PubMed:24097061
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-92 | Sentence | denotes | A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation. |
| TextSentencer_T2 | 93-212 | Sentence | denotes | A prompt and efficient DNA damage response (DDR) eliminates the detrimental effects of DNA lesions in eukaryotic cells. |
| TextSentencer_T3 | 213-328 | Sentence | denotes | Basic and preclinical studies suggest that the DDR is one of the primary anti-cancer barriers during tumorigenesis. |
| TextSentencer_T4 | 329-512 | Sentence | denotes | The DDR involves a complex network of processes that detect and repair DNA damage, in which long non-coding RNAs (lncRNAs), a new class of regulatory RNAs, may play an important role. |
| TextSentencer_T5 | 513-670 | Sentence | denotes | In the current study, we identified a novel lncRNA, lncRNA-JADE, that is induced after DNA damage in an ataxia-telangiectasia mutated (ATM)-dependent manner. |
| TextSentencer_T6 | 671-808 | Sentence | denotes | LncRNA-JADE transcriptionally activates Jade1, a key component in the HBO1 (human acetylase binding to ORC1) histone acetylation complex. |
| TextSentencer_T7 | 809-877 | Sentence | denotes | Consequently, lncRNA-JADE induces histone H4 acetylation in the DDR. |
| TextSentencer_T8 | 878-995 | Sentence | denotes | Markedly higher levels of lncRNA-JADE were observed in human breast tumours in comparison with normal breast tissues. |
| TextSentencer_T9 | 996-1074 | Sentence | denotes | Knockdown of lncRNA-JADE significantly inhibited breast tumour growth in vivo. |
| TextSentencer_T10 | 1075-1285 | Sentence | denotes | On the basis of these results, we propose that lncRNA-JADE is a key functional link that connects the DDR to histone H4 acetylation, and that dysregulation of lncRNA-JADE may contribute to breast tumorigenesis. |
| T1 | 0-92 | Sentence | denotes | A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation. |
| T2 | 93-212 | Sentence | denotes | A prompt and efficient DNA damage response (DDR) eliminates the detrimental effects of DNA lesions in eukaryotic cells. |
| T3 | 213-328 | Sentence | denotes | Basic and preclinical studies suggest that the DDR is one of the primary anti-cancer barriers during tumorigenesis. |
| T4 | 329-512 | Sentence | denotes | The DDR involves a complex network of processes that detect and repair DNA damage, in which long non-coding RNAs (lncRNAs), a new class of regulatory RNAs, may play an important role. |
| T5 | 513-670 | Sentence | denotes | In the current study, we identified a novel lncRNA, lncRNA-JADE, that is induced after DNA damage in an ataxia-telangiectasia mutated (ATM)-dependent manner. |
| T6 | 671-808 | Sentence | denotes | LncRNA-JADE transcriptionally activates Jade1, a key component in the HBO1 (human acetylase binding to ORC1) histone acetylation complex. |
| T7 | 809-877 | Sentence | denotes | Consequently, lncRNA-JADE induces histone H4 acetylation in the DDR. |
| T8 | 878-995 | Sentence | denotes | Markedly higher levels of lncRNA-JADE were observed in human breast tumours in comparison with normal breast tissues. |
| T9 | 996-1074 | Sentence | denotes | Knockdown of lncRNA-JADE significantly inhibited breast tumour growth in vivo. |
| T10 | 1075-1285 | Sentence | denotes | On the basis of these results, we propose that lncRNA-JADE is a key functional link that connects the DDR to histone H4 acetylation, and that dysregulation of lncRNA-JADE may contribute to breast tumorigenesis. |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 904-915 | gene:101669763 | denotes | lncRNA-JADE |
| T1 | 939-953 | disease:C1458155 | denotes | breast tumours |
| T2 | 1184-1194 | gene:8367 | denotes | histone H4 |
| T3 | 1271-1284 | disease:C0596263 | denotes | tumorigenesis |
| T4 | 1184-1194 | gene:8361 | denotes | histone H4 |
| T5 | 1271-1284 | disease:C0596263 | denotes | tumorigenesis |
