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PubMed:23913163 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-78 Sentence denotes Inhibition of cell adhesion by a cadherin-11 antibody thwarts bone metastasis.
TextSentencer_T2 79-90 Sentence denotes UNLABELLED:
TextSentencer_T3 91-211 Sentence denotes Cadherin-11 (CDH11) is a member of the cadherin superfamily mainly expressed in osteoblasts but not in epithelial cells.
TextSentencer_T4 212-349 Sentence denotes However, prostate cancer cells with a propensity for bone metastasis express high levels of cadherin-11 and reduced levels of E-cadherin.
TextSentencer_T5 350-529 Sentence denotes Downregulation of cadherin-11 inhibits interaction of prostate cancer cells with osteoblasts in vitro and homing of prostate cancer cells to bone in an animal model of metastasis.
TextSentencer_T6 530-625 Sentence denotes These findings indicate that targeting cadherin-11 may prevent prostate cancer bone metastasis.
TextSentencer_T7 626-764 Sentence denotes To explore this possibility, a panel of 21 monoclonal antibodies (mAb) was generated against the extracellular (EC) domain of cadherin-11.
TextSentencer_T8 765-904 Sentence denotes Two antibodies, mAbs 2C7 and 1A5, inhibited cadherin-11-mediated cell-cell aggregation in vitro using L-cells transfected with cadherin-11.
TextSentencer_T9 905-1055 Sentence denotes Both antibodies demonstrated specificity to cadherin-11, and neither antibody recognized E-cadherin or N-cadherin on C4-2B or PC3 cells, respectively.
TextSentencer_T10 1056-1189 Sentence denotes Furthermore, mAb 2C7 inhibited cadherin-11-mediated aggregation between the highly metastatic PC3-mm2 cells and MC3T3-E1 osteoblasts.
TextSentencer_T11 1190-1384 Sentence denotes Mechanistically, a series of deletion mutants revealed a unique motif, aa 343-348, in the cadherin-11 EC3 domain that is recognized by mAb 2C7 and that this motif coordinated cell-cell adhesion.
TextSentencer_T12 1385-1534 Sentence denotes Importantly, administration of mAb 2C7 in a prophylactic setting effectively prevented metastasis of PC3-mm2 cells to bone in an in vivo mouse model.
TextSentencer_T13 1535-1691 Sentence denotes These results show that targeting the extracellular domain of cadherin-11 can limit cellular adhesion and metastatic dissemination of prostate cancer cells.
TextSentencer_T14 1692-1705 Sentence denotes IMPLICATIONS:
TextSentencer_T15 1706-1806 Sentence denotes Monotherapy using a cadherin-11 antibody is a suitable option for the prevention of bone metastases.
T1 0-78 Sentence denotes Inhibition of cell adhesion by a cadherin-11 antibody thwarts bone metastasis.
T2 79-90 Sentence denotes UNLABELLED:
T3 91-211 Sentence denotes Cadherin-11 (CDH11) is a member of the cadherin superfamily mainly expressed in osteoblasts but not in epithelial cells.
T4 212-349 Sentence denotes However, prostate cancer cells with a propensity for bone metastasis express high levels of cadherin-11 and reduced levels of E-cadherin.
T5 350-529 Sentence denotes Downregulation of cadherin-11 inhibits interaction of prostate cancer cells with osteoblasts in vitro and homing of prostate cancer cells to bone in an animal model of metastasis.
T6 530-625 Sentence denotes These findings indicate that targeting cadherin-11 may prevent prostate cancer bone metastasis.
T7 626-764 Sentence denotes To explore this possibility, a panel of 21 monoclonal antibodies (mAb) was generated against the extracellular (EC) domain of cadherin-11.
T8 765-904 Sentence denotes Two antibodies, mAbs 2C7 and 1A5, inhibited cadherin-11-mediated cell-cell aggregation in vitro using L-cells transfected with cadherin-11.
T9 905-1055 Sentence denotes Both antibodies demonstrated specificity to cadherin-11, and neither antibody recognized E-cadherin or N-cadherin on C4-2B or PC3 cells, respectively.
T10 1056-1189 Sentence denotes Furthermore, mAb 2C7 inhibited cadherin-11-mediated aggregation between the highly metastatic PC3-mm2 cells and MC3T3-E1 osteoblasts.
T11 1190-1384 Sentence denotes Mechanistically, a series of deletion mutants revealed a unique motif, aa 343-348, in the cadherin-11 EC3 domain that is recognized by mAb 2C7 and that this motif coordinated cell-cell adhesion.
T12 1385-1534 Sentence denotes Importantly, administration of mAb 2C7 in a prophylactic setting effectively prevented metastasis of PC3-mm2 cells to bone in an in vivo mouse model.
T13 1535-1691 Sentence denotes These results show that targeting the extracellular domain of cadherin-11 can limit cellular adhesion and metastatic dissemination of prostate cancer cells.
T14 1692-1705 Sentence denotes IMPLICATIONS:
T15 1706-1806 Sentence denotes Monotherapy using a cadherin-11 antibody is a suitable option for the prevention of bone metastases.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1726-1737 gene:1009 denotes cadherin-11
T1 1790-1805 disease:C0153690 denotes bone metastases
R1 T0 T1 associated_with cadherin-11,bone metastases

Allie

Id Subject Object Predicate Lexical cue
SS1_23913163_2_0 91-102 expanded denotes Cadherin-11
SS2_23913163_2_0 104-109 abbr denotes CDH11
SS1_23913163_6_0 669-690 expanded denotes monoclonal antibodies
SS2_23913163_6_0 692-695 abbr denotes mAb
SS1_23913163_6_1 723-736 expanded denotes extracellular
SS2_23913163_6_1 738-740 abbr denotes EC
AE1_23913163_2_0 SS1_23913163_2_0 SS2_23913163_2_0 abbreviatedTo Cadherin-11,CDH11
AE1_23913163_6_0 SS1_23913163_6_0 SS2_23913163_6_0 abbreviatedTo monoclonal antibodies,mAb
AE1_23913163_6_1 SS1_23913163_6_1 SS2_23913163_6_1 abbreviatedTo extracellular,EC

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 171-182 HP_0011846 denotes osteoblasts
T2 221-236 HP_0012125 denotes prostate cancer
T3 230-236 HP_0002664 denotes cancer
T4 404-419 HP_0012125 denotes prostate cancer
T5 413-419 HP_0002664 denotes cancer
T6 431-442 HP_0011846 denotes osteoblasts
T7 466-481 HP_0012125 denotes prostate cancer
T8 475-481 HP_0002664 denotes cancer
T9 593-608 HP_0012125 denotes prostate cancer
T10 602-608 HP_0002664 denotes cancer
T11 1177-1188 HP_0011846 denotes osteoblasts
T12 1669-1684 HP_0012125 denotes prostate cancer
T13 1678-1684 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23913163-0#33#44#gene1009 33-44 gene1009 denotes cadherin-11
23913163-0#62#77#diseaseC0153690 62-77 diseaseC0153690 denotes bone metastasis
23913163-11#62#73#gene1009 1597-1608 gene1009 denotes cadherin-11
23913163-11#134#149#diseaseC0376358 1669-1684 diseaseC0376358 denotes prostate cancer
23913163-11#134#149#diseaseC0600139 1669-1684 diseaseC0600139 denotes prostate cancer
23913163-3#18#29#gene1009 368-379 gene1009 denotes cadherin-11
23913163-3#168#178#diseaseC0027627 518-528 diseaseC0027627 denotes metastasis
33#44#gene100962#77#diseaseC0153690 23913163-0#33#44#gene1009 23913163-0#62#77#diseaseC0153690 associated_with cadherin-11,bone metastasis
62#73#gene1009134#149#diseaseC0376358 23913163-11#62#73#gene1009 23913163-11#134#149#diseaseC0376358 associated_with cadherin-11,prostate cancer
62#73#gene1009134#149#diseaseC0600139 23913163-11#62#73#gene1009 23913163-11#134#149#diseaseC0600139 associated_with cadherin-11,prostate cancer
18#29#gene1009168#178#diseaseC0027627 23913163-3#18#29#gene1009 23913163-3#168#178#diseaseC0027627 associated_with cadherin-11,metastasis

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T790 368-379 gene:1009 denotes cadherin-11
T791 518-528 disease:C0027627 denotes metastasis
R1 T790 T791 associated_with cadherin-11,metastasis