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PubMed:23864035 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-143 Sentence denotes Bortezomib and dexamethasone as salvage therapy in patients with relapsed/refractory multiple myeloma: analysis of long-term clinical outcomes.
T2 144-258 Sentence denotes Bortezomib (bort)-dexamethasone (dex) is an effective therapy for relapsed/refractory (R/R) multiple myeloma (MM).
T3 259-552 Sentence denotes This retrospective study investigated the combination of bort (1.3 mg/m(2) on days 1, 4, 8, and 11 every 3 weeks) and dex (20 mg on the day of and the day after bort) as salvage treatment in 85 patients with R/R MM after prior autologous stem cell transplantation or conventional chemotherapy.
T4 553-603 Sentence denotes The median number of prior lines of therapy was 2.
T5 604-726 Sentence denotes Eighty-seven percent of the patients had received immunomodulatory drugs included in some line of therapy before bort-dex.
T6 727-800 Sentence denotes The median number of bort-dex cycles was 6, up to a maximum of 12 cycles.
T7 801-962 Sentence denotes On an intention-to-treat basis, 55 % of the patients achieved at least partial response, including 19 % CR and 35 % achieved at least very good partial response.
T8 963-1085 Sentence denotes Median durations of response, time to next therapy and treatment-free interval were 8, 11.2, and 5.1 months, respectively.
T9 1086-1262 Sentence denotes The most relevant adverse event was peripheral neuropathy, which occurred in 78 % of the patients (grade II, 38 %; grade III, 21 %) and led to treatment discontinuation in 6 %.
T10 1263-1430 Sentence denotes With a median follow up of 22 months, median time to progression, progression-free survival (PFS) and overall survival (OS) were 8.9, 8.7, and 22 months, respectively.
T11 1431-1545 Sentence denotes Prolonged PFS and OS were observed in patients achieving CR and receiving bort-dex a single line of prior therapy.
T12 1546-1647 Sentence denotes Bort-dex was an effective salvage treatment for MM patients, particularly for those in first relapse.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
9271 0-10 ChemicalEntity denotes Bortezomib MESH:D000069286
9272 15-28 ChemicalEntity denotes dexamethasone MESH:D003907
9273 51-59 OrganismTaxon denotes patients NCBITaxon:9606
9274 85-101 DiseaseOrPhenotypicFeature denotes multiple myeloma MESH:D009101
9275 144-154 ChemicalEntity denotes Bortezomib MESH:D000069286
9276 156-160 ChemicalEntity denotes bort MESH:D000069286
9277 162-175 ChemicalEntity denotes dexamethasone MESH:D003907
9278 177-180 ChemicalEntity denotes dex MESH:D003907
9279 236-252 DiseaseOrPhenotypicFeature denotes multiple myeloma MESH:D009101
9280 254-256 DiseaseOrPhenotypicFeature denotes MM MESH:D009101
9281 316-320 ChemicalEntity denotes bort MESH:D000069286
9282 377-380 ChemicalEntity denotes dex MESH:D003907
9283 420-424 ChemicalEntity denotes bort MESH:D000069286
9284 453-461 OrganismTaxon denotes patients NCBITaxon:9606
9285 471-473 DiseaseOrPhenotypicFeature denotes MM MESH:D009101
9286 632-640 OrganismTaxon denotes patients NCBITaxon:9606
9287 717-721 ChemicalEntity denotes bort MESH:D000069286
9288 722-725 ChemicalEntity denotes dex MESH:D003907
9289 748-752 ChemicalEntity denotes bort MESH:D000069286
9290 753-756 ChemicalEntity denotes dex MESH:D003907
9291 845-853 OrganismTaxon denotes patients NCBITaxon:9606
9292 1122-1143 DiseaseOrPhenotypicFeature denotes peripheral neuropathy MESH:D010523
9293 1175-1183 OrganismTaxon denotes patients NCBITaxon:9606
9294 1469-1477 OrganismTaxon denotes patients NCBITaxon:9606
9295 1505-1509 ChemicalEntity denotes bort MESH:D000069286
9296 1510-1513 ChemicalEntity denotes dex MESH:D003907
9297 1546-1550 ChemicalEntity denotes Bort MESH:D000069286
9298 1551-1554 ChemicalEntity denotes dex MESH:D003907
9299 1594-1596 DiseaseOrPhenotypicFeature denotes MM MESH:D009101
9300 1597-1605 OrganismTaxon denotes patients NCBITaxon:9606

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 1122-1143 DiseaseOrPhenotypicFeature denotes peripheral neuropathy 0005244

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 85-93 GeneOrGeneProduct denotes multiple
T2 115-119 GeneOrGeneProduct denotes long
T3 120-124 GeneOrGeneProduct denotes term
T4 236-244 GeneOrGeneProduct denotes multiple
T5 326-328 GeneOrGeneProduct denotes mg
T6 385-387 GeneOrGeneProduct denotes mg
T7 502-506 GeneOrGeneProduct denotes cell
T8 580-585 GeneOrGeneProduct denotes lines
T9 597-602 GeneOrGeneProduct denotes was 2
T10 694-698 GeneOrGeneProduct denotes line
T11 757-763 GeneOrGeneProduct denotes cycles
T12 793-799 GeneOrGeneProduct denotes cycles
T13 826-831 GeneOrGeneProduct denotes basis
T14 905-907 GeneOrGeneProduct denotes CR
T15 993-997 GeneOrGeneProduct denotes time
T16 1191-1193 GeneOrGeneProduct denotes II
T17 1207-1210 GeneOrGeneProduct denotes III
T18 1255-1259 GeneOrGeneProduct denotes in 6
T19 1308-1312 GeneOrGeneProduct denotes time
T20 1488-1490 GeneOrGeneProduct denotes CR
T21 1510-1515 GeneOrGeneProduct denotes dex a
T22 1523-1527 GeneOrGeneProduct denotes line

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 85-93 GeneOrGeneProduct denotes multiple
T2 120-124 GeneOrGeneProduct denotes term
T3 236-244 GeneOrGeneProduct denotes multiple
T4 502-506 GeneOrGeneProduct denotes cell
T5 580-585 GeneOrGeneProduct denotes lines

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 51-59 OrganismTaxon denotes patients
T2 453-461 OrganismTaxon denotes patients
T3 632-640 OrganismTaxon denotes patients
T4 845-853 OrganismTaxon denotes patients
T5 1175-1183 OrganismTaxon denotes patients
T6 1469-1477 OrganismTaxon denotes patients
T7 1597-1605 OrganismTaxon denotes patients

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 65-73 DiseaseOrPhenotypicFeature denotes relapsed D012008
T2 85-101 DiseaseOrPhenotypicFeature denotes multiple myeloma D009101
T3 210-218 DiseaseOrPhenotypicFeature denotes relapsed D012008
T4 236-252 DiseaseOrPhenotypicFeature denotes multiple myeloma D009101
T5 254-256 DiseaseOrPhenotypicFeature denotes MM D009101
T6 471-473 DiseaseOrPhenotypicFeature denotes MM D009101
T7 1122-1143 DiseaseOrPhenotypicFeature denotes peripheral neuropathy D010523
T8 1594-1596 DiseaseOrPhenotypicFeature denotes MM D009101
T9 1639-1646 DiseaseOrPhenotypicFeature denotes relapse D012008

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 85-101 DiseaseOrPhenotypicFeature denotes multiple myeloma 0009693
T2 236-252 DiseaseOrPhenotypicFeature denotes multiple myeloma 0009693
T3 254-256 DiseaseOrPhenotypicFeature denotes MM 0009685|0009693
T5 471-473 DiseaseOrPhenotypicFeature denotes MM 0009685|0009693
T7 1122-1143 DiseaseOrPhenotypicFeature denotes peripheral neuropathy 0005244
T8 1594-1596 DiseaseOrPhenotypicFeature denotes MM 0009685|0009693

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 85-101 DiseaseOrPhenotypicFeature denotes multiple myeloma D009101
T2 236-252 DiseaseOrPhenotypicFeature denotes multiple myeloma D009101
T3 254-256 DiseaseOrPhenotypicFeature denotes MM D009101
T4 471-473 DiseaseOrPhenotypicFeature denotes MM D009101
T5 1122-1143 DiseaseOrPhenotypicFeature denotes peripheral neuropathy D010523
T6 1594-1596 DiseaseOrPhenotypicFeature denotes MM D009101
T7 1639-1646 DiseaseOrPhenotypicFeature denotes relapse D012008

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 85-101 DiseaseOrPhenotypicFeature denotes multiple myeloma D009101
T2 236-252 DiseaseOrPhenotypicFeature denotes multiple myeloma D009101
T3 254-256 DiseaseOrPhenotypicFeature denotes MM D009101
T4 471-473 DiseaseOrPhenotypicFeature denotes MM D009101
T5 1122-1143 DiseaseOrPhenotypicFeature denotes peripheral neuropathy D010523
T6 1594-1596 DiseaseOrPhenotypicFeature denotes MM D009101

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 0-10 ChemicalEntity denotes Bortezomib D000069286|http://purl.obolibrary.org/obo/CHEBI_52717
T3 15-28 ChemicalEntity denotes dexamethasone D003907|http://purl.obolibrary.org/obo/CHEBI_41879
T5 144-154 ChemicalEntity denotes Bortezomib D000069286|http://purl.obolibrary.org/obo/CHEBI_52717
T7 156-160 ChemicalEntity denotes bort D000069286
T8 162-175 ChemicalEntity denotes dexamethasone D003907|http://purl.obolibrary.org/obo/CHEBI_41879
T10 177-180 ChemicalEntity denotes dex D003907
T11 316-320 ChemicalEntity denotes bort D000069286
T12 377-380 ChemicalEntity denotes dex D003907
T13 420-424 ChemicalEntity denotes bort D000069286
T14 717-721 ChemicalEntity denotes bort D000069286
T15 722-725 ChemicalEntity denotes dex D003907
T16 748-752 ChemicalEntity denotes bort D000069286
T17 753-756 ChemicalEntity denotes dex D003907
T18 1505-1509 ChemicalEntity denotes bort D000069286
T19 1510-1513 ChemicalEntity denotes dex D003907
T20 1546-1550 ChemicalEntity denotes Bort ChemicalEntity
T21 1551-1554 ChemicalEntity denotes dex D003907

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T21 1551-1554 ChemicalEntity denotes dex D003907
T20 1546-1550 ChemicalEntity denotes Bort ChemicalEntity
T19 1510-1513 ChemicalEntity denotes dex D003907
T18 1505-1509 ChemicalEntity denotes bort D000069286
T17 753-756 ChemicalEntity denotes dex D003907
T16 748-752 ChemicalEntity denotes bort D000069286
T15 722-725 ChemicalEntity denotes dex D003907
T14 717-721 ChemicalEntity denotes bort D000069286
T13 420-424 ChemicalEntity denotes bort D000069286
T12 377-380 ChemicalEntity denotes dex D003907
T11 316-320 ChemicalEntity denotes bort D000069286
T10 177-180 ChemicalEntity denotes dex D003907
T8 162-175 ChemicalEntity denotes dexamethasone http://purl.obolibrary.org/obo/CHEBI_41879|D003907
T7 156-160 ChemicalEntity denotes bort D000069286
T5 144-154 ChemicalEntity denotes Bortezomib http://purl.obolibrary.org/obo/CHEBI_52717|D000069286
T3 15-28 ChemicalEntity denotes dexamethasone http://purl.obolibrary.org/obo/CHEBI_41879|D003907
T1 0-10 ChemicalEntity denotes Bortezomib http://purl.obolibrary.org/obo/CHEBI_52717|D000069286
T6 1594-1596 DiseaseOrPhenotypicFeature denotes MM D009101
T28322 1122-1143 DiseaseOrPhenotypicFeature denotes peripheral neuropathy D010523
T4 471-473 DiseaseOrPhenotypicFeature denotes MM D009101
T88534 254-256 DiseaseOrPhenotypicFeature denotes MM D009101
T2 236-252 DiseaseOrPhenotypicFeature denotes multiple myeloma D009101
T90871 85-101 DiseaseOrPhenotypicFeature denotes multiple myeloma D009101
T70487 1597-1605 OrganismTaxon denotes patients
T55052 1469-1477 OrganismTaxon denotes patients
T49309 1175-1183 OrganismTaxon denotes patients
T53467 845-853 OrganismTaxon denotes patients
T64013 632-640 OrganismTaxon denotes patients
T25039 453-461 OrganismTaxon denotes patients
T70919 51-59 OrganismTaxon denotes patients

Allie

Id Subject Object Predicate Lexical cue
SS1_23864035_1_0 144-154 expanded denotes Bortezomib
SS2_23864035_1_0 156-160 abbr denotes bort
SS1_23864035_1_1 236-252 expanded denotes multiple myeloma
SS2_23864035_1_1 254-256 abbr denotes MM
SS1_23864035_1_2 210-229 expanded denotes relapsed/refractory
SS2_23864035_1_2 231-234 abbr denotes R/R
SS1_23864035_9_0 1329-1354 expanded denotes progression-free survival
SS2_23864035_9_0 1356-1359 abbr denotes PFS
SS1_23864035_9_1 1365-1381 expanded denotes overall survival
SS2_23864035_9_1 1383-1385 abbr denotes OS
AE1_23864035_1_0 SS1_23864035_1_0 SS2_23864035_1_0 abbreviatedTo Bortezomib,bort
AE1_23864035_1_1 SS1_23864035_1_1 SS2_23864035_1_1 abbreviatedTo multiple myeloma,MM
AE1_23864035_1_2 SS1_23864035_1_2 SS2_23864035_1_2 abbreviatedTo relapsed/refractory,R/R
AE1_23864035_9_0 SS1_23864035_9_0 SS2_23864035_9_0 abbreviatedTo progression-free survival,PFS
AE1_23864035_9_1 SS1_23864035_9_1 SS2_23864035_9_1 abbreviatedTo overall survival,OS

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 236-252 HP_0006775 denotes multiple myeloma
T2 1122-1143 HP_0009830 denotes peripheral neuropathy