PubMed:24023501
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-59 | Sentence | denotes | Hypermethylation of TGF-β1 gene promoter in gastric cancer. |
| TextSentencer_T2 | 60-64 | Sentence | denotes | AIM: |
| TextSentencer_T3 | 65-275 | Sentence | denotes | To examine transforming growth factor-β1 (TGF-β1) promoter methylation in gastric cancer and to determine if Helicobacter pylori (H. pylori) or interleukin (IL)-1β could induce TGF-β1 hypermethylation in vitro. |
| TextSentencer_T4 | 276-284 | Sentence | denotes | METHODS: |
| TextSentencer_T5 | 285-474 | Sentence | denotes | We examined the frequency and extent of TGF-β1 promoter methylation using methylation-specific PCR in the gastric tissues from 47 gastric cancer patients and 39 non-gastric cancer subjects. |
| TextSentencer_T6 | 475-608 | Sentence | denotes | H. pylori infection was confirmed by a positive result from either a serological test, histological analysis or C¹³ urea breath test. |
| TextSentencer_T7 | 609-761 | Sentence | denotes | GES-1 and MKN-45 cells co-cultured with H. pylori or treated with IL-1β for 12, 24 and 48 h in vitro tested the effects of H. pylori or IL-1β on TGF-β1. |
| TextSentencer_T8 | 762-770 | Sentence | denotes | RESULTS: |
| TextSentencer_T9 | 771-1101 | Sentence | denotes | Twenty-four/forty-seven (51%) cases of gastric cancer (GC) tissues showed TGF-β1 promoter methylation, 15/47 (31.9%) cases of matched non-cancerous gastric mucosa tissues from the GC patients, and 11/39 (28%) case of the normal gastric mucosa tissues from non-GC subjects showed TGF-β1 promoter methylation (51% vs 28%, P < 0.05). |
| TextSentencer_T10 | 1102-1356 | Sentence | denotes | Significantly higher levels of methylation of TGF-β1 were found in the tumor tissues than in non-tumor tissues from GC patients (0.24 ± 0.06 vs 0.17 ± 0.04, P < 0.05) and normal gastric tissues from non-GC subjects (0.24 ± 0.06 vs 0.15 ± 0.03, P < 0.05). |
| TextSentencer_T11 | 1357-1559 | Sentence | denotes | TGF-β1 methylation was found in 48.3% of H. pylori-positive gastric mucosal tissues whereas only 23.1% of H. pylori-negative gastric mucosal tissues showed TGF-β1 methylation (48.3% vs 23.1%, P < 0.05). |
| TextSentencer_T12 | 1560-1723 | Sentence | denotes | IL-1β appeared to induce a dose-dependent methylation of TGF-β1 and the strongest methylation was observed in GES-1 cells treated with 2.5 ng/mL of IL-1β for 48 h. |
| TextSentencer_T13 | 1724-1876 | Sentence | denotes | Further studies showed that pre-treatment of GES-1 cells with 20 ng/mL IL-1RA for 1 h could partially abolish the effect of IL-1β on TGF-β1 methylation. |
| TextSentencer_T14 | 1877-1979 | Sentence | denotes | Infection of GES-1 cells by H. pylori was not found to induce significant TGF-β1 promoter methylation. |
| TextSentencer_T15 | 1980-1991 | Sentence | denotes | CONCLUSION: |
| TextSentencer_T16 | 1992-2060 | Sentence | denotes | Our data revealed that TGF-β1 promoter is methylated in GC patients. |
| TextSentencer_T17 | 2061-2157 | Sentence | denotes | IL-1β may be an important mediator for H. pylori induced gene methylation during GC development. |
| T1 | 0-59 | Sentence | denotes | Hypermethylation of TGF-β1 gene promoter in gastric cancer. |
| T2 | 60-64 | Sentence | denotes | AIM: |
| T3 | 65-275 | Sentence | denotes | To examine transforming growth factor-β1 (TGF-β1) promoter methylation in gastric cancer and to determine if Helicobacter pylori (H. pylori) or interleukin (IL)-1β could induce TGF-β1 hypermethylation in vitro. |
| T4 | 276-284 | Sentence | denotes | METHODS: |
| T5 | 285-474 | Sentence | denotes | We examined the frequency and extent of TGF-β1 promoter methylation using methylation-specific PCR in the gastric tissues from 47 gastric cancer patients and 39 non-gastric cancer subjects. |
| T6 | 475-608 | Sentence | denotes | H. pylori infection was confirmed by a positive result from either a serological test, histological analysis or C¹³ urea breath test. |
| T7 | 609-761 | Sentence | denotes | GES-1 and MKN-45 cells co-cultured with H. pylori or treated with IL-1β for 12, 24 and 48 h in vitro tested the effects of H. pylori or IL-1β on TGF-β1. |
| T8 | 762-770 | Sentence | denotes | RESULTS: |
