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c_corpus

Id Subject Object Predicate Lexical cue
T2 25-32 6308 denotes leucine
T3 25-32 SO:0001437 denotes leucine
T1 25-32 CHEBI:15603 denotes leucine
T4 25-32 D007930 denotes leucine
T5 25-32 CHEBI:25017 denotes leucine
T6 25-32 D007930 denotes leucine
T7 38-44 SO:0001068 denotes repeat
T8 55-60 PR:Q5S006 denotes LRRK2
T9 55-60 PR:000003033 denotes LRRK2
T10 55-60 PR:Q5S007 denotes LRRK2
T15 105-124 D010300 denotes Parkinson's disease
T16 105-124 D010300 denotes Parkinson's disease
T23 178-186 3628 denotes dopamine
T19 178-186 CHEBI:59905 denotes dopamine
T20 178-186 CHEBI:18243 denotes dopamine
T21 178-186 D004298 denotes dopamine
T22 178-186 D004298 denotes dopamine
T28 198-217 D010300 denotes Parkinson's disease
T29 198-217 D010300 denotes Parkinson's disease
T33 239-246 6308 denotes Leucine
T34 239-246 SO:0001437 denotes Leucine
T32 239-246 CHEBI:15603 denotes Leucine
T35 239-246 D007930 denotes Leucine
T36 239-246 CHEBI:25017 denotes Leucine
T37 239-246 D007930 denotes Leucine
T38 252-258 SO:0001068 denotes repeat
T39 269-274 PR:Q5S006 denotes LRRK2
T40 269-274 PR:000003033 denotes LRRK2
T41 269-274 PR:Q5S007 denotes LRRK2
T42 313-317 SO:0000704 denotes gene
T43 326-331 PR:Q5S006 denotes LRRK2
T44 326-331 PR:000003033 denotes LRRK2
T45 326-331 PR:Q5S007 denotes LRRK2
T47 427-432 PR:Q5S006 denotes LRRK2
T48 427-432 PR:000003033 denotes LRRK2
T49 427-432 PR:Q5S007 denotes LRRK2
T50 450-460 CHEBI:36976 denotes nucleotide
T51 546-552 SO:0001026 denotes genome
T52 579-584 PR:Q5S006 denotes LRRK2
T53 579-584 PR:000003033 denotes LRRK2
T54 579-584 PR:Q5S007 denotes LRRK2
T58 613-620 PR:000000001 denotes protein
T56 613-620 CHEBI:36080 denotes protein
T57 613-620 CHEBI:11122 denotes protein
T59 613-620 SO:0000104 denotes protein
T55 613-620 GO:0003675 denotes protein
T63 640-647 PR:000000001 denotes protein
T64 640-647 SO:0000104 denotes protein
T60 640-647 GO:0003675 denotes protein
T65 640-654 D011494 denotes protein kinase
T66 698-715 CL:0000700 denotes dopaminergic cell
T67 740-745 D006801 denotes human
T68 746-751 PR:Q5S006 denotes LRRK2
T69 746-751 PR:000003033 denotes LRRK2
T70 746-751 PR:Q5S007 denotes LRRK2
T71 752-761 SO:0000817 denotes wild-type
T72 765-770 D006801 denotes human
T73 771-776 PR:Q5S006 denotes LRRK2
T74 771-776 PR:000003033 denotes LRRK2
T75 771-776 PR:Q5S007 denotes LRRK2
T76 814-819 PR:Q5S006 denotes LRRK2
T77 814-819 PR:000003033 denotes LRRK2
T78 814-819 PR:Q5S007 denotes LRRK2
T82 893-900 PR:000000001 denotes protein
T80 893-900 CHEBI:36080 denotes protein
T81 893-900 CHEBI:11122 denotes protein
