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sonoma2

Id Subject Object Predicate Lexical cue
T0 0-6 VAR denotes Mutant
T1 7-10 GENE denotes p53
T2 11-19 POSREG denotes prolongs
T3 41-49 POSREG denotes promotes
T4 50-70 CPA denotes chronic inflammation
T5 62-74 DISEASE denotes ammation and
T6 75-116 DISEASE denotes inflammation-associated colorectal cancer
T7 79-102 DISEASE denotes ammation-associated col
T8 103-120 DISEASE denotes rectal cancer. Th
T9 126-131 DISEASE denotes r sup
T10 139-142 GENE denotes p53
T11 143-146 GENE denotes is
T12 157-164 VAR denotes mutated
T13 178-184 DISEASE denotes er. Co
T14 189-195 VAR denotes mutant
T15 196-199 GENE denotes p53
T16 200-203 GENE denotes (mu
T17 201-207 GENE denotes mutp53
T18 231-238 POSREG denotes promote
T19 239-245 DISEASE denotes cancer
T22 272-275 POSREG denotes GOF
T20 243-249 DISEASE denotes er thr
T21 254-270 POSREG denotes gain-of-function
T23 304-310 VAR denotes mutp53
T24 311-319 POSREG denotes prolongs
T25 320-350 MPA denotes TNF-α-induced NF-κB activation
T26 324-341 GENE denotes α-induced NF-κB a
T27 481-484 GENE denotes p53
T28 485-493 VAR denotes mutation
T29 493-496 GENE denotes de
T30 494-501 REG denotes develop
T31 509-529 CPA denotes chronic inflammation
T32 529-541 DISEASE denotes and persist
T33 545-558 CPA denotes tissue damage
T34 596-619 DISEASE denotes -associated colon cance
T35 608-620 DISEASE denotes colon cancer
T36 620-632 DISEASE denotes . This mutp5
T37 634-637 POSREG denotes GOF
T38 641-651 REG denotes manifested
T39 682-705 DISEASE denotes tic lesions that progre
T40 699-707 REG denotes progress
T41 723-741 DISEASE denotes cinoma with mutp53
T42 735-741 GENE denotes mutp53
T43 742-754 POSREG denotes accumulation
T44 759-768 POSREG denotes augmented
T45 775-785 MPA denotes activation
T46 867-885 DISEASE denotes ed colorectal canc
T47 886-903 DISEASE denotes r (CAC). These fi
T48 889-892 DISEASE denotes CAC
T49 948-951 GENE denotes p53
T50 952-961 VAR denotes mutations
T51 964-967 GENE denotes hu
T52 971-974 DISEASE denotes CAC
R5 T10 T12 ThemeOf p53,mutated
R6 T14 T18 CauseOf mutant,promote
R7 T14 T21 CauseOf mutant,gain-of-function
R8 T14 T22 CauseOf mutant,GOF
R9 T15 T14 ThemeOf p53,mutant
R10 T15 T17 ThemeOf p53,mutp53
R11 T17 T14 ThemeOf mutp53,mutant
R12 T17 T18 CauseOf mutp53,promote
R13 T17 T21 CauseOf mutp53,gain-of-function
R14 T21 T18 CauseOf gain-of-function,promote
R15 T19 T18 ThemeOf cancer,promote
R16 T19 T21 ThemeOf cancer,gain-of-function
R17 T19 T22 ThemeOf cancer,GOF
R18 T22 T21 CauseOf GOF,gain-of-function
R19 T22 T18 CauseOf GOF,promote
R20 T23 T24 CauseOf mutp53,prolongs
R21 T25 T24 ThemeOf TNF-α-induced NF-κB activation,prolongs
R22 T27 T28 ThemeOf p53,mutation
R23 T28 T30 CauseOf mutation,develop
R24 T28 T31 CauseOf mutation,chronic inflammation
R25 T28 T33 CauseOf mutation,tissue damage
R26 T31 T30 ThemeOf chronic inflammation,develop
R27 T37 T38 CauseOf GOF,manifested
R28 T37 T40 CauseOf GOF,progress
R29 T42 T43 ThemeOf mutp53,accumulation
R30 T43 T40 CauseOf accumulation,progress
R31 T43 T44 CauseOf accumulation,augmented
R32 T45 T44 ThemeOf activation,augmented
R33 T48 T38 ThemeOf CAC,manifested
R34 T48 T44 ThemeOf CAC,augmented
R35 T48 T45 ThemeOf CAC,activation
R0 T0 T2 CauseOf Mutant,prolongs
R1 T0 T3 CauseOf Mutant,promotes
R2 T1 T0 ThemeOf p53,Mutant
R3 T4 T3 ThemeOf chronic inflammation,promotes
R4 T6 T3 ThemeOf inflammation-associated colorectal cancer,promotes
R36 T49 T50 ThemeOf p53,mutations

