PubMed:23697610 JSONTXT

{"project":"Allie","denotations":[{"id":"SS1_23697610_2_0","span":{"begin":202,"end":225},"obj":"expanded"},{"id":"SS2_23697610_2_0","span":{"begin":227,"end":231},"obj":"abbr"},{"id":"SS1_23697610_10_0","span":{"begin":1104,"end":1123},"obj":"expanded"},{"id":"SS2_23697610_10_0","span":{"begin":1125,"end":1127},"obj":"abbr"}],"relations":[{"id":"AE1_23697610_2_0","pred":"abbreviatedTo","subj":"SS1_23697610_2_0","obj":"SS2_23697610_2_0"},{"id":"AE1_23697610_10_0","pred":"abbreviatedTo","subj":"SS1_23697610_10_0","obj":"SS2_23697610_10_0"}],"text":"Low-fat diet and skin cancer risk: the women's health initiative randomized controlled dietary modification trial.\nBACKGROUND: Large cohort studies have reported no relationship between dietary fat and nonmelanoma skin cancer (NMSC), although a low-fat diet intervention reduced NMSC risk in a small clinical trial. In animal studies, skin tumor development has been reduced by low-fat diet. We evaluated the effect of a low-fat dietary pattern on NMSC and melanoma in the Women's Health Initiative Dietary Modification trial.\nMETHODS: Postmenopausal women aged 50 to 79 years (n = 48,835) were randomly assigned to the low-fat dietary pattern intervention (n = 19,541) or comparison group (n = 29,294). The intervention goals included decreasing fat intake to 20% or less of calories, increasing vegetable and fruit intake, and increasing grain intake. Self-reported incident NMSC (n = 4,907) and physician-adjudicated incident melanoma (n = 279) were ascertained every 6 months.\nRESULTS: Over 8.1 years of follow-up, the low-fat diet intervention did not affect overall incidence of NMSC [HR 0.98; 95% confidence interval (CI), 0.92-1.04] or melanoma (HR, 1.04; 95% CI, 0.82-1.32). In subgroup analyses of melanoma risk, baseline fat intake interacted significantly with group assignment (Pinteraction = 0.006). Among women with higher baseline fat intake, the dietary intervention significantly increased risk (HR, 1.48; 95% CI, 1.06-2.07), whereas, among women with lower baseline fat intake, the intervention tended to reduce melanoma risk (HR, 0.72; 95% CI, 0.50-1.02).\nCONCLUSIONS: In this large randomized trial, a low-fat dietary pattern did not affect overall incidence of NMSC or melanoma.\nIMPACT: A low-fat diet does not reduce incidence of NMSC, but an interaction between baseline fat intake and dietary intervention on melanoma risk warrants further investigation."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":214,"end":225},"obj":"HP_0008069"},{"id":"T2","span":{"begin":219,"end":225},"obj":"HP_0002664"},{"id":"T3","span":{"begin":335,"end":345},"obj":"HP_0008069"},{"id":"T4","span":{"begin":340,"end":345},"obj":"HP_0002664"},{"id":"T5","span":{"begin":457,"end":465},"obj":"HP_0002861"}],"text":"Low-fat diet and skin cancer risk: the women's health initiative randomized controlled dietary modification trial.\nBACKGROUND: Large cohort studies have reported no relationship between dietary fat and nonmelanoma skin cancer (NMSC), although a low-fat diet intervention reduced NMSC risk in a small clinical trial. In animal studies, skin tumor development has been reduced by low-fat diet. We evaluated the effect of a low-fat dietary pattern on NMSC and melanoma in the Women's Health Initiative Dietary Modification trial.\nMETHODS: Postmenopausal women aged 50 to 79 years (n = 48,835) were randomly assigned to the low-fat dietary pattern intervention (n = 19,541) or comparison group (n = 29,294). The intervention goals included decreasing fat intake to 20% or less of calories, increasing vegetable and fruit intake, and increasing grain intake. Self-reported incident NMSC (n = 4,907) and physician-adjudicated incident melanoma (n = 279) were ascertained every 6 months.\nRESULTS: Over 8.1 years of follow-up, the low-fat diet intervention did not affect overall incidence of NMSC [HR 0.98; 95% confidence interval (CI), 0.92-1.04] or melanoma (HR, 1.04; 95% CI, 0.82-1.32). In subgroup analyses of melanoma risk, baseline fat intake interacted significantly with group assignment (Pinteraction = 0.006). Among women with higher baseline fat intake, the dietary intervention significantly increased risk (HR, 1.48; 95% CI, 1.06-2.07), whereas, among women with lower baseline fat intake, the intervention tended to reduce melanoma risk (HR, 0.72; 95% CI, 0.50-1.02).\nCONCLUSIONS: In this large randomized trial, a low-fat dietary pattern did not affect overall incidence of NMSC or melanoma.\nIMPACT: A low-fat diet does not reduce incidence of NMSC, but an interaction between baseline fat intake and dietary intervention on melanoma risk warrants further investigation."}