T83 893-900 SO:0000104 denotes protein
T79 893-900 GO:0003675 denotes protein
T84 939-944 PR:Q5S006 denotes LRRK2
T85 939-944 PR:000003033 denotes LRRK2
T86 939-944 PR:Q5S007 denotes LRRK2
T87 945-949 SO:0000704 denotes gene
T88 945-960 GO:0010467 denotes gene expression
T89 991-995 SO:0000704 denotes gene
T90 1087-1094 GO:0043005 denotes neurite
T91 1087-1104 GO:1990138 denotes neurite extension
T92 1095-1104 UBERON:2000106 denotes extension
T94 1124-1139 GO:0016310 denotes phosphorylation
T95 1226-1231 PR:Q5S006 denotes LRRK2
T96 1226-1231 PR:000003033 denotes LRRK2
T97 1226-1231 PR:Q5S007 denotes LRRK2
T98 1311-1330 CHEBI:24432 denotes biological function
T99 1334-1339 PR:Q5S006 denotes LRRK2
T100 1334-1339 PR:000003033 denotes LRRK2
T101 1334-1339 PR:Q5S007 denotes LRRK2
T102 1374-1378 CHEBI:23888 denotes drug
T104 1428-1445 SO:0002031 denotes small hairpin RNA
T103 1428-1445 D034741 denotes small hairpin RNA
T107 1442-1445 GO:0005562 denotes RNA
T109 1455-1460 PR:Q5S006 denotes LRRK2
T110 1455-1460 PR:000003033 denotes LRRK2
T111 1455-1460 PR:Q5S007 denotes LRRK2
T112 1468-1472 SO:0000704 denotes gene
T113 1531-1536 PR:Q5S006 denotes LRRK2
T114 1531-1536 PR:000003033 denotes LRRK2
T115 1531-1536 PR:Q5S007 denotes LRRK2
T116 1537-1553 GO:0033673 denotes kinase inhibitor
T117 1544-1553 CHEBI:35222 denotes inhibitor
T118 1561-1565 CVCL_W473 denotes IN-1
T119 1577-1582 PR:Q5S006 denotes LRRK2
T120 1577-1582 PR:000003033 denotes LRRK2
T121 1577-1582 PR:Q5S007 denotes LRRK2
T122 1597-1612 GO:0016310 denotes phosphorylation
T123 1620-1623 PR:Q9D9V2 denotes MN9
T124 1669-1679 D016086 denotes Lentivirus
T125 1701-1706 PR:Q5S006 denotes LRRK2
T126 1701-1706 PR:000003033 denotes LRRK2
T127 1701-1706 PR:Q5S007 denotes LRRK2
T128 1714-1720 SO:0001023 denotes allele
T130 1730-1747 SO:0002031 denotes small hairpin RNA
T129 1730-1747 D034741 denotes small hairpin RNA
T133 1744-1747 GO:0005562 denotes RNA
T135 1773-1780 GO:0043005 denotes neurite
T136 1773-1790 GO:1990138 denotes neurite extension
T137 1781-1790 UBERON:2000106 denotes extension
T138 1801-1806 PR:Q5S006 denotes LRRK2
T139 1801-1806 PR:000003033 denotes LRRK2
T140 1801-1806 PR:Q5S007 denotes LRRK2
T141 1862-1867 PR:Q5S006 denotes LRRK2
T142 1862-1867 PR:000003033 denotes LRRK2
T143 1862-1867 PR:Q5S007 denotes LRRK2
T144 1892-1900 CHEBI:33893 denotes reagents
T145 1892-1900 D007202 denotes reagents
T146 1905-1910 PR:Q5S006 denotes LRRK2
T147 1905-1910 PR:000003033 denotes LRRK2
T148 1905-1910 PR:Q5S007 denotes LRRK2
T149 1962-1967 PR:Q5S006 denotes LRRK2
T150 1962-1967 PR:000003033 denotes LRRK2
T151 1962-1967 PR:Q5S007 denotes LRRK2

