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PubMed:23973224 JSONTXT

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Allie

Id Subject Object Predicate Lexical cue
SS1_23973224_1_0 134-144 expanded denotes tryptophan
SS2_23973224_1_0 146-149 abbr denotes Trp
SS1_23973224_3_0 618-646 expanded denotes an aryl hydrocarbon receptor
SS2_23973224_3_0 648-651 abbr denotes AhR
AE1_23973224_1_0 SS1_23973224_1_0 SS2_23973224_1_0 abbreviatedTo tryptophan,Trp
AE1_23973224_3_0 SS1_23973224_3_0 SS2_23973224_3_0 abbreviatedTo an aryl hydrocarbon receptor,AhR

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-122 Sentence denotes Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22.
T2 123-338 Sentence denotes Endogenous tryptophan (Trp) metabolites have an important role in mammalian gut immune homeostasis, yet the potential contribution of Trp metabolites from resident microbiota has never been addressed experimentally.
T3 339-456 Sentence denotes Here, we describe a metabolic pathway whereby Trp metabolites from the microbiota balance mucosal reactivity in mice.
T4 457-731 Sentence denotes Switching from sugar to Trp as an energy source (e.g., under conditions of unrestricted Trp availability), highly adaptive lactobacilli are expanded and produce an aryl hydrocarbon receptor (AhR) ligand-indole-3-aldehyde-that contributes to AhR-dependent Il22 transcription.
T5 732-948 Sentence denotes The resulting IL-22-dependent balanced mucosal response allows for survival of mixed microbial communities yet provides colonization resistance to the fungus Candida albicans and mucosal protection from inflammation.
T6 949-1122 Sentence denotes Thus, the microbiota-AhR axis might represent an important strategy pursued by coevolutive commensalism for fine tuning host mucosal reactivity contingent on Trp catabolism.
T1 0-122 Sentence denotes Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22.
T2 123-338 Sentence denotes Endogenous tryptophan (Trp) metabolites have an important role in mammalian gut immune homeostasis, yet the potential contribution of Trp metabolites from resident microbiota has never been addressed experimentally.
T3 339-456 Sentence denotes Here, we describe a metabolic pathway whereby Trp metabolites from the microbiota balance mucosal reactivity in mice.
T4 457-731 Sentence denotes Switching from sugar to Trp as an energy source (e.g., under conditions of unrestricted Trp availability), highly adaptive lactobacilli are expanded and produce an aryl hydrocarbon receptor (AhR) ligand-indole-3-aldehyde-that contributes to AhR-dependent Il22 transcription.
T5 732-948 Sentence denotes The resulting IL-22-dependent balanced mucosal response allows for survival of mixed microbial communities yet provides colonization resistance to the fungus Candida albicans and mucosal protection from inflammation.
T6 949-1122 Sentence denotes Thus, the microbiota-AhR axis might represent an important strategy pursued by coevolutive commensalism for fine tuning host mucosal reactivity contingent on Trp catabolism.