PubMed:23986452
Annnotations
ggdb-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 4-11 | https://acgg.asia/db/ggdb/info/gg003 | denotes | Lewis X |
| T2 | 4-11 | https://acgg.asia/db/ggdb/info/gg004 | denotes | Lewis X |
| T3 | 4-11 | https://acgg.asia/db/ggdb/info/gg005 | denotes | Lewis X |
| T4 | 4-11 | https://acgg.asia/db/ggdb/info/gg006 | denotes | Lewis X |
| T5 | 4-11 | https://acgg.asia/db/ggdb/info/gg007 | denotes | Lewis X |
| T6 | 4-11 | https://acgg.asia/db/ggdb/info/gg008 | denotes | Lewis X |
| T7 | 45-50 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| T8 | 110-117 | https://acgg.asia/db/ggdb/info/gg003 | denotes | Lewis X |
| T9 | 110-117 | https://acgg.asia/db/ggdb/info/gg004 | denotes | Lewis X |
| T10 | 110-117 | https://acgg.asia/db/ggdb/info/gg005 | denotes | Lewis X |
| T11 | 110-117 | https://acgg.asia/db/ggdb/info/gg006 | denotes | Lewis X |
| T12 | 110-117 | https://acgg.asia/db/ggdb/info/gg007 | denotes | Lewis X |
| T13 | 110-117 | https://acgg.asia/db/ggdb/info/gg008 | denotes | Lewis X |
| T14 | 985-990 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| T15 | 1072-1077 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| T16 | 1140-1145 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| T17 | 1245-1250 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| T18 | 1349-1354 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| T19 | 1441-1446 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 4-11 | Glycan_Motif | denotes | Lewis X | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO |
| T3 | 110-117 | Glycan_Motif | denotes | Lewis X | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO |
| T5 | 119-124 | Glycan_Motif | denotes | Le(X) | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC |
| T6 | 332-337 | Glycan_Motif | denotes | Le(X) | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC |
| T7 | 730-735 | Glycan_Motif | denotes | Le(X) | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC |
| T8 | 874-879 | Glycan_Motif | denotes | Le(X) | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC |
GGDB-2020
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 4-11 | https://acgg.asia/db/ggdb/info/gg004 | denotes | Lewis X |
| T2 | 4-11 | https://acgg.asia/db/ggdb/info/gg005 | denotes | Lewis X |
| T3 | 4-11 | https://acgg.asia/db/ggdb/info/gg006 | denotes | Lewis X |
| T4 | 4-11 | https://acgg.asia/db/ggdb/info/gg007 | denotes | Lewis X |
| T5 | 4-11 | https://acgg.asia/db/ggdb/info/gg008 | denotes | Lewis X |
| T6 | 4-11 | https://acgg.asia/db/ggdb/info/gg003 | denotes | Lewis X |
| T7 | 45-50 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| T8 | 110-117 | https://acgg.asia/db/ggdb/info/gg004 | denotes | Lewis X |
| T9 | 110-117 | https://acgg.asia/db/ggdb/info/gg005 | denotes | Lewis X |
| T10 | 110-117 | https://acgg.asia/db/ggdb/info/gg006 | denotes | Lewis X |
| T11 | 110-117 | https://acgg.asia/db/ggdb/info/gg007 | denotes | Lewis X |
| T12 | 110-117 | https://acgg.asia/db/ggdb/info/gg008 | denotes | Lewis X |
| T13 | 110-117 | https://acgg.asia/db/ggdb/info/gg003 | denotes | Lewis X |
| T14 | 985-990 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| T15 | 1072-1077 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| T16 | 1140-1145 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| T17 | 1245-1250 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| T18 | 1349-1354 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| T19 | 1441-1446 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 4-11 | https://glytoucan.org/Structures/Glycans/G00051MO | denotes | Lewis X |
| T2 | 110-117 | https://glytoucan.org/Structures/Glycans/G00051MO | denotes | Lewis X |
| T3 | 119-124 | https://glytoucan.org/Structures/Glycans/G01187XC | denotes | Le(X) |
| T4 | 332-337 | https://glytoucan.org/Structures/Glycans/G01187XC | denotes | Le(X) |
| T5 | 730-735 | https://glytoucan.org/Structures/Glycans/G01187XC | denotes | Le(X) |
| T6 | 874-879 | https://glytoucan.org/Structures/Glycans/G01187XC | denotes | Le(X) |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T1 | 4-11 | GlycoEpitope | denotes | Lewis X | http://www.glycoepitope.jp/epitopes/EP0011 |
| T2 | 110-117 | GlycoEpitope | denotes | Lewis X | http://www.glycoepitope.jp/epitopes/EP0011 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-109 | Sentence | denotes | The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations. |
| T2 | 110-331 | Sentence | denotes | Lewis X (Le(X), Galβ1-4(Fucα1-3)GlcNAc) is a carbohydrate epitope that is present at the nonreducing terminus of sugar chains of glycoproteins and glycolipids, and is abundantly expressed in several stem cell populations. |
| T3 | 332-498 | Sentence | denotes | Le(X) antigen can be used in conjunction with fluorescence-activated cell sorting to isolate neurosphere-forming neural stem cells (NSCs) from embryonic mouse brains. |
| T4 | 499-598 | Sentence | denotes | However, its function in the maintenance and differentiation of stem cells remains largely unknown. |
| T5 | 599-758 | Sentence | denotes | In this study, we examined mice deficient for fucosyltransferase 9 (Fut9), which is thought to synthesize most, if not all, of the Le(X) moieties in the brain. |
| T6 | 759-923 | Sentence | denotes | We found that the number of NSCs was increased in the brain of Fut9(-/-) embryos, suggesting that Fut9-synthesized Le(X) is dispensable for the maintenance of NSCs. |
| T7 | 924-1053 | Sentence | denotes | Another α1,3-fucosyltransferase gene, fucosyltransferase 10 (Fut10), is expressed in the ventricular zone of the embryonic brain. |
| T8 | 1054-1112 | Sentence | denotes | Overexpression of Fut10 enhanced the self-renewal of NSCs. |
| T9 | 1113-1218 | Sentence | denotes | Conversely, suppression of Fut10 expression induced the differentiation of NSCs and embryonic stem cells. |
| T10 | 1219-1418 | Sentence | denotes | In addition, knockdown of Fut10 expression in the cortical ventricular zone of the embryonic brain by in utero electroporation of Fut10-miRNAs impaired the radial migration of neural precursor cells. |
| T11 | 1419-1629 | Sentence | denotes | Our data suggest that Fut10 is involved in a unique α1,3-fucosyltransferase activity with stringent substrate specificity, and that this activity is required to maintain stem cells in an undifferentiated state. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 87-96 | http://purl.obolibrary.org/obo/MAT_0000185 | denotes | stem cell |
| T2 | 87-91 | http://purl.obolibrary.org/obo/MAT_0000239 | denotes | stem |
| T3 | 309-318 | http://purl.obolibrary.org/obo/MAT_0000185 | denotes | stem cell |
| T4 | 309-313 | http://purl.obolibrary.org/obo/MAT_0000239 | denotes | stem |
| T5 | 452-462 | http://purl.obolibrary.org/obo/MAT_0000185 | denotes | stem cells |
| T6 | 452-456 | http://purl.obolibrary.org/obo/MAT_0000239 | denotes | stem |
| T7 | 491-497 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brains |
| T8 | 563-573 | http://purl.obolibrary.org/obo/MAT_0000185 | denotes | stem cells |
| T9 | 563-567 | http://purl.obolibrary.org/obo/MAT_0000239 | denotes | stem |
| T10 | 752-757 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T11 | 813-818 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T12 | 832-839 | http://purl.obolibrary.org/obo/MAT_0000226 | denotes | embryos |
| T13 | 1047-1052 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T14 | 1207-1217 | http://purl.obolibrary.org/obo/MAT_0000185 | denotes | stem cells |
| T15 | 1207-1211 | http://purl.obolibrary.org/obo/MAT_0000239 | denotes | stem |
| T16 | 1312-1317 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T17 | 1589-1599 | http://purl.obolibrary.org/obo/MAT_0000185 | denotes | stem cells |
| T18 | 1589-1593 | http://purl.obolibrary.org/obo/MAT_0000239 | denotes | stem |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_23986452_2_0 | 445-462 | expanded | denotes | neural stem cells |
| SS2_23986452_2_0 | 464-468 | abbr | denotes | NSCs |
| SS1_23986452_4_0 | 645-665 | expanded | denotes | fucosyltransferase 9 |
| SS2_23986452_4_0 | 667-671 | abbr | denotes | Fut9 |
| SS1_23986452_6_0 | 962-983 | expanded | denotes | fucosyltransferase 10 |
| SS2_23986452_6_0 | 985-990 | abbr | denotes | Fut10 |
| AE1_23986452_2_0 | SS1_23986452_2_0 | SS2_23986452_2_0 | abbreviatedTo | neural stem cells,NSCs |
| AE1_23986452_4_0 | SS1_23986452_4_0 | SS2_23986452_4_0 | abbreviatedTo | fucosyltransferase 9,Fut9 |
| AE1_23986452_6_0 | SS1_23986452_6_0 | SS2_23986452_6_0 | abbreviatedTo | fucosyltransferase 10,Fut10 |
glycogenes
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoGenes20190927-B_T1 | 45-50 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| PD-GlycoGenes20190927-B_T2 | 582-589 | https://acgg.asia/db/ggdb/info/gg171 | denotes | largely |
| PD-GlycoGenes20190927-B_T3 | 667-671 | https://acgg.asia/db/ggdb/info/gg008 | denotes | Fut9 |
