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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-158 Sentence denotes Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition.
T2 159-322 Sentence denotes Alzheimer's disease (AD) is characterized by amyloid-β deposition in amyloid plaques, neurofibrillary tangles, inflammation, neuronal loss, and cognitive deficits.
T3 323-418 Sentence denotes Cannabinoids display neuromodulatory and neuroprotective effects and affect memory acquisition.
T4 419-647 Sentence denotes Here, we studied the impact of cannabinoid receptor type 1 (CB1) deficiency on the development of AD pathology by breeding amyloid precursor protein (APP) Swedish mutant mice (APP23), an AD animal model, with CB1-deficient mice.
T5 648-796 Sentence denotes In addition to the lower body weight of APP23/CB1(-/-) mice, most of these mice died at an age before typical AD-associated changes become apparent.
T6 797-983 Sentence denotes The surviving mice showed a reduced amount of APP and its fragments suggesting a regulatory influence of CB1 on APP processing, which was confirmed by modulating CB1 expression in vitro.
T7 984-1090 Sentence denotes Reduced APP levels were accompanied by a reduced plaque load and less inflammation in APP23/CB1(-/-) mice.
T8 1091-1213 Sentence denotes Nevertheless, compared to APP23 mice with an intact CB1, APP23/CB1(-/-) mice showed impaired learning and memory deficits.
T9 1214-1343 Sentence denotes These data argue against a direct correlation of amyloid plaque load with cognitive abilities in this AD mouse model lacking CB1.
T10 1344-1502 Sentence denotes Furthermore, the findings indicate that CB1 deficiency can worsen AD-related cognitive deficits and support a potential role of CB1 as a pharmacologic target.
T1 0-158 Sentence denotes Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition.
T2 159-322 Sentence denotes Alzheimer's disease (AD) is characterized by amyloid-β deposition in amyloid plaques, neurofibrillary tangles, inflammation, neuronal loss, and cognitive deficits.
T3 323-418 Sentence denotes Cannabinoids display neuromodulatory and neuroprotective effects and affect memory acquisition.
T4 419-647 Sentence denotes Here, we studied the impact of cannabinoid receptor type 1 (CB1) deficiency on the development of AD pathology by breeding amyloid precursor protein (APP) Swedish mutant mice (APP23), an AD animal model, with CB1-deficient mice.
T5 648-796 Sentence denotes In addition to the lower body weight of APP23/CB1(-/-) mice, most of these mice died at an age before typical AD-associated changes become apparent.
T6 797-983 Sentence denotes The surviving mice showed a reduced amount of APP and its fragments suggesting a regulatory influence of CB1 on APP processing, which was confirmed by modulating CB1 expression in vitro.
T7 984-1090 Sentence denotes Reduced APP levels were accompanied by a reduced plaque load and less inflammation in APP23/CB1(-/-) mice.
T8 1091-1213 Sentence denotes Nevertheless, compared to APP23 mice with an intact CB1, APP23/CB1(-/-) mice showed impaired learning and memory deficits.
T9 1214-1343 Sentence denotes These data argue against a direct correlation of amyloid plaque load with cognitive abilities in this AD mouse model lacking CB1.
T10 1344-1502 Sentence denotes Furthermore, the findings indicate that CB1 deficiency can worsen AD-related cognitive deficits and support a potential role of CB1 as a pharmacologic target.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 159-178 HP_0002511 denotes Alzheimer's disease
T2 204-211 HP_0011034 denotes amyloid
T3 228-235 HP_0011034 denotes amyloid
T4 245-268 HP_0002185 denotes neurofibrillary tangles
T5 284-297 HP_0002529 denotes neuronal loss
T6 303-321 HP_0100543 denotes cognitive deficits
T7 542-549 HP_0011034 denotes amyloid
T8 1175-1203 HP_0002354 denotes impaired learning and memory
T9 1263-1270 HP_0011034 denotes amyloid
T10 1421-1439 HP_0100543 denotes cognitive deficits

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-22 gene:1268 denotes Cannabinoid receptor 1
T1 92-112 disease:C0338656 denotes cognitive impairment
R1 T0 T1 associated_with Cannabinoid receptor 1,cognitive impairment

Allie

Id Subject Object Predicate Lexical cue
SS1_23838176_1_0 159-178 expanded denotes Alzheimer's disease
SS2_23838176_1_0 180-182 abbr denotes AD
SS1_23838176_3_0 450-477 expanded denotes cannabinoid receptor type 1
SS2_23838176_3_0 479-482 abbr denotes CB1
SS1_23838176_3_1 542-567 expanded denotes amyloid precursor protein
SS2_23838176_3_1 569-572 abbr denotes APP
AE1_23838176_1_0 SS1_23838176_1_0 SS2_23838176_1_0 abbreviatedTo Alzheimer's disease,AD
AE1_23838176_3_0 SS1_23838176_3_0 SS2_23838176_3_0 abbreviatedTo cannabinoid receptor type 1,CB1
AE1_23838176_3_1 SS1_23838176_3_1 SS2_23838176_3_1 abbreviatedTo amyloid precursor protein,APP

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23838176-0#0#22#gene1268 0-22 gene1268 denotes Cannabinoid receptor 1
23838176-0#54#73#diseaseC0002395 54-73 diseaseC0002395 denotes Alzheimer's disease
23838176-0#92#112#diseaseC0338656 92-112 diseaseC0338656 denotes cognitive impairment
23838176-0#139#146#diseaseC0002726 139-146 diseaseC0002726 denotes amyloid
23838176-3#123#148#gene351 542-567 gene351 denotes amyloid precursor protein
23838176-3#150#153#gene351 569-572 gene351 denotes APP
23838176-3#187#189#diseaseC0002395 606-608 diseaseC0002395 denotes AD
23838176-3#98#100#diseaseC0002395 517-519 diseaseC0002395 denotes AD
23838176-3#187#189#diseaseC0002395 606-608 diseaseC0002395 denotes AD
0#22#gene126854#73#diseaseC0002395 23838176-0#0#22#gene1268 23838176-0#54#73#diseaseC0002395 associated_with Cannabinoid receptor 1,Alzheimer's disease
0#22#gene126892#112#diseaseC0338656 23838176-0#0#22#gene1268 23838176-0#92#112#diseaseC0338656 associated_with Cannabinoid receptor 1,cognitive impairment
0#22#gene1268139#146#diseaseC0002726 23838176-0#0#22#gene1268 23838176-0#139#146#diseaseC0002726 associated_with Cannabinoid receptor 1,amyloid
123#148#gene351187#189#diseaseC0002395 23838176-3#123#148#gene351 23838176-3#187#189#diseaseC0002395 associated_with amyloid precursor protein,AD
123#148#gene35198#100#diseaseC0002395 23838176-3#123#148#gene351 23838176-3#98#100#diseaseC0002395 associated_with amyloid precursor protein,AD
123#148#gene351187#189#diseaseC0002395 23838176-3#123#148#gene351 23838176-3#187#189#diseaseC0002395 associated_with amyloid precursor protein,AD
150#153#gene351187#189#diseaseC0002395 23838176-3#150#153#gene351 23838176-3#187#189#diseaseC0002395 associated_with APP,AD
150#153#gene35198#100#diseaseC0002395 23838176-3#150#153#gene351 23838176-3#98#100#diseaseC0002395 associated_with APP,AD
150#153#gene351187#189#diseaseC0002395 23838176-3#150#153#gene351 23838176-3#187#189#diseaseC0002395 associated_with APP,AD