PubMed:24035784 / 105-906
Annnotations
PubMed_Structured_Abstracts
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-801 | BACKGROUND | denotes | O-linked β-N-acetylglucosamine (O-GlcNAc) is a nutrient-/stress-sensitive post-translational modification that affects nucleocytoplasmic proteins. The enzyme O-N-acetylglucosamine transferase (OGT) catalyzes the addition of O-GlcNAc, whereas O-N-acetylglucosaminidase (OGA) removes it. O-GlcNAcylation plays a role in fundamental regulatory mechanisms through the modification of proteins involved in cell division, metabolism, transcription, cell signaling and apoptosis. The effects of O-GlcNAcylation on apoptosis appear to be cell-dependent, as elevated levels played a protective role in primary neonatal rat ventricular myocytes but had a cytotoxic effect in rat pancreatic β-cells. The aim of the current study was to determine the implications of the O-GlcNAc modification on T cell apoptosis. |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_24035784_2_0 | 0-30 | expanded | denotes | O-linked β-N-acetylglucosamine |
| SS2_24035784_2_0 | 32-40 | abbr | denotes | O-GlcNAc |
| SS1_24035784_3_0 | 158-191 | expanded | denotes | O-N-acetylglucosamine transferase |
| SS2_24035784_3_0 | 193-196 | abbr | denotes | OGT |
| SS1_24035784_3_1 | 224-267 | expanded | denotes | O-GlcNAc, whereas O-N-acetylglucosaminidase |
| SS2_24035784_3_1 | 269-272 | abbr | denotes | OGA |
| AE1_24035784_2_0 | SS1_24035784_2_0 | SS2_24035784_2_0 | abbreviatedTo | O-linked β-N-acetylglucosamine,O-GlcNAc |
| AE1_24035784_3_0 | SS1_24035784_3_0 | SS2_24035784_3_0 | abbreviatedTo | O-N-acetylglucosamine transferase,OGT |
| AE1_24035784_3_1 | SS1_24035784_3_1 | SS2_24035784_3_1 | abbreviatedTo | "O-GlcNAc, whereas O-N-acetylglucosaminidase",OGA |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T2 | 11-30 | chem:24139 | denotes | N-acetylglucosamine |
| PD-NGLY1-deficiency-B_T3 | 34-40 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T4 | 160-179 | chem:24139 | denotes | N-acetylglucosamine |
| PD-NGLY1-deficiency-B_T5 | 226-232 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T6 | 761-767 | chem:24139 | denotes | GlcNAc |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T2 | 32-40 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T3 | 224-232 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T4 | 759-767 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 610-613 | OrganismTaxon | denotes | rat | 10114|10116 |
| T3 | 665-668 | OrganismTaxon | denotes | rat | 10114|10116 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T2 | 527-534 | Cell | denotes | be cell | http://purl.obolibrary.org/obo/CL:0000968 |
| T3 | 614-634 | Cell | denotes | ventricular myocytes | http://purl.obolibrary.org/obo/CL:0002131 |
| T4 | 784-790 | Cell | denotes | T cell | http://purl.obolibrary.org/obo/CL:0000084 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 119-136 | Body_part | denotes | nucleocytoplasmic | http://purl.obolibrary.org/obo/GO_0005622 |
| T2 | 401-414 | Body_part | denotes | cell division | http://purl.obolibrary.org/obo/UBERON_2000098 |
| T3 | 784-790 | Body_part | denotes | T cell | http://purl.obolibrary.org/obo/CL_0000084 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 147-285 | Sentence | denotes | The enzyme O-N-acetylglucosamine transferase (OGT) catalyzes the addition of O-GlcNAc, whereas O-N-acetylglucosaminidase (OGA) removes it. |
| T4 | 286-472 | Sentence | denotes | O-GlcNAcylation plays a role in fundamental regulatory mechanisms through the modification of proteins involved in cell division, metabolism, transcription, cell signaling and apoptosis. |
| T5 | 473-688 | Sentence | denotes | The effects of O-GlcNAcylation on apoptosis appear to be cell-dependent, as elevated levels played a protective role in primary neonatal rat ventricular myocytes but had a cytotoxic effect in rat pancreatic β-cells. |
| T6 | 689-801 | Sentence | denotes | The aim of the current study was to determine the implications of the O-GlcNAc modification on T cell apoptosis. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T2 | 32-40 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T3 | 224-232 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T4 | 759-767 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T2 | 32-40 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 224-232 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T4 | 759-767 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 610-613 | OrganismTaxon | denotes | rat | 10114|10116 |
| T3 | 665-668 | OrganismTaxon | denotes | rat | 10114|10116 |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T2 | 32-40 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 224-232 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T4 | 759-767 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 119-136 | Body_part | denotes | nucleocytoplasmic | http://purl.obolibrary.org/obo/GO_0005622 |
| T2 | 401-414 | Body_part | denotes | cell division | http://purl.obolibrary.org/obo/UBERON_2000098 |
| T3 | 784-790 | Body_part | denotes | T cell | http://purl.obolibrary.org/obo/CL_0000084 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T2 | 527-534 | Cell | denotes | be cell | http://purl.obolibrary.org/obo/CL:0000968 |
| T3 | 614-634 | Cell | denotes | ventricular myocytes | http://purl.obolibrary.org/obo/CL:0002131 |
| T4 | 784-790 | Cell | denotes | T cell | http://purl.obolibrary.org/obo/CL:0000084 |