| PD-GlycoGenes20190927-B_T4 | 822-826 | https://acgg.asia/db/ggdb/info/gg008 | denotes | Fut9 |
| PD-GlycoGenes20190927-B_T5 | 857-861 | https://acgg.asia/db/ggdb/info/gg008 | denotes | Fut9 |
| PD-GlycoGenes20190927-B_T6 | 985-990 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| PD-GlycoGenes20190927-B_T7 | 1072-1077 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| PD-GlycoGenes20190927-B_T8 | 1140-1145 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| PD-GlycoGenes20190927-B_T9 | 1245-1250 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| PD-GlycoGenes20190927-B_T10 | 1349-1354 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
| PD-GlycoGenes20190927-B_T11 | 1441-1446 | https://acgg.asia/db/ggdb/info/gg010 | denotes | Fut10 |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 142-148 | chem:24139 | denotes | GlcNAc |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 87-96 | Body_part | denotes | stem cell | http://purl.obolibrary.org/obo/MAT_0000185 |
| T2 | 309-318 | Body_part | denotes | stem cell | http://purl.obolibrary.org/obo/MAT_0000185 |
| T3 | 452-462 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/MAT_0000185 |
| T4 | 491-497 | Body_part | denotes | brains | http://purl.obolibrary.org/obo/MAT_0000098 |
| T5 | 563-573 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/MAT_0000185 |
| T6 | 752-757 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T7 | 813-818 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T8 | 832-839 | Body_part | denotes | embryos | http://purl.obolibrary.org/obo/MAT_0000226 |
| T9 | 1047-1052 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T10 | 1207-1217 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/MAT_0000185 |
| T11 | 1312-1317 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T12 | 1589-1599 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/MAT_0000185 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 4-11 | Glycan | denotes | Lewis X | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00051MO |
| T2 | 110-117 | Glycan | denotes | Lewis X | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00051MO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 4-11 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Lewis X | http://www.glycoepitope.jp/epitopes/EP0011 |
| T2 | 110-117 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Lewis X | http://www.glycoepitope.jp/epitopes/EP0011 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 485-490 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T3 | 626-630 | OrganismTaxon | denotes | mice | 10088 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 87-96 | Cell | denotes | stem cell | http://purl.obolibrary.org/obo/CL:0000034 |
| T2 | 309-318 | Cell | denotes | stem cell | http://purl.obolibrary.org/obo/CL:0000034 |
| T3 | 445-462 | Cell | denotes | neural stem cells | http://purl.obolibrary.org/obo/CL:0000047 |
| T4 | 464-468 | Cell | denotes | NSCs | http://purl.obolibrary.org/obo/CL:0000047 |
| T5 | 563-573 | Cell | denotes | stem cells | http://purl.obolibrary.org/obo/CL:0000034 |
| T6 | 787-791 | Cell | denotes | NSCs | http://purl.obolibrary.org/obo/CL:0000047 |
| T7 | 918-922 | Cell | denotes | NSCs | http://purl.obolibrary.org/obo/CL:0000047 |
| T8 | 1107-1111 | Cell | denotes | NSCs | http://purl.obolibrary.org/obo/CL:0000047 |
| T9 | 1188-1192 | Cell | denotes | NSCs | http://purl.obolibrary.org/obo/CL:0000047 |
| T10 | 1197-1217 | Cell | denotes | embryonic stem cells | http://purl.obolibrary.org/obo/CL:0002322 |
| T11 | 1402-1417 | Cell | denotes | precursor cells | http://purl.obolibrary.org/obo/CL:0011115 |
| T12 | 1589-1599 | Cell | denotes | stem cells | http://purl.obolibrary.org/obo/CL:0000034 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 87-96 | Body_part | denotes | stem cell | http://purl.obolibrary.org/obo/CL_0000034 |
| T2 | 309-318 | Body_part | denotes | stem cell | http://purl.obolibrary.org/obo/CL_0000034 |
| T3 | 452-462 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/CL_0000034 |
| T4 | 563-573 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/CL_0000034 |
| T5 | 752-757 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T7 | 813-818 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T9 | 1013-1029 | Body_part | denotes | ventricular zone | http://purl.obolibrary.org/obo/UBERON_0003053 |
| T10 | 1037-1052 | Body_part | denotes | embryonic brain | http://purl.obolibrary.org/obo/UBERON_0006238 |