| T9 | 771-1101 | Sentence | denotes | Twenty-four/forty-seven (51%) cases of gastric cancer (GC) tissues showed TGF-β1 promoter methylation, 15/47 (31.9%) cases of matched non-cancerous gastric mucosa tissues from the GC patients, and 11/39 (28%) case of the normal gastric mucosa tissues from non-GC subjects showed TGF-β1 promoter methylation (51% vs 28%, P < 0.05). |
| T10 | 1102-1356 | Sentence | denotes | Significantly higher levels of methylation of TGF-β1 were found in the tumor tissues than in non-tumor tissues from GC patients (0.24 ± 0.06 vs 0.17 ± 0.04, P < 0.05) and normal gastric tissues from non-GC subjects (0.24 ± 0.06 vs 0.15 ± 0.03, P < 0.05). |
| T11 | 1357-1559 | Sentence | denotes | TGF-β1 methylation was found in 48.3% of H. pylori-positive gastric mucosal tissues whereas only 23.1% of H. pylori-negative gastric mucosal tissues showed TGF-β1 methylation (48.3% vs 23.1%, P < 0.05). |
| T12 | 1560-1723 | Sentence | denotes | IL-1β appeared to induce a dose-dependent methylation of TGF-β1 and the strongest methylation was observed in GES-1 cells treated with 2.5 ng/mL of IL-1β for 48 h. |
| T13 | 1724-1876 | Sentence | denotes | Further studies showed that pre-treatment of GES-1 cells with 20 ng/mL IL-1RA for 1 h could partially abolish the effect of IL-1β on TGF-β1 methylation. |
| T14 | 1877-1979 | Sentence | denotes | Infection of GES-1 cells by H. pylori was not found to induce significant TGF-β1 promoter methylation. |
| T15 | 1980-1991 | Sentence | denotes | CONCLUSION: |
| T16 | 1992-2060 | Sentence | denotes | Our data revealed that TGF-β1 promoter is methylated in GC patients. |
| T17 | 2061-2157 | Sentence | denotes | IL-1β may be an important mediator for H. pylori induced gene methylation during GC development. |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 2015-2021 | gene:7040 | denotes | TGF-β1 |
| T1 | 2048-2050 | disease:C0024623 | denotes | GC |
| T2 | 2015-2021 | gene:7040 | denotes | TGF-β1 |
| T3 | 2048-2050 | disease:C0699791 | denotes | GC |
| T4 | 2061-2066 | gene:3553 | denotes | IL-1β |
| T5 | 2142-2144 | disease:C0024623 | denotes | GC |
| T6 | 2061-2066 | gene:3553 | denotes | IL-1β |
| T7 | 2142-2144 | disease:C0699791 | denotes | GC |
| R1 | T0 | T1 | associated_with | TGF-β1,GC |
| R2 | T2 | T3 | associated_with | TGF-β1,GC |
| R3 | T4 | T5 | associated_with | IL-1β,GC |
| R4 | T6 | T7 | associated_with | IL-1β,GC |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 139-153 | HP_0012126 | denotes | gastric cancer |
| T2 | 147-153 | HP_0002664 | denotes | cancer |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_24023501_2_0 | 76-105 | expanded | denotes | transforming growth factor-β1 |
| SS2_24023501_2_0 | 107-113 | abbr | denotes | TGF-β1 |
| SS1_24023501_2_1 | 174-193 | expanded | denotes | Helicobacter pylori |
| SS2_24023501_2_1 | 195-204 | abbr | denotes | H. pylori |
| SS1_24023501_2_2 | 209-220 | expanded | denotes | interleukin |
| SS2_24023501_2_2 | 222-224 | abbr | denotes | IL |
| SS1_24023501_8_0 | 810-824 | expanded | denotes | gastric cancer |
| SS2_24023501_8_0 | 826-828 | abbr | denotes | GC |
| AE1_24023501_2_0 | SS1_24023501_2_0 | SS2_24023501_2_0 | abbreviatedTo | transforming growth factor-β1,TGF-β1 |
| AE1_24023501_2_1 | SS1_24023501_2_1 | SS2_24023501_2_1 | abbreviatedTo | Helicobacter pylori,H. pylori |
| AE1_24023501_2_2 | SS1_24023501_2_2 | SS2_24023501_2_2 | abbreviatedTo | interleukin,IL |
| AE1_24023501_8_0 | SS1_24023501_8_0 | SS2_24023501_8_0 | abbreviatedTo | gastric cancer,GC |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 24023501-0#20#26#gene7040 | 1050-1056 | gene7040 | denotes | TGF-β1 |
| 24023501-0#44#58#diseaseC0024623 | 1475-1635 | diseaseC0024623 | denotes | gative gastric mucosal tissues showed TGF-β1 methylation (48.3% vs 23.1%, P < 0.05). IL-1β appeared to induce a dose-dependent methylation of TGF-β1 and the str |
| 24023501-0#44#58#diseaseC0699791 | 1475-1635 | diseaseC0699791 | denotes | gative gastric mucosal tissues showed TGF-β1 methylation (48.3% vs 23.1%, P < 0.05). IL-1β appeared to induce a dose-dependent methylation of TGF-β1 and the str |
| 24023501-1#11#40#gene7040 | 76-105 | gene7040 | denotes | transforming growth factor-β1 |
| 24023501-1#42#48#gene7040 | 107-113 | gene7040 | denotes | TGF-β1 |
