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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-105 Sentence denotes A randomized controlled trial to prevent post-operative atrial fibrillation by antioxidant reinforcement.
T2 106-117 Sentence denotes OBJECTIVES:
T3 118-336 Sentence denotes This study was designed to assess whether the reinforcement of the antioxidant system, through n-3 fatty acids plus antioxidant vitamin supplementation, could reduce the incidence of post-operative atrial fibrillation.
T4 337-348 Sentence denotes BACKGROUND:
T5 349-422 Sentence denotes Therapy to prevent post-operative atrial fibrillation remains suboptimal.
T6 423-567 Sentence denotes Although oxidative stress plays a key role in the pathogenesis of this arrhythmia, antioxidant reinforcement has produced controversial results.
T7 568-576 Sentence denotes METHODS:
T8 577-836 Sentence denotes A total of 203 patients scheduled for on-pump cardiac surgery were randomized to placebo or supplementation with n-3 polyunsaturated fatty acids (2 g/day) (eicosapentaenoic acid:docosahexaenoic acid ratio 1:2), vitamin C (1 g/day), and vitamin E (400 IU/day).
T9 837-914 Sentence denotes The primary outcome was the occurrence of post-operative atrial fibrillation.
T10 915-999 Sentence denotes Secondary outcomes were the biomarkers related to oxidative stress and inflammation.
T11 1000-1008 Sentence denotes RESULTS:
T12 1009-1173 Sentence denotes Post-operative atrial fibrillation occurred in 10 of 103 patients (9.7%) in the supplemented group versus 32 of 100 patients (32%) in the placebo group (p < 0.001).
T13 1174-1358 Sentence denotes Early after surgery, placebo patients presented with increased levels of biomarkers of inflammation and oxidative stress, which were markedly attenuated by antioxidant supplementation.
T14 1359-1561 Sentence denotes The activity of catalase, superoxide dismutase, and glutathione peroxidase in atrial tissue of the supplemented patients was 24.0%, 17.1%, and 19.7% higher than the respective placebo values (p < 0.05).
T15 1562-1771 Sentence denotes The atrial tissue of patients who developed atrial fibrillation showed NADPH oxidase p47-phox subunit protein and mRNA expression 38.4% and 35.7% higher, respectively, than patients in sinus rhythm (p < 0.05).
T16 1772-1784 Sentence denotes CONCLUSIONS:
T17 1785-2107 Sentence denotes This safe, well-tolerated, and low-cost regimen, consisting of n-3 polyunsaturated fatty acids plus vitamins C and E supplementation, favorably affected post-operative atrial fibrillation, increased antioxidant potential, and attenuated oxidative stress and inflammation. (Prevention of Post-Operative Atrial Fibrillation:
T18 2108-2249 Sentence denotes Pathophysiological Characterization of a Pharmacological Intervention Based on a Novel Model of Nonhypoxic Pre-Conditioning; ISRCTN45347268).
T1 0-105 Sentence denotes A randomized controlled trial to prevent post-operative atrial fibrillation by antioxidant reinforcement.
T2 106-117 Sentence denotes OBJECTIVES:
T3 118-336 Sentence denotes This study was designed to assess whether the reinforcement of the antioxidant system, through n-3 fatty acids plus antioxidant vitamin supplementation, could reduce the incidence of post-operative atrial fibrillation.
T4 337-348 Sentence denotes BACKGROUND:
T5 349-422 Sentence denotes Therapy to prevent post-operative atrial fibrillation remains suboptimal.
T6 423-567 Sentence denotes Although oxidative stress plays a key role in the pathogenesis of this arrhythmia, antioxidant reinforcement has produced controversial results.
T7 568-576 Sentence denotes METHODS:
T8 577-836 Sentence denotes A total of 203 patients scheduled for on-pump cardiac surgery were randomized to placebo or supplementation with n-3 polyunsaturated fatty acids (2 g/day) (eicosapentaenoic acid:docosahexaenoic acid ratio 1:2), vitamin C (1 g/day), and vitamin E (400 IU/day).
T9 837-914 Sentence denotes The primary outcome was the occurrence of post-operative atrial fibrillation.
T10 915-999 Sentence denotes Secondary outcomes were the biomarkers related to oxidative stress and inflammation.
T11 1000-1008 Sentence denotes RESULTS:
T12 1009-1173 Sentence denotes Post-operative atrial fibrillation occurred in 10 of 103 patients (9.7%) in the supplemented group versus 32 of 100 patients (32%) in the placebo group (p < 0.001).
T13 1174-1358 Sentence denotes Early after surgery, placebo patients presented with increased levels of biomarkers of inflammation and oxidative stress, which were markedly attenuated by antioxidant supplementation.
T14 1359-1561 Sentence denotes The activity of catalase, superoxide dismutase, and glutathione peroxidase in atrial tissue of the supplemented patients was 24.0%, 17.1%, and 19.7% higher than the respective placebo values (p < 0.05).
T15 1562-1771 Sentence denotes The atrial tissue of patients who developed atrial fibrillation showed NADPH oxidase p47-phox subunit protein and mRNA expression 38.4% and 35.7% higher, respectively, than patients in sinus rhythm (p < 0.05).
T16 1772-1784 Sentence denotes CONCLUSIONS:
T17 1785-2107 Sentence denotes This safe, well-tolerated, and low-cost regimen, consisting of n-3 polyunsaturated fatty acids plus vitamins C and E supplementation, favorably affected post-operative atrial fibrillation, increased antioxidant potential, and attenuated oxidative stress and inflammation. (Prevention of Post-Operative Atrial Fibrillation:
T18 2108-2249 Sentence denotes Pathophysiological Characterization of a Pharmacological Intervention Based on a Novel Model of Nonhypoxic Pre-Conditioning; ISRCTN45347268).

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 316-335 HP_0005110 denotes atrial fibrillation