| T11 | 1207-1217 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/CL_0000034 |
| T12 | 1278-1294 | Body_part | denotes | ventricular zone | http://purl.obolibrary.org/obo/UBERON_0003053 |
| T13 | 1302-1317 | Body_part | denotes | embryonic brain | http://purl.obolibrary.org/obo/UBERON_0006238 |
| T14 | 1402-1417 | Body_part | denotes | precursor cells | http://purl.obolibrary.org/obo/CL_0011115 |
| T15 | 1589-1599 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/CL_0000034 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 87-96 | Body_part | denotes | stem cell | http://purl.obolibrary.org/obo/MAT_0000185 |
| T2 | 309-318 | Body_part | denotes | stem cell | http://purl.obolibrary.org/obo/MAT_0000185 |
| T3 | 452-462 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/MAT_0000185 |
| T4 | 491-497 | Body_part | denotes | brains | http://purl.obolibrary.org/obo/MAT_0000098 |
| T5 | 563-573 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/MAT_0000185 |
| T6 | 752-757 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T7 | 813-818 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T8 | 832-839 | Body_part | denotes | embryos | http://purl.obolibrary.org/obo/MAT_0000226 |
| T9 | 1047-1052 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T10 | 1207-1217 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/MAT_0000185 |
| T11 | 1312-1317 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T12 | 1589-1599 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/MAT_0000185 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-109 | Sentence | denotes | The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations. |
| T2 | 110-331 | Sentence | denotes | Lewis X (Le(X), Galβ1-4(Fucα1-3)GlcNAc) is a carbohydrate epitope that is present at the nonreducing terminus of sugar chains of glycoproteins and glycolipids, and is abundantly expressed in several stem cell populations. |
| T3 | 332-498 | Sentence | denotes | Le(X) antigen can be used in conjunction with fluorescence-activated cell sorting to isolate neurosphere-forming neural stem cells (NSCs) from embryonic mouse brains. |
| T4 | 499-598 | Sentence | denotes | However, its function in the maintenance and differentiation of stem cells remains largely unknown. |
| T5 | 599-758 | Sentence | denotes | In this study, we examined mice deficient for fucosyltransferase 9 (Fut9), which is thought to synthesize most, if not all, of the Le(X) moieties in the brain. |
| T6 | 759-923 | Sentence | denotes | We found that the number of NSCs was increased in the brain of Fut9(-/-) embryos, suggesting that Fut9-synthesized Le(X) is dispensable for the maintenance of NSCs. |
| T7 | 924-1053 | Sentence | denotes | Another α1,3-fucosyltransferase gene, fucosyltransferase 10 (Fut10), is expressed in the ventricular zone of the embryonic brain. |
| T8 | 1054-1112 | Sentence | denotes | Overexpression of Fut10 enhanced the self-renewal of NSCs. |
| T9 | 1113-1218 | Sentence | denotes | Conversely, suppression of Fut10 expression induced the differentiation of NSCs and embryonic stem cells. |
| T10 | 1219-1418 | Sentence | denotes | In addition, knockdown of Fut10 expression in the cortical ventricular zone of the embryonic brain by in utero electroporation of Fut10-miRNAs impaired the radial migration of neural precursor cells. |
| T11 | 1419-1629 | Sentence | denotes | Our data suggest that Fut10 is involved in a unique α1,3-fucosyltransferase activity with stringent substrate specificity, and that this activity is required to maintain stem cells in an undifferentiated state. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-109 | Sentence | denotes | The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations. |
| T2 | 110-331 | Sentence | denotes | Lewis X (Le(X), Galβ1-4(Fucα1-3)GlcNAc) is a carbohydrate epitope that is present at the nonreducing terminus of sugar chains of glycoproteins and glycolipids, and is abundantly expressed in several stem cell populations. |
| T3 | 332-498 | Sentence | denotes | Le(X) antigen can be used in conjunction with fluorescence-activated cell sorting to isolate neurosphere-forming neural stem cells (NSCs) from embryonic mouse brains. |
| T4 | 499-598 | Sentence | denotes | However, its function in the maintenance and differentiation of stem cells remains largely unknown. |
| T5 | 599-758 | Sentence | denotes | In this study, we examined mice deficient for fucosyltransferase 9 (Fut9), which is thought to synthesize most, if not all, of the Le(X) moieties in the brain. |
| T6 | 759-923 | Sentence | denotes | We found that the number of NSCs was increased in the brain of Fut9(-/-) embryos, suggesting that Fut9-synthesized Le(X) is dispensable for the maintenance of NSCs. |
| T7 | 924-1053 | Sentence | denotes | Another α1,3-fucosyltransferase gene, fucosyltransferase 10 (Fut10), is expressed in the ventricular zone of the embryonic brain. |
| T8 | 1054-1112 | Sentence | denotes | Overexpression of Fut10 enhanced the self-renewal of NSCs. |
| T9 | 1113-1218 | Sentence | denotes | Conversely, suppression of Fut10 expression induced the differentiation of NSCs and embryonic stem cells. |
| T10 | 1219-1418 | Sentence | denotes | In addition, knockdown of Fut10 expression in the cortical ventricular zone of the embryonic brain by in utero electroporation of Fut10-miRNAs impaired the radial migration of neural precursor cells. |
| T11 | 1419-1629 | Sentence | denotes | Our data suggest that Fut10 is involved in a unique α1,3-fucosyltransferase activity with stringent substrate specificity, and that this activity is required to maintain stem cells in an undifferentiated state. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | glycosmos_id | image |
|---|---|---|---|---|---|---|
| T1 | 4-11 | Glycan | denotes | Lewis X | https://glycosmos.org/glycans/show/G00051MO | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00051MO |
| T2 | 110-117 | Glycan | denotes | Lewis X | https://glycosmos.org/glycans/show/G00051MO | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00051MO |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 4-11 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Lewis X | http://www.glycoepitope.jp/epitopes/EP0011 |
| T2 | 110-117 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Lewis X | http://www.glycoepitope.jp/epitopes/EP0011 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 485-490 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T3 | 626-630 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 87-96 | Body_part | denotes | stem cell | http://purl.obolibrary.org/obo/CL_0000034 |
| T2 | 309-318 | Body_part | denotes | stem cell | http://purl.obolibrary.org/obo/CL_0000034 |
| T3 | 452-462 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/CL_0000034 |
| T4 | 563-573 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/CL_0000034 |
| T5 | 752-757 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T7 | 813-818 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T9 | 1013-1029 | Body_part | denotes | ventricular zone | http://purl.obolibrary.org/obo/UBERON_0003053 |
| T10 | 1037-1052 | Body_part | denotes | embryonic brain | http://purl.obolibrary.org/obo/UBERON_0006238 |
| T11 | 1207-1217 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/CL_0000034 |
| T12 | 1278-1294 | Body_part | denotes | ventricular zone | http://purl.obolibrary.org/obo/UBERON_0003053 |
| T13 | 1302-1317 | Body_part | denotes | embryonic brain | http://purl.obolibrary.org/obo/UBERON_0006238 |
| T14 | 1402-1417 | Body_part | denotes | precursor cells | http://purl.obolibrary.org/obo/CL_0011115 |
| T15 | 1589-1599 | Body_part | denotes | stem cells | http://purl.obolibrary.org/obo/CL_0000034 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 87-96 | Cell | denotes | stem cell | http://purl.obolibrary.org/obo/CL:0000034 |
| T2 | 309-318 | Cell | denotes | stem cell | http://purl.obolibrary.org/obo/CL:0000034 |
| T3 | 445-462 | Cell | denotes | neural stem cells | http://purl.obolibrary.org/obo/CL:0000047 |
| T4 | 464-468 | Cell | denotes | NSCs | http://purl.obolibrary.org/obo/CL:0000047 |
| T5 | 563-573 | Cell | denotes | stem cells | http://purl.obolibrary.org/obo/CL:0000034 |
| T6 | 787-791 | Cell | denotes | NSCs | http://purl.obolibrary.org/obo/CL:0000047 |
| T7 | 918-922 | Cell | denotes | NSCs | http://purl.obolibrary.org/obo/CL:0000047 |
| T8 | 1107-1111 | Cell | denotes | NSCs | http://purl.obolibrary.org/obo/CL:0000047 |
| T9 | 1188-1192 | Cell | denotes | NSCs | http://purl.obolibrary.org/obo/CL:0000047 |
| T10 | 1197-1217 | Cell | denotes | embryonic stem cells | http://purl.obolibrary.org/obo/CL:0002322 |
| T11 | 1402-1417 | Cell | denotes | precursor cells | http://purl.obolibrary.org/obo/CL:0011115 |
| T12 | 1589-1599 | Cell | denotes | stem cells | http://purl.obolibrary.org/obo/CL:0000034 |