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-117 Sentence denotes Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.
T2 118-181 Sentence denotes The tumor suppressor p53 is frequently mutated in human cancer.
T3 182-288 Sentence denotes Common mutant p53 (mutp53) isoforms can actively promote cancer through gain-of-function (GOF) mechanisms.
T4 289-402 Sentence denotes We report that mutp53 prolongs TNF-α-induced NF-κB activation in cultured cells and intestinal organoid cultures.
T5 403-621 Sentence denotes Remarkably, when exposed to dextran sulfate sodium, mice harboring a germline p53 mutation develop severe chronic inflammation and persistent tissue damage, and are highly prone to inflammation-associated colon cancer.
T6 622-894 Sentence denotes This mutp53 GOF is manifested by rapid onset of flat dysplastic lesions that progress to invasive carcinoma with mutp53 accumulation and augmented NF-κB activation, faithfully recapitulating features frequently observed in human colitis-associated colorectal cancer (CAC).
T7 895-975 Sentence denotes These findings might explain the early appearance of p53 mutations in human CAC.
T1 0-117 Sentence denotes Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.
T2 118-181 Sentence denotes The tumor suppressor p53 is frequently mutated in human cancer.
T3 182-288 Sentence denotes Common mutant p53 (mutp53) isoforms can actively promote cancer through gain-of-function (GOF) mechanisms.
T4 289-402 Sentence denotes We report that mutp53 prolongs TNF-α-induced NF-κB activation in cultured cells and intestinal organoid cultures.
T5 403-621 Sentence denotes Remarkably, when exposed to dextran sulfate sodium, mice harboring a germline p53 mutation develop severe chronic inflammation and persistent tissue damage, and are highly prone to inflammation-associated colon cancer.
T6 622-894 Sentence denotes This mutp53 GOF is manifested by rapid onset of flat dysplastic lesions that progress to invasive carcinoma with mutp53 accumulation and augmented NF-κB activation, faithfully recapitulating features frequently observed in human colitis-associated colorectal cancer (CAC).
T7 895-975 Sentence denotes These findings might explain the early appearance of p53 mutations in human CAC.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 7-10 gene:7157 denotes p53
T1 99-116 disease:C0009402 denotes colorectal cancer
T2 7-10 gene:7157 denotes p53
T3 99-116 disease:C1527249 denotes colorectal cancer
T4 20-25 gene:4790 denotes NF-κB
T5 99-116 disease:C0009402 denotes colorectal cancer
T6 20-25 gene:4790 denotes NF-κB
T7 99-116 disease:C1527249 denotes colorectal cancer
R1 T0 T1 associated_with p53,colorectal cancer
R2 T2 T3 associated_with p53,colorectal cancer
R3 T4 T5 associated_with NF-κB,colorectal cancer
R4 T6 T7 associated_with NF-κB,colorectal cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_23680148_2_0 189-199 expanded denotes mutant p53
SS2_23680148_2_0 201-207 abbr denotes mutp53
SS1_23680148_2_1 254-270 expanded denotes gain-of-function
SS2_23680148_2_1 272-275 abbr denotes GOF
SS1_23680148_5_0 851-887 expanded denotes colitis-associated colorectal cancer
SS2_23680148_5_0 889-892 abbr denotes CAC
AE1_23680148_2_0 SS1_23680148_2_0 SS2_23680148_2_0 abbreviatedTo mutant p53,mutp53
AE1_23680148_2_1 SS1_23680148_2_1 SS2_23680148_2_1 abbreviatedTo gain-of-function,GOF
AE1_23680148_5_0 SS1_23680148_5_0 SS2_23680148_5_0 abbreviatedTo colitis-associated colorectal cancer,CAC

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 122-127 HP_0002664 denotes tumor
T2 174-180 HP_0002664 denotes cancer
T3 239-245 HP_0002664 denotes cancer
T4 608-620 HP_0003003 denotes colon cancer
T5 608-620 HP_0100273 denotes colon cancer
T6 614-620 HP_0002664 denotes cancer
T7 881-887 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23680148-0#7#10#gene7157 7-10 gene7157 denotes p53
23680148-0#20#25#gene4790 20-25 gene4790 denotes NF-κB
23680148-0#99#116#diseaseC0009402 99-116 diseaseC0009402 denotes colorectal cancer
23680148-0#99#116#diseaseC1527249 99-116 diseaseC1527249 denotes colorectal cancer
23680148-0#99#116#diseaseC0009402 99-116 diseaseC0009402 denotes colorectal cancer
23680148-0#99#116#diseaseC1527249 99-116 diseaseC1527249 denotes colorectal cancer
23680148-4#78#81#gene7157 481-484 gene7157 denotes p53
23680148-4#78#81#gene7157 481-484 gene7157 denotes p53
23680148-4#205#217#diseaseC0007102 608-620 diseaseC0007102 denotes colon cancer
23680148-4#205#217#diseaseC0699790 608-620 diseaseC0699790 denotes colon cancer
23680148-4#131#141#diseaseC0332996 534-544 diseaseC0332996 denotes persistent
23680148-5#147#152#gene4790 769-774 gene4790 denotes NF-κB
23680148-5#89#107#diseaseC1334274 711-729 diseaseC1334274 denotes invasive carcinoma
23680148-5#229#236#diseaseC0009319 851-858 diseaseC0009319 denotes colitis
7#10#gene715799#116#diseaseC0009402 23680148-0#7#10#gene7157 23680148-0#99#116#diseaseC0009402 associated_with p53,colorectal cancer
7#10#gene715799#116#diseaseC1527249 23680148-0#7#10#gene7157 23680148-0#99#116#diseaseC1527249 associated_with p53,colorectal cancer
7#10#gene715799#116#diseaseC0009402 23680148-0#7#10#gene7157 23680148-0#99#116#diseaseC0009402 associated_with p53,colorectal cancer
7#10#gene715799#116#diseaseC1527249 23680148-0#7#10#gene7157 23680148-0#99#116#diseaseC1527249 associated_with p53,colorectal cancer
20#25#gene479099#116#diseaseC0009402 23680148-0#20#25#gene4790 23680148-0#99#116#diseaseC0009402 associated_with NF-κB,colorectal cancer
20#25#gene479099#116#diseaseC1527249 23680148-0#20#25#gene4790 23680148-0#99#116#diseaseC1527249 associated_with NF-κB,colorectal cancer
20#25#gene479099#116#diseaseC0009402 23680148-0#20#25#gene4790 23680148-0#99#116#diseaseC0009402 associated_with NF-κB,colorectal cancer
20#25#gene479099#116#diseaseC1527249 23680148-0#20#25#gene4790 23680148-0#99#116#diseaseC1527249 associated_with NF-κB,colorectal cancer
78#81#gene7157205#217#diseaseC0007102 23680148-4#78#81#gene7157 23680148-4#205#217#diseaseC0007102 associated_with p53,colon cancer
78#81#gene7157205#217#diseaseC0699790 23680148-4#78#81#gene7157 23680148-4#205#217#diseaseC0699790 associated_with p53,colon cancer
78#81#gene7157131#141#diseaseC0332996 23680148-4#78#81#gene7157 23680148-4#131#141#diseaseC0332996 associated_with p53,persistent
78#81#gene7157205#217#diseaseC0007102 23680148-4#78#81#gene7157 23680148-4#205#217#diseaseC0007102 associated_with p53,colon cancer
78#81#gene7157205#217#diseaseC0699790 23680148-4#78#81#gene7157 23680148-4#205#217#diseaseC0699790 associated_with p53,colon cancer
78#81#gene7157131#141#diseaseC0332996 23680148-4#78#81#gene7157 23680148-4#131#141#diseaseC0332996 associated_with p53,persistent
147#152#gene479089#107#diseaseC1334274 23680148-5#147#152#gene4790 23680148-5#89#107#diseaseC1334274 associated_with NF-κB,invasive carcinoma
147#152#gene4790229#236#diseaseC0009319 23680148-5#147#152#gene4790 23680148-5#229#236#diseaseC0009319 associated_with NF-κB,colitis

kaiyin_test

Id Subject Object Predicate Lexical cue
T17 699-707 PosReg denotes progress
T19 711-729 Disease denotes invasive carcinoma
T20 735-741 Var denotes mutp53
T21 742-754 PosReg denotes accumulation
T22 769-774 Protein denotes NF-κB
T23 775-785 PosReg denotes activation
T24 851-887 Disease denotes colitis-associated colorectal cancer
R13 T20 T21 CauseOf mutp53,accumulation
R14 T22 T23 CauseOf NF-κB,activation
R15 T23 T17 CauseOf activation,progress
R16 T19 T17 ThemeOf invasive carcinoma,progress
R17 T21 T17 CauseOf accumulation,progress
R20 T20 T23 CauseOf mutp53,activation
R21 T24 T17 ThemeOf colitis-associated colorectal cancer,progress

name_no

Id Subject Object Predicate Lexical cue
T17 699-707 PosReg denotes progress
T19 711-729 Disease denotes invasive carcinoma
T20 735-741 Var denotes mutp53
T21 742-754 PosReg denotes accumulation
T22 769-774 Protein denotes NF-κB
T23 775-785 PosReg denotes activation
T24 851-887 Disease denotes colitis-associated colorectal cancer
R13 T20 T21 CauseOf mutp53,accumulation
R14 T22 T23 CauseOf NF-κB,activation
R15 T23 T17 CauseOf activation,progress
R16 T19 T17 ThemeOf invasive carcinoma,progress
R17 T21 T17 CauseOf accumulation,progress
R20 T20 T23 CauseOf mutp53,activation
R21 T24 T17 ThemeOf colitis-associated colorectal cancer,progress