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PubMed:23999868 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 24-27 Glycan_Motif denotes GM4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G77824XV|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G30207PZ
T3 51-54 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T5 97-100 Glycan_Motif denotes GM4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G77824XV|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G30207PZ
T7 147-150 Glycan_Motif denotes GM4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G77824XV|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G30207PZ
T9 156-167 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T10 251-254 Glycan_Motif denotes GM4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G77824XV|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G30207PZ
T12 292-310 Glycan_Motif denotes galactosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T13 312-318 Glycan_Motif denotes GalCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T14 343-346 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T16 384-400 Glycan_Motif denotes lactosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G74621DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20420WT
T19 402-408 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T20 432-435 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T22 494-497 Glycan_Motif denotes GM4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G77824XV|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G30207PZ
T24 545-548 Glycan_Motif denotes GM4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G77824XV|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G30207PZ
T26 627-630 Glycan_Motif denotes GM4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G77824XV|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G30207PZ
T28 679-682 Glycan_Motif denotes GM4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G77824XV|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G30207PZ
T30 709-712 Glycan_Motif denotes GM4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G77824XV|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G30207PZ
T32 760-766 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T33 768-774 Glycan_Motif denotes GalCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T34 780-783 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T36 796-799 Glycan_Motif denotes GM4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G77824XV|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G30207PZ
T38 866-872 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T39 877-880 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T41 914-920 Glycan_Motif denotes GalCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T42 946-949 Glycan_Motif denotes GM4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G77824XV|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G30207PZ
T44 982-985 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T46 986-989 Glycan_Motif denotes GM4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G77824XV|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G30207PZ
T48 1000-1003 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T50 1151-1157 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T51 1220-1226 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T52 1240-1243 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T54 1250-1256 Glycan_Motif denotes GalCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T55 1379-1382 Glycan_Motif denotes GM4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G77824XV|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G30207PZ
T57 1435-1441 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T58 1446-1452 Glycan_Motif denotes GalCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T59 1457-1460 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T61 1496-1499 Glycan_Motif denotes GM4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G77824XV|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G30207PZ
T63 1566-1569 Glycan_Motif denotes GM4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G77824XV|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G30207PZ
T65 1629-1632 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 227-232 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-130 Sentence denotes Expression machinery of GM4: the excess amounts of GM3/GM4S synthase (ST3GAL5) are necessary for GM4 synthesis in mammalian cells.
TextSentencer_T2 131-250 Sentence denotes The ganglioside GM4 is a sialic acid-containing glycosphingolipid mainly expressed in mammalian brain and erythrocytes.
TextSentencer_T3 251-410 Sentence denotes GM4 is synthesized by the sialylation of galactosylceramide (GalCer), while the ganglioside GM3 is synthesized by the sialylation of lactosylceramide (LacCer).
TextSentencer_T4 411-585 Sentence denotes Recently, the enzyme GM3 synthase was found to be responsible for the synthesis of GM4 in vitro and in vivo, yet the mechanism behind GM4 expression in cells remains unclear.
TextSentencer_T5 586-693 Sentence denotes In this study, we attempted to establish GM4-reconstituted cells to reveal the regulation of GM4 synthesis.
TextSentencer_T6 694-784 Sentence denotes Interestingly, GM4 was not detected in RPMI 1846 cells expressing LacCer, GalCer, and GM3.
TextSentencer_T7 785-945 Sentence denotes Similarly, GM4 was not detected in CHO-K1 cells, even when such cells expressing LacCer and GM3 were stably transfected with the GalCer synthase (GalCerS) gene.
TextSentencer_T8 946-1086 Sentence denotes GM4 became detectable only when the GM3/GM4 synthase (GM3/GM4S, ST3GAL5) gene was overexpressed in either RPMI 1846 or CHO-K1/GalCerS cells.
TextSentencer_T9 1087-1249 Sentence denotes A mutant of the B16 melanoma cell line, GM-95, lacks GlcCer and LacCer, due to an absence of GlcCer synthase, but carries endogenous LacCer synthase and GM3/GM4S.
TextSentencer_T10 1250-1510 Sentence denotes GalCer became detectable after transfection of GalCerS into GM95 cells, but the GM95/GalCerS reconstituted cells did not express GM4, indicating that competition between the substrates LacCer and GalCer for GM3/GM4S does not cause the failure of GM4 synthesis.
TextSentencer_T11 1511-1633 Sentence denotes These results suggest that the expression machinery of GM4 under physiological conditions is independent from that of GM3.
T1 0-130 Sentence denotes Expression machinery of GM4: the excess amounts of GM3/GM4S synthase (ST3GAL5) are necessary for GM4 synthesis in mammalian cells.
T2 131-250 Sentence denotes The ganglioside GM4 is a sialic acid-containing glycosphingolipid mainly expressed in mammalian brain and erythrocytes.
T3 251-410 Sentence denotes GM4 is synthesized by the sialylation of galactosylceramide (GalCer), while the ganglioside GM3 is synthesized by the sialylation of lactosylceramide (LacCer).
T4 411-585 Sentence denotes Recently, the enzyme GM3 synthase was found to be responsible for the synthesis of GM4 in vitro and in vivo, yet the mechanism behind GM4 expression in cells remains unclear.
T5 586-693 Sentence denotes In this study, we attempted to establish GM4-reconstituted cells to reveal the regulation of GM4 synthesis.
T6 694-784 Sentence denotes Interestingly, GM4 was not detected in RPMI 1846 cells expressing LacCer, GalCer, and GM3.
T7 785-945 Sentence denotes Similarly, GM4 was not detected in CHO-K1 cells, even when such cells expressing LacCer and GM3 were stably transfected with the GalCer synthase (GalCerS) gene.
T8 946-1086 Sentence denotes GM4 became detectable only when the GM3/GM4 synthase (GM3/GM4S, ST3GAL5) gene was overexpressed in either RPMI 1846 or CHO-K1/GalCerS cells.
T9 1087-1249 Sentence denotes A mutant of the B16 melanoma cell line, GM-95, lacks GlcCer and LacCer, due to an absence of GlcCer synthase, but carries endogenous LacCer synthase and GM3/GM4S.
T10 1250-1510 Sentence denotes GalCer became detectable after transfection of GalCerS into GM95 cells, but the GM95/GalCerS reconstituted cells did not express GM4, indicating that competition between the substrates LacCer and GalCer for GM3/GM4S does not cause the failure of GM4 synthesis.
T11 1511-1633 Sentence denotes These results suggest that the expression machinery of GM4 under physiological conditions is independent from that of GM3.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 24-27 https://glytoucan.org/Structures/Glycans/G30207PZ denotes GM4
T2 24-27 https://glytoucan.org/Structures/Glycans/G77824XV denotes GM4
T3 51-54 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T4 51-54 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T5 97-100 https://glytoucan.org/Structures/Glycans/G30207PZ denotes GM4
T6 97-100 https://glytoucan.org/Structures/Glycans/G77824XV denotes GM4
T7 147-150 https://glytoucan.org/Structures/Glycans/G30207PZ denotes GM4
T8 147-150 https://glytoucan.org/Structures/Glycans/G77824XV denotes GM4
T9 156-167 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T10 251-254 https://glytoucan.org/Structures/Glycans/G30207PZ denotes GM4
T11 251-254 https://glytoucan.org/Structures/Glycans/G77824XV denotes GM4
T12 292-310 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactosylceramide
T13 343-346 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T14 343-346 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T15 384-400 https://glytoucan.org/Structures/Glycans/G20420WT denotes lactosylceramide
T16 384-400 https://glytoucan.org/Structures/Glycans/G74621DY denotes lactosylceramide
T17 384-400 https://glytoucan.org/Structures/Glycans/G84224TW denotes lactosylceramide
T18 432-435 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T19 432-435 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T20 494-497 https://glytoucan.org/Structures/Glycans/G30207PZ denotes GM4
T21 494-497 https://glytoucan.org/Structures/Glycans/G77824XV denotes GM4
T22 545-548 https://glytoucan.org/Structures/Glycans/G30207PZ denotes GM4
T23 545-548 https://glytoucan.org/Structures/Glycans/G77824XV denotes GM4
T24 627-630 https://glytoucan.org/Structures/Glycans/G30207PZ denotes GM4
T25 627-630 https://glytoucan.org/Structures/Glycans/G77824XV denotes GM4
T26 679-682 https://glytoucan.org/Structures/Glycans/G30207PZ denotes GM4
T27 679-682 https://glytoucan.org/Structures/Glycans/G77824XV denotes GM4
T28 709-712 https://glytoucan.org/Structures/Glycans/G30207PZ denotes GM4
T29 709-712 https://glytoucan.org/Structures/Glycans/G77824XV denotes GM4
T30 780-783 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T31 780-783 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T32 796-799 https://glytoucan.org/Structures/Glycans/G30207PZ denotes GM4
T33 796-799 https://glytoucan.org/Structures/Glycans/G77824XV denotes GM4
T34 877-880 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T35 877-880 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T36 946-949 https://glytoucan.org/Structures/Glycans/G30207PZ denotes GM4