| T6 | 1184-1194 | gene:8360 | denotes | histone H4 |
| T7 | 1271-1284 | disease:C0596263 | denotes | tumorigenesis |
| T8 | 1184-1194 | gene:8363 | denotes | histone H4 |
| T9 | 1271-1284 | disease:C0596263 | denotes | tumorigenesis |
| T10 | 1184-1194 | gene:8362 | denotes | histone H4 |
| T11 | 1271-1284 | disease:C0596263 | denotes | tumorigenesis |
| T12 | 1184-1194 | gene:8365 | denotes | histone H4 |
| T13 | 1271-1284 | disease:C0596263 | denotes | tumorigenesis |
| T14 | 1184-1194 | gene:8364 | denotes | histone H4 |
| T15 | 1271-1284 | disease:C0596263 | denotes | tumorigenesis |
| T16 | 1122-1133 | gene:101669763 | denotes | lncRNA-JADE |
| T17 | 1271-1284 | disease:C0596263 | denotes | tumorigenesis |
| T18 | 1184-1194 | gene:8366 | denotes | histone H4 |
| T19 | 1271-1284 | disease:C0596263 | denotes | tumorigenesis |
| T20 | 1184-1194 | gene:8368 | denotes | histone H4 |
| T21 | 1271-1284 | disease:C0596263 | denotes | tumorigenesis |
| T22 | 1184-1194 | gene:8359 | denotes | histone H4 |
| T23 | 1271-1284 | disease:C0596263 | denotes | tumorigenesis |
| T24 | 1184-1194 | gene:8370 | denotes | histone H4 |
| T25 | 1271-1284 | disease:C0596263 | denotes | tumorigenesis |
| T26 | 1184-1194 | gene:8294 | denotes | histone H4 |
| T27 | 1271-1284 | disease:C0596263 | denotes | tumorigenesis |
| T28 | 1184-1194 | gene:554313 | denotes | histone H4 |
| T29 | 1271-1284 | disease:C0596263 | denotes | tumorigenesis |
| T30 | 1184-1194 | gene:121504 | denotes | histone H4 |
| T31 | 1271-1284 | disease:C0596263 | denotes | tumorigenesis |
| T32 | 1234-1245 | gene:101669763 | denotes | lncRNA-JADE |
| T33 | 1271-1284 | disease:C0596263 | denotes | tumorigenesis |
| R1 | T0 | T1 | associated_with | lncRNA-JADE,breast tumours |
| R2 | T2 | T3 | associated_with | histone H4,tumorigenesis |
| R3 | T4 | T5 | associated_with | histone H4,tumorigenesis |
| R4 | T6 | T7 | associated_with | histone H4,tumorigenesis |
| R5 | T8 | T9 | associated_with | histone H4,tumorigenesis |
| R6 | T10 | T11 | associated_with | histone H4,tumorigenesis |
| R7 | T12 | T13 | associated_with | histone H4,tumorigenesis |
| R8 | T14 | T15 | associated_with | histone H4,tumorigenesis |
| R9 | T16 | T17 | associated_with | lncRNA-JADE,tumorigenesis |
| R10 | T18 | T19 | associated_with | histone H4,tumorigenesis |
| R11 | T20 | T21 | associated_with | histone H4,tumorigenesis |
| R12 | T22 | T23 | associated_with | histone H4,tumorigenesis |
| R13 | T24 | T25 | associated_with | histone H4,tumorigenesis |
| R14 | T26 | T27 | associated_with | histone H4,tumorigenesis |
| R15 | T28 | T29 | associated_with | histone H4,tumorigenesis |
| R16 | T30 | T31 | associated_with | histone H4,tumorigenesis |
| R17 | T32 | T33 | associated_with | lncRNA-JADE,tumorigenesis |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 291-297 | HP_0002664 | denotes | cancer |
| T2 | 617-623 | HP_0001251 | denotes | ataxia |
| T3 | 624-638 | HP_0001009 | denotes | telangiectasia |
| T4 | 939-953 | HP_0003002 | denotes | breast tumours |
| T5 | 939-953 | HP_0100013 | denotes | breast tumours |
| T6 | 946-953 | HP_0002664 | denotes | tumours |
| T7 | 1045-1058 | HP_0003002 | denotes | breast tumour |
| T8 | 1045-1058 | HP_0100013 | denotes | breast tumour |
| T9 | 1052-1058 | HP_0002664 | denotes | tumour |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_24097061_1_0 | 116-135 | expanded | denotes | DNA damage response |
| SS2_24097061_1_0 | 137-140 | abbr | denotes | DDR |
| SS1_24097061_3_0 | 421-441 | expanded | denotes | long non-coding RNAs |
| SS2_24097061_3_0 | 443-450 | abbr | denotes | lncRNAs |
| SS1_24097061_4_0 | 617-646 | expanded | denotes | ataxia-telangiectasia mutated |
| SS2_24097061_4_0 | 648-651 | abbr | denotes | ATM |
| AE1_24097061_1_0 | SS1_24097061_1_0 | SS2_24097061_1_0 | abbreviatedTo | DNA damage response,DDR |
