PubMed:23883891 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23883891","sourcedb":"PubMed","sourceid":"23883891","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23883891","text":"Daily electronic self-monitoring of subjective and objective symptoms in bipolar disorder--the MONARCA trial protocol (MONitoring, treAtment and pRediCtion of bipolAr disorder episodes): a randomised controlled single-blind trial.\nINTRODUCTION: Electronic self-monitoring of affective symptoms using cell phones is suggested as a practical and inexpensive way to monitor illness activity and identify early signs of affective symptoms. It has never been tested in a randomised clinical trial whether electronic self-monitoring improves outcomes in bipolar disorder. We are conducting a trial testing the effect of using a Smartphone for self-monitoring in bipolar disorder.\nMETHODS: We developed the MONARCA application for Android-based Smartphones, allowing patients suffering from bipolar disorder to do daily self-monitoring-including an interactive feedback loop between patients and clinicians through a web-based interface. The effect of the application was tested in a parallel-group, single-blind randomised controlled trial so far including 78 patients suffering from bipolar disorder in the age group 18-60 years who were given the use of a Smartphone with the MONARCA application (intervention group) or to the use of a cell phone without the application (placebo group) during a 6-month study period. The study was carried out from September 2011. The outcomes were changes in affective symptoms (primary), social functioning, perceived stress, self-rated depressive and manic symptoms, quality of life, adherence to medication, stress and cognitive functioning (secondary and tertiary).\nANALYSIS: Recruitment is ongoing.\nETHICS: Ethical permission has been obtained.\nDISSEMINATION: Positive, neutral and negative findings of the study will be published.\nREGISTRATION DETAILS: The trial is approved by the Regional Ethics Committee in The Capital Region of Denmark (H-2-2011-056) and The Danish Data Protection Agency (2013-41-1710). The trial is registered at ClinicalTrials.gov as NCT01446406.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":548,"end":564},"obj":"HP_0007302"},{"id":"T2","span":{"begin":656,"end":672},"obj":"HP_0007302"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"}]},{"project":"luoyt2021_800_3","denotations":[{"id":"T1","span":{"begin":73,"end":89},"obj":"DP"},{"id":"T2","span":{"begin":1078,"end":1094},"obj":"DP"},{"id":"T3","span":{"begin":784,"end":800},"obj":"DP"},{"id":"T4","span":{"begin":656,"end":672},"obj":"DP"},{"id":"T5","span":{"begin":548,"end":564},"obj":"DP"},{"id":"T6","span":{"begin":159,"end":175},"obj":"DP"}],"attributes":[{"subj":"T1","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T2","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T3","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T4","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T5","pred":"source","obj":"luoyt2021_800_3"},{"subj":"T6","pred":"source","obj":"luoyt2021_800_3"}]},{"project":"Linmchun_800_3","denotations":[{"id":"T1","span":{"begin":73,"end":89},"obj":"DP"},{"id":"T2","span":{"begin":784,"end":800},"obj":"DP"},{"id":"T3","span":{"begin":159,"end":175},"obj":"DP"},{"id":"T4","span":{"begin":548,"end":564},"obj":"DP"},{"id":"T5","span":{"begin":656,"end":672},"obj":"DP"},{"id":"T6","span":{"begin":1078,"end":1094},"obj":"DP"}],"attributes":[{"subj":"T1","pred":"source","obj":"Linmchun_800_3"},{"subj":"T2","pred":"source","obj":"Linmchun_800_3"},{"subj":"T3","pred":"source","obj":"Linmchun_800_3"},{"subj":"T4","pred":"source","obj":"Linmchun_800_3"},{"subj":"T5","pred":"source","obj":"Linmchun_800_3"},{"subj":"T6","pred":"source","obj":"Linmchun_800_3"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#db93ec","default":true},{"id":"luoyt2021_800_3","color":"#93ecc1"},{"id":"Linmchun_800_3","color":"#eca793"}]}]}}