PubMed:24085799
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-83 | Sentence | denotes | miR-720 inhibits tumor invasion and migration in breast cancer by targeting TWIST1. |
| TextSentencer_T2 | 84-239 | Sentence | denotes | Breast cancer is the leading cause of cancer death among females, with tumor metastasis being primarily responsible for breast cancer-associated mortality. |
| TextSentencer_T3 | 240-330 | Sentence | denotes | Current literatures have shown that microRNAs (miRNAs) are implicated in tumor metastasis. |
| TextSentencer_T4 | 331-493 | Sentence | denotes | In this study, we found that the expression of miR-720 was significantly downregulated in primary breast cancer, with greater downregulation in metastatic tumors. |
| TextSentencer_T5 | 494-651 | Sentence | denotes | Statistical analysis of 105 cases of primary human breast cancer demonstrated that decreased expression of miR-720 was correlated with lymph node metastasis. |
| TextSentencer_T6 | 652-791 | Sentence | denotes | Furthermore, reexpression of miR-720 in breast cancer cells remarkably inhibited cell invasiveness and migration both in vitro and in vivo. |
| TextSentencer_T7 | 792-969 | Sentence | denotes | Mechanistically, downregulation of TWIST1, a promoter of metastasis that was identified as a direct functional target of miR-720, was attributed to the inhibition of metastasis. |
| TextSentencer_T8 | 970-1217 | Sentence | denotes | Consistent with the reduced TWIST1 levels in breast cancer, reexpression of miR-720 upregulated epithelial markers (E-cadherin and β-catenin) and downregulated mesenchymal markers (N-cadherin, fibronectin, vimentin and matrix metalloproteinase-2). |
| TextSentencer_T9 | 1218-1308 | Sentence | denotes | Expression of miR-720 was inversely associated with TWIST1 in human breast cancer tissues. |
| TextSentencer_T10 | 1309-1540 | Sentence | denotes | Knockdown of TWIST1 expression by small interfering RNA exhibited similar effects to reintroduction of miR-720, whereas overexpression of TWIST1 (without the 3'-untranslated region) abrogated miR-720-mediated metastasis inhibition. |
| TextSentencer_T11 | 1541-1769 | Sentence | denotes | Collectively, our data indicate that miR-720 is frequently decreased in breast cancer and manifests antimetastatic activity by downregulating TWIST1, presenting a novel mechanism of miRNA-mediated regulation of tumor metastasis. |
| T1 | 0-83 | Sentence | denotes | miR-720 inhibits tumor invasion and migration in breast cancer by targeting TWIST1. |
| T2 | 84-239 | Sentence | denotes | Breast cancer is the leading cause of cancer death among females, with tumor metastasis being primarily responsible for breast cancer-associated mortality. |
| T3 | 240-330 | Sentence | denotes | Current literatures have shown that microRNAs (miRNAs) are implicated in tumor metastasis. |
| T4 | 331-493 | Sentence | denotes | In this study, we found that the expression of miR-720 was significantly downregulated in primary breast cancer, with greater downregulation in metastatic tumors. |
| T5 | 494-651 | Sentence | denotes | Statistical analysis of 105 cases of primary human breast cancer demonstrated that decreased expression of miR-720 was correlated with lymph node metastasis. |
| T6 | 652-791 | Sentence | denotes | Furthermore, reexpression of miR-720 in breast cancer cells remarkably inhibited cell invasiveness and migration both in vitro and in vivo. |
| T7 | 792-969 | Sentence | denotes | Mechanistically, downregulation of TWIST1, a promoter of metastasis that was identified as a direct functional target of miR-720, was attributed to the inhibition of metastasis. |
| T8 | 970-1217 | Sentence | denotes | Consistent with the reduced TWIST1 levels in breast cancer, reexpression of miR-720 upregulated epithelial markers (E-cadherin and β-catenin) and downregulated mesenchymal markers (N-cadherin, fibronectin, vimentin and matrix metalloproteinase-2). |