T37 946-949 https://glytoucan.org/Structures/Glycans/G77824XV denotes GM4
T38 982-985 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T39 982-985 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T40 986-989 https://glytoucan.org/Structures/Glycans/G30207PZ denotes GM4
T41 986-989 https://glytoucan.org/Structures/Glycans/G77824XV denotes GM4
T42 1000-1003 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T43 1000-1003 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T44 1240-1243 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T45 1240-1243 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T46 1379-1382 https://glytoucan.org/Structures/Glycans/G30207PZ denotes GM4
T47 1379-1382 https://glytoucan.org/Structures/Glycans/G77824XV denotes GM4
T48 1457-1460 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T49 1457-1460 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T50 1496-1499 https://glytoucan.org/Structures/Glycans/G30207PZ denotes GM4
T51 1496-1499 https://glytoucan.org/Structures/Glycans/G77824XV denotes GM4
T52 1566-1569 https://glytoucan.org/Structures/Glycans/G30207PZ denotes GM4
T53 1566-1569 https://glytoucan.org/Structures/Glycans/G77824XV denotes GM4
T54 1629-1632 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T55 1629-1632 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 24-27 http://www.glycoepitope.jp/epitopes/EP0055 denotes GM4
T2 97-100 http://www.glycoepitope.jp/epitopes/EP0055 denotes GM4
T3 147-150 http://www.glycoepitope.jp/epitopes/EP0055 denotes GM4
T4 251-254 http://www.glycoepitope.jp/epitopes/EP0055 denotes GM4
T5 292-310 http://www.glycoepitope.jp/epitopes/EP0074 denotes galactosylceramide
T6 312-318 http://www.glycoepitope.jp/epitopes/EP0074 denotes GalCer
T7 384-400 http://www.glycoepitope.jp/epitopes/EP0078 denotes lactosylceramide
T8 402-408 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T9 494-497 http://www.glycoepitope.jp/epitopes/EP0055 denotes GM4
T10 545-548 http://www.glycoepitope.jp/epitopes/EP0055 denotes GM4
T11 627-630 http://www.glycoepitope.jp/epitopes/EP0055 denotes GM4
T12 679-682 http://www.glycoepitope.jp/epitopes/EP0055 denotes GM4
T13 709-712 http://www.glycoepitope.jp/epitopes/EP0055 denotes GM4
T14 760-766 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T15 768-774 http://www.glycoepitope.jp/epitopes/EP0074 denotes GalCer
T16 796-799 http://www.glycoepitope.jp/epitopes/EP0055 denotes GM4
T17 866-872 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T18 914-920 http://www.glycoepitope.jp/epitopes/EP0074 denotes GalCer
T19 946-949 http://www.glycoepitope.jp/epitopes/EP0055 denotes GM4
T20 986-989 http://www.glycoepitope.jp/epitopes/EP0055 denotes GM4
T21 1151-1157 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T22 1220-1226 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T23 1250-1256 http://www.glycoepitope.jp/epitopes/EP0074 denotes GalCer
T24 1379-1382 http://www.glycoepitope.jp/epitopes/EP0055 denotes GM4
T25 1435-1441 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T26 1446-1452 http://www.glycoepitope.jp/epitopes/EP0074 denotes GalCer
T27 1496-1499 http://www.glycoepitope.jp/epitopes/EP0055 denotes GM4
T28 1566-1569 http://www.glycoepitope.jp/epitopes/EP0055 denotes GM4

Allie

Id Subject Object Predicate Lexical cue
SS1_23999868_2_0 292-310 expanded denotes galactosylceramide
SS2_23999868_2_0 312-318 abbr denotes GalCer
SS1_23999868_2_1 294-310 expanded denotes lactosylceramide
SS2_23999868_2_1 402-408 abbr denotes LacCer
SS1_23999868_6_0 914-929 expanded denotes GalCer synthase
SS2_23999868_6_0 931-938 abbr denotes GalCerS
AE1_23999868_2_0 SS1_23999868_2_0 SS2_23999868_2_0 abbreviatedTo galactosylceramide,GalCer
AE1_23999868_2_1 SS1_23999868_2_1 SS2_23999868_2_1 abbreviatedTo lactosylceramide,LacCer
AE1_23999868_6_0 SS1_23999868_6_0 SS2_23999868_6_0 abbreviatedTo GalCer synthase,GalCerS

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 237-249 HP_0001901 denotes erythrocytes
T2 1107-1115 HP_0002861 denotes melanoma

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1107-1115 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 227-232 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1107-1115 Phenotype denotes melanoma HP:0002861

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 24-27 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T2 51-54 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 97-100 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T4 147-150 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T5 251-254 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T6 292-310 Glycan denotes galactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T7 312-318 Glycan denotes GalCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T8 343-346 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T9 384-400 Glycan denotes lactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T10 402-408 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T11 432-435 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T12 494-497 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T13 545-548 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T14 627-630 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T15 679-682 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T16 709-712 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T17 760-766 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T18 768-774 Glycan denotes GalCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T19 780-783 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T20 796-799 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T21 866-872 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T22 877-880 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T23 914-920 Glycan denotes GalCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T24 946-949 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T25 982-985 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T26 986-989 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T27 1000-1003 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T28 1151-1157 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T29 1220-1226 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T30 1240-1243 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T31 1250-1256 Glycan denotes GalCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T32 1379-1382 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T33 1435-1441 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T34 1446-1452 Glycan denotes GalCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T35 1457-1460 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T36 1496-1499 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T37 1566-1569 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T38 1629-1632 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 24-27 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T2 97-100 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T3 147-150 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T4 251-254 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T5 292-310 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes galactosylceramide http://www.glycoepitope.jp/epitopes/EP0074
T6 312-318 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GalCer http://www.glycoepitope.jp/epitopes/EP0074
T7 384-400 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078
T8 402-408 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T9 494-497 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T10 545-548 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T11 627-630 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T12 679-682 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T13 709-712 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T14 760-766 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T15 768-774 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GalCer http://www.glycoepitope.jp/epitopes/EP0074
T16 796-799 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T17 866-872 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T18 914-920 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GalCer http://www.glycoepitope.jp/epitopes/EP0074
T19 946-949 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T20 986-989 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T21 1151-1157 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T22 1220-1226 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T23 1250-1256 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GalCer http://www.glycoepitope.jp/epitopes/EP0074
T24 1379-1382 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T25 1435-1441 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T26 1446-1452 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GalCer http://www.glycoepitope.jp/epitopes/EP0074
T27 1496-1499 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T28 1566-1569 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1107-1115 Phenotype denotes melanoma HP:0002861

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 1107-1115 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 237-249 Cell denotes erythrocytes http://purl.obolibrary.org/obo/CL:0000232

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 227-232 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T3 237-249 Body_part denotes erythrocytes http://purl.obolibrary.org/obo/CL_0000232

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 227-232 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-130 Sentence denotes Expression machinery of GM4: the excess amounts of GM3/GM4S synthase (ST3GAL5) are necessary for GM4 synthesis in mammalian cells.
TextSentencer_T2 131-250 Sentence denotes The ganglioside GM4 is a sialic acid-containing glycosphingolipid mainly expressed in mammalian brain and erythrocytes.
