PubMed:23941739 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23941739","sourcedb":"PubMed","sourceid":"23941739","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23941739","text":"Three-month treatment with adaptive servoventilation improves cardiac function and physical activity in patients with chronic heart failure and cheyne-stokes respiration: a prospective randomized controlled trial.\nBACKGROUND: Cheyne-Stokes respiration frequently occurs in patients with congestive heart failure (CHF). Adaptive servoventilation (ASV) is a novel therapy with potential benefits. This prospective randomized trial investigated the effects of ASV on myocardial function and physical capacity.\nMETHODS: Patients with severe CHF, despite optimal cardiac medication and/or left ventricular ejection fraction (LVEF) ≤40% and Cheyne-Stokes breathing for \u003e25% of sleeping time were included. Fifty-one patients, age 57-81 years (4 were women), were randomized to either an ASV or a control group; 30 patients completed the study (15 from each group). The primary end point was any change in LVEF. The secondary end points were alterations in physical capacity according to the 6-min walk test or the New York Heart Association (NYHA) class.\nRESULTS: In the ASV-treatment group, LVEF improved from baseline (32 ± 11%) to study end (36 ± 13%), p = 0.013. The 6-min walk test improved from 377 ± 115 to 430 ± 123 m (p = 0.014) and the NYHA class from 3.2 (3.0-3.0) to 2.0 (2.0-3.0) (p \u003c 0.001). No changes occurred in the control group.\nCONCLUSION: Three months of ASV treatment improved LVEF and physical capacity in CHF patients with Cheyne-Stokes respiration. These results suggest that ASV may be a beneficial supplement to standard medication in these patients.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_23941739_2_0","span":{"begin":287,"end":311},"obj":"expanded"},{"id":"SS2_23941739_2_0","span":{"begin":313,"end":316},"obj":"abbr"},{"id":"SS1_23941739_3_0","span":{"begin":319,"end":344},"obj":"expanded"},{"id":"SS2_23941739_3_0","span":{"begin":346,"end":349},"obj":"abbr"},{"id":"SS1_23941739_6_0","span":{"begin":584,"end":618},"obj":"expanded"},{"id":"SS2_23941739_6_0","span":{"begin":620,"end":624},"obj":"abbr"},{"id":"SS1_23941739_9_0","span":{"begin":1008,"end":1034},"obj":"expanded"},{"id":"SS2_23941739_9_0","span":{"begin":1036,"end":1040},"obj":"abbr"}],"relations":[{"id":"AE1_23941739_2_0","pred":"abbreviatedTo","subj":"SS1_23941739_2_0","obj":"SS2_23941739_2_0"},{"id":"AE1_23941739_3_0","pred":"abbreviatedTo","subj":"SS1_23941739_3_0","obj":"SS2_23941739_3_0"},{"id":"AE1_23941739_6_0","pred":"abbreviatedTo","subj":"SS1_23941739_6_0","obj":"SS2_23941739_6_0"},{"id":"AE1_23941739_9_0","pred":"abbreviatedTo","subj":"SS1_23941739_9_0","obj":"SS2_23941739_9_0"}],"attributes":[{"subj":"SS1_23941739_2_0","pred":"source","obj":"Allie"},{"subj":"SS2_23941739_2_0","pred":"source","obj":"Allie"},{"subj":"SS1_23941739_3_0","pred":"source","obj":"Allie"},{"subj":"SS2_23941739_3_0","pred":"source","obj":"Allie"},{"subj":"SS1_23941739_6_0","pred":"source","obj":"Allie"},{"subj":"SS2_23941739_6_0","pred":"source","obj":"Allie"},{"subj":"SS1_23941739_9_0","pred":"source","obj":"Allie"},{"subj":"SS2_23941739_9_0","pred":"source","obj":"Allie"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":226,"end":251},"obj":"HP_0012196"},{"id":"T2","span":{"begin":287,"end":311},"obj":"HP_0001635"},{"id":"T3","span":{"begin":298,"end":311},"obj":"HP_0001635"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"}]},{"project":"Zierdiyeerkenaili_800_3","denotations":[{"id":"T1","span":{"begin":313,"end":316},"obj":"DP"},{"id":"T2","span":{"begin":537,"end":540},"obj":"DP"},{"id":"T3","span":{"begin":1423,"end":1426},"obj":"DP"},{"id":"T4","span":{"begin":287,"end":311},"obj":"DP"},{"id":"T7","span":{"begin":118,"end":139},"obj":"DP"}],"attributes":[{"subj":"T1","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T2","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T3","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T4","pred":"source","obj":"Zierdiyeerkenaili_800_3"},{"subj":"T7","pred":"source","obj":"Zierdiyeerkenaili_800_3"}]},{"project":"yaoziqian_800_3","denotations":[{"id":"T3","span":{"begin":313,"end":316},"obj":"DP"},{"id":"T4","span":{"begin":537,"end":540},"obj":"DP"},{"id":"T5","span":{"begin":1423,"end":1426},"obj":"DP"},{"id":"T6","span":{"begin":118,"end":139},"obj":"DP"},{"id":"T7","span":{"begin":287,"end":311},"obj":"DP"}],"attributes":[{"subj":"T3","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T4","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T5","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T6","pred":"source","obj":"yaoziqian_800_3"},{"subj":"T7","pred":"source","obj":"yaoziqian_800_3"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#9398ec","default":true},{"id":"PubmedHPO","color":"#b2ec93"},{"id":"Zierdiyeerkenaili_800_3","color":"#ec93cc"},{"id":"yaoziqian_800_3","color":"#93e6ec"}]}]}}