| 24023501-1#177#183#gene7040 | 242-248 | gene7040 | denotes | TGF-β1 |
| 24023501-1#109#139#diseaseC0374997 | 174-204 | diseaseC0374997 | denotes | Helicobacter pylori (H. pylori |
| 24023501-11#0#5#gene3553 | 2061-2066 | gene3553 | denotes | IL-1β |
| 24023501-11#81#83#diseaseC0024623 | 2142-2144 | diseaseC0024623 | denotes | GC |
| 24023501-11#81#83#diseaseC0699791 | 2142-2144 | diseaseC0699791 | denotes | GC |
| 20#26#gene704044#58#diseaseC0024623 | 24023501-0#20#26#gene7040 | 24023501-0#44#58#diseaseC0024623 | associated_with | TGF-β1,"gative gastric mucosal tissues showed TGF-β1 methylation (48.3% vs 23.1%, P < 0.05). IL-1β appeared to induce a dose-dependent methylation of TGF-β1 and the str" |
| 20#26#gene704044#58#diseaseC0699791 | 24023501-0#20#26#gene7040 | 24023501-0#44#58#diseaseC0699791 | associated_with | TGF-β1,"gative gastric mucosal tissues showed TGF-β1 methylation (48.3% vs 23.1%, P < 0.05). IL-1β appeared to induce a dose-dependent methylation of TGF-β1 and the str" |
| 11#40#gene7040109#139#diseaseC0374997 | 24023501-1#11#40#gene7040 | 24023501-1#109#139#diseaseC0374997 | associated_with | transforming growth factor-β1,Helicobacter pylori (H. pylori |
| 42#48#gene7040109#139#diseaseC0374997 | 24023501-1#42#48#gene7040 | 24023501-1#109#139#diseaseC0374997 | associated_with | TGF-β1,Helicobacter pylori (H. pylori |
| 177#183#gene7040109#139#diseaseC0374997 | 24023501-1#177#183#gene7040 | 24023501-1#109#139#diseaseC0374997 | associated_with | TGF-β1,Helicobacter pylori (H. pylori |
| 0#5#gene355381#83#diseaseC0024623 | 24023501-11#0#5#gene3553 | 24023501-11#81#83#diseaseC0024623 | associated_with | IL-1β,GC |
| 0#5#gene355381#83#diseaseC0699791 | 24023501-11#0#5#gene3553 | 24023501-11#81#83#diseaseC0699791 | associated_with | IL-1β,GC |
DisGeNet-2017-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T756 | 1050-1056 | gene:7040 | denotes | TGF-β1 |
| T757 | 1475-1635 | disease:C0024623 | denotes | gative gastric mucosal tissues showed TGF-β1 methylation (48.3% vs 23.1%, P < 0.05). IL-1β appeared to induce a dose-dependent methylation of TGF-β1 and the str |
| R1 | T756 | T757 | associated_with | TGF-β1,"gative gastric mucosal tissues showed TGF-β1 methylation (48.3% vs 23.1%, P < 0.05). IL-1β appeared to induce a dose-dependent methylation of TGF-β1 and the str" |
| R2 | T756 | T757 | associated_with | TGF-β1,"gative gastric mucosal tissues showed TGF-β1 methylation (48.3% vs 23.1%, P < 0.05). IL-1β appeared to induce a dose-dependent methylation of TGF-β1 and the str" |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 399-406 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T2 | 830-837 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T3 | 934-941 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T4 | 1014-1021 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T5 | 1179-1186 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T6 | 1205-1212 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T7 | 1288-1295 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T8 | 1433-1440 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T9 | 1498-1505 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T10 | 927-933 | http://purl.obolibrary.org/obo/UBERON_0000344 | denotes | mucosa |
| PD-UBERON-AE-B_T11 | 1007-1013 | http://purl.obolibrary.org/obo/UBERON_0000344 | denotes | mucosa |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 927-933 | http://purl.obolibrary.org/obo/UBERON_0000344 | denotes | mucosa |
| PD-UBERON-AE-B_T2 | 1007-1013 | http://purl.obolibrary.org/obo/UBERON_0000344 | denotes | mucosa |
| PD-UBERON-AE-B_T3 | 399-406 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T4 | 830-837 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T5 | 934-941 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T6 | 1014-1021 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T7 | 1179-1186 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T8 | 1205-1212 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T9 | 1288-1295 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T10 | 1433-1440 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
| PD-UBERON-AE-B_T11 | 1498-1505 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |