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PubMed:23685310 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 124-133 HP_0009792 denotes teratomas
T2 208-217 HP_0009792 denotes teratomas
T3 316-331 HP_0100028 denotes ectopic thyroid
T4 450-463 HP_0003006 denotes neuroblastoma
T5 528-537 HP_0009792 denotes teratomas

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-34 Sentence denotes Mediastinal teratomas in children.
TextSentencer_T2 35-77 Sentence denotes Case reports and review of the literature.
TextSentencer_T3 78-89 Sentence denotes BACKGROUND:
TextSentencer_T4 90-218 Sentence denotes In the pediatric age, mediastinal teratomas are an infrequent observation, accounting for only 7%-11% of extragonadal teratomas.
TextSentencer_T5 219-464 Sentence denotes Mainly located in the anterior mediastinum arising from the thymic gland, or exceptionally, from ectopic thyroid tissue, they may rarely be observed in the posterior mediastinum, sometimes in a paravertebral position, simulating a neuroblastoma.
TextSentencer_T6 465-619 Sentence denotes The Authors have extrapolated, from their entire experience of teratomas, 3 cases, mostly operated as emergencies; 1 of them was treated just after birth.
TextSentencer_T7 620-851 Sentence denotes Aim of this paper is to report the clinical and pathologic findings, to evaluate the surgical approach and the long-term biological behaviour in these cases, in the light of survival and current insights reported in the literature.
TextSentencer_T8 852-874 Sentence denotes MATERIALS AND METHODS:
TextSentencer_T9 875-1164 Sentence denotes The Authors reviewed the most significant clinical, laboratory, radiologic and pathologic findings, surgical procedures, and early and long-term results in 3 children, 2 males and 1 female, suffering from extragonadal teratomas, located in the mediastinum, treated immediately after birth.
TextSentencer_T10 1165-1276 Sentence denotes In 1 of them the lesion was prenatally diagnosed by US scanning between the 2nd and 3rd trimester of pregnancy.
TextSentencer_T11 1277-1461 Sentence denotes All the infants were born by scheduled caesarean section in a tertiary care hospital and were then immediately referred to the N.I.C.U. because of a mostly acute clinical presentation.
TextSentencer_T12 1462-1584 Sentence denotes The 3 patients were referred to the surgical unit at different ages, namely 2 days, 10 years and 12.5 years, respectively.
TextSentencer_T13 1585-1684 Sentence denotes The initial clinical presentation was consistent with the site of the mass and/or its side-effects.
TextSentencer_T14 1685-1878 Sentence denotes The first patient, a female newborn, presented a worsening condition of respiratory distress, immediately after birth, that required mechanical ventilation and stabilization of the vital signs.
TextSentencer_T15 1879-1917 Sentence denotes Likewise, the presentation of case No.
TextSentencer_T16 1918-1986 Sentence denotes 2 was acute with dyspnea associated with an upper airways infection.
TextSentencer_T17 1987-2028 Sentence denotes Instead, the initial symptoms in case No.
TextSentencer_T18 2029-2159 Sentence denotes 3 were subacute and non-specific, characterized by worsening pain at the right shoulder extending to the neck and homolateral arm.
TextSentencer_T19 2160-2335 Sentence denotes The patients underwent laboratory and radiologic investigations that confirmed the clinical diagnosis of teratoma on the basis of elevated AFP values in 2 cases only (Case No.
TextSentencer_T20 2336-2345 Sentence denotes 1 and No.
TextSentencer_T21 2346-2413 Sentence denotes 2), while calcifications were lacking at imaging in all 3 patients.
TextSentencer_T22 2414-2539 Sentence denotes Emergency surgical management was required and, in accordance with recommended practice, the procedure was complete exeresis.
TextSentencer_T23 2540-2548 Sentence denotes RESULTS:
TextSentencer_T24 2549-2727 Sentence denotes All the patients underwent close long-term clinical, laboratory and imaging surveillance at shorter intervals during the first 5 years after the exeresis and annually thereafter.
TextSentencer_T25 2728-2892 Sentence denotes At the present time they are alive, disease-free and have not suffered any recurrence and/or distant metastases, with a follow-up of 7, 30 and 3 years respectively.
TextSentencer_T26 2893-2905 Sentence denotes CONCLUSIONS:
TextSentencer_T27 2906-2983 Sentence denotes Some extragonadal teratomas of childhood may rarely arise in the mediastinum.
TextSentencer_T28 2984-3308 Sentence denotes Being congenital tumors, prenatal diagnosis by US scan is extremely important in order to organize proper perinatal care in appropriate facilities where it is possible to define the diagnosis, and equipped with appropriate tools to carry out emergency surgery at minimal risk and to prevent severe complications after birth.
TextSentencer_T29 3309-3503 Sentence denotes An emergency procedure is frequently dictated both by complications related to the mass effect, and by the need to define the histology of the whole mass rather than just small biopsy specimens.
TextSentencer_T30 3504-3638 Sentence denotes Some teratomas can hide more or less extensive islands of immaturity or signs of malignant transformation that are clinically evident.
TextSentencer_T31 3639-3843 Sentence denotes It should be noted that calcifications and high levels of AFP and/or beta-HCG, usually pathognomonic elements for diagnosis, may not always be evident during the diagnostic work-up in mediastinal lesions.
TextSentencer_T32 3844-4118 Sentence denotes The prognosis is generally benign, although the AIEOP 2004 guidelines pointed out that high levels of circulating markers, including AFP, in children affected by mature or immature teratomas would indicate the presence of micro-foci of YST, marking them out as at high risk.
TextSentencer_T33 4119-4432 Sentence denotes The UKCCSG II and the SFOP indicated AFP values exceeding 10,000 ng / ml as the threshold identifying a group of patients with a severe prognosis.The treatment indicated is early, complete exeresis, followed by a careful, extensive microscopic examination and associated, if necessary, with adjuvant chemotherapy.
TextSentencer_T34 4433-4625 Sentence denotes Finally, in accordance with recommended practice, close, long-term clinical, laboratory and imaging surveillance is necessary, at shorter intervals during the first 5 years after the exeresis.
T1 0-34 Sentence denotes Mediastinal teratomas in children.
T2 35-77 Sentence denotes Case reports and review of the literature.
T3 78-89 Sentence denotes BACKGROUND:
T4 90-218 Sentence denotes In the pediatric age, mediastinal teratomas are an infrequent observation, accounting for only 7%-11% of extragonadal teratomas.
T5 219-464 Sentence denotes Mainly located in the anterior mediastinum arising from the thymic gland, or exceptionally, from ectopic thyroid tissue, they may rarely be observed in the posterior mediastinum, sometimes in a paravertebral position, simulating a neuroblastoma.
T6 465-619 Sentence denotes The Authors have extrapolated, from their entire experience of teratomas, 3 cases, mostly operated as emergencies; 1 of them was treated just after birth.
T7 620-851 Sentence denotes Aim of this paper is to report the clinical and pathologic findings, to evaluate the surgical approach and the long-term biological behaviour in these cases, in the light of survival and current insights reported in the literature.
T8 852-874 Sentence denotes MATERIALS AND METHODS:
T9 875-1164 Sentence denotes The Authors reviewed the most significant clinical, laboratory, radiologic and pathologic findings, surgical procedures, and early and long-term results in 3 children, 2 males and 1 female, suffering from extragonadal teratomas, located in the mediastinum, treated immediately after birth.
T10 1165-1276 Sentence denotes In 1 of them the lesion was prenatally diagnosed by US scanning between the 2nd and 3rd trimester of pregnancy.
T11 1277-1461 Sentence denotes All the infants were born by scheduled caesarean section in a tertiary care hospital and were then immediately referred to the N.I.C.U. because of a mostly acute clinical presentation.