| AE1_24097061_3_0 | SS1_24097061_3_0 | SS2_24097061_3_0 | abbreviatedTo | long non-coding RNAs,lncRNAs |
| AE1_24097061_4_0 | SS1_24097061_4_0 | SS2_24097061_4_0 | abbreviatedTo | ataxia-telangiectasia mutated,ATM |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 24097061-7#26#37#gene101669763 | 904-915 | gene101669763 | denotes | lncRNA-JADE |
| 24097061-7#61#75#diseaseC1458155 | 939-953 | diseaseC1458155 | denotes | breast tumours |
| 24097061-9#109#119#gene8294 | 1184-1194 | gene8294 | denotes | histone H4 |
| 24097061-9#109#119#gene8359 | 1184-1194 | gene8359 | denotes | histone H4 |
| 24097061-9#109#119#gene8360 | 1184-1194 | gene8360 | denotes | histone H4 |
| 24097061-9#109#119#gene8361 | 1184-1194 | gene8361 | denotes | histone H4 |
| 24097061-9#109#119#gene8362 | 1184-1194 | gene8362 | denotes | histone H4 |
| 24097061-9#109#119#gene8363 | 1184-1194 | gene8363 | denotes | histone H4 |
| 24097061-9#109#119#gene8364 | 1184-1194 | gene8364 | denotes | histone H4 |
| 24097061-9#109#119#gene8365 | 1184-1194 | gene8365 | denotes | histone H4 |
| 24097061-9#109#119#gene8366 | 1184-1194 | gene8366 | denotes | histone H4 |
| 24097061-9#109#119#gene8367 | 1184-1194 | gene8367 | denotes | histone H4 |
| 24097061-9#109#119#gene8368 | 1184-1194 | gene8368 | denotes | histone H4 |
| 24097061-9#109#119#gene8370 | 1184-1194 | gene8370 | denotes | histone H4 |
| 24097061-9#109#119#gene121504 | 1184-1194 | gene121504 | denotes | histone H4 |
| 24097061-9#109#119#gene554313 | 1184-1194 | gene554313 | denotes | histone H4 |
| 24097061-9#47#58#gene101669763 | 1122-1133 | gene101669763 | denotes | lncRNA-JADE |
| 24097061-9#159#170#gene101669763 | 1234-1245 | gene101669763 | denotes | lncRNA-JADE |
| 24097061-9#196#209#diseaseC0596263 | 1271-1284 | diseaseC0596263 | denotes | tumorigenesis |
| 24097061-9#196#209#diseaseC0596263 | 1271-1284 | diseaseC0596263 | denotes | tumorigenesis |
| 26#37#gene10166976361#75#diseaseC1458155 | 24097061-7#26#37#gene101669763 | 24097061-7#61#75#diseaseC1458155 | associated_with | lncRNA-JADE,breast tumours |
| 109#119#gene8294196#209#diseaseC0596263 | 24097061-9#109#119#gene8294 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8294196#209#diseaseC0596263 | 24097061-9#109#119#gene8294 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8359196#209#diseaseC0596263 | 24097061-9#109#119#gene8359 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8359196#209#diseaseC0596263 | 24097061-9#109#119#gene8359 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8360196#209#diseaseC0596263 | 24097061-9#109#119#gene8360 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8360196#209#diseaseC0596263 | 24097061-9#109#119#gene8360 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8361196#209#diseaseC0596263 | 24097061-9#109#119#gene8361 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8361196#209#diseaseC0596263 | 24097061-9#109#119#gene8361 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8362196#209#diseaseC0596263 | 24097061-9#109#119#gene8362 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8362196#209#diseaseC0596263 | 24097061-9#109#119#gene8362 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8363196#209#diseaseC0596263 | 24097061-9#109#119#gene8363 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8363196#209#diseaseC0596263 | 24097061-9#109#119#gene8363 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8364196#209#diseaseC0596263 | 24097061-9#109#119#gene8364 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8364196#209#diseaseC0596263 | 24097061-9#109#119#gene8364 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8365196#209#diseaseC0596263 | 24097061-9#109#119#gene8365 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8365196#209#diseaseC0596263 | 24097061-9#109#119#gene8365 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8366196#209#diseaseC0596263 | 