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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-156 Sentence denotes [Comparison of the effect of fluid resuscitation as guided either by lactate clearance rate or by central venous oxygen saturation in patients with sepsis].
T2 157-167 Sentence denotes OBJECTIVE:
T3 168-326 Sentence denotes To compare the efficacy of fluid resuscitation as guided by lactate clearance rate (LCR) and central venous oxygen saturation (ScvO2) in patients with sepsis.
T4 327-335 Sentence denotes METHODS:
T5 336-389 Sentence denotes A prospective randomized control study was conducted.
T6 390-599 Sentence denotes Fifty patients diagnosed with severe sepsis or septic shock from January 2011 to February 2012 in department of critical care medicine of Fourth Hospital of Hebei Medical University were enrolled in the study.
T7 600-689 Sentence denotes The patients were randomly divided into two groups according to the sequence (each n=25):
T8 690-716 Sentence denotes ScvO2 group and LCR group.
T9 717-947 Sentence denotes After ICU admission, the patients were treated symptomatically timely, and fluid resuscitation was started as early as possible according to Surviving Sepsis Campaign guidance for management of severe sepsis and septic shock 2008.
T10 948-1265 Sentence denotes Central venous pressure (CVP)≥8 mm Hg (1 mm Hg=0.133 kPa), mean arterial pressure (MAP)≥65 mm Hg and ScvO2≥0.70 served as goal values to accomplish the fluid resuscitation therapy in ScvO2 group, while CVP≥8 mm Hg, MAP≥65 mm Hg, LCR≥10% served as goal value to accomplish the fluid resuscitation therapy in LCR group.
T11 1266-1529 Sentence denotes The general condition and clinical characteristics on arrival in ICU, changes in CVP, MAP, ScvO2, lactate level and/or LCR before (0 hour) and 3, 6, 72 hours after the start of fluid resuscitation and the other related conditions during the therapy were recorded.
T12 1530-1538 Sentence denotes RESULTS:
T13 1539-1768 Sentence denotes There was no significant difference in general data or clinical characteristics before the start of therapy, occurrence of organ dysfunction, or treatment measures during different time periods after start of fluid resuscitation.
T14 1769-2145 Sentence denotes Compared with the condition immediately before fluid resuscitation, at 3 hours after start of fluid resuscitation, CVP were improved in LCR and ScvO2 groups (8.58±1.17 mm Hg vs. 6.33±1.21 mm Hg, 9.08±2.43 mm Hg vs. 5.33±0.98 mm Hg, both P<0.05); at 6 hours after start of fluid resuscitation, heart rate (HR) and respiratory rate (RR) were lowered in LCR and ScvO2 groups (HR:
T15 2146-2201 Sentence denotes 96±18 bpm vs. 127±13 bpm, 98±13 bpm vs. 116±19 bpm, RR:
T16 2202-2490 Sentence denotes 23±3 times/min vs. 33±9 times/min, 24±5 times/min vs. 35±6 times/min, all P<0.05), oxygenation index (PaO2/FiO2) was increased in LCR and ScvO2 groups (179±41 mm Hg vs. 86±21 mm Hg, 202±33 mm Hg vs. 95±17 mm Hg, both P<0.05), and there was no significant difference in MAP in both groups.
T17 2491-2561 Sentence denotes There was no significant difference in all indexes between two groups.
T18 2562-2710 Sentence denotes In LCR group, 3 hours after start of fluid resuscitation, lactate level was significantly decreased (2.81±0.18 mmol/L vs. 3.43±1.31 mmol/L, P<0.05).
T19 2711-2944 Sentence denotes Compared with the value 3 hours after start of fluid resuscitation, LCR was significantly improved at 6 hours and 72 hours after start of fluid resuscitation in LCR group [(42.69±8.75)%, (48.87±9.69)% vs. (20.32±4.58)%, both P<0.05].
T20 2945-3130 Sentence denotes Compared with that immediately before fluid resuscitation, ScvO2 was significant improved in ScvO2 group at 3 hours after start of fluid resuscitation (0.65±0.04 vs. 0.53±0.06, P<0.05).
T21 3131-3262 Sentence denotes There was no significant difference in success rate of fluid resuscitation comparing that of 6 hours and that of 72 hours [6 hours:
T22 3263-3322 Sentence denotes 72% (18/25) vs. 64% (16/25), χ(2)=0.368, P=0.762; 72 hours:
T23 3323-3673 Sentence denotes 88% (22/25) vs. 88% (22/25) ,χ(2)=0.000, P=1.000], length of ICU stay (8±3 days vs. 10±4 days, t=0.533, P=0.874), length of hospital stay (29±11 days vs. 35±16 days, t=0.692, P=0.531), improvement rate [84% (21/25) vs. 76%(19/25), χ(2)=0.500, P=0.480] or 28-day mortality [20% (5/25) vs. 28% (7/25), χ(2)=0.439, P=0.742] between LCR and ScvO2 groups.
T24 3674-3686 Sentence denotes CONCLUSIONS:
T25 3687-3831 Sentence denotes Both LCR and ScvO2 can be taken as the index in confirming the endpoint of fluid resuscitation for patients with severe sepsis and septic shock.
T26 3832-3959 Sentence denotes Fluid resuscitation therapy under the guidance of LCR is accurate and reliable in patients with severe sepsis and septic shock.
T1 0-156 Sentence denotes [Comparison of the effect of fluid resuscitation as guided either by lactate clearance rate or by central venous oxygen saturation in patients with sepsis].
T2 157-167 Sentence denotes OBJECTIVE:
T3 168-326 Sentence denotes To compare the efficacy of fluid resuscitation as guided by lactate clearance rate (LCR) and central venous oxygen saturation (ScvO2) in patients with sepsis.
T4 327-335 Sentence denotes METHODS:
T5 336-389 Sentence denotes A prospective randomized control study was conducted.
T6 390-599 Sentence denotes Fifty patients diagnosed with severe sepsis or septic shock from January 2011 to February 2012 in department of critical care medicine of Fourth Hospital of Hebei Medical University were enrolled in the study.
T7 600-689 Sentence denotes The patients were randomly divided into two groups according to the sequence (each n=25):
T8 690-716 Sentence denotes ScvO2 group and LCR group.
T9 717-947 Sentence denotes After ICU admission, the patients were treated symptomatically timely, and fluid resuscitation was started as early as possible according to Surviving Sepsis Campaign guidance for management of severe sepsis and septic shock 2008.
T10 948-1265 Sentence denotes Central venous pressure (CVP)≥8 mm Hg (1 mm Hg=0.133 kPa), mean arterial pressure (MAP)≥65 mm Hg and ScvO2≥0.70 served as goal values to accomplish the fluid resuscitation therapy in ScvO2 group, while CVP≥8 mm Hg, MAP≥65 mm Hg, LCR≥10% served as goal value to accomplish the fluid resuscitation therapy in LCR group.
T11 1266-1529 Sentence denotes The general condition and clinical characteristics on arrival in ICU, changes in CVP, MAP, ScvO2, lactate level and/or LCR before (0 hour) and 3, 6, 72 hours after the start of fluid resuscitation and the other related conditions during the therapy were recorded.
T12 1530-1538 Sentence denotes RESULTS:
T13 1539-1768 Sentence denotes There was no significant difference in general data or clinical characteristics before the start of therapy, occurrence of organ dysfunction, or treatment measures during different time periods after start of fluid resuscitation.
T14 1769-2145 Sentence denotes Compared with the condition immediately before fluid resuscitation, at 3 hours after start of fluid resuscitation, CVP were improved in LCR and ScvO2 groups (8.58±1.17 mm Hg vs. 6.33±1.21 mm Hg, 9.08±2.43 mm Hg vs. 5.33±0.98 mm Hg, both P<0.05); at 6 hours after start of fluid resuscitation, heart rate (HR) and respiratory rate (RR) were lowered in LCR and ScvO2 groups (HR:
T15 2146-2201 Sentence denotes 96±18 bpm vs. 127±13 bpm, 98±13 bpm vs. 116±19 bpm, RR:
T16 2202-2490 Sentence denotes 23±3 times/min vs. 33±9 times/min, 24±5 times/min vs. 35±6 times/min, all P<0.05), oxygenation index (PaO2/FiO2) was increased in LCR and ScvO2 groups (179±41 mm Hg vs. 86±21 mm Hg, 202±33 mm Hg vs. 95±17 mm Hg, both P<0.05), and there was no significant difference in MAP in both groups.
T17 2491-2561 Sentence denotes There was no significant difference in all indexes between two groups.
T18 2562-2710 Sentence denotes In LCR group, 3 hours after start of fluid resuscitation, lactate level was significantly decreased (2.81±0.18 mmol/L vs. 3.43±1.31 mmol/L, P<0.05).
T19 2711-2944 Sentence denotes Compared with the value 3 hours after start of fluid resuscitation, LCR was significantly improved at 6 hours and 72 hours after start of fluid resuscitation in LCR group [(42.69±8.75)%, (48.87±9.69)% vs. (20.32±4.58)%, both P<0.05].
T20 2945-3130 Sentence denotes Compared with that immediately before fluid resuscitation, ScvO2 was significant improved in ScvO2 group at 3 hours after start of fluid resuscitation (0.65±0.04 vs. 0.53±0.06, P<0.05).
T21 3131-3262 Sentence denotes There was no significant difference in success rate of fluid resuscitation comparing that of 6 hours and that of 72 hours [6 hours:
T22 3263-3322 Sentence denotes 72% (18/25) vs. 64% (16/25), χ(2)=0.368, P=0.762; 72 hours:
T23 3323-3673 Sentence denotes 88% (22/25) vs. 88% (22/25) ,χ(2)=0.000, P=1.000], length of ICU stay (8±3 days vs. 10±4 days, t=0.533, P=0.874), length of hospital stay (29±11 days vs. 35±16 days, t=0.692, P=0.531), improvement rate [84% (21/25) vs. 76%(19/25), χ(2)=0.500, P=0.480] or 28-day mortality [20% (5/25) vs. 28% (7/25), χ(2)=0.439, P=0.742] between LCR and ScvO2 groups.
T24 3674-3686 Sentence denotes CONCLUSIONS:
T25 3687-3831 Sentence denotes Both LCR and ScvO2 can be taken as the index in confirming the endpoint of fluid resuscitation for patients with severe sepsis and septic shock.
T26 3832-3959 Sentence denotes Fluid resuscitation therapy under the guidance of LCR is accurate and reliable in patients with severe sepsis and septic shock.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 319-325 HP_0100806 denotes sepsis

Allie

Id Subject Object Predicate Lexical cue
SS1_24119693_2_0 228-250 expanded denotes lactate clearance rate
SS2_24119693_2_0 252-255 abbr denotes LCR
SS1_24119693_8_0 948-971 expanded denotes Central venous pressure
SS2_24119693_8_0 973-976 abbr denotes CVP
SS1_24119693_8_1 1007-1029 expanded denotes mean arterial pressure
SS2_24119693_8_1 1031-1034 abbr denotes MAP
SS1_24119693_12_0 2062-2072 expanded denotes heart rate
SS2_24119693_12_0 2074-2076 abbr denotes HR
SS1_24119693_12_1 2082-2098 expanded denotes respiratory rate
SS2_24119693_12_1 2100-2102 abbr denotes RR
AE1_24119693_2_0 SS1_24119693_2_0 SS2_24119693_2_0 abbreviatedTo lactate clearance rate,LCR
AE1_24119693_8_0 SS1_24119693_8_0 SS2_24119693_8_0 abbreviatedTo Central venous pressure,CVP
AE1_24119693_8_1 SS1_24119693_8_1 SS2_24119693_8_1 abbreviatedTo mean arterial pressure,MAP
AE1_24119693_12_0 SS1_24119693_12_0 SS2_24119693_12_0 abbreviatedTo heart rate,HR
AE1_24119693_12_1 SS1_24119693_12_1 SS2_24119693_12_1 abbreviatedTo respiratory rate,RR

yangbin123xm_800_3

Id Subject Object Predicate Lexical cue
T1 148-154 DP denotes sepsis
T2 319-325 DP denotes sepsis
T3 427-433 DP denotes sepsis
T4 918-924 DP denotes sepsis
T5 3807-3813 DP denotes sepsis
T6 3935-3941 DP denotes sepsis
T7 437-449 DP denotes septic shock
T8 929-941 DP denotes septic shock
T9 3818-3830 DP denotes septic shock
T10 3946-3958 DP denotes septic shock

chenxin_473849_800_3

Id Subject Object Predicate Lexical cue
T1 148-154 DP denotes sepsis
T2 319-325 DP denotes sepsis
T3 427-433 DP denotes sepsis
T4 918-924 DP denotes sepsis
T5 3807-3813 DP denotes sepsis
T6 3935-3941 DP denotes sepsis
T7 437-449 DP denotes septic shock
T8 929-941 DP denotes septic shock
T9 3818-3830 DP denotes septic shock
T10 3946-3958 DP denotes septic shock