PubMed:23867612 JSONTXT

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    PubMed_ArguminSci

    {"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":123,"end":253},"obj":"DRI_Approach"},{"id":"T2","span":{"begin":254,"end":425},"obj":"DRI_Outcome"},{"id":"T3","span":{"begin":426,"end":665},"obj":"DRI_Background"},{"id":"T4","span":{"begin":666,"end":809},"obj":"DRI_Outcome"}],"text":"Interleukin-10 prevents epithelial cell apoptosis by regulating IFNγ and TNFα expression in rhesus macaque colon explants.\nInterleukin-10 (IL-10) is an important immunomodulatory cytokine that plays an obligate role in regulating inflammatory responses. Here we demonstrated the role of IL-10 in regulating crypts length and breadth as well as maintaining the survival of epithelial cells using rhesus colon explant cultures. Anti-IL-10 antibody treatment of colon explant cultures induced increased production of inflammatory cytokines/molecules like IFNγ, TNFα, CD107a and perforin as well as increased epithelial cell apoptosis compared to media controls tested. Our results suggest that IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNγ and TNFα cytokine production."}

    Goldhamster2_Cellosaurus

    {"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T1","span":{"begin":149,"end":151},"obj":"CVCL_8754|Cancer_cell_line|Homo sapiens"},{"id":"T2","span":{"begin":149,"end":151},"obj":"CVCL_H241|Cancer_cell_line|Homo sapiens"},{"id":"T3","span":{"begin":199,"end":201},"obj":"CVCL_8754|Cancer_cell_line|Homo sapiens"},{"id":"T4","span":{"begin":199,"end":201},"obj":"CVCL_H241|Cancer_cell_line|Homo sapiens"},{"id":"T5","span":{"begin":259,"end":261},"obj":"CVCL_5M23|Cancer_cell_line|Mesocricetus auratus"},{"id":"T6","span":{"begin":703,"end":704},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"}],"text":"Interleukin-10 prevents epithelial cell apoptosis by regulating IFNγ and TNFα expression in rhesus macaque colon explants.\nInterleukin-10 (IL-10) is an important immunomodulatory cytokine that plays an obligate role in regulating inflammatory responses. Here we demonstrated the role of IL-10 in regulating crypts length and breadth as well as maintaining the survival of epithelial cells using rhesus colon explant cultures. Anti-IL-10 antibody treatment of colon explant cultures induced increased production of inflammatory cytokines/molecules like IFNγ, TNFα, CD107a and perforin as well as increased epithelial cell apoptosis compared to media controls tested. Our results suggest that IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNγ and TNFα cytokine production."}

    GoldHamster

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prevents epithelial cell apoptosis by regulating IFNγ and TNFα expression in rhesus macaque colon explants.\nInterleukin-10 (IL-10) is an important immunomodulatory cytokine that plays an obligate role in regulating inflammatory responses. Here we demonstrated the role of IL-10 in regulating crypts length and breadth as well as maintaining the survival of epithelial cells using rhesus colon explant cultures. Anti-IL-10 antibody treatment of colon explant cultures induced increased production of inflammatory cytokines/molecules like IFNγ, TNFα, CD107a and perforin as well as increased epithelial cell apoptosis compared to media controls tested. Our results suggest that IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNγ and TNFα cytokine production."}

    Allie

    {"project":"Allie","denotations":[{"id":"SS1_23867612_1_0","span":{"begin":123,"end":137},"obj":"expanded"},{"id":"SS2_23867612_1_0","span":{"begin":139,"end":144},"obj":"abbr"}],"relations":[{"id":"AE1_23867612_1_0","pred":"abbreviatedTo","subj":"SS1_23867612_1_0","obj":"SS2_23867612_1_0"}],"text":"Interleukin-10 prevents epithelial cell apoptosis by regulating IFNγ and TNFα expression in rhesus macaque colon explants.\nInterleukin-10 (IL-10) is an important immunomodulatory cytokine that plays an obligate role in regulating inflammatory responses. Here we demonstrated the role of IL-10 in regulating crypts length and breadth as well as maintaining the survival of epithelial cells using rhesus colon explant cultures. Anti-IL-10 antibody treatment of colon explant cultures induced increased production of inflammatory cytokines/molecules like IFNγ, TNFα, CD107a and perforin as well as increased epithelial cell apoptosis compared to media controls tested. Our results suggest that IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNγ and TNFα cytokine production."}