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Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 302-307 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-104 Sentence denotes Tumor cell migration and invasion are enhanced by depletion of Rap1 GTPase-activating protein (Rap1GAP).
TextSentencer_T2 105-277 Sentence denotes The functional significance of the widespread down-regulation of Rap1 GTPase-activating protein (Rap1GAP), a negative regulator of Rap activity, in human tumors is unknown.
TextSentencer_T3 278-408 Sentence denotes Here we show that human colon cancer cells depleted of Rap1GAP are endowed with more aggressive migratory and invasive properties.
TextSentencer_T4 409-480 Sentence denotes Silencing Rap1GAP enhanced the migration of confluent and single cells.
TextSentencer_T5 481-560 Sentence denotes In the latter, migration distance, velocity, and directionality were increased.
TextSentencer_T6 561-725 Sentence denotes Enhanced migration was a consequence of increased endogenous Rap activity as silencing Rap expression selectively abolished the migration of Rap1GAP-depleted cells.
TextSentencer_T7 726-879 Sentence denotes ROCK-mediated cell contractility was suppressed in Rap1GAP-depleted cells, which exhibited a spindle-shaped morphology and abundant membrane protrusions.
TextSentencer_T8 880-998 Sentence denotes Tumor cells can switch between Rho/ROCK-mediated contractility-based migration and Rac1-mediated mesenchymal motility.
TextSentencer_T9 999-1152 Sentence denotes Strikingly, the migration of Rap1GAP-depleted, but not control cells required Rac1 activity, suggesting that loss of Rap1GAP alters migratory mechanisms.
TextSentencer_T10 1153-1332 Sentence denotes Inhibition of Rac1 activity restored membrane blebbing and increased ROCK activity in Rap1GAP-depleted cells, suggesting that Rac1 contributes to the suppression of contractility.
TextSentencer_T11 1333-1556 Sentence denotes Collectively, these findings identify Rap1GAP as a critical regulator of aggressive tumor cell behavior and suggest that the level of Rap1GAP expression influences the migratory mechanisms that are operative in tumor cells.
T1 0-104 Sentence denotes Tumor cell migration and invasion are enhanced by depletion of Rap1 GTPase-activating protein (Rap1GAP).
T2 105-277 Sentence denotes The functional significance of the widespread down-regulation of Rap1 GTPase-activating protein (Rap1GAP), a negative regulator of Rap activity, in human tumors is unknown.
T3 278-408 Sentence denotes Here we show that human colon cancer cells depleted of Rap1GAP are endowed with more aggressive migratory and invasive properties.
T4 409-480 Sentence denotes Silencing Rap1GAP enhanced the migration of confluent and single cells.
T5 481-560 Sentence denotes In the latter, migration distance, velocity, and directionality were increased.
T6 561-725 Sentence denotes Enhanced migration was a consequence of increased endogenous Rap activity as silencing Rap expression selectively abolished the migration of Rap1GAP-depleted cells.
T7 726-879 Sentence denotes ROCK-mediated cell contractility was suppressed in Rap1GAP-depleted cells, which exhibited a spindle-shaped morphology and abundant membrane protrusions.
T8 880-998 Sentence denotes Tumor cells can switch between Rho/ROCK-mediated contractility-based migration and Rac1-mediated mesenchymal motility.
T9 999-1152 Sentence denotes Strikingly, the migration of Rap1GAP-depleted, but not control cells required Rac1 activity, suggesting that loss of Rap1GAP alters migratory mechanisms.
T10 1153-1332 Sentence denotes Inhibition of Rac1 activity restored membrane blebbing and increased ROCK activity in Rap1GAP-depleted cells, suggesting that Rac1 contributes to the suppression of contractility.
T11 1333-1556 Sentence denotes Collectively, these findings identify Rap1GAP as a critical regulator of aggressive tumor cell behavior and suggest that the level of Rap1GAP expression influences the migratory mechanisms that are operative in tumor cells.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 333-340 gene:5909 denotes Rap1GAP
T1 302-314 disease:C0007102 denotes colon cancer
T2 333-340 gene:5909 denotes Rap1GAP
T3 302-314 disease:C0699790 denotes colon cancer
R1 T0 T1 associated_with Rap1GAP,colon cancer
R2 T2 T3 associated_with Rap1GAP,colon cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_23864657_0_0 63-93 expanded denotes Rap1 GTPase-activating protein
SS2_23864657_0_0 95-102 abbr denotes Rap1GAP
SS1_23864657_1_0 170-200 expanded denotes Rap1 GTPase-activating protein
SS2_23864657_1_0 202-209 abbr denotes Rap1GAP
AE1_23864657_0_0 SS1_23864657_0_0 SS2_23864657_0_0 abbreviatedTo Rap1 GTPase-activating protein,Rap1GAP
AE1_23864657_1_0 SS1_23864657_1_0 SS2_23864657_1_0 abbreviatedTo Rap1 GTPase-activating protein,Rap1GAP

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 259-265 HP_0002664 denotes tumors
T2 302-314 HP_0003003 denotes colon cancer
T3 302-314 HP_0100273 denotes colon cancer
T4 308-314 HP_0002664 denotes cancer
T5 363-373 HP_0000718 denotes aggressive
T6 745-758 HP_0001371 denotes contractility
T7 880-885 HP_0002664 denotes Tumor
T8 929-942 HP_0001371 denotes contractility
T9 1318-1331 HP_0001371 denotes contractility
T10 1406-1416 HP_0000718 denotes aggressive
T11 1417-1422 HP_0002664 denotes tumor
T12 1544-1549 HP_0002664 denotes tumor

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23864657-0#63#93#gene5909 63-93 gene5909 denotes Rap1 GTPase-activating protein
23864657-0#95#102#gene5909 95-102 gene5909 denotes Rap1GAP
23864657-0#0#20#diseaseC0027627 0-20 diseaseC0027627 denotes Tumor cell migration
23864657-2#55#62#gene5909 333-340 gene5909 denotes Rap1GAP
23864657-2#24#36#diseaseC0007102 302-314 diseaseC0007102 denotes colon cancer
23864657-2#24#36#diseaseC0699790 302-314 diseaseC0699790 denotes colon cancer
63#93#gene59090#20#diseaseC0027627 23864657-0#63#93#gene5909 23864657-0#0#20#diseaseC0027627 associated_with Rap1 GTPase-activating protein,Tumor cell migration
95#102#gene59090#20#diseaseC0027627 23864657-0#95#102#gene5909 23864657-0#0#20#diseaseC0027627 associated_with Rap1GAP,Tumor cell migration
55#62#gene590924#36#diseaseC0007102 23864657-2#55#62#gene5909 23864657-2#24#36#diseaseC0007102 associated_with Rap1GAP,colon cancer
55#62#gene590924#36#diseaseC0699790 23864657-2#55#62#gene5909 23864657-2#24#36#diseaseC0699790 associated_with Rap1GAP,colon cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T543 333-340 gene:5909 denotes Rap1GAP
T544 302-314 disease:C0007102 denotes colon cancer
R1 T543 T544 associated_with Rap1GAP,colon cancer
R2 T543 T544 associated_with Rap1GAP,colon cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 302-307 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T2 977-988 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 977-988 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T2 302-307 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 0-5 Disease denotes Tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 259-265 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T3 302-314 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T4 880-885 Disease denotes Tumor http://purl.obolibrary.org/obo/MONDO_0005070
T5 1417-1422 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T6 1544-1549 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 253-258 OrganismTaxon denotes human 9606
T2 296-301 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 302-307 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T2 858-866 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T5 867-878 Body_part denotes protrusions http://purl.obolibrary.org/obo/UBERON_0004529
T6 1190-1198 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 302-307 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 0-5 Phenotype denotes Tumor HP:0002664
T2 302-314 Phenotype denotes colon cancer HP:0003003
T3 363-373 Phenotype denotes aggressive HP:0000718
T4 880-885 Phenotype denotes Tumor HP:0002664
T5 1406-1416 Phenotype denotes aggressive HP:0000718
T6 1417-1422 Phenotype denotes tumor HP:0002664
T7 1544-1549 Phenotype denotes tumor HP:0002664

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 0-10 Cell denotes Tumor cell http://purl.obolibrary.org/obo/CL:0001063
T2 308-320 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T3 880-891 Cell denotes Tumor cells http://purl.obolibrary.org/obo/CL:0001063
T4 1417-1427 Cell denotes tumor cell http://purl.obolibrary.org/obo/CL:0001063
T5 1544-1555 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063