24097061-9#109#119#gene8366 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8366196#209#diseaseC0596263 | 24097061-9#109#119#gene8366 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8367196#209#diseaseC0596263 | 24097061-9#109#119#gene8367 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8367196#209#diseaseC0596263 | 24097061-9#109#119#gene8367 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8368196#209#diseaseC0596263 | 24097061-9#109#119#gene8368 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8368196#209#diseaseC0596263 | 24097061-9#109#119#gene8368 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8370196#209#diseaseC0596263 | 24097061-9#109#119#gene8370 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene8370196#209#diseaseC0596263 | 24097061-9#109#119#gene8370 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene121504196#209#diseaseC0596263 | 24097061-9#109#119#gene121504 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene121504196#209#diseaseC0596263 | 24097061-9#109#119#gene121504 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene554313196#209#diseaseC0596263 | 24097061-9#109#119#gene554313 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 109#119#gene554313196#209#diseaseC0596263 | 24097061-9#109#119#gene554313 | 24097061-9#196#209#diseaseC0596263 | associated_with | histone H4,tumorigenesis |
| 47#58#gene101669763196#209#diseaseC0596263 | 24097061-9#47#58#gene101669763 | 24097061-9#196#209#diseaseC0596263 | associated_with | lncRNA-JADE,tumorigenesis |
| 47#58#gene101669763196#209#diseaseC0596263 | 24097061-9#47#58#gene101669763 | 24097061-9#196#209#diseaseC0596263 | associated_with | lncRNA-JADE,tumorigenesis |
| 159#170#gene101669763196#209#diseaseC0596263 | 24097061-9#159#170#gene101669763 | 24097061-9#196#209#diseaseC0596263 | associated_with | lncRNA-JADE,tumorigenesis |
| 159#170#gene101669763196#209#diseaseC0596263 | 24097061-9#159#170#gene101669763 | 24097061-9#196#209#diseaseC0596263 | associated_with | lncRNA-JADE,tumorigenesis |
DisGeNet-2017-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1241 | 1184-1194 | gene:8294 | denotes | histone H4 |
| T1242 | 1271-1284 | disease:C0596263 | denotes | tumorigenesis |
| R1 | T1241 | T1242 | associated_with | histone H4,tumorigenesis |
| R2 | T1241 | T1242 | associated_with | histone H4,tumorigenesis |
| R3 | T1241 | T1242 | associated_with | histone H4,tumorigenesis |
| R4 | T1241 | T1242 | associated_with | histone H4,tumorigenesis |
| R5 | T1241 | T1242 | associated_with | histone H4,tumorigenesis |
| R6 | T1241 | T1242 | associated_with | histone H4,tumorigenesis |
| R7 | T1241 | T1242 | associated_with | histone H4,tumorigenesis |
| R8 | T1241 | T1242 | associated_with | histone H4,tumorigenesis |
| R9 | T1241 | T1242 | associated_with | histone H4,tumorigenesis |
| R10 | T1241 | T1242 | associated_with | histone H4,tumorigenesis |
| R11 | T1241 | T1242 | associated_with | histone H4,tumorigenesis |
| R12 | T1241 | T1242 | associated_with | histone H4,tumorigenesis |
| R13 | T1241 | T1242 | associated_with | histone H4,tumorigenesis |
| R14 | T1241 | T1242 | associated_with | histone H4,tumorigenesis |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 939-945 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T2 | 980-986 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T3 | 1045-1051 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T4 | 1264-1270 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T5 | 987-994 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 939-945 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T2 | 980-986 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T3 | 1045-1051 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T4 | 1264-1270 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T5 | 987-994 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |