide inhibits glycosylation of Sp1, inhibiting the hexosamine biosynthesis pathway, particularly the enzyme O-GlcNAc transferase. |
| T8 | 957-1066 | Sentence | denotes | Inhibition of O-GlcNAc transferase prevents nuclear localization of Sp1 and affects its DNA binding activity. |
| T9 | 1067-1197 | Sentence | denotes | This in turn down-regulates prosurvival pathways like NF-κB, leading to inhibition of HSF1 and HSP70 and eventually to cell death. |
| T10 | 1198-1380 | Sentence | denotes | In this study, we evaluated the mechanism by which triptolide affects glycosylation of Sp1, which in turn affects downstream pathways controlling survival of pancreatic cancer cells. |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 530-542 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T2 | 1367-1379 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |