PubMed:23687948 JSONTXT

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    sentences

    {"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":141},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":142,"end":152},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":153,"end":373},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":374,"end":397},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":398,"end":629},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":630,"end":740},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":741,"end":928},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":929,"end":937},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":938,"end":1044},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":1045,"end":1165},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":1166,"end":1391},"obj":"Sentence"},{"id":"TextSentencer_T12","span":{"begin":1392,"end":1404},"obj":"Sentence"},{"id":"TextSentencer_T13","span":{"begin":1405,"end":1571},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":141},"obj":"Sentence"},{"id":"T2","span":{"begin":142,"end":152},"obj":"Sentence"},{"id":"T3","span":{"begin":153,"end":373},"obj":"Sentence"},{"id":"T4","span":{"begin":374,"end":397},"obj":"Sentence"},{"id":"T5","span":{"begin":398,"end":629},"obj":"Sentence"},{"id":"T6","span":{"begin":630,"end":740},"obj":"Sentence"},{"id":"T7","span":{"begin":741,"end":928},"obj":"Sentence"},{"id":"T8","span":{"begin":929,"end":937},"obj":"Sentence"},{"id":"T9","span":{"begin":938,"end":1044},"obj":"Sentence"},{"id":"T10","span":{"begin":1045,"end":1165},"obj":"Sentence"},{"id":"T11","span":{"begin":1166,"end":1391},"obj":"Sentence"},{"id":"T12","span":{"begin":1392,"end":1404},"obj":"Sentence"},{"id":"T13","span":{"begin":1405,"end":1571},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Poor pregnancy outcome in women with type 1 diabetes is predicted by elevated HbA1c and spikes of high glucose values in the third trimester.\nOBJECTIVE: To analyse data from a randomised, controlled study of prandial insulin aspart versus human insulin, both with NPH insulin, in pregnant women with type 1 diabetes for potential factors predicting poor pregnancy outcomes. RESEARCH DESIGN/METHOD: Post hoc analysis including 91 subjects randomised prior to pregnancy with known outcome in early pregnancy and 259 subjects randomised prior to pregnancy/during pregnancy of \u003c10 weeks' gestation with known late-pregnancy outcomes. Poor early-pregnancy outcomes included fetal loss \u003c22 gestational weeks and/or congenital malformation (n=18). Poor late-pregnancy outcomes included: composite endpoint including pre-eclampsia, preterm delivery and perinatal death (n=78); preterm delivery (n=63); and excessive fetal growth (n=88).\nRESULTS: 18 patients experienced a malformed/lost fetus in early pregnancy - none preceded by severe hypoglycaemia. Albuminuria in early pregnancy was a significant predictor of poor late-pregnancy outcome (composite endpoint; p=0.012). In the third trimester, elevated HbA1c, ≥ 1 plasma glucose (PG) measurement \u003e11 mmol/L (198 mg/dL) and %PG values outside 3.9-7.0 mmol/L (70-126 mg/dL) were significant predictors of poor late-pregnancy outcomes (all p\u003c0.05).\nCONCLUSIONS: Elevated HbA1c, high glucose spikes and out-of-range %PG in the third trimester, and albuminuria in early pregnancy, are associated with poor late-pregnancy outcomes."}

    PubmedHPO

    {"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":809,"end":822},"obj":"HP_0100602"},{"id":"T2","span":{"begin":813,"end":822},"obj":"HP_0100601"},{"id":"T3","span":{"begin":824,"end":840},"obj":"HP_0001622"},{"id":"T4","span":{"begin":869,"end":885},"obj":"HP_0001622"}],"text":"Poor pregnancy outcome in women with type 1 diabetes is predicted by elevated HbA1c and spikes of high glucose values in the third trimester.\nOBJECTIVE: To analyse data from a randomised, controlled study of prandial insulin aspart versus human insulin, both with NPH insulin, in pregnant women with type 1 diabetes for potential factors predicting poor pregnancy outcomes. RESEARCH DESIGN/METHOD: Post hoc analysis including 91 subjects randomised prior to pregnancy with known outcome in early pregnancy and 259 subjects randomised prior to pregnancy/during pregnancy of \u003c10 weeks' gestation with known late-pregnancy outcomes. Poor early-pregnancy outcomes included fetal loss \u003c22 gestational weeks and/or congenital malformation (n=18). Poor late-pregnancy outcomes included: composite endpoint including pre-eclampsia, preterm delivery and perinatal death (n=78); preterm delivery (n=63); and excessive fetal growth (n=88).\nRESULTS: 18 patients experienced a malformed/lost fetus in early pregnancy - none preceded by severe hypoglycaemia. Albuminuria in early pregnancy was a significant predictor of poor late-pregnancy outcome (composite endpoint; p=0.012). In the third trimester, elevated HbA1c, ≥ 1 plasma glucose (PG) measurement \u003e11 mmol/L (198 mg/dL) and %PG values outside 3.9-7.0 mmol/L (70-126 mg/dL) were significant predictors of poor late-pregnancy outcomes (all p\u003c0.05).\nCONCLUSIONS: Elevated HbA1c, high glucose spikes and out-of-range %PG in the third trimester, and albuminuria in early pregnancy, are associated with poor late-pregnancy outcomes."}

    Allie

    {"project":"Allie","denotations":[{"id":"SS1_23687948_9_0","span":{"begin":1210,"end":1224},"obj":"expanded"},{"id":"SS2_23687948_9_0","span":{"begin":1226,"end":1228},"obj":"abbr"}],"relations":[{"id":"AE1_23687948_9_0","pred":"abbreviatedTo","subj":"SS1_23687948_9_0","obj":"SS2_23687948_9_0"}],"text":"Poor pregnancy outcome in women with type 1 diabetes is predicted by elevated HbA1c and spikes of high glucose values in the third trimester.\nOBJECTIVE: To analyse data from a randomised, controlled study of prandial insulin aspart versus human insulin, both with NPH insulin, in pregnant women with type 1 diabetes for potential factors predicting poor pregnancy outcomes. RESEARCH DESIGN/METHOD: Post hoc analysis including 91 subjects randomised prior to pregnancy with known outcome in early pregnancy and 259 subjects randomised prior to pregnancy/during pregnancy of \u003c10 weeks' gestation with known late-pregnancy outcomes. Poor early-pregnancy outcomes included fetal loss \u003c22 gestational weeks and/or congenital malformation (n=18). Poor late-pregnancy outcomes included: composite endpoint including pre-eclampsia, preterm delivery and perinatal death (n=78); preterm delivery (n=63); and excessive fetal growth (n=88).\nRESULTS: 18 patients experienced a malformed/lost fetus in early pregnancy - none preceded by severe hypoglycaemia. Albuminuria in early pregnancy was a significant predictor of poor late-pregnancy outcome (composite endpoint; p=0.012). In the third trimester, elevated HbA1c, ≥ 1 plasma glucose (PG) measurement \u003e11 mmol/L (198 mg/dL) and %PG values outside 3.9-7.0 mmol/L (70-126 mg/dL) were significant predictors of poor late-pregnancy outcomes (all p\u003c0.05).\nCONCLUSIONS: Elevated HbA1c, high glucose spikes and out-of-range %PG in the third trimester, and albuminuria in early pregnancy, are associated with poor late-pregnancy outcomes."}

    Preeclampsia

    {"project":"Preeclampsia","denotations":[{"id":"PD-Preeclampsia-B_T1","span":{"begin":809,"end":822},"obj":"ORPHA:275555"}],"namespaces":[{"prefix":"ORPHA","uri":"www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN\u0026Expert="}],"text":"Poor pregnancy outcome in women with type 1 diabetes is predicted by elevated HbA1c and spikes of high glucose values in the third trimester.\nOBJECTIVE: To analyse data from a randomised, controlled study of prandial insulin aspart versus human insulin, both with NPH insulin, in pregnant women with type 1 diabetes for potential factors predicting poor pregnancy outcomes. RESEARCH DESIGN/METHOD: Post hoc analysis including 91 subjects randomised prior to pregnancy with known outcome in early pregnancy and 259 subjects randomised prior to pregnancy/during pregnancy of \u003c10 weeks' gestation with known late-pregnancy outcomes. Poor early-pregnancy outcomes included fetal loss \u003c22 gestational weeks and/or congenital malformation (n=18). Poor late-pregnancy outcomes included: composite endpoint including pre-eclampsia, preterm delivery and perinatal death (n=78); preterm delivery (n=63); and excessive fetal growth (n=88).\nRESULTS: 18 patients experienced a malformed/lost fetus in early pregnancy - none preceded by severe hypoglycaemia. Albuminuria in early pregnancy was a significant predictor of poor late-pregnancy outcome (composite endpoint; p=0.012). In the third trimester, elevated HbA1c, ≥ 1 plasma glucose (PG) measurement \u003e11 mmol/L (198 mg/dL) and %PG values outside 3.9-7.0 mmol/L (70-126 mg/dL) were significant predictors of poor late-pregnancy outcomes (all p\u003c0.05).\nCONCLUSIONS: Elevated HbA1c, high glucose spikes and out-of-range %PG in the third trimester, and albuminuria in early pregnancy, are associated with poor late-pregnancy outcomes."}

    Preeclampsia-compare

    {"project":"Preeclampsia-compare","denotations":[{"id":"PD-Preeclampsia-B_T1","span":{"begin":809,"end":822},"obj":"ORPHA:275555"}],"namespaces":[{"prefix":"ORPHA","uri":"www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN\u0026Expert="}],"text":"Poor pregnancy outcome in women with type 1 diabetes is predicted by elevated HbA1c and spikes of high glucose values in the third trimester.\nOBJECTIVE: To analyse data from a randomised, controlled study of prandial insulin aspart versus human insulin, both with NPH insulin, in pregnant women with type 1 diabetes for potential factors predicting poor pregnancy outcomes. RESEARCH DESIGN/METHOD: Post hoc analysis including 91 subjects randomised prior to pregnancy with known outcome in early pregnancy and 259 subjects randomised prior to pregnancy/during pregnancy of \u003c10 weeks' gestation with known late-pregnancy outcomes. Poor early-pregnancy outcomes included fetal loss \u003c22 gestational weeks and/or congenital malformation (n=18). Poor late-pregnancy outcomes included: composite endpoint including pre-eclampsia, preterm delivery and perinatal death (n=78); preterm delivery (n=63); and excessive fetal growth (n=88).\nRESULTS: 18 patients experienced a malformed/lost fetus in early pregnancy - none preceded by severe hypoglycaemia. Albuminuria in early pregnancy was a significant predictor of poor late-pregnancy outcome (composite endpoint; p=0.012). In the third trimester, elevated HbA1c, ≥ 1 plasma glucose (PG) measurement \u003e11 mmol/L (198 mg/dL) and %PG values outside 3.9-7.0 mmol/L (70-126 mg/dL) were significant predictors of poor late-pregnancy outcomes (all p\u003c0.05).\nCONCLUSIONS: Elevated HbA1c, high glucose spikes and out-of-range %PG in the third trimester, and albuminuria in early pregnancy, are associated with poor late-pregnancy outcomes."}

    preeclampsia_genes

    {"project":"preeclampsia_genes","denotations":[{"id":"PD-PreeclampsiaGenes-B_T1","span":{"begin":217,"end":224},"obj":"HGNC:INS"},{"id":"PD-PreeclampsiaGenes-B_T2","span":{"begin":245,"end":252},"obj":"HGNC:INS"},{"id":"PD-PreeclampsiaGenes-B_T3","span":{"begin":268,"end":275},"obj":"HGNC:INS"}],"text":"Poor pregnancy outcome in women with type 1 diabetes is predicted by elevated HbA1c and spikes of high glucose values in the third trimester.\nOBJECTIVE: To analyse data from a randomised, controlled study of prandial insulin aspart versus human insulin, both with NPH insulin, in pregnant women with type 1 diabetes for potential factors predicting poor pregnancy outcomes. RESEARCH DESIGN/METHOD: Post hoc analysis including 91 subjects randomised prior to pregnancy with known outcome in early pregnancy and 259 subjects randomised prior to pregnancy/during pregnancy of \u003c10 weeks' gestation with known late-pregnancy outcomes. Poor early-pregnancy outcomes included fetal loss \u003c22 gestational weeks and/or congenital malformation (n=18). Poor late-pregnancy outcomes included: composite endpoint including pre-eclampsia, preterm delivery and perinatal death (n=78); preterm delivery (n=63); and excessive fetal growth (n=88).\nRESULTS: 18 patients experienced a malformed/lost fetus in early pregnancy - none preceded by severe hypoglycaemia. Albuminuria in early pregnancy was a significant predictor of poor late-pregnancy outcome (composite endpoint; p=0.012). In the third trimester, elevated HbA1c, ≥ 1 plasma glucose (PG) measurement \u003e11 mmol/L (198 mg/dL) and %PG values outside 3.9-7.0 mmol/L (70-126 mg/dL) were significant predictors of poor late-pregnancy outcomes (all p\u003c0.05).\nCONCLUSIONS: Elevated HbA1c, high glucose spikes and out-of-range %PG in the third trimester, and albuminuria in early pregnancy, are associated with poor late-pregnancy outcomes."}

    Zierdiyeerkenaili_800_3

    {"project":"Zierdiyeerkenaili_800_3","denotations":[{"id":"T1","span":{"begin":37,"end":52},"obj":"DP"},{"id":"T2","span":{"begin":300,"end":315},"obj":"DP"},{"id":"T3","span":{"begin":208,"end":231},"obj":"CI"},{"id":"T4","span":{"begin":239,"end":252},"obj":"CI"}],"text":"Poor pregnancy outcome in women with type 1 diabetes is predicted by elevated HbA1c and spikes of high glucose values in the third trimester.\nOBJECTIVE: To analyse data from a randomised, controlled study of prandial insulin aspart versus human insulin, both with NPH insulin, in pregnant women with type 1 diabetes for potential factors predicting poor pregnancy outcomes. RESEARCH DESIGN/METHOD: Post hoc analysis including 91 subjects randomised prior to pregnancy with known outcome in early pregnancy and 259 subjects randomised prior to pregnancy/during pregnancy of \u003c10 weeks' gestation with known late-pregnancy outcomes. Poor early-pregnancy outcomes included fetal loss \u003c22 gestational weeks and/or congenital malformation (n=18). Poor late-pregnancy outcomes included: composite endpoint including pre-eclampsia, preterm delivery and perinatal death (n=78); preterm delivery (n=63); and excessive fetal growth (n=88).\nRESULTS: 18 patients experienced a malformed/lost fetus in early pregnancy - none preceded by severe hypoglycaemia. Albuminuria in early pregnancy was a significant predictor of poor late-pregnancy outcome (composite endpoint; p=0.012). In the third trimester, elevated HbA1c, ≥ 1 plasma glucose (PG) measurement \u003e11 mmol/L (198 mg/dL) and %PG values outside 3.9-7.0 mmol/L (70-126 mg/dL) were significant predictors of poor late-pregnancy outcomes (all p\u003c0.05).\nCONCLUSIONS: Elevated HbA1c, high glucose spikes and out-of-range %PG in the third trimester, and albuminuria in early pregnancy, are associated with poor late-pregnancy outcomes."}

    yaoziqian_800_3

    {"project":"yaoziqian_800_3","denotations":[{"id":"T2","span":{"begin":208,"end":231},"obj":"CI"},{"id":"T3","span":{"begin":239,"end":252},"obj":"CI"},{"id":"T4","span":{"begin":300,"end":315},"obj":"DP"},{"id":"T5","span":{"begin":37,"end":52},"obj":"DP"}],"text":"Poor pregnancy outcome in women with type 1 diabetes is predicted by elevated HbA1c and spikes of high glucose values in the third trimester.\nOBJECTIVE: To analyse data from a randomised, controlled study of prandial insulin aspart versus human insulin, both with NPH insulin, in pregnant women with type 1 diabetes for potential factors predicting poor pregnancy outcomes. RESEARCH DESIGN/METHOD: Post hoc analysis including 91 subjects randomised prior to pregnancy with known outcome in early pregnancy and 259 subjects randomised prior to pregnancy/during pregnancy of \u003c10 weeks' gestation with known late-pregnancy outcomes. Poor early-pregnancy outcomes included fetal loss \u003c22 gestational weeks and/or congenital malformation (n=18). Poor late-pregnancy outcomes included: composite endpoint including pre-eclampsia, preterm delivery and perinatal death (n=78); preterm delivery (n=63); and excessive fetal growth (n=88).\nRESULTS: 18 patients experienced a malformed/lost fetus in early pregnancy - none preceded by severe hypoglycaemia. Albuminuria in early pregnancy was a significant predictor of poor late-pregnancy outcome (composite endpoint; p=0.012). In the third trimester, elevated HbA1c, ≥ 1 plasma glucose (PG) measurement \u003e11 mmol/L (198 mg/dL) and %PG values outside 3.9-7.0 mmol/L (70-126 mg/dL) were significant predictors of poor late-pregnancy outcomes (all p\u003c0.05).\nCONCLUSIONS: Elevated HbA1c, high glucose spikes and out-of-range %PG in the third trimester, and albuminuria in early pregnancy, are associated with poor late-pregnancy outcomes."}