T12 1462-1584 Sentence denotes The 3 patients were referred to the surgical unit at different ages, namely 2 days, 10 years and 12.5 years, respectively.
T13 1585-1684 Sentence denotes The initial clinical presentation was consistent with the site of the mass and/or its side-effects.
T14 1685-1878 Sentence denotes The first patient, a female newborn, presented a worsening condition of respiratory distress, immediately after birth, that required mechanical ventilation and stabilization of the vital signs.
T15 1879-1917 Sentence denotes Likewise, the presentation of case No.
T16 1918-1986 Sentence denotes 2 was acute with dyspnea associated with an upper airways infection.
T17 1987-2028 Sentence denotes Instead, the initial symptoms in case No.
T18 2029-2159 Sentence denotes 3 were subacute and non-specific, characterized by worsening pain at the right shoulder extending to the neck and homolateral arm.
T19 2160-2335 Sentence denotes The patients underwent laboratory and radiologic investigations that confirmed the clinical diagnosis of teratoma on the basis of elevated AFP values in 2 cases only (Case No.
T20 2336-2345 Sentence denotes 1 and No.
T21 2346-2413 Sentence denotes 2), while calcifications were lacking at imaging in all 3 patients.
T22 2414-2539 Sentence denotes Emergency surgical management was required and, in accordance with recommended practice, the procedure was complete exeresis.
T23 2540-2548 Sentence denotes RESULTS:
T24 2549-2727 Sentence denotes All the patients underwent close long-term clinical, laboratory and imaging surveillance at shorter intervals during the first 5 years after the exeresis and annually thereafter.
T25 2728-2892 Sentence denotes At the present time they are alive, disease-free and have not suffered any recurrence and/or distant metastases, with a follow-up of 7, 30 and 3 years respectively.
T26 2893-2905 Sentence denotes CONCLUSIONS:
T27 2906-2983 Sentence denotes Some extragonadal teratomas of childhood may rarely arise in the mediastinum.
T28 2984-3308 Sentence denotes Being congenital tumors, prenatal diagnosis by US scan is extremely important in order to organize proper perinatal care in appropriate facilities where it is possible to define the diagnosis, and equipped with appropriate tools to carry out emergency surgery at minimal risk and to prevent severe complications after birth.
T29 3309-3503 Sentence denotes An emergency procedure is frequently dictated both by complications related to the mass effect, and by the need to define the histology of the whole mass rather than just small biopsy specimens.
T30 3504-3638 Sentence denotes Some teratomas can hide more or less extensive islands of immaturity or signs of malignant transformation that are clinically evident.
T31 3639-3843 Sentence denotes It should be noted that calcifications and high levels of AFP and/or beta-HCG, usually pathognomonic elements for diagnosis, may not always be evident during the diagnostic work-up in mediastinal lesions.
T32 3844-4118 Sentence denotes The prognosis is generally benign, although the AIEOP 2004 guidelines pointed out that high levels of circulating markers, including AFP, in children affected by mature or immature teratomas would indicate the presence of micro-foci of YST, marking them out as at high risk.
T33 4119-4432 Sentence denotes The UKCCSG II and the SFOP indicated AFP values exceeding 10,000 ng / ml as the threshold identifying a group of patients with a severe prognosis.The treatment indicated is early, complete exeresis, followed by a careful, extensive microscopic examination and associated, if necessary, with adjuvant chemotherapy.