| T9 | 1218-1308 | Sentence | denotes | Expression of miR-720 was inversely associated with TWIST1 in human breast cancer tissues. |
| T10 | 1309-1540 | Sentence | denotes | Knockdown of TWIST1 expression by small interfering RNA exhibited similar effects to reintroduction of miR-720, whereas overexpression of TWIST1 (without the 3'-untranslated region) abrogated miR-720-mediated metastasis inhibition. |
| T11 | 1541-1769 | Sentence | denotes | Collectively, our data indicate that miR-720 is frequently decreased in breast cancer and manifests antimetastatic activity by downregulating TWIST1, presenting a novel mechanism of miRNA-mediated regulation of tumor metastasis. |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 827-833 | gene:7291 | denotes | TWIST1 |
| T1 | 849-859 | disease:C2939420 | denotes | metastasis |
| T2 | 827-833 | gene:7291 | denotes | TWIST1 |
| T3 | 958-968 | disease:C2939420 | denotes | metastasis |
| T4 | 827-833 | gene:7291 | denotes | TWIST1 |
| T5 | 849-859 | disease:C0027627 | denotes | metastasis |
| T6 | 827-833 | gene:7291 | denotes | TWIST1 |
| T7 | 958-968 | disease:C0027627 | denotes | metastasis |
| T8 | 998-1004 | gene:7291 | denotes | TWIST1 |
| T9 | 1015-1028 | disease:C0006142 | denotes | breast cancer |
| T10 | 998-1004 | gene:7291 | denotes | TWIST1 |
| T11 | 1015-1028 | disease:C0678222 | denotes | breast cancer |
| T12 | 1270-1276 | gene:7291 | denotes | TWIST1 |
| T13 | 1286-1299 | disease:C0006142 | denotes | breast cancer |
| T14 | 1270-1276 | gene:7291 | denotes | TWIST1 |
| T15 | 1286-1299 | disease:C0678222 | denotes | breast cancer |
| T16 | 1447-1453 | gene:7291 | denotes | TWIST1 |
| T17 | 1518-1528 | disease:C0027627 | denotes | metastasis |
| T18 | 1447-1453 | gene:7291 | denotes | TWIST1 |
| T19 | 1518-1528 | disease:C2939420 | denotes | metastasis |
| T20 | 1322-1328 | gene:7291 | denotes | TWIST1 |
| T21 | 1518-1528 | disease:C2939420 | denotes | metastasis |
| T22 | 1322-1328 | gene:7291 | denotes | TWIST1 |
| T23 | 1518-1528 | disease:C0027627 | denotes | metastasis |
| R1 | T0 | T1 | associated_with | TWIST1,metastasis |
| R2 | T2 | T3 | associated_with | TWIST1,metastasis |
| R3 | T4 | T5 | associated_with | TWIST1,metastasis |
| R4 | T6 | T7 | associated_with | TWIST1,metastasis |
| R5 | T8 | T9 | associated_with | TWIST1,breast cancer |
| R6 | T10 | T11 | associated_with | TWIST1,breast cancer |
| R7 | T12 | T13 | associated_with | TWIST1,breast cancer |
| R8 | T14 | T15 | associated_with | TWIST1,breast cancer |
| R9 | T16 | T17 | associated_with | TWIST1,metastasis |
| R10 | T18 | T19 | associated_with | TWIST1,metastasis |
| R11 | T20 | T21 | associated_with | TWIST1,metastasis |
| R12 | T22 | T23 | associated_with | TWIST1,metastasis |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 84-97 | HP_0003002 | denotes | Breast cancer |
| T2 | 84-97 | HP_0100013 | denotes | Breast cancer |
| T3 | 91-97 | HP_0002664 | denotes | cancer |
| T4 | 122-128 | HP_0002664 | denotes | cancer |
| T5 | 155-160 | HP_0002664 | denotes | tumor |
| T6 | 204-217 | HP_0003002 | denotes | breast cancer |
| T7 | 204-217 | HP_0100013 | denotes | breast cancer |
| T8 | 211-217 | HP_0002664 | denotes | cancer |
| T9 | 313-318 | HP_0002664 | denotes | tumor |
| T10 | 429-442 | HP_0003002 | denotes | breast cancer |
| T11 | 429-442 | HP_0100013 | denotes | breast cancer |
| T12 | 436-442 | HP_0002664 | denotes | cancer |
| T13 | 486-492 | HP_0002664 | denotes | tumors |
| T14 | 545-558 | HP_0003002 | denotes | breast cancer |
| T15 | 545-558 | HP_0100013 | denotes | breast cancer |
| T16 | 552-558 | HP_0002664 | denotes | cancer |
| T17 | 692-705 | HP_0003002 | denotes | breast cancer |
| T18 | 692-705 | HP_0100013 | denotes | breast cancer |
| T19 | 699-705 | HP_0002664 | denotes | cancer |
| T20 | 1015-1028 | HP_0003002 | denotes | breast cancer |
