PubMed:23742188
Annnotations
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 176-182 | HP_0002099 | denotes | asthma |
| T2 | 187-196 | HP_0001369 | denotes | arthritis |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 240-255 | Glycan | denotes | sialyl Lewis(x) |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 147-168 | Disease | denotes | inflammatory diseases | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T2 | 176-182 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
| T3 | 187-196 | Disease | denotes | arthritis | http://purl.obolibrary.org/obo/MONDO_0005578 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 240-255 | Glycan | denotes | sialyl Lewis(x) | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 176-182 | Phenotype | denotes | asthma | HP:0002099 |
| T2 | 187-196 | Phenotype | denotes | arthritis | HP:0001369 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 147-168 | Disease | denotes | inflammatory diseases | MONDO:0021166 |
| T2 | 176-182 | Disease | denotes | asthma | MONDO:0004979 |
| T3 | 187-196 | Disease | denotes | arthritis | MONDO:0005578 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-88 | Sentence | denotes | Nanomolar E-selectin antagonists with prolonged half-lives by a fragment-based approach. |
| T2 | 89-198 | Sentence | denotes | Selectins, a family of C-type lectins, play a key role in inflammatory diseases (e.g., asthma and arthritis). |
| T3 | 199-447 | Sentence | denotes | However, the only millimolar affinity of sialyl Lewis(x) (sLe(x)), which is the common tetrasaccharide epitope of all physiological selectin ligands, has been a major obstacle to the development of selectin antagonists for therapeutic applications. |
| T4 | 448-578 | Sentence | denotes | In a fragment-based approach guided by NMR, ligands binding to a second site in close proximity to a sLe(x) mimic were identified. |
| T5 | 579-760 | Sentence | denotes | A library of antagonists obtained by connecting the sLe(x) mimic to the best second-site ligand via triazole linkers of different lengths was evaluated by surface plasmon resonance. |
| T6 | 761-880 | Sentence | denotes | Detailed analysis of the five most promising candidates revealed antagonists with K(D) values ranging from 30 to 89 nM. |
| T7 | 881-1071 | Sentence | denotes | In contrast to carbohydrate-lectin complexes with typical half-lives (t(1/2)) in the range of one second or even less, these fragment-based selectin antagonists show t1/2 of several minutes. |
| T8 | 1072-1165 | Sentence | denotes | They exhibit a promising starting point for the development of novel anti-inflammatory drugs. |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 240-255 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis(x) | http://www.glycoepitope.jp/epitopes/EP0012 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 534-543 | Body_part | denotes | proximity | http://purl.obolibrary.org/obo/MAT_0000491 |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 240-255 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis(x) | http://www.glycoepitope.jp/epitopes/EP0012 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 534-543 | Body_part | denotes | proximity | http://purl.obolibrary.org/obo/MAT_0000491 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 176-182 | Phenotype | denotes | asthma | HP:0002099 |
| T2 | 187-196 | Phenotype | denotes | arthritis | HP:0001369 |
| T3 | 257-260 | Phenotype | denotes | sLe | HP:0002725 |
| T4 | 549-552 | Phenotype | denotes | sLe | HP:0002725 |
| T5 | 631-634 | Phenotype | denotes | sLe | HP:0002725 |
GlyCosmos15-Lectin
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 10-20 | GL_002002 | denotes | E-selectin |
Lectin_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 10-20 | GL_002002 | denotes | E-selectin |