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PubMed:24089523 JSONTXT

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Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 1007-1028 Cell denotes embryonic fibroblasts http://purl.obolibrary.org/obo/CL:2000042

sentences

Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migration.
T2 133-289 Sentence denotes Histone deacetylase 6 (HDAC6) is well known for its ability to promote cell migration through deacetylation of its cytoplasmic substrates such as α-tubulin.
T3 290-370 Sentence denotes However, how HDAC6 itself is regulated to control cell motility remains elusive.
T4 371-518 Sentence denotes Previous studies have shown that one third of extracellular signal-regulated kinase (ERK) is associated with the microtubule cytoskeleton in cells.
T5 519-580 Sentence denotes Yet, no connection between HDAC6 and ERK has been discovered.
T6 581-717 Sentence denotes Here, for the first time, we reveal that ERK binds to and phosphorylates HDAC6 to promote cell migration via deacetylation of α-tubulin.
T7 718-823 Sentence denotes We have identified two novel ERK-mediated phosphorylation sites: threonine 1031 and serine 1035 in HDAC6.
T8 824-989 Sentence denotes Both sites were phosphorylated by ERK1 in vitro, whereas Ser-1035 was phosphorylated in response to the activation of EGFR-Ras-Raf-MEK-ERK signaling pathway in vivo.
T9 990-1172 Sentence denotes HDAC6-null mouse embryonic fibroblasts rescued by the nonphosphorylation mimicking mutant displayed significantly reduced cell migration compared with those rescued by the wild type.
T10 1173-1306 Sentence denotes Consistently, the nonphosphorylation mimicking mutant exerted lower tubulin deacetylase activity in vivo compared with the wild type.
T11 1307-1403 Sentence denotes These data indicate that ERK/HDAC6-mediated cell motility is through deacetylation of α-tubulin.
T12 1404-1520 Sentence denotes Overall, our results suggest that HDAC6-mediated cell migration could be governed by EGFR-Ras-Raf-MEK-ERK signaling.

Allie

Id Subject Object Predicate Lexical cue
SS1_24089523_0_0 0-37 expanded denotes Extracellular signal-regulated kinase
SS2_24089523_0_0 39-42 abbr denotes ERK
SS1_24089523_0_1 59-80 expanded denotes histone deacetylase 6
SS2_24089523_0_1 82-87 abbr denotes HDAC6
SS1_24089523_1_0 133-154 expanded denotes Histone deacetylase 6
SS2_24089523_1_0 156-161 abbr denotes HDAC6
SS1_24089523_3_0 417-454 expanded denotes extracellular signal-regulated kinase
SS2_24089523_3_0 456-459 abbr denotes ERK
AE1_24089523_0_0 SS1_24089523_0_0 SS2_24089523_0_0 abbreviatedTo Extracellular signal-regulated kinase,ERK
AE1_24089523_0_1 SS1_24089523_0_1 SS2_24089523_0_1 abbreviatedTo histone deacetylase 6,HDAC6
AE1_24089523_1_0 SS1_24089523_1_0 SS2_24089523_1_0 abbreviatedTo Histone deacetylase 6,HDAC6
AE1_24089523_3_0 SS1_24089523_3_0 SS2_24089523_3_0 abbreviatedTo extracellular signal-regulated kinase,ERK

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1001-1006 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-13 Body_part denotes Extracellular http://purl.obolibrary.org/obo/GO_0005576
T2 248-259 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T3 417-430 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T4 484-508 Body_part denotes microtubule cytoskeleton http://purl.obolibrary.org/obo/GO_0015630
T5 1007-1028 Body_part denotes embryonic fibroblasts http://purl.obolibrary.org/obo/CL_2000042