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PubMed:24120837 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 766-778 Cell denotes neutrophilic http://purl.obolibrary.org/obo/CL:0000775
T2 1059-1071 Cell denotes neutrophilic http://purl.obolibrary.org/obo/CL:0000775

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-78 Sentence denotes Functional heterogeneity of pulmonary surfactant protein-D in cystic fibrosis.
T2 79-219 Sentence denotes Pulmonary surfactant protein-D (SP-D) is a soluble collagenous C-type lectin with important anti-microbial and anti-inflammatory properties.
T3 220-405 Sentence denotes Although it is subject to functionally relevant modification by common polymorphisms and unregulated inflammation, the functional status of SP-D in cystic fibrosis (CF) remains unclear.
T4 406-570 Sentence denotes Given the importance of infection and inflammation in CF lung pathology we have undertaken the first systematic analysis of SP-D lectin activity in this population.
T5 571-792 Sentence denotes By ELISA, we found that airway lavage fluid SP-D expression was greater in CF compared to control patients but was reduced in CF patients with infection and correlated negatively with markers of neutrophilic inflammation.
T6 793-991 Sentence denotes In a functional assay, the percentage of SP-D capable of binding zymosan rarely exceeded 60% in CF or control patients and similarly restricted binding activity was observed towards maltose-agarose.
T7 992-1179 Sentence denotes SP-D lectin activity also correlated negatively with infection and neutrophilic inflammation but there was little evidence of major proteolytic degradation amongst the non-bound material.
T8 1180-1327 Sentence denotes SP-D which failed to bind zymosan exhibited features of lower oligomeric form compared to bound material when tested by native gel electrophoresis.
T9 1328-1554 Sentence denotes Furthermore, when separated by gel chromatography, high and low oligomeric populations of SP-D were observed in CF lavage fluid but only high oligomeric forms exhibited substantial lectin activity towards yeast derived mannan.
T10 1555-1759 Sentence denotes Our data demonstrate that oligomeric heterogeneity underlies functional diversity amongst SP-D in health and disease and that dynamic regulation of oligomerisation is an important feature of SP-D biology.
T1 0-78 Sentence denotes Functional heterogeneity of pulmonary surfactant protein-D in cystic fibrosis.
T2 79-219 Sentence denotes Pulmonary surfactant protein-D (SP-D) is a soluble collagenous C-type lectin with important anti-microbial and anti-inflammatory properties.
T3 220-405 Sentence denotes Although it is subject to functionally relevant modification by common polymorphisms and unregulated inflammation, the functional status of SP-D in cystic fibrosis (CF) remains unclear.
T4 406-570 Sentence denotes Given the importance of infection and inflammation in CF lung pathology we have undertaken the first systematic analysis of SP-D lectin activity in this population.
T5 571-792 Sentence denotes By ELISA, we found that airway lavage fluid SP-D expression was greater in CF compared to control patients but was reduced in CF patients with infection and correlated negatively with markers of neutrophilic inflammation.
T6 793-991 Sentence denotes In a functional assay, the percentage of SP-D capable of binding zymosan rarely exceeded 60% in CF or control patients and similarly restricted binding activity was observed towards maltose-agarose.
T7 992-1179 Sentence denotes SP-D lectin activity also correlated negatively with infection and neutrophilic inflammation but there was little evidence of major proteolytic degradation amongst the non-bound material.
T8 1180-1327 Sentence denotes SP-D which failed to bind zymosan exhibited features of lower oligomeric form compared to bound material when tested by native gel electrophoresis.
T9 1328-1554 Sentence denotes Furthermore, when separated by gel chromatography, high and low oligomeric populations of SP-D were observed in CF lavage fluid but only high oligomeric forms exhibited substantial lectin activity towards yeast derived mannan.
T10 1555-1759 Sentence denotes Our data demonstrate that oligomeric heterogeneity underlies functional diversity amongst SP-D in health and disease and that dynamic regulation of oligomerisation is an important feature of SP-D biology.

Allie

Id Subject Object Predicate Lexical cue
SS1_24120837_1_0 89-109 expanded denotes surfactant protein-D
SS2_24120837_1_0 111-115 abbr denotes SP-D
SS1_24120837_2_0 368-383 expanded denotes cystic fibrosis
SS2_24120837_2_0 385-387 abbr denotes CF
AE1_24120837_1_0 SS1_24120837_1_0 SS2_24120837_1_0 abbreviatedTo surfactant protein-D,SP-D
AE1_24120837_2_0 SS1_24120837_2_0 SS2_24120837_2_0 abbreviatedTo cystic fibrosis,CF

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 975-982 Glycan denotes maltose https://api.glycosmos.org/wurcs2image/latest/png/binary/G44653LT

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 62-77 Disease denotes cystic fibrosis http://purl.obolibrary.org/obo/MONDO_0009061
T2 111-115 Disease denotes SP-D http://purl.obolibrary.org/obo/MONDO_0019683
T3 321-333 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T4 360-364 Disease denotes SP-D http://purl.obolibrary.org/obo/MONDO_0019683
T5 368-383 Disease denotes cystic fibrosis http://purl.obolibrary.org/obo/MONDO_0009061
T6 385-387 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T7 430-439 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T8 444-456 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T9 460-462 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T10 530-534 Disease denotes SP-D http://purl.obolibrary.org/obo/MONDO_0019683
T11 615-619 Disease denotes SP-D http://purl.obolibrary.org/obo/MONDO_0019683
T12 646-648 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T13 697-699 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T14 714-723 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T15 779-791 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T16 834-838 Disease denotes SP-D http://purl.obolibrary.org/obo/MONDO_0019683
T17 889-891 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T18 992-996 Disease denotes SP-D http://purl.obolibrary.org/obo/MONDO_0019683
T19 1045-1054 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T20 1072-1084 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T21 1180-1184 Disease denotes SP-D http://purl.obolibrary.org/obo/MONDO_0019683
T22 1418-1422 Disease denotes SP-D http://purl.obolibrary.org/obo/MONDO_0019683
T23 1440-1442 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T24 1645-1649 Disease denotes SP-D http://purl.obolibrary.org/obo/MONDO_0019683
T25 1746-1750 Disease denotes SP-D http://purl.obolibrary.org/obo/MONDO_0019683

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 463-467 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 975-982 Glycan denotes maltose https://api.glycosmos.org/wurcs2image/latest/png/binary/G44653LT

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 62-77 Disease denotes cystic fibrosis MONDO:0009061
T2 368-383 Disease denotes cystic fibrosis MONDO:0009061
T3 385-387 Disease denotes CF MONDO:0009061
T4 430-439 Disease denotes infection MONDO:0005550
T5 460-462 Disease denotes CF MONDO:0009061
T6 646-648 Disease denotes CF MONDO:0009061
T7 697-699 Disease denotes CF MONDO:0009061
T8 714-723 Disease denotes infection MONDO:0005550
T9 889-891 Disease denotes CF MONDO:0009061
T10 1045-1054 Disease denotes infection MONDO:0005550
T11 1440-1442 Disease denotes CF MONDO:0009061

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 766-778 Cell denotes neutrophilic http://purl.obolibrary.org/obo/CL:0000775
T2 1059-1071 Cell denotes neutrophilic http://purl.obolibrary.org/obo/CL:0000775

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 28-48 Body_part denotes pulmonary surfactant http://purl.obolibrary.org/obo/UBERON_0008826
T2 79-99 Body_part denotes Pulmonary surfactant http://purl.obolibrary.org/obo/UBERON_0008826
T3 463-467 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T4 595-601 Body_part denotes airway http://purl.obolibrary.org/obo/UBERON_0000117|http://purl.obolibrary.org/obo/UBERON_0001005
T6 609-614 Body_part denotes fluid http://purl.obolibrary.org/obo/UBERON_0006314
T7 766-778 Body_part denotes neutrophilic http://purl.obolibrary.org/obo/CL_0000775
T8 1059-1071 Body_part denotes neutrophilic http://purl.obolibrary.org/obo/CL_0000775
T9 1450-1455 Body_part denotes fluid http://purl.obolibrary.org/obo/UBERON_0006314

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 669-677 Organism denotes patients 9606
T2 700-708 Organism denotes patients 9606
T3 903-911 Organism denotes patients 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-78 Sentence denotes Functional heterogeneity of pulmonary surfactant protein-D in cystic fibrosis.
T2 79-219 Sentence denotes Pulmonary surfactant protein-D (SP-D) is a soluble collagenous C-type lectin with important anti-microbial and anti-inflammatory properties.
T3 220-405 Sentence denotes Although it is subject to functionally relevant modification by common polymorphisms and unregulated inflammation, the functional status of SP-D in cystic fibrosis (CF) remains unclear.
T4 406-570 Sentence denotes Given the importance of infection and inflammation in CF lung pathology we have undertaken the first systematic analysis of SP-D lectin activity in this population.
T5 571-792 Sentence denotes By ELISA, we found that airway lavage fluid SP-D expression was greater in CF compared to control patients but was reduced in CF patients with infection and correlated negatively with markers of neutrophilic inflammation.
T6 793-991 Sentence denotes In a functional assay, the percentage of SP-D capable of binding zymosan rarely exceeded 60% in CF or control patients and similarly restricted binding activity was observed towards maltose-agarose.
T7 992-1179 Sentence denotes SP-D lectin activity also correlated negatively with infection and neutrophilic inflammation but there was little evidence of major proteolytic degradation amongst the non-bound material.
T8 1180-1327 Sentence denotes SP-D which failed to bind zymosan exhibited features of lower oligomeric form compared to bound material when tested by native gel electrophoresis.
T9 1328-1554 Sentence denotes Furthermore, when separated by gel chromatography, high and low oligomeric populations of SP-D were observed in CF lavage fluid but only high oligomeric forms exhibited substantial lectin activity towards yeast derived mannan.
T10 1555-1759 Sentence denotes Our data demonstrate that oligomeric heterogeneity underlies functional diversity amongst SP-D in health and disease and that dynamic regulation of oligomerisation is an important feature of SP-D biology.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 463-467 Body_part denotes lung FMA:7195
T2 766-778 Body_part denotes neutrophilic FMA:62860
T3 1059-1071 Body_part denotes neutrophilic FMA:62860

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 463-467 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 28-48 Body_part denotes pulmonary surfactant http://purl.obolibrary.org/obo/UBERON_0008826
T2 79-99 Body_part denotes Pulmonary surfactant http://purl.obolibrary.org/obo/UBERON_0008826
T3 463-467 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T4 595-601 Body_part denotes airway http://purl.obolibrary.org/obo/UBERON_0000117|http://purl.obolibrary.org/obo/UBERON_0001005
T6 609-614 Body_part denotes fluid http://purl.obolibrary.org/obo/UBERON_0006314
T7 766-778 Body_part denotes neutrophilic http://purl.obolibrary.org/obo/CL_0000775
T8 1059-1071 Body_part denotes neutrophilic http://purl.obolibrary.org/obo/CL_0000775
T9 1450-1455 Body_part denotes fluid http://purl.obolibrary.org/obo/UBERON_0006314