PubMed:23994799 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23994799","sourcedb":"PubMed","sourceid":"23994799","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23994799","text":"Anti-RANKL antibody was approved for the treatment of osteoporosis in Japan.\nFifteen years have passed since discovery of RANKL (receptor activator of NF-κB ligand), resulting in identification of the mechanisms regulating osteoclast differentiation and function. The discovery of RANKL contributed to development of a fully human anti-RANKL monoclonal neutralizing antibody (denosumab). Denosumab has been clinically available for treatment of osteoporosis and cancer-induced bone diseases in the US, Europe and many countries since 2010. In Japan denosumab has been clinically available for treatment of cancer-induced bone diseases since 2012 and it was approved for the treatment of osteoporosis in March 2013. Because RANKL is the absolute factor for osteoclast differentiation, anti-RANKL antibody is very effective and its application is good news for many patients. In this review I described the mechanisms regulating osteoclast differentiation and the strong increase of bone mass in normal mice with anti-mouse RANKL antibody. The single injection of the antibody markedly reduced the number of osteoclasts, inhibited bone resorption, and increased bone mass within several days.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_23994799_1_0","span":{"begin":129,"end":163},"obj":"expanded"},{"id":"SS2_23994799_1_0","span":{"begin":122,"end":127},"obj":"abbr"}],"relations":[{"id":"AE1_23994799_1_0","pred":"abbreviatedTo","subj":"SS1_23994799_1_0","obj":"SS2_23994799_1_0"}],"attributes":[{"subj":"SS1_23994799_1_0","pred":"source","obj":"Allie"},{"subj":"SS2_23994799_1_0","pred":"source","obj":"Allie"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":445,"end":457},"obj":"HP_0000939"},{"id":"T2","span":{"begin":462,"end":468},"obj":"HP_0002664"},{"id":"T3","span":{"begin":606,"end":612},"obj":"HP_0002664"},{"id":"T4","span":{"begin":687,"end":699},"obj":"HP_0000939"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#93eccd","default":true},{"id":"PubmedHPO","color":"#ecb393"}]}]}}