T34 4433-4625 Sentence denotes Finally, in accordance with recommended practice, close, long-term clinical, laboratory and imaging surveillance is necessary, at shorter intervals during the first 5 years after the exeresis.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 241-261 http://purl.obolibrary.org/obo/UBERON_0008820 denotes anterior mediastinum
PD-UBERON-AE-B_T2 250-261 http://purl.obolibrary.org/obo/UBERON_0003728 denotes mediastinum
PD-UBERON-AE-B_T3 385-396 http://purl.obolibrary.org/obo/UBERON_0003728 denotes mediastinum
PD-UBERON-AE-B_T4 1119-1130 http://purl.obolibrary.org/obo/UBERON_0003728 denotes mediastinum
PD-UBERON-AE-B_T5 2971-2982 http://purl.obolibrary.org/obo/UBERON_0003728 denotes mediastinum
PD-UBERON-AE-B_T6 286-291 http://purl.obolibrary.org/obo/UBERON_0002530 denotes gland
PD-UBERON-AE-B_T7 332-338 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T8 375-396 http://purl.obolibrary.org/obo/UBERON_0008822 denotes posterior mediastinum
PD-UBERON-AE-B_T9 2108-2116 http://purl.obolibrary.org/obo/UBERON_0001467 denotes shoulder
PD-UBERON-AE-B_T10 2134-2138 http://purl.obolibrary.org/obo/UBERON_0000974 denotes neck
PD-UBERON-AE-B_T11 2155-2158 http://purl.obolibrary.org/obo/UBERON_0001460 denotes arm
PD-UBERON-AE-B_T12 3074-3082 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organize
PD-UBERON-AE-B_T13 3541-3550 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive
PD-UBERON-AE-B_T14 4341-4350 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive

PubCasesHPO

Id Subject Object Predicate Lexical cue
TI1 0-21 HP:0030741 denotes Mediastinal teratomas
AB1 112-133 HP:0030741 denotes mediastinal teratomas
AB2 208-217 HP:0009792 denotes teratomas
AB3 316-331 HP:0100028 denotes ectopic thyroid
AB4 450-463 HP:0003006 denotes neuroblastoma
AB5 528-537 HP:0009792 denotes teratomas
AB6 1093-1102 HP:0009792 denotes teratomas
AB7 1757-1777 HP:0002098 denotes respiratory distress
AB8 1935-1942 HP:0002094 denotes dyspnea
AB9 2090-2094 HP:0012531 denotes pain
AB10 2265-2273 HP:0009792 denotes teratoma
AB11 2924-2933 HP:0009792 denotes teratomas
AB12 3509-3518 HP:0009792 denotes teratomas
AB13 4025-4034 HP:0009792 denotes teratomas

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 195-217 ORDO:883 denotes extragonadal teratomas
AB2 450-463 ORDO:635 denotes neuroblastoma
AB3 1080-1102 ORDO:883 denotes extragonadal teratomas
AB4 2911-2933 ORDO:883 denotes extragonadal teratomas

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 3541-3550 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive
PD-UBERON-AE-B_T2 4341-4350 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive
PD-UBERON-AE-B_T3 2155-2158 http://purl.obolibrary.org/obo/UBERON_0001460 denotes arm
PD-UBERON-AE-B_T4 332-338 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T5 2134-2138 http://purl.obolibrary.org/obo/UBERON_0000974 denotes neck
PD-UBERON-AE-B_T6 3074-3082 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organize
PD-UBERON-AE-B_T7 241-261 http://purl.obolibrary.org/obo/UBERON_0008820 denotes anterior mediastinum
PD-UBERON-AE-B_T8 250-261 http://purl.obolibrary.org/obo/UBERON_0003728 denotes mediastinum
PD-UBERON-AE-B_T9 385-396 http://purl.obolibrary.org/obo/UBERON_0003728 denotes mediastinum
PD-UBERON-AE-B_T10 1119-1130 http://purl.obolibrary.org/obo/UBERON_0003728 denotes mediastinum
PD-UBERON-AE-B_T11 2971-2982 http://purl.obolibrary.org/obo/UBERON_0003728 denotes mediastinum
PD-UBERON-AE-B_T12 286-291 http://purl.obolibrary.org/obo/UBERON_0002530 denotes gland
PD-UBERON-AE-B_T13 375-396 http://purl.obolibrary.org/obo/UBERON_0008822 denotes posterior mediastinum
PD-UBERON-AE-B_T14 2108-2116 http://purl.obolibrary.org/obo/UBERON_0001467 denotes shoulder