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PubMed:23994798 JSONTXT

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Allie

Id	Subject	Object	Predicate	Lexical cue
SS1_23994798_1_0	46-54	expanded	denotes	T helper
SS2_23994798_1_0	56-58	abbr	denotes	Th
SS1_23994798_2_0	159-173	expanded	denotes	Interleukin 17
SS2_23994798_2_0	175-180	abbr	denotes	IL-17
AE1_23994798_1_0	SS1_23994798_1_0	SS2_23994798_1_0	abbreviatedTo	T helper,Th
AE1_23994798_2_0	SS1_23994798_2_0	SS2_23994798_2_0	abbreviatedTo	Interleukin 17,IL-17

PubmedHPO

Id	Subject	Object	Predicate	Lexical cue
T1	810-819	HP_0003765	denotes	psoriasis

Inflammaging

Id	Subject	Object	Predicate	Lexical cue
T1	0-45	Sentence	denotes	The IL-23/IL-17 axis as a therapeutic target.
T2	46-154	Sentence	denotes	T helper (Th) cells are known to differentiate into several distinct subsets depending on their environment.
T3	155-349	Sentence	denotes	The Interleukin 17 (IL-17)-producing subset Th17, which was reported and named in 2005, has been extensively analyzed because a strong association with inflammatory disorders has been suggested.
T4	350-540	Sentence	denotes	The condition in which Th17 cells are differentiated, critical transcription factors, and similarity and difference between mouse and human Th17 cells have been reported one after the other.
T5	541-672	Sentence	denotes	IL-23, which is believed to be important for the activation of Th17 cells, and IL-17 became promising targets for drug development.
T6	673-860	Sentence	denotes	In fact, biological drugs that block the IL-23/IL-17 axis have demonstrated to be highly effective against the inflammatory skin disease psoriasis and have been approved for clinical use.
T7	861-1014	Sentence	denotes	Here an overview and brief history of the basic research on Th17 cells are provided, with the latter full of surprises and unexpected twists in the plot.
T8	1015-1082	Sentence	denotes	The current state of biological drug development is also described.
T1	0-45	Sentence	denotes	The IL-23/IL-17 axis as a therapeutic target.
T2	46-154	Sentence	denotes	T helper (Th) cells are known to differentiate into several distinct subsets depending on their environment.
T3	155-349	Sentence	denotes	The Interleukin 17 (IL-17)-producing subset Th17, which was reported and named in 2005, has been extensively analyzed because a strong association with inflammatory disorders has been suggested.
T4	350-540	Sentence	denotes	The condition in which Th17 cells are differentiated, critical transcription factors, and similarity and difference between mouse and human Th17 cells have been reported one after the other.
T5	541-672	Sentence	denotes	IL-23, which is believed to be important for the activation of Th17 cells, and IL-17 became promising targets for drug development.
T6	673-860	Sentence	denotes	In fact, biological drugs that block the IL-23/IL-17 axis have demonstrated to be highly effective against the inflammatory skin disease psoriasis and have been approved for clinical use.
T7	861-1014	Sentence	denotes	Here an overview and brief history of the basic research on Th17 cells are provided, with the latter full of surprises and unexpected twists in the plot.
T8	1015-1082	Sentence	denotes	The current state of biological drug development is also described.