| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-90 |
Sentence |
denotes |
Case report evidence of relationships between hepatocellular carcinoma and ochratoxicosis. |
| TextSentencer_T2 |
91-99 |
Sentence |
denotes |
PURPOSE: |
| TextSentencer_T3 |
100-218 |
Sentence |
denotes |
The incidence of Hepatocellular carcinoma (HCC) is on the rise, but what is causing that trend has remained a mystery. |
| TextSentencer_T4 |
219-341 |
Sentence |
denotes |
Mycotoxins are almost entirely ignored health problems, and sometimes actually naively belittled in advanced medical care. |
| TextSentencer_T5 |
342-508 |
Sentence |
denotes |
Ochratoxin A (OTA) is one of the most abundant food contaminating mycotoxins worldwide that is carcinogenic, but no studies have evaluated its levels in HCC patients. |
| TextSentencer_T6 |
509-672 |
Sentence |
denotes |
Therefore, this study was designed to monitor the presence of OTA in the serum of HCC patients and to quantify the strength of the association between OTA and HCC. |
| TextSentencer_T7 |
673-681 |
Sentence |
denotes |
METHODS: |
| TextSentencer_T8 |
682-741 |
Sentence |
denotes |
We conducted a case control-based study on 61 participants. |
| TextSentencer_T9 |
742-897 |
Sentence |
denotes |
Thirty-nine were HCC cases identified between 2010 and 2012 and individually matched by age, sex, residence and date of recruitment to 22 healthy controls. |
| TextSentencer_T10 |
898-1058 |
Sentence |
denotes |
Serum OTA and alpha-fetoprotein levels were measured by using high-performance liquid chromatography (HPLC) and enzyme-linked immunosorbent assay, respectively. |
| TextSentencer_T11 |
1059-1230 |
Sentence |
denotes |
RESULTS: HPLC analysis of 61 serum samples indicated that the highest incidence of elevated OTA was found in the HCC group and was 5-fold higher than in the control group. |
| TextSentencer_T12 |
1231-1455 |
Sentence |
denotes |
The concentration of OTA in the HCC group ranged between 0.129 and 10.93 ng/mL with a mean value±SD of 1.1±0.3 ng/mL, while in the normal group it ranged between 0.005 and 0.50 ng/mL with a mean value±SD of 0.201±0.02 ng/mL. |
| TextSentencer_T13 |
1456-1767 |
Sentence |
denotes |
The odds ratio for HCC patients presenting OTA levels above the cut-off of 0.207 (calculated by the receiver operating characteristic curve) was 9.78 (95% confidence interval = 2.9095-32.9816, P = 0.0002) with respect to normal controls, suggesting that HCC is 9.8 times as frequent in the exposed group to OTA. |
| TextSentencer_T14 |
1768-1779 |
Sentence |
denotes |
CONCLUSION: |
| TextSentencer_T15 |
1780-1992 |
Sentence |
denotes |
Our results reveal a strong association between the presence of OTA and HCC, which may offer a coherent explanation for much of the descriptive epidemiology of HCC and suggest new avenues for analytical research. |
| T1 |
0-90 |
Sentence |
denotes |
Case report evidence of relationships between hepatocellular carcinoma and ochratoxicosis. |
| T2 |
91-99 |
Sentence |
denotes |
PURPOSE: |
| T3 |
100-218 |
Sentence |
denotes |
The incidence of Hepatocellular carcinoma (HCC) is on the rise, but what is causing that trend has remained a mystery. |
| T4 |
219-341 |
Sentence |
denotes |
Mycotoxins are almost entirely ignored health problems, and sometimes actually naively belittled in advanced medical care. |
| T5 |
342-508 |
Sentence |
denotes |
Ochratoxin A (OTA) is one of the most abundant food contaminating mycotoxins worldwide that is carcinogenic, but no studies have evaluated its levels in HCC patients. |
| T6 |
509-672 |
Sentence |
denotes |
Therefore, this study was designed to monitor the presence of OTA in the serum of HCC patients and to quantify the strength of the association between OTA and HCC. |
| T7 |
673-681 |
Sentence |
denotes |
METHODS: |
| T8 |
682-741 |
Sentence |
denotes |
We conducted a case control-based study on 61 participants. |
| T9 |
742-897 |
Sentence |
denotes |
Thirty-nine were HCC cases identified between 2010 and 2012 and individually matched by age, sex, residence and date of recruitment to 22 healthy controls. |
| T10 |
898-1058 |
Sentence |
denotes |
Serum OTA and alpha-fetoprotein levels were measured by using high-performance liquid chromatography (HPLC) and enzyme-linked immunosorbent assay, respectively. |
| T11 |
1059-1230 |
Sentence |
denotes |
RESULTS: HPLC analysis of 61 serum samples indicated that the highest incidence of elevated OTA was found in the HCC group and was 5-fold higher than in the control group. |
| T12 |
1231-1455 |
Sentence |
denotes |
The concentration of OTA in the HCC group ranged between 0.129 and 10.93 ng/mL with a mean value±SD of 1.1±0.3 ng/mL, while in the normal group it ranged between 0.005 and 0.50 ng/mL with a mean value±SD of 0.201±0.02 ng/mL. |
| T13 |
1456-1767 |
Sentence |
denotes |
The odds ratio for HCC patients presenting OTA levels above the cut-off of 0.207 (calculated by the receiver operating characteristic curve) was 9.78 (95% confidence interval = 2.9095-32.9816, P = 0.0002) with respect to normal controls, suggesting that HCC is 9.8 times as frequent in the exposed group to OTA. |
| T14 |
1768-1779 |
Sentence |
denotes |
CONCLUSION: |
| T15 |
1780-1992 |
Sentence |
denotes |
Our results reveal a strong association between the presence of OTA and HCC, which may offer a coherent explanation for much of the descriptive epidemiology of HCC and suggest new avenues for analytical research. |