| T21 | 1015-1028 | HP_0100013 | denotes | breast cancer |
| T22 | 1022-1028 | HP_0002664 | denotes | cancer |
| T23 | 1286-1299 | HP_0003002 | denotes | breast cancer |
| T24 | 1286-1299 | HP_0100013 | denotes | breast cancer |
| T25 | 1293-1299 | HP_0002664 | denotes | cancer |
| T26 | 1613-1626 | HP_0003002 | denotes | breast cancer |
| T27 | 1613-1626 | HP_0100013 | denotes | breast cancer |
| T28 | 1620-1626 | HP_0002664 | denotes | cancer |
| T29 | 1752-1757 | HP_0002664 | denotes | tumor |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_24085799_2_0 | 276-285 | expanded | denotes | microRNAs |
| SS2_24085799_2_0 | 287-293 | abbr | denotes | miRNAs |
| AE1_24085799_2_0 | SS1_24085799_2_0 | SS2_24085799_2_0 | abbreviatedTo | microRNAs,miRNAs |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 24085799-10#142#148#gene7291 | 1683-1689 | gene7291 | denotes | TWIST1 |
| 24085799-10#72#85#diseaseC0006142 | 1613-1626 | diseaseC0006142 | denotes | breast cancer |
| 24085799-10#72#85#diseaseC0678222 | 1613-1626 | diseaseC0678222 | denotes | breast cancer |
| 24085799-7#193#204#gene2335 | 1163-1174 | gene2335 | denotes | fibronectin |
| 24085799-7#206#214#gene7431 | 1176-1184 | gene7431 | denotes | vimentin |
| 24085799-7#219#245#gene4313 | 1189-1215 | gene4313 | denotes | matrix metalloproteinase-2 |
| 24085799-7#45#58#diseaseC0006142 | 1015-1028 | diseaseC0006142 | denotes | breast cancer |
| 24085799-7#45#58#diseaseC0678222 | 1015-1028 | diseaseC0678222 | denotes | breast cancer |
| 24085799-7#45#58#diseaseC0006142 | 1015-1028 | diseaseC0006142 | denotes | breast cancer |
| 24085799-7#45#58#diseaseC0678222 | 1015-1028 | diseaseC0678222 | denotes | breast cancer |
| 24085799-7#45#58#diseaseC0006142 | 1015-1028 | diseaseC0006142 | denotes | breast cancer |
| 24085799-7#45#58#diseaseC0678222 | 1015-1028 | diseaseC0678222 | denotes | breast cancer |
| 24085799-9#13#19#gene7291 | 1322-1328 | gene7291 | denotes | TWIST1 |
| 24085799-9#138#144#gene7291 | 1447-1453 | gene7291 | denotes | TWIST1 |
| 24085799-9#209#219#diseaseC0027627 | 1518-1528 | diseaseC0027627 | denotes | metastasis |
| 142#148#gene729172#85#diseaseC0006142 | 24085799-10#142#148#gene7291 | 24085799-10#72#85#diseaseC0006142 | associated_with | TWIST1,breast cancer |
| 142#148#gene729172#85#diseaseC0678222 | 24085799-10#142#148#gene7291 | 24085799-10#72#85#diseaseC0678222 | associated_with | TWIST1,breast cancer |
| 193#204#gene233545#58#diseaseC0006142 | 24085799-7#193#204#gene2335 | 24085799-7#45#58#diseaseC0006142 | associated_with | fibronectin,breast cancer |
| 193#204#gene233545#58#diseaseC0678222 | 24085799-7#193#204#gene2335 | 24085799-7#45#58#diseaseC0678222 | associated_with | fibronectin,breast cancer |
| 193#204#gene233545#58#diseaseC0006142 | 24085799-7#193#204#gene2335 | 24085799-7#45#58#diseaseC0006142 | associated_with | fibronectin,breast cancer |
| 193#204#gene233545#58#diseaseC0678222 | 24085799-7#193#204#gene2335 | 24085799-7#45#58#diseaseC0678222 | associated_with | fibronectin,breast cancer |
| 193#204#gene233545#58#diseaseC0006142 | 24085799-7#193#204#gene2335 | 24085799-7#45#58#diseaseC0006142 | associated_with | fibronectin,breast cancer |
| 193#204#gene233545#58#diseaseC0678222 | 24085799-7#193#204#gene2335 | 24085799-7#45#58#diseaseC0678222 | associated_with | fibronectin,breast cancer |
| 206#214#gene743145#58#diseaseC0006142 | 24085799-7#206#214#gene7431 | 24085799-7#45#58#diseaseC0006142 | associated_with | vimentin,breast cancer |
| 206#214#gene743145#58#diseaseC0678222 | 24085799-7#206#214#gene7431 | 24085799-7#45#58#diseaseC0678222 | associated_with | vimentin,breast cancer |
| 206#214#gene743145#58#diseaseC0006142 | 24085799-7#206#214#gene7431 | 24085799-7#45#58#diseaseC0006142 | associated_with | vimentin,breast cancer |
| 206#214#gene743145#58#diseaseC0678222 | 24085799-7#206#214#gene7431 | 24085799-7#45#58#diseaseC0678222 | associated_with | vimentin,breast cancer |