TextSentencer_T3 251-410 Sentence denotes GM4 is synthesized by the sialylation of galactosylceramide (GalCer), while the ganglioside GM3 is synthesized by the sialylation of lactosylceramide (LacCer).
TextSentencer_T4 411-585 Sentence denotes Recently, the enzyme GM3 synthase was found to be responsible for the synthesis of GM4 in vitro and in vivo, yet the mechanism behind GM4 expression in cells remains unclear.
TextSentencer_T5 586-693 Sentence denotes In this study, we attempted to establish GM4-reconstituted cells to reveal the regulation of GM4 synthesis.
TextSentencer_T6 694-784 Sentence denotes Interestingly, GM4 was not detected in RPMI 1846 cells expressing LacCer, GalCer, and GM3.
TextSentencer_T7 785-945 Sentence denotes Similarly, GM4 was not detected in CHO-K1 cells, even when such cells expressing LacCer and GM3 were stably transfected with the GalCer synthase (GalCerS) gene.
TextSentencer_T8 946-1086 Sentence denotes GM4 became detectable only when the GM3/GM4 synthase (GM3/GM4S, ST3GAL5) gene was overexpressed in either RPMI 1846 or CHO-K1/GalCerS cells.
TextSentencer_T9 1087-1249 Sentence denotes A mutant of the B16 melanoma cell line, GM-95, lacks GlcCer and LacCer, due to an absence of GlcCer synthase, but carries endogenous LacCer synthase and GM3/GM4S.
TextSentencer_T10 1250-1510 Sentence denotes GalCer became detectable after transfection of GalCerS into GM95 cells, but the GM95/GalCerS reconstituted cells did not express GM4, indicating that competition between the substrates LacCer and GalCer for GM3/GM4S does not cause the failure of GM4 synthesis.
TextSentencer_T11 1511-1633 Sentence denotes These results suggest that the expression machinery of GM4 under physiological conditions is independent from that of GM3.
T1 0-130 Sentence denotes Expression machinery of GM4: the excess amounts of GM3/GM4S synthase (ST3GAL5) are necessary for GM4 synthesis in mammalian cells.
T2 131-250 Sentence denotes The ganglioside GM4 is a sialic acid-containing glycosphingolipid mainly expressed in mammalian brain and erythrocytes.
T3 251-410 Sentence denotes GM4 is synthesized by the sialylation of galactosylceramide (GalCer), while the ganglioside GM3 is synthesized by the sialylation of lactosylceramide (LacCer).
T4 411-585 Sentence denotes Recently, the enzyme GM3 synthase was found to be responsible for the synthesis of GM4 in vitro and in vivo, yet the mechanism behind GM4 expression in cells remains unclear.
T5 586-693 Sentence denotes In this study, we attempted to establish GM4-reconstituted cells to reveal the regulation of GM4 synthesis.
T6 694-784 Sentence denotes Interestingly, GM4 was not detected in RPMI 1846 cells expressing LacCer, GalCer, and GM3.
T7 785-945 Sentence denotes Similarly, GM4 was not detected in CHO-K1 cells, even when such cells expressing LacCer and GM3 were stably transfected with the GalCer synthase (GalCerS) gene.
T8 946-1086 Sentence denotes GM4 became detectable only when the GM3/GM4 synthase (GM3/GM4S, ST3GAL5) gene was overexpressed in either RPMI 1846 or CHO-K1/GalCerS cells.
T9 1087-1249 Sentence denotes A mutant of the B16 melanoma cell line, GM-95, lacks GlcCer and LacCer, due to an absence of GlcCer synthase, but carries endogenous LacCer synthase and GM3/GM4S.
T10 1250-1510 Sentence denotes GalCer became detectable after transfection of GalCerS into GM95 cells, but the GM95/GalCerS reconstituted cells did not express GM4, indicating that competition between the substrates LacCer and GalCer for GM3/GM4S does not cause the failure of GM4 synthesis.
T11 1511-1633 Sentence denotes These results suggest that the expression machinery of GM4 under physiological conditions is independent from that of GM3.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes Expression machinery of GM4: the excess amounts of GM3/GM4S synthase (ST3GAL5) are necessary for GM4 synthesis in mammalian cells.
T2 131-250 Sentence denotes The ganglioside GM4 is a sialic acid-containing glycosphingolipid mainly expressed in mammalian brain and erythrocytes.
T3 251-410 Sentence denotes GM4 is synthesized by the sialylation of galactosylceramide (GalCer), while the ganglioside GM3 is synthesized by the sialylation of lactosylceramide (LacCer).
T4 411-585 Sentence denotes Recently, the enzyme GM3 synthase was found to be responsible for the synthesis of GM4 in vitro and in vivo, yet the mechanism behind GM4 expression in cells remains unclear.
T5 586-693 Sentence denotes In this study, we attempted to establish GM4-reconstituted cells to reveal the regulation of GM4 synthesis.
T6 694-784 Sentence denotes Interestingly, GM4 was not detected in RPMI 1846 cells expressing LacCer, GalCer, and GM3.
T7 785-945 Sentence denotes Similarly, GM4 was not detected in CHO-K1 cells, even when such cells expressing LacCer and GM3 were stably transfected with the GalCer synthase (GalCerS) gene.
T8 946-1086 Sentence denotes GM4 became detectable only when the GM3/GM4 synthase (GM3/GM4S, ST3GAL5) gene was overexpressed in either RPMI 1846 or CHO-K1/GalCerS cells.
T9 1087-1249 Sentence denotes A mutant of the B16 melanoma cell line, GM-95, lacks GlcCer and LacCer, due to an absence of GlcCer synthase, but carries endogenous LacCer synthase and GM3/GM4S.
T10 1250-1510 Sentence denotes GalCer became detectable after transfection of GalCerS into GM95 cells, but the GM95/GalCerS reconstituted cells did not express GM4, indicating that competition between the substrates LacCer and GalCer for GM3/GM4S does not cause the failure of GM4 synthesis.
T11 1511-1633 Sentence denotes These results suggest that the expression machinery of GM4 under physiological conditions is independent from that of GM3.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 24-27 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T2 51-54 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 97-100 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T4 147-150 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T5 251-254 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T6 292-310 Glycan denotes galactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T7 312-318 Glycan denotes GalCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T8 343-346 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T9 384-400 Glycan denotes lactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T10 402-408 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T11 432-435 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T12 494-497 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T13 545-548 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T14 627-630 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T15 679-682 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T16 709-712 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T17 760-766 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T18 768-774 Glycan denotes GalCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T19 780-783 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T20 796-799 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T21 866-872 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T22 877-880 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T23 914-920 Glycan denotes GalCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T24 946-949 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T25 982-985 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T26 986-989 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T27 1000-1003 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T28 1151-1157 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T29 1220-1226 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T30 1240-1243 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T31 1250-1256 Glycan denotes GalCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T32 1379-1382 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T33 1435-1441 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T34 1446-1452 Glycan denotes GalCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE
T35 1457-1460 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T36 1496-1499 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T37 1566-1569 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T38 1629-1632 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 24-27 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T2 97-100 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T3 147-150 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T4 251-254 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T5 292-310 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes galactosylceramide http://www.glycoepitope.jp/epitopes/EP0074
T6 312-318 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GalCer http://www.glycoepitope.jp/epitopes/EP0074
T7 384-400 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078
T8 402-408 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T9 494-497 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T10 545-548 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T11 627-630 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T12 679-682 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T13 709-712 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T14 760-766 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T15 768-774 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GalCer http://www.glycoepitope.jp/epitopes/EP0074
T16 796-799 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T17 866-872 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T18 914-920 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GalCer http://www.glycoepitope.jp/epitopes/EP0074
T19 946-949 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T20 986-989 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T21 1151-1157 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T22 1220-1226 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T23 1250-1256 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GalCer http://www.glycoepitope.jp/epitopes/EP0074
T24 1379-1382 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T25 1435-1441 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T26 1446-1452 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GalCer http://www.glycoepitope.jp/epitopes/EP0074
T27 1496-1499 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055
T28 1566-1569 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 227-232 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T3 237-249 Body_part denotes erythrocytes http://purl.obolibrary.org/obo/CL_0000232

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 237-249 Cell denotes erythrocytes http://purl.obolibrary.org/obo/CL:0000232