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 198-207 HP_0001300 denotes Parkinson

Allie

Id Subject Object Predicate Lexical cue
SS1_23963789_0_0 25-53 expanded denotes leucine-rich repeat kinase 2
SS2_23963789_0_0 55-60 abbr denotes LRRK2
SS1_23963789_1_0 198-217 expanded denotes Parkinson's disease
SS2_23963789_1_0 219-221 abbr denotes PD
SS1_23963789_2_0 239-267 expanded denotes Leucine-rich repeat kinase 2
SS2_23963789_2_0 269-274 abbr denotes LRRK2
AE1_23963789_0_0 SS1_23963789_0_0 SS2_23963789_0_0 abbreviatedTo leucine-rich repeat kinase 2,LRRK2
AE1_23963789_1_0 SS1_23963789_1_0 SS2_23963789_1_0 abbreviatedTo Parkinson's disease,PD
AE1_23963789_2_0 SS1_23963789_2_0 SS2_23963789_2_0 abbreviatedTo Leucine-rich repeat kinase 2,LRRK2

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 126-238 DRI_Challenge denotes The pathogenic mechanism(s) contributing to loss of dopamine neurons in Parkinson's disease (PD) remain obscure.
T2 239-325 DRI_Approach denotes Leucine-rich repeat kinase 2 (LRRK2) mutations are linked, as a causative gene, to PD.
T3 326-426 DRI_Approach denotes LRRK2 mutations are estimated to account for 10% of familial and between 1 % and 3 % of sporadic PD.
T4 427-578 DRI_Approach denotes LRRK2 proximate single nucleotide polymorphisms have also been significantly associated with idiopathic/sporadic PD by genome-wide association studies.
T5 579-668 DRI_Background denotes LRRK2 is a multidomain-containing protein and belongs to the protein kinase super-family.
T6 669-793 DRI_Approach denotes We constructed two inducible dopaminergic cell lines expressing either human-LRRK2-wild-type or human-LRRK2-mutant (G2019S).
T7 794-961 DRI_Background denotes Phenotypes of these LRRK2 cell lines were examined with respect to cell viability, morphology, and protein function with or without induction of LRRK2 gene expression.
T8 962-1157 DRI_Background denotes The overexpression of G2019S gene promoted (1) low cellular metabolic activity without affecting cell viability, (2) blunted neurite extension, and (3) increased phosphorylation at S910 and S935.
T9 1158-1266 DRI_Approach denotes Our observations are consistent with reported general phenotypes in LRRK2 cell lines by other investigators.
T10 1267-1441 DRI_Approach denotes We used these cell lines to interrogate the biological function of LRRK2, to evaluate their potential as a drug-screening tool, and to investigate screening for small hairpin
T11 1468-1519 DRI_Approach denotes gene knockdown as a potential therapeutic strategy.
T12 1520-1576 DRI_Approach denotes A proposed LRRK2 kinase inhibitor (i.e., IN-1) decreased
T13 1588-1668 DRI_Approach denotes and S935 phosphorylation in our MN9DLRRK2 cell lines in a dose-dependent manner.
T14 1669-1700 DRI_Outcome denotes Lentivirus-mediated transfer of
T15 1730-1800 DRI_Outcome denotes small hairpin RNA reversed the blunting of neurite extension caused by
T16 1814-1829 DRI_Outcome denotes overexpression.
T17 1830-1981 DRI_Approach denotes Taken together, these inducible LRRK2 cell lines are suitable reagents for LRRK2 functional studies, and the screening of potential LRRK2 therapeutics.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23963789-0#25#53#gene120892 25-53 gene120892 denotes leucine-rich repeat kinase 2
23963789-0#55#60#gene120892 55-60 gene120892 denotes LRRK2
23963789-0#105#124#diseaseC0030567 105-124 diseaseC0030567 denotes Parkinson's disease
25#53#gene120892105#124#diseaseC0030567 23963789-0#25#53#gene120892 23963789-0#105#124#diseaseC0030567 associated_with leucine-rich repeat kinase 2,Parkinson's disease
55#60#gene120892105#124#diseaseC0030567 23963789-0#55#60#gene120892 23963789-0#105#124#diseaseC0030567 associated_with LRRK2,Parkinson's disease