| 206#214#gene743145#58#diseaseC0006142 | 24085799-7#206#214#gene7431 | 24085799-7#45#58#diseaseC0006142 | associated_with | vimentin,breast cancer |
| 206#214#gene743145#58#diseaseC0678222 | 24085799-7#206#214#gene7431 | 24085799-7#45#58#diseaseC0678222 | associated_with | vimentin,breast cancer |
| 219#245#gene431345#58#diseaseC0006142 | 24085799-7#219#245#gene4313 | 24085799-7#45#58#diseaseC0006142 | associated_with | matrix metalloproteinase-2,breast cancer |
| 219#245#gene431345#58#diseaseC0678222 | 24085799-7#219#245#gene4313 | 24085799-7#45#58#diseaseC0678222 | associated_with | matrix metalloproteinase-2,breast cancer |
| 219#245#gene431345#58#diseaseC0006142 | 24085799-7#219#245#gene4313 | 24085799-7#45#58#diseaseC0006142 | associated_with | matrix metalloproteinase-2,breast cancer |
| 219#245#gene431345#58#diseaseC0678222 | 24085799-7#219#245#gene4313 | 24085799-7#45#58#diseaseC0678222 | associated_with | matrix metalloproteinase-2,breast cancer |
| 219#245#gene431345#58#diseaseC0006142 | 24085799-7#219#245#gene4313 | 24085799-7#45#58#diseaseC0006142 | associated_with | matrix metalloproteinase-2,breast cancer |
| 219#245#gene431345#58#diseaseC0678222 | 24085799-7#219#245#gene4313 | 24085799-7#45#58#diseaseC0678222 | associated_with | matrix metalloproteinase-2,breast cancer |
| 13#19#gene7291209#219#diseaseC0027627 | 24085799-9#13#19#gene7291 | 24085799-9#209#219#diseaseC0027627 | associated_with | TWIST1,metastasis |
| 138#144#gene7291209#219#diseaseC0027627 | 24085799-9#138#144#gene7291 | 24085799-9#209#219#diseaseC0027627 | associated_with | TWIST1,metastasis |
DisGeNet-2017-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T749 | 1683-1689 | gene:7291 | denotes | TWIST1 |
| T750 | 1613-1626 | disease:C0006142 | denotes | breast cancer |
| R1 | T749 | T750 | associated_with | TWIST1,breast cancer |
| R2 | T749 | T750 | associated_with | TWIST1,breast cancer |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 49-55 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T2 | 204-210 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T3 | 429-435 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T4 | 545-551 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T5 | 692-698 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T6 | 1015-1021 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T7 | 1286-1292 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T8 | 1613-1619 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T9 | 629-634 | http://purl.obolibrary.org/obo/UBERON_0002391 | denotes | lymph |
| PD-UBERON-AE-B_T10 | 629-639 | http://purl.obolibrary.org/obo/UBERON_0000029 | denotes | lymph node |
| PD-UBERON-AE-B_T11 | 1130-1141 | http://purl.obolibrary.org/obo/UBERON_0003104 | denotes | mesenchymal |
| PD-UBERON-AE-B_T12 | 1300-1307 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 1130-1141 | http://purl.obolibrary.org/obo/UBERON_0003104 | denotes | mesenchymal |
| PD-UBERON-AE-B_T2 | 1300-1307 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T3 | 49-55 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T4 | 84-90 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | Breast |
| PD-UBERON-AE-B_T5 | 204-210 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T6 | 429-435 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T7 | 545-551 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T8 | 692-698 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T9 | 1015-1021 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T10 | 1286-1292 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T11 | 1613-1619 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T12 | 629-634 | http://purl.obolibrary.org/obo/UBERON_0002391 | denotes | lymph |
| PD-UBERON-AE-B_T13 | 629-639 | http://purl.obolibrary.org/obo/UBERON_0000029 | denotes | lymph node |