{"project":"luoyt2021_800_3","denotations":[{"id":"T1","span":{"begin":17,"end":28},"obj":"DP"},{"id":"T2","span":{"begin":202,"end":225},"obj":"DP"},{"id":"T3","span":{"begin":227,"end":231},"obj":"DP"},{"id":"T4","span":{"begin":1753,"end":1757},"obj":"DP"},{"id":"T5","span":{"begin":1683,"end":1687},"obj":"DP"},{"id":"T6","span":{"begin":1085,"end":1089},"obj":"DP"},{"id":"T7","span":{"begin":877,"end":881},"obj":"DP"},{"id":"T8","span":{"begin":448,"end":452},"obj":"DP"},{"id":"T9","span":{"begin":279,"end":283},"obj":"DP"}],"text":"Low-fat diet and skin cancer risk: the women's health initiative randomized controlled dietary modification trial.\nBACKGROUND: Large cohort studies have reported no relationship between dietary fat and nonmelanoma skin cancer (NMSC), although a low-fat diet intervention reduced NMSC risk in a small clinical trial. In animal studies, skin tumor development has been reduced by low-fat diet. We evaluated the effect of a low-fat dietary pattern on NMSC and melanoma in the Women's Health Initiative Dietary Modification trial.\nMETHODS: Postmenopausal women aged 50 to 79 years (n = 48,835) were randomly assigned to the low-fat dietary pattern intervention (n = 19,541) or comparison group (n = 29,294). The intervention goals included decreasing fat intake to 20% or less of calories, increasing vegetable and fruit intake, and increasing grain intake. Self-reported incident NMSC (n = 4,907) and physician-adjudicated incident melanoma (n = 279) were ascertained every 6 months.\nRESULTS: Over 8.1 years of follow-up, the low-fat diet intervention did not affect overall incidence of NMSC [HR 0.98; 95% confidence interval (CI), 0.92-1.04] or melanoma (HR, 1.04; 95% CI, 0.82-1.32). In subgroup analyses of melanoma risk, baseline fat intake interacted significantly with group assignment (Pinteraction = 0.006). Among women with higher baseline fat intake, the dietary intervention significantly increased risk (HR, 1.48; 95% CI, 1.06-2.07), whereas, among women with lower baseline fat intake, the intervention tended to reduce melanoma risk (HR, 0.72; 95% CI, 0.50-1.02).\nCONCLUSIONS: In this large randomized trial, a low-fat dietary pattern did not affect overall incidence of NMSC or melanoma.\nIMPACT: A low-fat diet does not reduce incidence of NMSC, but an interaction between baseline fat intake and dietary intervention on melanoma risk warrants further investigation."}

{"project":"Linmchun_800_3","denotations":[{"id":"T1","span":{"begin":227,"end":231},"obj":"DP"},{"id":"T2","span":{"begin":279,"end":283},"obj":"DP"},{"id":"T3","span":{"begin":448,"end":452},"obj":"DP"},{"id":"T4","span":{"begin":202,"end":225},"obj":"DP"},{"id":"T5","span":{"begin":877,"end":881},"obj":"DP"},{"id":"T6","span":{"begin":1085,"end":1089},"obj":"DP"},{"id":"T7","span":{"begin":1683,"end":1687},"obj":"DP"},{"id":"T8","span":{"begin":1753,"end":1757},"obj":"DP"},{"id":"T9","span":{"begin":17,"end":28},"obj":"DP"}],"text":"Low-fat diet and skin cancer risk: the women's health initiative randomized controlled dietary modification trial.\nBACKGROUND: Large cohort studies have reported no relationship between dietary fat and nonmelanoma skin cancer (NMSC), although a low-fat diet intervention reduced NMSC risk in a small clinical trial. In animal studies, skin tumor development has been reduced by low-fat diet. We evaluated the effect of a low-fat dietary pattern on NMSC and melanoma in the Women's Health Initiative Dietary Modification trial.\nMETHODS: Postmenopausal women aged 50 to 79 years (n = 48,835) were randomly assigned to the low-fat dietary pattern intervention (n = 19,541) or comparison group (n = 29,294). The intervention goals included decreasing fat intake to 20% or less of calories, increasing vegetable and fruit intake, and increasing grain intake. Self-reported incident NMSC (n = 4,907) and physician-adjudicated incident melanoma (n = 279) were ascertained every 6 months.\nRESULTS: Over 8.1 years of follow-up, the low-fat diet intervention did not affect overall incidence of NMSC [HR 0.98; 95% confidence interval (CI), 0.92-1.04] or melanoma (HR, 1.04; 95% CI, 0.82-1.32). In subgroup analyses of melanoma risk, baseline fat intake interacted significantly with group assignment (Pinteraction = 0.006). Among women with higher baseline fat intake, the dietary intervention significantly increased risk (HR, 1.48; 95% CI, 1.06-2.07), whereas, among women with lower baseline fat intake, the intervention tended to reduce melanoma risk (HR, 0.72; 95% CI, 0.50-1.02).\nCONCLUSIONS: In this large randomized trial, a low-fat dietary pattern did not affect overall incidence of NMSC or melanoma.\nIMPACT: A low-fat diet does not reduce incidence of NMSC, but an interaction between baseline fat intake and dietary intervention on melanoma risk warrants further investigation."}