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PubMed:24088574 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-132 Sentence denotes The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia.
TextSentencer_T2 133-144 Sentence denotes BACKGROUND:
TextSentencer_T3 145-216 Sentence denotes Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer.
TextSentencer_T4 217-351 Sentence denotes While current treatment regimens achieve almost 80% overall survival, long-term side effects of chemotherapeutic agents can be severe.
TextSentencer_T5 352-502 Sentence denotes The functional BCL2-938C > A promoter polymorphism is known to influence the balance between survival and apoptosis of malignant hematolymphoid cells.
TextSentencer_T6 503-597 Sentence denotes We investigated its usefulness as a marker for treatment stratification for children with ALL.
TextSentencer_T7 598-606 Sentence denotes METHODS:
TextSentencer_T8 607-747 Sentence denotes We analyzed DNA from 182 children suffering from ALL in this study to determine genotypes of the -938 C > A polymorphism by "slow-down" PCR.
TextSentencer_T9 748-873 Sentence denotes RESULTS: ALL patients with the BCL2-938CC genotype had an approximately 3-fold higher risk of belonging to a high-risk group.
TextSentencer_T10 874-1093 Sentence denotes Within the high-risk group, 50% of BCL2-938CC patients were classified as high-risk due to poor prednisone response whereas only 33% of patients with AC and AA genotypes were classified as high-risk for the same reason.
TextSentencer_T11 1094-1106 Sentence denotes CONCLUSIONS:
TextSentencer_T12 1107-1349 Sentence denotes Our results suggest that BCL2-938C > A genotyping may be beneficial for therapy response prediction in ALL patients, and warrant examination in a larger cohort to validate its usefulness for treatment stratification of pediatric ALL patients.
T1 0-132 Sentence denotes The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia.
T2 133-144 Sentence denotes BACKGROUND:
T3 145-216 Sentence denotes Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer.
T4 217-351 Sentence denotes While current treatment regimens achieve almost 80% overall survival, long-term side effects of chemotherapeutic agents can be severe.
T5 352-502 Sentence denotes The functional BCL2-938C > A promoter polymorphism is known to influence the balance between survival and apoptosis of malignant hematolymphoid cells.
T6 503-597 Sentence denotes We investigated its usefulness as a marker for treatment stratification for children with ALL.
T7 598-606 Sentence denotes METHODS:
T8 607-747 Sentence denotes We analyzed DNA from 182 children suffering from ALL in this study to determine genotypes of the -938 C > A polymorphism by "slow-down" PCR.
T9 748-873 Sentence denotes RESULTS: ALL patients with the BCL2-938CC genotype had an approximately 3-fold higher risk of belonging to a high-risk group.
T10 874-1093 Sentence denotes Within the high-risk group, 50% of BCL2-938CC patients were classified as high-risk due to poor prednisone response whereas only 33% of patients with AC and AA genotypes were classified as high-risk for the same reason.
T11 1094-1106 Sentence denotes CONCLUSIONS:
T12 1107-1349 Sentence denotes Our results suggest that BCL2-938C > A genotyping may be beneficial for therapy response prediction in ALL patients, and warrant examination in a larger cohort to validate its usefulness for treatment stratification of pediatric ALL patients.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 4-8 gene:596 denotes BCL2
T1 103-131 disease:C0023449 denotes acute lymphoblastic leukemia
T2 4-8 gene:596 denotes BCL2
T3 103-131 disease:C1961102 denotes acute lymphoblastic leukemia
R1 T0 T1 associated_with BCL2,acute lymphoblastic leukemia
R2 T2 T3 associated_with BCL2,acute lymphoblastic leukemia

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 145-173 HP_0006721 denotes Acute lymphoblastic leukemia
T2 165-173 HP_0001909 denotes leukemia
T3 209-215 HP_0002664 denotes cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_24088574_2_0 145-173 expanded denotes Acute lymphoblastic leukemia
SS2_24088574_2_0 175-178 abbr denotes ALL
AE1_24088574_2_0 SS1_24088574_2_0 SS2_24088574_2_0 abbreviatedTo Acute lymphoblastic leukemia,ALL

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
24088574-0#4#8#gene596 4-8 gene596 denotes BCL2
24088574-0#103#131#diseaseC0023449 103-131 diseaseC0023449 denotes acute lymphoblastic leukemia
24088574-0#103#131#diseaseC1961102 103-131 diseaseC1961102 denotes acute lymphoblastic leukemia
4#8#gene596103#131#diseaseC0023449 24088574-0#4#8#gene596 24088574-0#103#131#diseaseC0023449 associated_with BCL2,acute lymphoblastic leukemia
4#8#gene596103#131#diseaseC1961102 24088574-0#4#8#gene596 24088574-0#103#131#diseaseC1961102 associated_with BCL2,acute lymphoblastic leukemia

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T782 4-8 gene:596 denotes BCL2
T783 103-131 disease:C0023449 denotes acute lymphoblastic leukemia
R1 T782 T783 associated_with BCL2,acute lymphoblastic leukemia
R2 T782 T783 associated_with BCL2,acute lymphoblastic leukemia