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PubMed:23974200 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-137 Sentence denotes Transcription factor C/EBPα-induced microRNA-30c inactivates Notch1 during granulopoiesis and is downregulated in acute myeloid leukemia.
TextSentencer_T2 138-305 Sentence denotes The transcription factor CCAAT enhancer binding protein α (C/EBPα) is a master regulator in granulopoiesis and is frequently disrupted in acute myeloid leukemia (AML).
TextSentencer_T3 306-421 Sentence denotes We have previously shown that C/EBPα exerts its effects by regulating microRNAs (miRs) such as miR-223 and miR-34a.
TextSentencer_T4 422-507 Sentence denotes Here, we confirm miR-30c as a novel important target of C/EBPα during granulopoiesis.
TextSentencer_T5 508-718 Sentence denotes Thus, wild-type C/EBPα-p42 directly upregulates miR-30c expression, whereas C/EBPα-p30, found in AML, does not. miR-30c is downregulated in AML, especially in normal karyotype AML patients with CEBPA mutations.
TextSentencer_T6 719-835 Sentence denotes An induced C/EBPα knockout in mice leads to a significant downregulation of miR-30c expression in bone marrow cells.
TextSentencer_T7 836-887 Sentence denotes We identified NOTCH1 as a direct target of miR-30c.
TextSentencer_T8 888-1040 Sentence denotes Finally, a block of miR-30c prevents C/EBPα-induced downregulation of Notch1 protein and leads to a reduced CD11b expression in myeloid differentiation.
TextSentencer_T9 1041-1228 Sentence denotes Our study presents the first evidence that C/EBPα, miR-30c, and Notch1 together play a critical role in granulocytic differentiation and AML, and particularly in AML with CEBPA mutations.
TextSentencer_T10 1229-1370 Sentence denotes These data reveal the importance of deregulated miRNA expression in leukemia and may provide novel biomarkers and therapeutic targets in AML.
T1 0-137 Sentence denotes Transcription factor C/EBPα-induced microRNA-30c inactivates Notch1 during granulopoiesis and is downregulated in acute myeloid leukemia.
T2 138-305 Sentence denotes The transcription factor CCAAT enhancer binding protein α (C/EBPα) is a master regulator in granulopoiesis and is frequently disrupted in acute myeloid leukemia (AML).
T3 306-421 Sentence denotes We have previously shown that C/EBPα exerts its effects by regulating microRNAs (miRs) such as miR-223 and miR-34a.
T4 422-507 Sentence denotes Here, we confirm miR-30c as a novel important target of C/EBPα during granulopoiesis.
T5 508-718 Sentence denotes Thus, wild-type C/EBPα-p42 directly upregulates miR-30c expression, whereas C/EBPα-p30, found in AML, does not. miR-30c is downregulated in AML, especially in normal karyotype AML patients with CEBPA mutations.
T6 719-835 Sentence denotes An induced C/EBPα knockout in mice leads to a significant downregulation of miR-30c expression in bone marrow cells.
T7 836-887 Sentence denotes We identified NOTCH1 as a direct target of miR-30c.
T8 888-1040 Sentence denotes Finally, a block of miR-30c prevents C/EBPα-induced downregulation of Notch1 protein and leads to a reduced CD11b expression in myeloid differentiation.
T9 1041-1228 Sentence denotes Our study presents the first evidence that C/EBPα, miR-30c, and Notch1 together play a critical role in granulocytic differentiation and AML, and particularly in AML with CEBPA mutations.
T10 1229-1370 Sentence denotes These data reveal the importance of deregulated miRNA expression in leukemia and may provide novel biomarkers and therapeutic targets in AML.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 21-27 gene:1050 denotes C/EBPα
T1 114-136 disease:C0023467 denotes acute myeloid leukemia
T2 61-67 gene:4851 denotes Notch1
T3 114-136 disease:C0023467 denotes acute myeloid leukemia
T4 163-195 gene:1050 denotes CCAAT enhancer binding protein α
T5 276-298 disease:C0023467 denotes acute myeloid leukemia
T6 163-195 gene:1050 denotes CCAAT enhancer binding protein α
T7 300-303 disease:C0023467 denotes AML
T8 1212-1217 gene:1050 denotes CEBPA
T9 1203-1206 disease:C0023467 denotes AML
T10 1212-1217 gene:1050 denotes CEBPA
T11 1178-1181 disease:C0023467 denotes AML
T12 1105-1111 gene:4851 denotes Notch1
T13 1178-1181 disease:C0023467 denotes AML
T14 1084-1090 gene:1050 denotes C/EBPα
T15 1178-1181 disease:C0023467 denotes AML
R1 T0 T1 associated_with C/EBPα,acute myeloid leukemia
R2 T2 T3 associated_with Notch1,acute myeloid leukemia
R3 T4 T5 associated_with CCAAT enhancer binding protein α,acute myeloid leukemia
R4 T6 T7 associated_with CCAAT enhancer binding protein α,AML
R5 T8 T9 associated_with CEBPA,AML
R6 T10 T11 associated_with CEBPA,AML
R7 T12 T13 associated_with Notch1,AML
R8 T14 T15 associated_with C/EBPα,AML

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 276-298 HP_0004808 denotes acute myeloid leukemia
T2 282-298 HP_0012324 denotes myeloid leukemia
T3 290-298 HP_0001909 denotes leukemia
T4 1297-1305 HP_0001909 denotes leukemia

Allie

Id Subject Object Predicate Lexical cue
SS1_23974200_1_0 276-298 expanded denotes acute myeloid leukemia
SS2_23974200_1_0 300-303 abbr denotes AML
SS1_23974200_2_0 376-385 expanded denotes microRNAs
SS2_23974200_2_0 387-391 abbr denotes miRs
AE1_23974200_1_0 SS1_23974200_1_0 SS2_23974200_1_0 abbreviatedTo acute myeloid leukemia,AML
AE1_23974200_2_0 SS1_23974200_2_0 SS2_23974200_2_0 abbreviatedTo microRNAs,miRs

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23974200-0#61#67#gene4851 61-67 gene4851 denotes Notch1
23974200-0#114#136#diseaseC0023467 114-136 diseaseC0023467 denotes acute myeloid leukemia
23974200-4#112#119#gene407031 620-627 gene407031 denotes miR-30c
23974200-4#112#119#gene407032 620-627 gene407032 denotes miR-30c
23974200-4#140#143#diseaseC0023467 648-651 diseaseC0023467 denotes AML
23974200-8#171#176#gene1050 1212-1217 gene1050 denotes CEBPA
23974200-8#162#165#diseaseC0023467 1203-1206 diseaseC0023467 denotes AML
61#67#gene4851114#136#diseaseC0023467 23974200-0#61#67#gene4851 23974200-0#114#136#diseaseC0023467 associated_with Notch1,acute myeloid leukemia
112#119#gene407031140#143#diseaseC0023467 23974200-4#112#119#gene407031 23974200-4#140#143#diseaseC0023467 associated_with miR-30c,AML
112#119#gene407032140#143#diseaseC0023467 23974200-4#112#119#gene407032 23974200-4#140#143#diseaseC0023467 associated_with miR-30c,AML
171#176#gene1050162#165#diseaseC0023467 23974200-8#171#176#gene1050 23974200-8#162#165#diseaseC0023467 associated_with CEBPA,AML

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T524 620-627 gene:407031 denotes miR-30c
T525 648-651 disease:C0023467 denotes AML
R1 T524 T525 associated_with miR-30c,AML
R2 T524 T525 associated_with miR-30c,AML

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 817-828 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 817-828 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow